Age-related differences in neural integrity are unrelated to prospective memory age effects

Journal article

Henry, Julie D., Coundouris, Sarah P., Labuschagne, Izelle, Liu, Kirra, Haines, Simon J., Grainger, Sarah A., Domínguez, Juan F., Puckett, Alex, Rendell, Peter G. and Taubert, Jessica. (2025). Age-related differences in neural integrity are unrelated to prospective memory age effects. Brain and Cognition. 187, p. Article 106301. https://doi.org/10.1016/j.bandc.2025.106301
AuthorsHenry, Julie D., Coundouris, Sarah P., Labuschagne, Izelle, Liu, Kirra, Haines, Simon J., Grainger, Sarah A., Domínguez, Juan F., Puckett, Alex, Rendell, Peter G. and Taubert, Jessica
Abstract

Prospective memory refers to memory for future intentions. In general, prospective memory appears to decline with age when tested in laboratory settings but is preserved or enhanced when tasks need to be completed in daily life. No study to date has tested whether age-related differences in specific brain structures and networks mediate prospective memory age effects in both settings. Here, measures of regional brain volume (anterior prefrontal cortex, frontoparietal networks, and temporal lobes), white matter integrity (prefrontal white matter hypointensities) and prospective memory were obtained from 41 younger and 41 older adults. The results showed that, as expected, older age was associated with smaller regional brain volumes, as well as poorer prefrontal white matter integrity. In addition, age was negatively associated with prospective memory function in the laboratory-based assessment, but positively associated with performance on the task completed in daily life. However, none of these behavioural effects were mediated by age-related differences in neural integrity. These data show that, in contrast to literature focused on neurodegenerative disease in which neural losses have been shown to be predictive of PM impairment, age-related differences in brain integrity may not be the best indicator of normal variation in prospective memory function.

Keywordsprospective memory; neuroimaging; neural integrity; normal ageing
Year2025
JournalBrain and Cognition
Journal citation187, p. Article 106301
PublisherElsevier Inc.
ISSN0278-2626
Digital Object Identifier (DOI)https://doi.org/10.1016/j.bandc.2025.106301
PubMed ID40311230
Scopus EID2-s2.0-105003830883
Open accessPublished as ‘gold’ (paid) open access
Page range1-9
FunderAustralian Research Council (ARC)
Australian Catholic University (ACU)
Publisher's version
License
File Access Level
Open
Output statusPublished
Publication dates
Online30 Apr 2025
Publication process dates
Accepted11 Apr 2025
Deposited13 Jun 2025
ARC Funded ResearchThis output has been funded, wholly or partially, under the Australian Research Council Act 2001
Grant IDLP150100140
DP230100759
FT200100843
Additional information

© 2025 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

Permalink -

https://acuresearchbank.acu.edu.au/item/91yzw/age-related-differences-in-neural-integrity-are-unrelated-to-prospective-memory-age-effects

Log in to edit

Download files

Publisher's version
OA_Henry_2025_Age_related_differences_in_neural_integrity.pdf
License: CC BY 4.0
File access level: Open

  • 2
    total views
  • 2
    total downloads
  • 2
    views this month
  • 2
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Executive control contributes little to prospective memory function in older age : Evidence from more ecologically valid paradigms
Haines, Simon J., Busija, Lucy, Hering, Alexandra, Terrett, Gill, McLennan, Skye, Wells, Yvonne, Rendell, Peter G. and Henry, Julie D.. (2025). Executive control contributes little to prospective memory function in older age : Evidence from more ecologically valid paradigms. Memory. 33(2), pp. 233-247. https://doi.org/10.1080/09658211.2024.2431672
