Evaluation of longitudinal 12 and 24 month cognitive outcomes in premanifest and early Huntington's disease

Journal article

Stout, Julie, Jones, Rebecca, Labuschagne, Izelle, O'Regan, Alison, Say, Miranda, Dumas, Eve, Queller, Sarah, Justo, Damian, Dar Santos, Rachelle, Coleman, Allison, Hart, Ellen, Durr, Alexandra, Leavitt, Blair, Roos, Raymund, Langbehn, Doug, Tabrizi, Sarah J. and Frost, Chris. (2012). Evaluation of longitudinal 12 and 24 month cognitive outcomes in premanifest and early Huntington's disease. Journal of Neurology, Neurosurgery and Psychiatry. 83(7), pp. 687 - 694. https://doi.org/10.1136/jnnp-2011-301940
AuthorsStout, Julie, Jones, Rebecca, Labuschagne, Izelle, O'Regan, Alison, Say, Miranda, Dumas, Eve, Queller, Sarah, Justo, Damian, Dar Santos, Rachelle, Coleman, Allison, Hart, Ellen, Durr, Alexandra, Leavitt, Blair, Roos, Raymund, Langbehn, Doug, Tabrizi, Sarah J. and Frost, Chris
Abstract

Background: Deterioration of cognitive functioning is a debilitating symptom in many neurodegenerative diseases, such as Huntington's disease (HD). To date, there are no effective treatments for the cognitive problems associated with HD. Cognitive assessment outcomes will have a central role in the efforts to develop treatments to delay onset or slow the progression of the disease. The TRACK-HD study was designed to build a rational basis for the selection of cognitive outcomes for HD clinical trials. Methods: There were a total of 349 participants, including controls (n=116), premanifest HD (n=117) and early HD (n=116). A standardised cognitive assessment battery (including nine cognitive tests comprising 12 outcome measures) was administered at baseline, and at 12 and 24 months, and consisted of a combination of paper and pencil and computerised tasks selected to be sensitive to cortical-striatal damage or HD. Each cognitive outcome was analysed separately using a generalised least squares regression model. Results are expressed as effect sizes to permit comparisons between tasks. Results: 10 of the 12 cognitive outcomes showed evidence of deterioration in the early HD group, relative to controls, over 24 months, with greatest sensitivity in Symbol Digit, Circle Tracing direct and indirect, and Stroop word reading. In contrast, there was very little evidence of deterioration in the premanifest HD group relative to controls. Conclusions: The findings describe tests that are sensitive to longitudinal cognitive change in HD and elucidate important considerations for selecting cognitive outcomes for clinical trials of compounds aimed at ameliorating cognitive decline in HD.

Year2012
JournalJournal of Neurology, Neurosurgery and Psychiatry
Journal citation83 (7), pp. 687 - 694
ISSN0022-3050
Digital Object Identifier (DOI)https://doi.org/10.1136/jnnp-2011-301940
Page range687 - 694
Publisher's version
File Access Level
Controlled
Permalink -

https://acuresearchbank.acu.edu.au/item/89284/evaluation-of-longitudinal-12-and-24-month-cognitive-outcomes-in-premanifest-and-early-huntington-s-disease

Log in to edit

Restricted files

Publisher's version

  • 133
    total views
  • 0
    total downloads
  • 4
    views this month
  • 0
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Cannabis dependence is associated with reduced hippocampal subregion volumes independently of sex : Findings from an ENIGMA addiction working group multi-country study
Lorenzetti, Valentina, Gaillard, Alexandra, McTavish, Eugene, Sally, Grace, Rossetti, Maria Gloria, Batalla, Albert, Bellani, Marcella, Brambilla, Paolo, Chye, Yann, Conrod, Patricia, Cousijn, Janna, Labuschagne, Izelle, Clemente, Adam, Mackey, Scott, Rendell, Peter, Solowij, Nadia, Suo, Chao, Li, Chiang-Shan R., Terrett, Gillian, ... Roberts, Carl A.. (2024). Cannabis dependence is associated with reduced hippocampal subregion volumes independently of sex : Findings from an ENIGMA addiction working group multi-country study. Cannabis and Cannabinoid Research. X(X), pp. 1-14. https://doi.org/10.1089/can.2023.0204
Concordance in salivary cortisol and subjective anxiety to the trier social stress test in social anxiety disorder
Grace, Caitlin, Heinrichs, Markus, Koval, Peter, Gorelik, Alexandra, von Dawans, Bernadette, Terrett, Gill, Rendell, Peter and Labuschagne, Izelle. (2022). Concordance in salivary cortisol and subjective anxiety to the trier social stress test in social anxiety disorder. Biological Psychology. 175, p. Article 108444. https://doi.org/10.1016/j.biopsycho.2022.108444
