High-intensity interval training in chronic kidney disease: A randomized pilot study

Journal article


Beetham, Kassia S., Howden, Erin J., Fassett, Robert G., Petersen, Aaron, Trewin, Adam J., Isbel, Nicole M. and Coombes, Jeff S.. (2019). High-intensity interval training in chronic kidney disease: A randomized pilot study. Scandinavian Journal of Medicine & Science in Sports. 29(8), pp. 1197 - 1204. https://doi.org/10.1111/sms.13436
AuthorsBeetham, Kassia S., Howden, Erin J., Fassett, Robert G., Petersen, Aaron, Trewin, Adam J., Isbel, Nicole M. and Coombes, Jeff S.
Abstract

Introduction High‐intensity interval training (HIIT) increases mitochondrial biogenesis and cardiorespiratory fitness in chronic disease populations, however has not been studied in people with chronic kidney disease (CKD). The aim of this study was to compare the feasibility, safety, and efficacy of HIIT with moderate‐intensity continuous training (MICT) in people with CKD. Methods Fourteen individuals with stage 3‐4 CKD were randomized to 3 supervised sessions/wk for 12 weeks, of HIIT (n = 9, 4 × 4 minute intervals, 80%‐95% peak heart rate [PHR]) or MICT (n = 5, 40 minutes, 65% PHR). Feasibility was assessed via session attendance and adherence to the exercise intensity. Safety was examined by adverse event reporting. Efficacy was determined from changes in cardiorespiratory fitness (VO2peak), exercise capacity (METs), and markers of mitochondrial biogenesis (PGC1α protein levels), muscle protein catabolism (MuRF1), and muscle protein synthesis (p‐P70S6k Thr389). Results Participants completed a similar number of sessions in each group (HIIT = 33.0[7.0] vs MICT = 33.5[3.3] sessions), and participants adhered to the target heart rates. There were no adverse events attributable to exercise training. There was a significant time effect for exercise capacity (HIIT = +0.8 ± 1.2; MICT = +1.3 ± 1.6 METs; P = 0.01) and muscle protein synthesis (HIIT = +0.6 ± 1.1; MICT = +1.4 ± 1.7 au; P = 0.04). However, there were no significant (P > 0.05) group × time effects for any outcomes. Conclusion This pilot study demonstrated that HIIT is a feasible and safe option for people with CKD, and there were similar benefits of HIIT and MICT on exercise capacity and skeletal muscle protein synthesis. These data support a larger trial to further evaluate the effectiveness of HIIT.

Keywordshigh‐volume training; intermittent training; muscle atrophy; muscle wasting; nephrology; renal
Year2019
JournalScandinavian Journal of Medicine & Science in Sports
Journal citation29 (8), pp. 1197 - 1204
PublisherWiley-Blackwell Publishing Ltd.
ISSN0905-7188
Digital Object Identifier (DOI)https://doi.org/10.1111/sms.13436
Scopus EID2-s2.0-85066504724
Page range1197 - 1204
Research GroupSports Performance, Recovery, Injury and New Technologies (SPRINT) Research Centre
Publisher's version
File Access Level
Controlled
Place of publicationUnited Kingdom
Permalink -

https://acuresearchbank.acu.edu.au/item/87q4x/high-intensity-interval-training-in-chronic-kidney-disease-a-randomized-pilot-study