Specialization of amygdala subregions in emotion processing
Labuschagne, Izelle, Dominguez, Juan F., Sally, Grace, Mizzi, Simone, Henry, Julie D., Peters, Craig, Rabinak, Christine A., Sinclair, Erin, Lorenzetti, Valentina, Terrett, Gill, Rendell, Peter G., Pedersen, Mangor, Hocking, Darren R. and Heinrichs, Markus. (2024). Specialization of amygdala subregions in emotion processing. Human Brain Mapping. 45(5), p. Article e26673. https://doi.org/10.1002/hbm.26673
Prospective memory functions in traumatic brain injury : The role of neuropsychological deficits, metamemory and impaired self-awareness
Lencsés, Anita, Mikula, Bernadett, Mioni, Giovanna, Rendell, Peter G., Dénes, Zoltán and Demeter, Gyula. (2024). Prospective memory functions in traumatic brain injury : The role of neuropsychological deficits, metamemory and impaired self-awareness. Journal of Neuropsychology. 19(1), pp. 51-66. https://doi.org/10.1111/jnp.12388
Resting-state amygdala subregion and precuneus connectivity provide evidence for a dimensional approach to studying social anxiety disorder
Mizzi, Simone, Pedersen, Mangor, Rossell, Susan L., Rendell, Peter, Terrett, Gill, Heinrichs, Markus and Labuschagne, Izelle. (2024). Resting-state amygdala subregion and precuneus connectivity provide evidence for a dimensional approach to studying social anxiety disorder. Translational Psychiatry. 14(1), p. Article 147. https://doi.org/10.1038/s41398-024-02844-9
Cannabis dependence is associated with reduced hippocampal subregion volumes independently of sex : Findings from an ENIGMA addiction working group multi-country study
Lorenzetti, Valentina, Gaillard, Alexandra, McTavish, Eugene, Sally, Grace, Rossetti, Maria Gloria, Batalla, Albert, Bellani, Marcella, Brambilla, Paolo, Chye, Yann, Conrod, Patricia, Cousijn, Janna, Labuschagne, Izelle, Clemente, Adam, Mackey, Scott, Rendell, Peter, Solowij, Nadia, Suo, Chao, Li, Chiang-Shan R., Terrett, Gillian, ... Roberts, Carl A.. (2024). Cannabis dependence is associated with reduced hippocampal subregion volumes independently of sex : Findings from an ENIGMA addiction working group multi-country study. Cannabis and Cannabinoid Research. X(X), pp. 1-14. https://doi.org/10.1089/can.2023.0204
Episodic foresight is impaired following acute alcohol intoxication
Elliott, Morgan, Terrett, Gillian, Curran, H. Valerie, Rendell, Peter G. and Henry, Julie D.. (2023). Episodic foresight is impaired following acute alcohol intoxication. Journal of Psychopharmacology. 37(5), pp. 490-497. https://doi.org/10.1177/02698811231154851
Parkinson's disease disrupts the ability to initiate and apply episodic foresight
Coundouris, Sarah P., Henry, Julie D., Rendell, Peter G. and Lehn, Alexander C.. (2023). Parkinson's disease disrupts the ability to initiate and apply episodic foresight. Journal of the International Neuropsychological Society. 29(3), pp. 290-297. https://doi.org/10.1017/S1355617722000182
Self-initiating and applying episodic foresight in middle childhood
Horner, Katherine, Coundouris, Sarah P., Terrett, Gill, Rendell, Peter G. and Henry, Julie D.. (2023). Self-initiating and applying episodic foresight in middle childhood. Journal of Experimental Child Psychology. 233, p. Article 105696. https://doi.org/10.1016/j.jecp.2023.105696
Cognitive reappraisal impairs negative affect regulation in the context of social rejection for youth with early-stage borderline personality disorder
Pizarro-Campagna, Elizabeth, Terrett, Gill, Jovev, Martina, Rendell, Peter G., Henry, Julie D. and Chanen, Andrew M.. (2023). Cognitive reappraisal impairs negative affect regulation in the context of social rejection for youth with early-stage borderline personality disorder. Journal of Personality Disorders. 37(2), pp. 156-176. https://doi.org/10.1521/pedi.2023.37.2.156