Intellectual enrichment and genetic modifiers of cognition and brain volume in Huntington's disease
Papoutsi, Marina, Flower, Michael, Hensman Moss, Davina J., Holmans, Peter, Estevez-Fraga, Carlos, Johnson, Eileanoir B., Scahill, Rachael I., Rees, Geraint, Langbehn, Douglas, Tabrizi, Sarah J., Kraus, Peter, Hoffman, Rainer, Tobin, Alan, Borowsky, Beth, Keenan, S., Whitlock, Kathryn B., Queller, Sarah, Campbell, Colin, Wang, Chiachi, ... Landwehrmeyer, Bernhard. (2022). Intellectual enrichment and genetic modifiers of cognition and brain volume in Huntington's disease. Brain Communications. 4(6), p. Article fcac279. https://doi.org/10.1093/braincomms/fcac279
Is resting-state functional connectivity altered in regular cannabis users? A systematic review of the literature
Thomson, Hannah, Labuschagne, Izelle, Greenwood, Lisa-Marie, Robinson, Emily, Sehl, Hannah, Suo, Chao and Lorenzetti, Valentina. (2022). Is resting-state functional connectivity altered in regular cannabis users? A systematic review of the literature. Psychopharmacology. 239, pp. 1191-1209. https://doi.org/10.1007/s00213-021-05938-0
Resting-state neuroimaging in social anxiety disorder : A systematic review
Mizzi, Simone, Pedersen, Mangor, Lorenzetti, Valentina, Heinrichs, Markus and Labuschagne, Izelle. (2022). Resting-state neuroimaging in social anxiety disorder : A systematic review. Molecular Psychiatry. 27(1), pp. 164-179. https://doi.org/10.1038/s41380-021-01154-6
Identity and shame in body dysmorphic disorder as compared to obsessive-compulsive disorder
Malcolm, Amy, Pikoos, Toni, Castle, David J., Labuschagne, Izelle and Rossell, Susan L.. (2021). Identity and shame in body dysmorphic disorder as compared to obsessive-compulsive disorder. Journal of Obsessive-Compulsive and Related Disorders. 31, p. Article 100686. https://doi.org/10.1016/j.jocrd.2021.100686
Sex differences in the neuroanatomy of alcohol dependence : Hippocampus and amygdala subregions in a sample of 966 people from the ENIGMA Addiction Working Group
Grace, Sally, Rossetti, Maria Gloria, Allen, Nicholas, Batalla, Albert, Bellani, Marcella, Brambilla, Paolo, Chye, Yann, Cousijn, Janna, Goudriaan, Anna E., Hester, Robert, Hutchison, Kent, Labuschagne, Izelle, Momenan, Reza, Martin-Santos, Rocio, Rendell, Peter, Solowij, Nadia, Sinha, Rajita, Li, Chiang-shan Ray, Schmaal, Lianne, ... Lorenzetti, Valentina. (2021). Sex differences in the neuroanatomy of alcohol dependence : Hippocampus and amygdala subregions in a sample of 966 people from the ENIGMA Addiction Working Group. Translational Psychiatry. 11(1), p. Article 156. https://doi.org/10.1038/s41398-021-01204-1
Empirical evidence for cognitive subgroups in body dysmorphic disorder
Malcolm, Amy, Brennan, Sarah N., Grace, Sally A., Pikoos, Toni D., Toh, Wei Lin, Labuschagne, Izelle, Buchanan, Ben, Kaplan, Ryan A., Castle, David J. and Rossell, Susan L.. (2021). Empirical evidence for cognitive subgroups in body dysmorphic disorder. Australian and New Zealand Journal of Psychiatry. 55(4), pp. 381-390. https://doi.org/10.1177/0004867421998762
Age differences in emotion regulation and facial muscle reactivity to emotional films
Labuschagne, Izelle, Pedder, David J., Henry, Julie D., Terrett, Gill and Rendell, Peter G.. (2020). Age differences in emotion regulation and facial muscle reactivity to emotional films. Gerontology. 66, pp. 74-84. https://doi.org/10.1159/000501584
Task characteristics influence facial emotion recognition age-effects : A meta-analytic review
Hayes, Grace S., McLennan, Skye N., Henry, Julie D., Phillips, Louise H., Terrett, Gill, Rendell, Peter G., Pelly, Rachel M. and Labuschagne, Izelle. (2020). Task characteristics influence facial emotion recognition age-effects : A meta-analytic review. Psychology and Aging. 35(2), pp. 295-315. https://doi.org/10.1037/pag0000441
Delusional themes in Body Dysmorphic Disorder (BDD) : Comparisons with psychotic disorders and non-clinical Controls
Rossell, Susan L., Labuschagne, Izelle, Castle, David J. and Toh, Wei Lin. (2020). Delusional themes in Body Dysmorphic Disorder (BDD) : Comparisons with psychotic disorders and non-clinical Controls. Psychiatry Research. 284, p. 112694. https://doi.org/10.1016/j.psychres.2019.112694
An introductory guide to conducting the Trier Social Stress Test
