Standing up to the cardiometabolic consequences of hematological cancers
Journal article
Howden, Erin J., La Gerche, Andre, Arthur, Jane F., McMullen, Julie R., Jennings, Garry L., Dunstan, David, Owen, Neville, Avery, Sharon and Kingwell, Bronwyn A.. (2018). Standing up to the cardiometabolic consequences of hematological cancers. Blood Reviews. 32(5), pp. 349 - 360. https://doi.org/10.1016/j.blre.2018.02.005
Authors | Howden, Erin J., La Gerche, Andre, Arthur, Jane F., McMullen, Julie R., Jennings, Garry L., Dunstan, David, Owen, Neville, Avery, Sharon and Kingwell, Bronwyn A. |
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Abstract | Hematological cancer survivors are highly vulnerable to cardiometabolic complications impacting long-term health status, quality of life and survival. Elevated risk of diabetes and cardiovascular disease arises not only from the effects of the cancers themselves, but also from the toxic effects of cancer therapies, and deconditioning arising from reduced physical activity levels. Regular physical activity can circumvent or reverse adverse effects on the heart, skeletal muscle, vasculature and blood cells, through a combination of systemic and molecular mechanisms. We review the link between hematological cancers and cardiometabolic risk with a focus on adult survivors, including the contributing mechanisms and discuss the potential for physical activity interventions, which may act to oppose the negative effects of both physical deconditioning and therapies (conventional and targeted) on metabolic and growth signaling (kinase) pathways in the heart and beyond. In this context, we focus particularly on strategies targeting reducing and breaking up sedentary time and provide recommendations for future research. |
Keywords | Hematological cancer; Leukemia; Sedentary behavior; Physical activity; Obesity; Diabetes; Cardiovascular disease; Cardiac function; Cardiotoxicity |
Year | 2018 |
Journal | Blood Reviews |
Journal citation | 32 (5), pp. 349 - 360 |
Publisher | Churchill Livingstone |
ISSN | 0268-960X |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.blre.2018.02.005 |
Scopus EID | 2-s2.0-85042413763 |
Page range | 349 - 360 |
Research Group | Mary MacKillop Institute for Health Research |
Publisher's version | File Access Level Controlled |
Place of publication | United Kingdom |
https://acuresearchbank.acu.edu.au/item/8q1x8/standing-up-to-the-cardiometabolic-consequences-of-hematological-cancers
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