Deficits in episodic future thinking following acute alcohol consumption
Elliott, Morgan, Terrett, Gillian, Curran, H. Valerie, De Bono, Natalie, Rendell, Peter G. and Henry, Julie D.. (2022). Deficits in episodic future thinking following acute alcohol consumption. Psychopharmacology. 239(8), pp. 2445-2455. https://doi.org/10.1007/s00213-022-06136-2
Episodic foresight in multiple sclerosis
Manchery, Nithin, Henry, Julie D., Blum, Stefan, Swayne, Andrew, Beer, Reuben, Rendell, Peter G. and Nangle, Matthew R.. (2022). Episodic foresight in multiple sclerosis. Neuropsychology. 36(2), pp. 140-149. https://doi.org/10.1037/neu0000785
Concordance in salivary cortisol and subjective anxiety to the trier social stress test in social anxiety disorder
Grace, Caitlin, Heinrichs, Markus, Koval, Peter, Gorelik, Alexandra, von Dawans, Bernadette, Terrett, Gill, Rendell, Peter and Labuschagne, Izelle. (2022). Concordance in salivary cortisol and subjective anxiety to the trier social stress test in social anxiety disorder. Biological Psychology. 175, p. Article 108444. https://doi.org/10.1016/j.biopsycho.2022.108444
Intellectual enrichment and genetic modifiers of cognition and brain volume in Huntington's disease
Papoutsi, Marina, Flower, Michael, Hensman Moss, Davina J., Holmans, Peter, Estevez-Fraga, Carlos, Johnson, Eileanoir B., Scahill, Rachael I., Rees, Geraint, Langbehn, Douglas, Tabrizi, Sarah J., Kraus, Peter, Hoffman, Rainer, Tobin, Alan, Borowsky, Beth, Keenan, S., Whitlock, Kathryn B., Queller, Sarah, Campbell, Colin, Wang, Chiachi, ... Landwehrmeyer, Bernhard. (2022). Intellectual enrichment and genetic modifiers of cognition and brain volume in Huntington's disease. Brain Communications. 4(6), p. Article fcac279. https://doi.org/10.1093/braincomms/fcac279
Is resting-state functional connectivity altered in regular cannabis users? A systematic review of the literature
Thomson, Hannah, Labuschagne, Izelle, Greenwood, Lisa-Marie, Robinson, Emily, Sehl, Hannah, Suo, Chao and Lorenzetti, Valentina. (2022). Is resting-state functional connectivity altered in regular cannabis users? A systematic review of the literature. Psychopharmacology. 239, pp. 1191-1209. https://doi.org/10.1007/s00213-021-05938-0
Resting-state neuroimaging in social anxiety disorder : A systematic review
Mizzi, Simone, Pedersen, Mangor, Lorenzetti, Valentina, Heinrichs, Markus and Labuschagne, Izelle. (2022). Resting-state neuroimaging in social anxiety disorder : A systematic review. Molecular Psychiatry. 27(1), pp. 164-179. https://doi.org/10.1038/s41380-021-01154-6
Acting with the future in mind : Testing competing prospective memory interventions
Henry, Julie D., Hering, Alexandra, Haines, Simon, Grainger, Sarah A., Koleits, Nick, McLennan, Skye, Pelly, Rachel, Doyle, Colleen, Rose, Nathan S., Kliegel, Matthias and Rendell, Peter G.. (2021). Acting with the future in mind : Testing competing prospective memory interventions. Psychology and Aging. 36(4), pp. 491-503. https://doi.org/10.1037/pag0000593
Prospective memory deficits following acute alcohol consumption
Elliott, Morgan, Terrett, Gill, Curran, H. Valerie, De Bono, Natalie, Rendell, Peter G. and Henry, Julie D.. (2021). Prospective memory deficits following acute alcohol consumption. Journal of Psychopharmacology. 35(11), pp. 1386-1397. https://doi.org/10.1177/02698811211056195
Event-based but not time-based prospective memory is related to oral health in late adulthood
Manchery, Nithin, Nangle, Matthew R., Grainger, Sarah A., Haines, Simon, Pradhan, Archana, Rendell, Peter G. and Henry, Julie D.. (2021). Event-based but not time-based prospective memory is related to oral health in late adulthood. Gerontology. 67(1), pp. 112-120. https://doi.org/10.1159/000511607