Labuschagne, Izelle, Grace, Caitlin, Rendell, Peter, Terrett, Gillian and Heinrichs, Markus. (2019). An introductory guide to conducting the Trier Social Stress Test. Neuroscience and Biobehavioral Reviews. 107, pp. 686-695. https://doi.org/10.1016/j.neubiorev.2019.09.032
MSH3 modifies somatic instability and disease severity in Huntington's and myotonic dystrophy type 1
Flower, Michael, Lomeikaite, Vilija, Ciosi, Marc, Cumming, Sarah, Morales, Fernando, Lo, Kitty, Hensman Moss, Davina, Jones, Lesley, Holmans, Peter, Kraus, Peter, Hoffman, Rainer, Tobin, Alan, Borowsky, Beth, Keenan, S, Whitlock, Kathryn B., Queller, Sarah, Campbell, Colin, Wang, Chiachi, Langbehn, Doug, ... Tabrizi, Sarah J,. (2019). MSH3 modifies somatic instability and disease severity in Huntington's and myotonic dystrophy type 1. Brain. 142(7), pp. 1876-1886. https://doi.org/10.1093/brain/awz115
Intranasal oxytocin alters amygdala-temporal resting-state functional connectivity in body dysmorphic disorder : A double-blind placebo-controlled randomized trial
Grace, Sally A., Labuschagne, Izelle, Castle, David J. and Rossell, Susan L.. (2019). Intranasal oxytocin alters amygdala-temporal resting-state functional connectivity in body dysmorphic disorder : A double-blind placebo-controlled randomized trial. Psychoneuroendocrinology. 107, pp. 179-186. https://doi.org/10.1016/j.psyneuen.2019.05.022
Apathy associated with impaired recognition of happy facial expressions in Huntington's disease
Osborne-Crowley, Katherine, Andrews, Sophie C., Labuschagne, Izelle, Nair, Akshay, Scahill, Rachael, Craufurd, David, Tabrizi, Sarah J. and Stout, Julie C.. (2019). Apathy associated with impaired recognition of happy facial expressions in Huntington's disease. Journal of the International Neuropsychological Society. 25(5), pp. 453-461. https://doi.org/10.1017/S1355617718001224
The relationship between episodic future thinking and prospective memory in middle childhood : Mechanisms depend on task type
Terrett, Gill, Horner, Katherine, White, Roxanne, Henry, Julie D., Kliegel, Matthias, Labuschagne, Izelle and Rendell, Peter G.. (2019). The relationship between episodic future thinking and prospective memory in middle childhood : Mechanisms depend on task type. Journal of Experimental Child Psychology. 178, pp. 198-213. https://doi.org/10.1016/j.jecp.2018.10.003
Brain regions showing white matter loss in Huntington's Disease are enriched for synaptic and metabolic genes
McColgan, Peter, Gregory, Sarah, Seunarine, Kiran K., Razi, Adeel, Papoutsi, Marina, Johnson, Eileanoir B., Dürr, Alexandra, Roos, Raymund, Leavitt, Blair R., Holmans, Peter, Scahill, Rachael I., Clark, Chris A., Rees, Geraint, Tabrizi, Sarah J., Coleman, A., Decolongon, J., Fan, M., Petkau, T., Jauffret, C., ... Crawfurd, D.. (2018). Brain regions showing white matter loss in Huntington's Disease are enriched for synaptic and metabolic genes. Biological Psychiatry. 83(5), pp. 456-465. https://doi.org/10.1016/j.biopsych.2017.10.019
Testing a longitudinal compensation model in premanifest Huntington's disease
Gregory, Sarah, Long, Jeffrey D., Klöppel, Stefan, Razi, Adeel, Scheller, Elisa, Minkova, Lora, Johnson, Eileanoir B., Durr, Alexandra, Roos, Raymund A. C., Leavitt, Blair R., Mills, James A., Stout, Julie C., Scahill, Rachael I., Tabrizi, Sarah J., Rees, Geraint, the Track-On investigators and Labuschagne, Izelle*. (2018). Testing a longitudinal compensation model in premanifest Huntington's disease. Brain. 141(7), pp. 2156-2166. https://doi.org/10.1093/brain/awy122
Working memory-related effective connectivity in Huntington's disease patients
Lahr, Jacob, Minkova, Lora, Tabrizi, Sarah J., Stout, Julie C., Klöppel, Stefan, Scheller, Elisa, the TrackOn-HD Investigators and Labuschagne, I.. (2018). Working memory-related effective connectivity in Huntington's disease patients. Frontiers in Neurology. 9, p. Article 370. https://doi.org/10.3389/fneur.2018.00370
The relationship between body dysmorphic disorder and obsessive-compulsive disorder: A systematic review of direct comparative studies
Malcolm, Amy, Labuschagne, Izelle, Castle, David J, Terrett, Gill, Rendell, Peter and Rossell, Susan. (2018). The relationship between body dysmorphic disorder and obsessive-compulsive disorder: A systematic review of direct comparative studies. Australian and New Zealand Journal of Psychiatry. 52(11), pp. 1030-1049. https://doi.org/10.1177/0004867418799925
Visual scanning of the eye region of human faces predicts emotion recognition performance in Huntington's disease
