A 12-month lifestyle intervention does not improve cardiac autonomic function in patients with chronic kidney disease

Journal article


Huppertz, Nina, Beetham, Kassia S., Howden, Erin J., Leicht, Anthony S., Isbel, Nicole M. and Coombes, Jeff S.. (2020) A 12-month lifestyle intervention does not improve cardiac autonomic function in patients with chronic kidney disease. Autonomic Neuroscience: Basic and Clinical. 224, pp. 1 - 6. https://doi.org/10.1016/j.autneu.2020.102642
AuthorsHuppertz, Nina, Beetham, Kassia S., Howden, Erin J., Leicht, Anthony S., Isbel, Nicole M. and Coombes, Jeff S.
Abstract

Objectives Patients with chronic kidney disease (CKD) are at a high risk of future autonomic dysfunction and cardiovascular disease. The aim of this study was to examine the effects of a 12-month lifestyle intervention (LI) involving regular aerobic exercise on cardiac autonomic function in CKD patients. Design Pooled exploratory analysis. Methods 113 eligible patients with stage 3–4 CKD (eGFR 25–60 ml/min/1.75m2) participated in a LI program, including an 8-week individualised gym-based exercise program followed by a 10-month home-based program. The control (CON) group underwent standard nephrological care. The following parameters were assessed prior to and following the 12-month study period: cardiorespiratory fitness (VO2peak) from a graded exercise test; cardiac autonomic function from time, frequency, and non-linear measures of heart rate variability (HRV), heart rate (HR) recovery following peak exercise, and chronotropic competence during exercise. Results Compared to the CON group, the LI group significantly increased VO2peak (CON = -1.0 vs. LI = +1.8 ml/kg/min, p < 0.01) while there was no significant improvement in any HRV measure (p = 0.85), HR recovery (p = 0.38) or chronotropic competence (p = 0.28). Changes in relative VO2peak were significantly associated with changes in a non-linear HRV measure, α1 (p < 0.01), independent of age and eGFR (r2 = 0.196, p = 0.03). Conclusions Despite the significant increase in cardiorespiratory fitness for the LI group, there were no changes in cardiac autonomic function. However, α1 may be a sensitive measure to assess VO2peak changes in this clinical cohort. Further research is required to investigate the role of different modalities of exercise training to enhance cardiac autonomic function in patients with CKD.

Keywordsautonomic dysfunction; heart rate variability; heart rate recovery; heart rate reserve; exercise; renal insufficiency
Year2020
JournalAutonomic Neuroscience: Basic and Clinical
Journal citation224, pp. 1 - 6
PublisherElsevier BV
ISSN1566-0702
Digital Object Identifier (DOI)https://doi.org/10.1016/j.autneu.2020.102642
Scopus EID2-s2.0-85079056766
Page range1 - 6
Research GroupSports Performance, Recovery, Injury and New Technologies (SPRINT) Research Centre
Publisher's version
File Access Level
Controlled
Place of publicationNetherlands
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