Identity and shame in body dysmorphic disorder as compared to obsessive-compulsive disorder
Malcolm, Amy, Pikoos, Toni, Castle, David J., Labuschagne, Izelle and Rossell, Susan L.. (2021). Identity and shame in body dysmorphic disorder as compared to obsessive-compulsive disorder. Journal of Obsessive-Compulsive and Related Disorders. 31, p. Article 100686. https://doi.org/10.1016/j.jocrd.2021.100686
Sex differences in the neuroanatomy of alcohol dependence : Hippocampus and amygdala subregions in a sample of 966 people from the ENIGMA Addiction Working Group
Grace, Sally, Rossetti, Maria Gloria, Allen, Nicholas, Batalla, Albert, Bellani, Marcella, Brambilla, Paolo, Chye, Yann, Cousijn, Janna, Goudriaan, Anna E., Hester, Robert, Hutchison, Kent, Labuschagne, Izelle, Momenan, Reza, Martin-Santos, Rocio, Rendell, Peter, Solowij, Nadia, Sinha, Rajita, Li, Chiang-shan Ray, Schmaal, Lianne, ... Lorenzetti, Valentina. (2021). Sex differences in the neuroanatomy of alcohol dependence : Hippocampus and amygdala subregions in a sample of 966 people from the ENIGMA Addiction Working Group. Translational Psychiatry. 11(1), p. Article 156. https://doi.org/10.1038/s41398-021-01204-1
Empirical evidence for cognitive subgroups in body dysmorphic disorder
Malcolm, Amy, Brennan, Sarah N., Grace, Sally A., Pikoos, Toni D., Toh, Wei Lin, Labuschagne, Izelle, Buchanan, Ben, Kaplan, Ryan A., Castle, David J. and Rossell, Susan L.. (2021). Empirical evidence for cognitive subgroups in body dysmorphic disorder. Australian and New Zealand Journal of Psychiatry. 55(4), pp. 381-390. https://doi.org/10.1177/0004867421998762
Age differences in emotion regulation and facial muscle reactivity to emotional films
Labuschagne, Izelle, Pedder, David J., Henry, Julie D., Terrett, Gill and Rendell, Peter G.. (2020). Age differences in emotion regulation and facial muscle reactivity to emotional films. Gerontology. 66, pp. 74-84. https://doi.org/10.1159/000501584
Task characteristics influence facial emotion recognition age-effects : A meta-analytic review
Hayes, Grace S., McLennan, Skye N., Henry, Julie D., Phillips, Louise H., Terrett, Gill, Rendell, Peter G., Pelly, Rachel M. and Labuschagne, Izelle. (2020). Task characteristics influence facial emotion recognition age-effects : A meta-analytic review. Psychology and Aging. 35(2), pp. 295-315. https://doi.org/10.1037/pag0000441
Delusional themes in Body Dysmorphic Disorder (BDD) : Comparisons with psychotic disorders and non-clinical Controls
Rossell, Susan L., Labuschagne, Izelle, Castle, David J. and Toh, Wei Lin. (2020). Delusional themes in Body Dysmorphic Disorder (BDD) : Comparisons with psychotic disorders and non-clinical Controls. Psychiatry Research. 284, p. 112694. https://doi.org/10.1016/j.psychres.2019.112694
An introductory guide to conducting the Trier Social Stress Test
Labuschagne, Izelle, Grace, Caitlin, Rendell, Peter, Terrett, Gillian and Heinrichs, Markus. (2019). An introductory guide to conducting the Trier Social Stress Test. Neuroscience and Biobehavioral Reviews. 107, pp. 686-695. https://doi.org/10.1016/j.neubiorev.2019.09.032
MSH3 modifies somatic instability and disease severity in Huntington's and myotonic dystrophy type 1
Flower, Michael, Lomeikaite, Vilija, Ciosi, Marc, Cumming, Sarah, Morales, Fernando, Lo, Kitty, Hensman Moss, Davina, Jones, Lesley, Holmans, Peter, Kraus, Peter, Hoffman, Rainer, Tobin, Alan, Borowsky, Beth, Keenan, S, Whitlock, Kathryn B., Queller, Sarah, Campbell, Colin, Wang, Chiachi, Langbehn, Doug, ... Tabrizi, Sarah J,. (2019). MSH3 modifies somatic instability and disease severity in Huntington's and myotonic dystrophy type 1. Brain. 142(7), pp. 1876-1886. https://doi.org/10.1093/brain/awz115