Catarina C. Kordsachia, Izelle Labuschagne and Julie C Stout. (2018). Visual scanning of the eye region of human faces predicts emotion recognition performance in Huntington's disease. Neuropsychology. 32(3), pp. 356-365. https://doi.org/10.1037/neu0000424
Oxytocin selectively modulates brain processing of disgust in Huntington's disease gene carriers
Izelle Labuschagne, Govinda Poudel, Catarina C. Kordsachia, Qizhu Wu, Hannah Thomson, Nellie Georgiou-Karistianis and Julie C Stout. (2018). Oxytocin selectively modulates brain processing of disgust in Huntington's disease gene carriers. Progress in Neuropsychopharmacology and Biological Psychiatry. 81, pp. 11-16. https://doi.org/10.1016/j.pnpbp.2017.09.023
Oxytocin and brain activity in humans: A systematic review and coordinate-based meta-analysis of functional MRI studies
Sally A. Grace, Susan Rossell, Markus Heinrichs, Catarina C. Kordsachia and Izelle Labuschagne. (2018). Oxytocin and brain activity in humans: A systematic review and coordinate-based meta-analysis of functional MRI studies. Psychoneuroendocrinology. 96, pp. 6-24. https://doi.org/10.1016/j.psyneuen.2018.05.031
Intranasal oxytocin does not reduce age-related difficulties in social cognition
Sarah A. Grainger, Julie Henry, Henriette R. Steinvik, Eric J Vanman, Peter Rendell and Izelle Labuschagne. (2018). Intranasal oxytocin does not reduce age-related difficulties in social cognition. Hormones and Behaviour. 99, pp. 25-34. https://doi.org/10.1016/j.yhbeh.2018.01.009
Diminished facial EMG responses to disgusting scenes and happy and fearful faces in Huntington's disease
Catarina C. Kordsachia, Izelle Labuschagne, Sophie C. Andrews and Julie C. Stout. (2018). Diminished facial EMG responses to disgusting scenes and happy and fearful faces in Huntington's disease. Cortex. 106, pp. 185-199. https://doi.org/10.1016/j.cortex.2018.05.019
Decision-making, somatic markers and emotion processing in opiate users
Kathryn Biernacki, Gill Terrett, Skye McLennan, Izelle Labuschagne, Phoebe Morton and Peter Rendell. (2018). Decision-making, somatic markers and emotion processing in opiate users. Psychopharmacology. 235(1), pp. 223-232. https://doi.org/10.1007/s00213-017-4760-0
Brief Report: The Impact of Sensory Hypersensitivity and Intolerance of Uncertainty on Anxiety in Williams Syndrome
Mirko Uljarević, Izelle Labuschagne, Rebecca Bobin, Anna Atkinson and Darren R. Hocking. (2018). Brief Report: The Impact of Sensory Hypersensitivity and Intolerance of Uncertainty on Anxiety in Williams Syndrome. Journal of Autism and Developmental Disorders. 48(11), pp. 3958-3964. https://doi.org/10.1007/s10803-018-3631-9
Intranasal oxytocin reduces heart rate variability during a mental arithmetic task: A randomised, double-blind, placebo-controlled cross-over study
Tracy, Lincoln M., Gibson, Stephen J., Labuschagne, Izelle, Georgiou-Karistianis, Nellie and Giummarra, Melita J.. (2018). Intranasal oxytocin reduces heart rate variability during a mental arithmetic task: A randomised, double-blind, placebo-controlled cross-over study. Progress in Neuropsychopharmacology and Biological Psychiatry. 81, pp. 408 - 415. https://doi.org/10.1016/j.pnpbp.2017.08.016
Families affected by Huntington's Disease report difficulties in communication, emotional involvement, and problem solving
Jona, Celine M. H., Labuschagne, Izelle, Mercieca, Emily-Clare, Fisher, Fiona, Gluyas, Cathy, Stout, Julie C. and Andrews, Sophie C.. (2017). Families affected by Huntington's Disease report difficulties in communication, emotional involvement, and problem solving. Journal of Huntington's Disease. 6(3), pp. 169-177. https://doi.org/10.3233/JHD-170250
Sex-specific effects of intranasal oxytocin on thermal pain perception: A randomised, double-blind, placebo-controlled cross-over study
Tracy, Lincoln M., Labuschagne, Izelle, Georgiou-Karistianis, Nellie, Gibson, Stephen J. and Giummarra, Melita J.. (2017). Sex-specific effects of intranasal oxytocin on thermal pain perception: A randomised, double-blind, placebo-controlled cross-over study. Psychoneuroendocrinology. 83, pp. 101 - 110. https://doi.org/10.1016/j.psyneuen.2017.05.028
Beyond emotion recognition deficits: A theory guided analysis of emotion processing in Huntington's disease
Kordsachia, Catarina C., Labuschagne, Izelle and Stout, Julie C.. (2017). Beyond emotion recognition deficits: A theory guided analysis of emotion processing in Huntington's disease. Neuroscience and Biobehavioral Reviews. 73, pp. 276 - 292. https://doi.org/10.1016/j.neubiorev.2016.11.020