Restricted files

Publisher's version

  • 78
    total views
  • 0
    total downloads
  • 0
    views this month
  • 0
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Traditional markers of cardiac toxicity fail to detect marked reductions in cardiorespiratory fitness among cancer patients undergoing anti-cancer treatment
Howden, Erin J., Foulkes, Steve, Dillon, Hayley T., Bigaran, Ashley, Wright, Leah, Janssens, Kristel, Comie, Prue, Costello, Benedict and La Gerche, André. (2021). Traditional markers of cardiac toxicity fail to detect marked reductions in cardiorespiratory fitness among cancer patients undergoing anti-cancer treatment. European Heart Journal: Cardiovascular Imaging. 22(4), pp. 451-458. https://doi.org/10.1093/ehjci/jeaa421
A 12-month lifestyle intervention does not improve cardiac autonomic function in patients with chronic kidney disease
Huppertz, Nina, Beetham, Kassia S., Howden, Erin J., Leicht, Anthony S., Isbel, Nicole M. and Coombes, Jeff S.. (2020). A 12-month lifestyle intervention does not improve cardiac autonomic function in patients with chronic kidney disease. Autonomic Neuroscience: Basic and Clinical. 224, pp. 1 - 6. https://doi.org/10.1016/j.autneu.2020.102642
Exercise as a diagnostic and therapeutic tool for the prevention of cardiovascular dysfunction in breast cancer patients
Howden, Erin J., Bigaran, Ashley, Beaudry, Rhys, Fraser, Steve, Selig, Steve, Foulkes, Steve, Antill, Yoland, Nightingale, Sophie, Loi, Sherene, Haykowsky, Mark J. and La Gerche, Andre´. (2019). Exercise as a diagnostic and therapeutic tool for the prevention of cardiovascular dysfunction in breast cancer patients. European Journal of Preventative Cardiology. 26(3), pp. 305 - 315. https://doi.org/10.1177/2047487318811181
Persistent impairment in cardiopulmonary fitness after breast cancer chemotherapy
Foulkes, Stephen J., Howden, Erin J., Bigaran, Ashley, Janssens, Kristel, Antill, Yoland, Loi, Sherene, Claus, Piet, Haykowsky, Mark J., Daly, Robin M., Fraser, Steve F. and La Gerche, Andre. (2019). Persistent impairment in cardiopulmonary fitness after breast cancer chemotherapy. Medicine and Science in Sports and Exercise. 51(8), pp. 1573 - 1581. https://doi.org/10.1249/MSS.0000000000001970
Determinants of exercise intolerance in breast cancer patients prior to anthracycline chemotherapy
Beaudry, Rhys I., Howden, Erin J., Foulkes, Stephen J., Bigaran, Ashley, Claus, Piet, Haykowsky, Mark J. and La Gerche, Andre. (2019). Determinants of exercise intolerance in breast cancer patients prior to anthracycline chemotherapy. Physiological Reports. 7(1), pp. 1 - 8. https://doi.org/10.14814/phy2.13971
Agreement between cystatin-C and creatinine based eGFR estimates after a 12-month exercise intervention in patients with chronic kidney disease
Beetham, Kassia S., Howden, Erin J., Isbel, Nicole M. and Coombes, Jeff S.. (2018). Agreement between cystatin-C and creatinine based eGFR estimates after a 12-month exercise intervention in patients with chronic kidney disease. BMC Nephrology. 19(1), pp. 1 - 11. https://doi.org/10.1186/s12882-018-1146-4
Standing up to the cardiometabolic consequences of hematological cancers
Howden, Erin J., La Gerche, Andre, Arthur, Jane F., McMullen, Julie R., Jennings, Garry L., Dunstan, David, Owen, Neville, Avery, Sharon and Kingwell, Bronwyn A.. (2018). Standing up to the cardiometabolic consequences of hematological cancers. Blood Reviews. 32(5), pp. 349 - 360. https://doi.org/10.1016/j.blre.2018.02.005
Feasibility of higher intensity exercise in patients with chronic kidney disease
Weston, Kassia S., Howden, Erin, Krishnasamy, Rathika, Isbel, Nicole and Coombes, Jeff S.. (2018). Feasibility of higher intensity exercise in patients with chronic kidney disease. The Journal of Sports Medicine and Physical Fitness. 58(1-2), pp. 1 - 1. https://doi.org/10.23736/S0022-4707.16.06575-0
Effects of exercise and lifestyle intervention on oxidative stress in chronic kidney disease
Small, David, Beetham, Kassia, Howden, Erin, Briskey, David, Johnson, David, Isbel, Nicole, Gobe, Glenda and Coombes, Jeff S.. (2017). Effects of exercise and lifestyle intervention on oxidative stress in chronic kidney disease. Redox Report. 22(3), pp. 127 - 136. https://doi.org/10.1080/13510002.2016.1276314
Oxidative stress is associated with decreased heart rate variability in patients with chronic kidney disease
Fadaee, Shannon, Weston, Kassia S., Howden, Erin, Stanton, Tony, Isbel, Nicole and Coombes, Jeff S.. (2017). Oxidative stress is associated with decreased heart rate variability in patients with chronic kidney disease. Redox Report: Communications in Free Radical Research. 22(5), pp. 197 - 204. https://doi.org/10.1080/13510002.2016.1173326
Association between left ventricular global longitudinal strain, health-related quality of life and functional capacity in chronic kidney disease patients with preserved ejection fraction
Krishnasamy, Rathika, Hawley, Carmel, Stanton, Tony, Howden, Erin, Weston, Kassia S., Strand, Haakan, Leano, Rodel, Haluska, Brian, Coombes, Jeff S. and Isbel, Nicole. (2016). Association between left ventricular global longitudinal strain, health-related quality of life and functional capacity in chronic kidney disease patients with preserved ejection fraction. Nephrology. 21(2), pp. 108 - 115. https://doi.org/10.1111/nep.12557
Oxidative stress contributes to muscle atrophy in chronic kidney disease patients
Beetham, Kassia S., Howden, Erin, Small, David, Briskey, David, Rossi, Megan, Isbel, Nicole and Coombes, Jeff S.. (2015). Oxidative stress contributes to muscle atrophy in chronic kidney disease patients. Redox Report: Communications in Free Radical Research. 20(3), pp. 126 - 132. https://doi.org/10.1179/1351000214Y.0000000114
Cardiorespiratory fitness and cardiovascular burden in chronic kidney disease
Howden, Erin, Weston, Kassia S., Leano, Rodel, Sharman, James E., Marwick, Thomas, Isbel, Nicole and Coombes, Jeff S.. (2015). Cardiorespiratory fitness and cardiovascular burden in chronic kidney disease. Journal of Science and Medicine in Sport. 18(4), pp. 492 - 497. https://doi.org/10.1016/j.jsams.2014.07.005