Intranasal oxytocin alters amygdala-temporal resting-state functional connectivity in body dysmorphic disorder : A double-blind placebo-controlled randomized trial
Grace, Sally A., Labuschagne, Izelle, Castle, David J. and Rossell, Susan L.. (2019). Intranasal oxytocin alters amygdala-temporal resting-state functional connectivity in body dysmorphic disorder : A double-blind placebo-controlled randomized trial. Psychoneuroendocrinology. 107, pp. 179-186. https://doi.org/10.1016/j.psyneuen.2019.05.022
Apathy associated with impaired recognition of happy facial expressions in Huntington's disease
Osborne-Crowley, Katherine, Andrews, Sophie C., Labuschagne, Izelle, Nair, Akshay, Scahill, Rachael, Craufurd, David, Tabrizi, Sarah J. and Stout, Julie C.. (2019). Apathy associated with impaired recognition of happy facial expressions in Huntington's disease. Journal of the International Neuropsychological Society. 25(5), pp. 453-461. https://doi.org/10.1017/S1355617718001224
The relationship between episodic future thinking and prospective memory in middle childhood : Mechanisms depend on task type
Terrett, Gill, Horner, Katherine, White, Roxanne, Henry, Julie D., Kliegel, Matthias, Labuschagne, Izelle and Rendell, Peter G.. (2019). The relationship between episodic future thinking and prospective memory in middle childhood : Mechanisms depend on task type. Journal of Experimental Child Psychology. 178, pp. 198-213. https://doi.org/10.1016/j.jecp.2018.10.003
Brain regions showing white matter loss in Huntington's Disease are enriched for synaptic and metabolic genes
McColgan, Peter, Gregory, Sarah, Seunarine, Kiran K., Razi, Adeel, Papoutsi, Marina, Johnson, Eileanoir B., Dürr, Alexandra, Roos, Raymund, Leavitt, Blair R., Holmans, Peter, Scahill, Rachael I., Clark, Chris A., Rees, Geraint, Tabrizi, Sarah J., Coleman, A., Decolongon, J., Fan, M., Petkau, T., Jauffret, C., ... Crawfurd, D.. (2018). Brain regions showing white matter loss in Huntington's Disease are enriched for synaptic and metabolic genes. Biological Psychiatry. 83(5), pp. 456-465. https://doi.org/10.1016/j.biopsych.2017.10.019
Testing a longitudinal compensation model in premanifest Huntington's disease
Gregory, Sarah, Long, Jeffrey D., Klöppel, Stefan, Razi, Adeel, Scheller, Elisa, Minkova, Lora, Johnson, Eileanoir B., Durr, Alexandra, Roos, Raymund A. C., Leavitt, Blair R., Mills, James A., Stout, Julie C., Scahill, Rachael I., Tabrizi, Sarah J., Rees, Geraint, the Track-On investigators and Labuschagne, Izelle*. (2018). Testing a longitudinal compensation model in premanifest Huntington's disease. Brain. 141(7), pp. 2156-2166. https://doi.org/10.1093/brain/awy122
Working memory-related effective connectivity in Huntington's disease patients
Lahr, Jacob, Minkova, Lora, Tabrizi, Sarah J., Stout, Julie C., Klöppel, Stefan, Scheller, Elisa, the TrackOn-HD Investigators and Labuschagne, I.. (2018). Working memory-related effective connectivity in Huntington's disease patients. Frontiers in Neurology. 9, p. Article 370. https://doi.org/10.3389/fneur.2018.00370
The relationship between body dysmorphic disorder and obsessive-compulsive disorder: A systematic review of direct comparative studies
Malcolm, Amy, Labuschagne, Izelle, Castle, David J, Terrett, Gill, Rendell, Peter and Rossell, Susan. (2018). The relationship between body dysmorphic disorder and obsessive-compulsive disorder: A systematic review of direct comparative studies. Australian and New Zealand Journal of Psychiatry. 52(11), pp. 1030-1049. https://doi.org/10.1177/0004867418799925
Visual scanning of the eye region of human faces predicts emotion recognition performance in Huntington's disease