Impairments in spatiotemporal gait adaptation during obstacle navigation in Huntington’s disease
Anwar, Naznine, Labuschagne, Izelle, Simpson, Katrina, Smith, Luke and Georgiou-Karistianis, Nellie. (2017). Impairments in spatiotemporal gait adaptation during obstacle navigation in Huntington’s disease. Neurorehabilitation and Neural Repair. 31(10-11), pp. 934 - 943. https://doi.org/10.1177/1545968317736818
Abnormal visual scanning of emotionally evocative natural scenes in Huntington's disease
Kordsachia, Catarina C., Labuschagne, Izelle and Stout, Julie C.. (2017). Abnormal visual scanning of emotionally evocative natural scenes in Huntington's disease. Frontiers in Psychology. 8(March), pp. 1 - 10. https://doi.org/10.3389/fpsyg.2017.00405
White matter predicts functional connectivity in premanifest Huntington's disease
McColgan, Peter, Gregory, Sarah, Razi, Adeel, Seunarine, Kiran K., Gargouri, Fatma, Durr, Alexandra, Roos, Raymund A. C., Leavitt, Blair R., Scahill, Rachael I., Clark, Chris A., Tabrizi, Sarah J., Rees, Geraint, Coleman, Allison J., Decolongon, J., Fan, M., Petkau, T., Jauffret, Céline, Justo, Damian, Lehericy, S., ... Johnson, H.. (2017). White matter predicts functional connectivity in premanifest Huntington's disease. Annals of Clinical and Translational Neurology. 4(2), pp. 106 - 118. https://doi.org/10.1002/acn3.384
The neurobiology of body dysmorphic disorder: A systematic review and theoretical model
Grace, Sally A., Labuschagne, Izelle, Kaplan, Ryan A. and Rossell, Susan L.. (2017). The neurobiology of body dysmorphic disorder: A systematic review and theoretical model. Neuroscience and Biobehavioral Reviews. 83, pp. 83 - 96. https://doi.org/10.1016/j.neubiorev.2017.10.003
Emotion processing in persons who respond vicariously towards others in pain: Disinhibited left-lateralized neural activity for threatening expressions
Giummarra, Melita J., Poudel, Govinda, Niu, P. Amanda, Nicholls, Michael E. R., Fielding, Joanne, Verdejo-Garcia, Antonio and Labuschagne, Izelle. (2017). Emotion processing in persons who respond vicariously towards others in pain: Disinhibited left-lateralized neural activity for threatening expressions. Laterality: Assymetries of body, brain and cognition. 23(2), pp. 184 - 208. https://doi.org/10.1080/1357650X.2017.1349781
Identification of genetic variants associated with Huntington's disease progression: A genome-wide association study
Hensman Moss, Davina J., Pardiñas, Antonio F., Langbehn, Douglas, Lo, Kitty, Leavitt, Blair R., Roos, Raymund, Durr, Alexandra, Mead, Simon, TRACK-HD investigators,, REGISTRY investigators,, Labuschagne, Izelle, TRACK-HD investigators and REGISTRY investigators. (2017). Identification of genetic variants associated with Huntington's disease progression: A genome-wide association study. The Lancet Neurology. 16(9), pp. 701 - 711. https://doi.org/10.1016/S1474-4422(17)30161-8
The wisdom to know the difference : Strategy-situation fit in emotion regulation in daily life is associated with well-being
Haines, Simon J., Gleeson, John, Kuppens, Peter, Hollenstein, Tom, Ciarrochi, Joseph, Labuschagne, Izelle, Grace, Caitlin and Koval, Peter. (2016). The wisdom to know the difference : Strategy-situation fit in emotion regulation in daily life is associated with well-being. Psychological Science. 27(12), pp. 1651-1659. https://doi.org/10.1177/0956797616669086
Improving research standards to restore trust in intranasal oxytocin
Carson, Dean S., Yuan, Hsiangkuo and Labuschagne, Izelle. (2016). Improving research standards to restore trust in intranasal oxytocin. Biological Psychiatry. 79(8), pp. e53 - e54. https://doi.org/10.1016/j.biopsych.2015.08.031
Effects of oxytocin and genetic variants on brain and behaviour : Implications for treatment in schizophrenia
Bartholomeusz, Cali, Ganella, Eleni, Labuschagne, Izelle, Bousman, Chad and Pantelis, Christos. (2015). Effects of oxytocin and genetic variants on brain and behaviour : Implications for treatment in schizophrenia. Schizophrenia Research. 168(3), pp. 614 - 627. https://doi.org/10.1016/j.schres.2015.06.007
Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder
Gorka, Stephanie M., Fitzgerald, Daniel A., Labuschagne, Izelle, Hosanagar, Avinash, Wood, Amanda G., Nathan, Pradeep J. and Phan, K. Luan. (2015). Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder. Neuropsychopharmacology. 40(2), pp. 278 - 286. https://doi.org/10.1038/npp.2014.168
Detection of motor changes in huntington's disease using dynamic causal modeling
Minkova, Lora, Scheller, Elisa, Peter, Jessica, Abdulkadir, Ahmed, Kaller, Christoph P., Roos, Raymund A. C., Dürr, Alexandra, Leavitt, Blair R., Tabrizi, Sarah J., Kloppel, Stefan, Coleman, Allison J., Decolongon, J., Fan, M., Koren, T., Jauffret, Céline, Justo, Damian, Lehericy, Stephane, Nigaud, Kevin, Valabrègue, Romain, ... Mills, J.. (2015). Detection of motor changes in huntington's disease using dynamic causal modeling. Frontiers in Human Neuroscience. 9, pp. 1 - 13. https://doi.org/10.3389/fnhum.2015.00634
Compensation in preclinical Huntington's disease: Evidence from the track-on hd study
Kloppel, Stefan, Gregory, Sarah, Scheller, Elisa, Minkova, Lora, Razi, Adeel, Durr, Alexandra, Roos, Raymund A. C., Leavitt, Blair R., Papoutsi, Marina, Landwehrmeyer, G. Bernhard, Reilmann, Ralf, Borowsky, Beth, Johnson, Hans, Mills, James A., Owen, Gail N., Stout, Julie C., Scahill, Rachael I., Long, Jeffrey D., Rees, Geraint, ... Orth, M.. (2015). Compensation in preclinical Huntington's disease: Evidence from the track-on hd study. EBioMedicine. 2(10), pp. 1420 - 1429. https://doi.org/10.1016/j.ebiom.2015.08.002
Neuropsychiatry and white matter microstructure in Huntington's Disease
Gregory, Sarah L., Scahill, Rachael I., Seunarine, Kiran K., Stopford, Cheryl, Zhang, Hui, Zhang, Jiaying, Orth, Michael, Dürr, Alexandra, Roos, Raymund A. C., Langbehn, Douglas R., Long, Jeffrey D., Johnson, Hans, Rees, Geraint, Tabrizi, Sarah J., Craufurd, David I. O., Campbell, C., Campbell, Melissa, Labuschagne, Izelle, Milchman, C., ... Campbell, Colin. (2015). Neuropsychiatry and white matter microstructure in Huntington's Disease. Journal of Huntington's Disease. 4(3), pp. 239 - 249. https://doi.org/10.3233/JHD-150160
Differential effects of social stress on laboratory-based decision-making are related to both impulsive personality traits and gender
Wise, Richard J., Phung, Alissa L., Labuschagne, Izelle and Stout, Julie C.. (2015). Differential effects of social stress on laboratory-based decision-making are related to both impulsive personality traits and gender. Cognition and Emotion. 29, pp. 1475 - 1485. https://doi.org/10.1080/02699931.2014.989815
Safety, tolerability, and efficacy of PBT2 in Huntington's disease: A phase 2, randomised, double-blind, placebo-controlled trial
Angus, D., Herd, C., Stone, C., Stout, Julie, Wieler, Marguerite, Reilmann, Ralf, Ritchie, C. W., Dorsey, Earl Ray, Helles, K., Kayson, Elise, Oakes, David, Rosas, Herminia Diana, Vaughan, Carr J., Panegyres, Peter K., Ames, David J., Goh, Anita, Agarwal, Pinky, Churchyard, Andrew, Murathodizic, M., ... Targum, S.. (2015). Safety, tolerability, and efficacy of PBT2 in Huntington's disease: A phase 2, randomised, double-blind, placebo-controlled trial. Lancet Neurology. 14(1), pp. 39 - 47. https://doi.org/10.1016/S1474-4422(14)70262-5
The impact of occipital lobe cortical thickness on cognitive task performance : An investigation in Huntington's Disease
Johnson, Eileanoir, Rees, Elin, Labuschagne, Izelle, Durr, Alexandra, Leavitt, Blair, Roos, Raymund, Reilmann, Ralf, Johnson, Hans, Hobbs, Nicola, Langbehn, Douglas, Stout, Julie, Tabrizi, Sarah and Scahill, Rachael. (2015). The impact of occipital lobe cortical thickness on cognitive task performance : An investigation in Huntington's Disease. Neuropsychologia. 79, pp. 138 - 146. https://doi.org/10.1016/j.neuropsychologia.2015.10.033
Modulation of resting-state amygdala-frontal functional connectivity by oxytocin in generalized social anxiety disorder
Dodhia, Sonam, Hosanagar, Avinash, Fitzgerald, Daniel A., Labuschagne, Izelle, Wood, Amanda G., Nathan, Pradeep J. and Phan, Kinhluan Luan. (2014). Modulation of resting-state amygdala-frontal functional connectivity by oxytocin in generalized social anxiety disorder. Neuropsychopharmacology. 39(9), pp. 2061 - 2069. https://doi.org/10.1038/npp.2014.53
Using theories of delusion formation to explain abnormal beliefs in Body Dysmorphic Disorder (BDD)
Rossell, Susan L., Labuschagne, Izelle, Dunai, Judith, Kyrios, Michael and Castle, David. (2014). Using theories of delusion formation to explain abnormal beliefs in Body Dysmorphic Disorder (BDD). Psychiatry Research. 215(3), pp. 599 - 605. https://doi.org/10.1016/j.psychres.2013.12.030
The potential of composite cognitive scores for tracking progression in Huntington's disease.