Catarina C. Kordsachia, Izelle Labuschagne and Julie C Stout. (2018). Visual scanning of the eye region of human faces predicts emotion recognition performance in Huntington's disease. Neuropsychology. 32(3), pp. 356-365. https://doi.org/10.1037/neu0000424
Oxytocin selectively modulates brain processing of disgust in Huntington's disease gene carriers
Izelle Labuschagne, Govinda Poudel, Catarina C. Kordsachia, Qizhu Wu, Hannah Thomson, Nellie Georgiou-Karistianis and Julie C Stout. (2018). Oxytocin selectively modulates brain processing of disgust in Huntington's disease gene carriers. Progress in Neuropsychopharmacology and Biological Psychiatry. 81, pp. 11-16. https://doi.org/10.1016/j.pnpbp.2017.09.023
Oxytocin and brain activity in humans: A systematic review and coordinate-based meta-analysis of functional MRI studies
Sally A. Grace, Susan Rossell, Markus Heinrichs, Catarina C. Kordsachia and Izelle Labuschagne. (2018). Oxytocin and brain activity in humans: A systematic review and coordinate-based meta-analysis of functional MRI studies. Psychoneuroendocrinology. 96, pp. 6-24. https://doi.org/10.1016/j.psyneuen.2018.05.031
Intranasal oxytocin does not reduce age-related difficulties in social cognition
Sarah A. Grainger, Julie Henry, Henriette R. Steinvik, Eric J Vanman, Peter Rendell and Izelle Labuschagne. (2018). Intranasal oxytocin does not reduce age-related difficulties in social cognition. Hormones and Behaviour. 99, pp. 25-34. https://doi.org/10.1016/j.yhbeh.2018.01.009
Diminished facial EMG responses to disgusting scenes and happy and fearful faces in Huntington's disease
Catarina C. Kordsachia, Izelle Labuschagne, Sophie C. Andrews and Julie C. Stout. (2018). Diminished facial EMG responses to disgusting scenes and happy and fearful faces in Huntington's disease. Cortex. 106, pp. 185-199. https://doi.org/10.1016/j.cortex.2018.05.019
Decision-making, somatic markers and emotion processing in opiate users
Kathryn Biernacki, Gill Terrett, Skye McLennan, Izelle Labuschagne, Phoebe Morton and Peter Rendell. (2018). Decision-making, somatic markers and emotion processing in opiate users. Psychopharmacology. 235(1), pp. 223-232. https://doi.org/10.1007/s00213-017-4760-0
Brief Report: The Impact of Sensory Hypersensitivity and Intolerance of Uncertainty on Anxiety in Williams Syndrome
Mirko Uljarević, Izelle Labuschagne, Rebecca Bobin, Anna Atkinson and Darren R. Hocking. (2018). Brief Report: The Impact of Sensory Hypersensitivity and Intolerance of Uncertainty on Anxiety in Williams Syndrome. Journal of Autism and Developmental Disorders. 48(11), pp. 3958-3964. https://doi.org/10.1007/s10803-018-3631-9
Intranasal oxytocin reduces heart rate variability during a mental arithmetic task: A randomised, double-blind, placebo-controlled cross-over study
Tracy, Lincoln M., Gibson, Stephen J., Labuschagne, Izelle, Georgiou-Karistianis, Nellie and Giummarra, Melita J.. (2018). Intranasal oxytocin reduces heart rate variability during a mental arithmetic task: A randomised, double-blind, placebo-controlled cross-over study. Progress in Neuropsychopharmacology and Biological Psychiatry. 81, pp. 408 - 415. https://doi.org/10.1016/j.pnpbp.2017.08.016
Families affected by Huntington's Disease report difficulties in communication, emotional involvement, and problem solving
Jona, Celine M. H., Labuschagne, Izelle, Mercieca, Emily-Clare, Fisher, Fiona, Gluyas, Cathy, Stout, Julie C. and Andrews, Sophie C.. (2017). Families affected by Huntington's Disease report difficulties in communication, emotional involvement, and problem solving. Journal of Huntington's Disease. 6(3), pp. 169-177. https://doi.org/10.3233/JHD-170250