Jones, Rebecca D., Stout, Julie C., Labuschagne, Izelle, Say, Miranda Julia, Justo, Damian, Coleman, Allison J., Dumas, Eve M., Hart, Ellen P., Owen, Gail N., Durr, Alexandra, Leavitt, Blair R., Roos, Raymund A. C., O'Regan, Alison M., Langbehn, Doug R., Tabrizi, Sarah J. and Frost, Chris D.. (2014). The potential of composite cognitive scores for tracking progression in Huntington's disease. Journal of Huntington's Disease. 3(2), pp. 197 - 207. https://doi.org/10.3233/JHD-140101
The cognitive burden in Huntington's disease: Pathology, phenotype and mechanisms of compensation
Papoutsi, Marina, Labuschagne, Izelle, Tabrizi, Sarah J. and Stout, Julie C.. (2014). The cognitive burden in Huntington's disease: Pathology, phenotype and mechanisms of compensation. Movement Disorders Society. 29(5), pp. 673 - 683. https://doi.org/10.1002/mds.25864
A comparison of executive function in Body Dysmorphic Disorder (BDD) and Obsessive-Compulsive Disorder (OCD)
Labuschagne, Izelle, Rossell, Susan, Dunai, Judith, Castle, David and Kyrios, Michael. (2013). A comparison of executive function in Body Dysmorphic Disorder (BDD) and Obsessive-Compulsive Disorder (OCD). Journal of Obsessive-Compulsive and Related Disorders. 2(3), pp. 257 - 262. https://doi.org/10.1016/j.jocrd.2013.05.003
Oxytocin enhances resting-state connectivity between amygdala and medial frontal cortex
Sripada, Chandra, Phan, Kinhluan, Labuschagne, Izelle, Welsh, Robert, Nathan, Pradeep and Wood, Amanda. (2013). Oxytocin enhances resting-state connectivity between amygdala and medial frontal cortex. International Journal of Neuropsychopharmacology (print). 16(2), pp. 255 - 260. https://doi.org/10.1017/S1461145712000533
Emotional face recognition deficits and medication effects in pre-manifest through stage-II Huntington's disease
Labuschagne, Izelle, Jones, Rebecca, Callaghan, Jenny, Whitehead, Daisy, Dumas, Eve, Say, Miranda, Hart, Ellen, Justo, Damian, Coleman, Allison, Dar Santos, Rachelle, Frost, Chris, Craufurd, David, Trabrizi, Sarah and Stout, Julie. (2013). Emotional face recognition deficits and medication effects in pre-manifest through stage-II Huntington's disease. Psychiatry Research. 207(1-2), pp. 118 - 126. https://doi.org/10.1016/j.psychres.2012.09.022
Emotional face recognition deficits and medication effects in pre-manifest through stage-II Huntington's disease
Labuschagne, Izelle, Jones, Rebecca, Callaghan, Jenny, Whitehead, Daisy, Dumas, Eve, Say, Miranda, Hart, Ellen, Justo, Damian, Coleman, Allison, Dar Santos, Rachelle, Frost, Chris, Craufurd, David, Tabrizi, Sarah and Stout, Julie. (2013). Emotional face recognition deficits and medication effects in pre-manifest through stage-II Huntington's disease. Psychiatry Research. 207(1-2), pp. 118 - 126. https://doi.org/10.1016/j.psychres.2012.09.022
Oxytocin enhances resting-state connectivity between amygdala and medial frontal cortex
Sripada, Chandra, Phan, Kinhluan, Labuschagne, Izelle, Welsh, Robert, Nathan, Pradeep and Wood, Amanda. (2013). Oxytocin enhances resting-state connectivity between amygdala and medial frontal cortex. International Journal of Neuropsychopharmacology. 16(2), pp. 255 - 260. https://doi.org/10.1017/S1461145712000533
Visual working memory impairment in premanifest gene-carriers and early Huntington's Disease
Dumas, Eve M., Say, Miranda Julia, Jones, Rebecca D., Labuschagne, Izelle, O'Regan, Alison M., Hart, Ellen P., van den Bogaard, Simon J. A., Queller, Sarah, Justo, Damian, Coleman, Allison J., dar Santos, Rachelle C., Durr, Alexandra, Leavitt, Blair R., Tabrizi, Sarah J., Roos, Raymund A. C. and Stout, Julie C.. (2012). Visual working memory impairment in premanifest gene-carriers and early Huntington's Disease. Journal of Huntington's Disease. 1(1), pp. 97 - 106. https://doi.org/10.3233/JHD-2012-120010
Medial frontal hyperactivity to sad faces in generalized social anxiety disorder and modulation by oxytocin
Labuschagne, Izelle, Phan, K. Luan, Wood, Amanda, Angstadt, Mike, Chua, Phyllis, Heinrichs, Markus, Stout, Julie C., Nathan, Pradeep J. and Pradeep,. (2012). Medial frontal hyperactivity to sad faces in generalized social anxiety disorder and modulation by oxytocin. International Journal of Neuropsychopharmacology (print). 15(7), pp. 883 - 896. https://doi.org/10.1017/S1461145711001489
Evaluation of longitudinal 12 and 24 month cognitive outcomes in premanifest and early Huntington's disease
Stout, Julie, Jones, Rebecca, Labuschagne, Izelle, O'Regan, Alison, Say, Miranda, Dumas, Eve, Queller, Sarah, Justo, Damian, Dar Santos, Rachelle, Coleman, Allison, Hart, Ellen, Durr, Alexandra, Leavitt, Blair, Roos, Raymund, Langbehn, Douglas, Tabrizi, Sarah J. and Frost, Chris. (2012). Evaluation of longitudinal 12 and 24 month cognitive outcomes in premanifest and early Huntington's disease. Journal of Neurology, Neurosurgery and Psychiatry. 83(7), pp. 687 - 694. https://doi.org/10.1136/jnnp-2011-301940
What the cognitive deficits in body dysmorphic disorder tell us about the underlying neurobiology: An investigation of three cases
Labuschagne, Izelle, Castle, David and Rossell, Susan L.. (2011). What the cognitive deficits in body dysmorphic disorder tell us about the underlying neurobiology: An investigation of three cases. International Journal of Cognitive Therapy. 4(1), pp. 21 - 33. https://doi.org/10.1521/ijct.2011.4.1.21
Oxytocin attenuates amygdala reactivity to fear in generalized social anxiety disorder
Labuschagne, Izelle, Phan, K. Luan, Wood, Amanda G., Angstadt, Mike, Chua, Phyllis, Heinrichs, Markus, Stout, Julie C. and Nathan, Pradeep. (2010). Oxytocin attenuates amygdala reactivity to fear in generalized social anxiety disorder. Neuropsychopharmacology. 35(12), pp. 2403 - 2413. https://doi.org/10.1038/npp.2010.123
Augmenting serotonin neurotransmission with citalopram modulates emotional expression decoding but not structural encoding of moderate intensity sad facial emotional stimuli: An event-related potential (ERP) investigation
Labuschagne, Izelle, Croft, Rodney, Phan, K. Luan and Nathan, Pradeep. (2010). Augmenting serotonin neurotransmission with citalopram modulates emotional expression decoding but not structural encoding of moderate intensity sad facial emotional stimuli: An event-related potential (ERP) investigation. Journal of Psychopharmacology. 24(8), pp. 1153 - 1164. https://doi.org/10.1177/0269881108097878
Executive function in body dysmorphic disorder
Dunai, Judith, Labuschagne, Izelle, Castle, David J., Kyrios, Michael and Rossell, Susan. (2010). Executive function in body dysmorphic disorder. Psychological Medicine. 40(9), pp. 1541 - 1548. https://doi.org/10.1017/S003329170999198X
An examination of delusional thinking and cognitive styles in body dysmorphic disorder
Labuschagne, Izelle, Castle, David J., Dunai, Judith, Kyrios, Michael and Rossell, Susan. (2010). An examination of delusional thinking and cognitive styles in body dysmorphic disorder. Australian and New Zealand Journal of Psychiatry. 44(8), pp. 706 - 712. https://doi.org/10.3109/00048671003671007
Evidence for modulation of facial emotional processing bias during emotional expression decoding by serotonergic and noradrenergic antidepressants: An event-related potential (ERP) study
Kerestes, Rebecca, Labuschagne, Izelle, Croft, Rodney, O'Neill, Barry, Bhagwagar, Zubin M., Phan, K Luan and Nathan, Pradeep. (2009). Evidence for modulation of facial emotional processing bias during emotional expression decoding by serotonergic and noradrenergic antidepressants: An event-related potential (ERP) study. Psychopharmacology. 202(4), pp. 621 - 634. https://doi.org/10.1007/s00213-008-1340-3