Sex-specific effects of intranasal oxytocin on thermal pain perception: A randomised, double-blind, placebo-controlled cross-over study
Tracy, Lincoln M., Labuschagne, Izelle, Georgiou-Karistianis, Nellie, Gibson, Stephen J. and Giummarra, Melita J.. (2017). Sex-specific effects of intranasal oxytocin on thermal pain perception: A randomised, double-blind, placebo-controlled cross-over study. Psychoneuroendocrinology. 83, pp. 101 - 110. https://doi.org/10.1016/j.psyneuen.2017.05.028
Beyond emotion recognition deficits: A theory guided analysis of emotion processing in Huntington's disease
Kordsachia, Catarina C., Labuschagne, Izelle and Stout, Julie C.. (2017). Beyond emotion recognition deficits: A theory guided analysis of emotion processing in Huntington's disease. Neuroscience and Biobehavioral Reviews. 73, pp. 276 - 292. https://doi.org/10.1016/j.neubiorev.2016.11.020
Impairments in spatiotemporal gait adaptation during obstacle navigation in Huntington’s disease
Anwar, Naznine, Labuschagne, Izelle, Simpson, Katrina, Smith, Luke and Georgiou-Karistianis, Nellie. (2017). Impairments in spatiotemporal gait adaptation during obstacle navigation in Huntington’s disease. Neurorehabilitation and Neural Repair. 31(10-11), pp. 934 - 943. https://doi.org/10.1177/1545968317736818
Abnormal visual scanning of emotionally evocative natural scenes in Huntington's disease
Kordsachia, Catarina C., Labuschagne, Izelle and Stout, Julie C.. (2017). Abnormal visual scanning of emotionally evocative natural scenes in Huntington's disease. Frontiers in Psychology. 8(March), pp. 1 - 10. https://doi.org/10.3389/fpsyg.2017.00405
White matter predicts functional connectivity in premanifest Huntington's disease
McColgan, Peter, Gregory, Sarah, Razi, Adeel, Seunarine, Kiran K., Gargouri, Fatma, Durr, Alexandra, Roos, Raymund A. C., Leavitt, Blair R., Scahill, Rachael I., Clark, Chris A., Tabrizi, Sarah J., Rees, Geraint, Coleman, Allison J., Decolongon, J., Fan, M., Petkau, T., Jauffret, Céline, Justo, Damian, Lehericy, S., ... Johnson, H.. (2017). White matter predicts functional connectivity in premanifest Huntington's disease. Annals of Clinical and Translational Neurology. 4(2), pp. 106 - 118. https://doi.org/10.1002/acn3.384
The neurobiology of body dysmorphic disorder: A systematic review and theoretical model
Grace, Sally A., Labuschagne, Izelle, Kaplan, Ryan A. and Rossell, Susan L.. (2017). The neurobiology of body dysmorphic disorder: A systematic review and theoretical model. Neuroscience and Biobehavioral Reviews. 83, pp. 83 - 96. https://doi.org/10.1016/j.neubiorev.2017.10.003
Emotion processing in persons who respond vicariously towards others in pain: Disinhibited left-lateralized neural activity for threatening expressions
Giummarra, Melita J., Poudel, Govinda, Niu, P. Amanda, Nicholls, Michael E. R., Fielding, Joanne, Verdejo-Garcia, Antonio and Labuschagne, Izelle. (2017). Emotion processing in persons who respond vicariously towards others in pain: Disinhibited left-lateralized neural activity for threatening expressions. Laterality: Assymetries of body, brain and cognition. 23(2), pp. 184 - 208. https://doi.org/10.1080/1357650X.2017.1349781
Identification of genetic variants associated with Huntington's disease progression: A genome-wide association study
Hensman Moss, Davina J., Pardiñas, Antonio F., Langbehn, Douglas, Lo, Kitty, Leavitt, Blair R., Roos, Raymund, Durr, Alexandra, Mead, Simon, TRACK-HD investigators,, REGISTRY investigators,, Labuschagne, Izelle, TRACK-HD investigators and REGISTRY investigators. (2017). Identification of genetic variants associated with Huntington's disease progression: A genome-wide association study. The Lancet Neurology. 16(9), pp. 701 - 711. https://doi.org/10.1016/S1474-4422(17)30161-8
The wisdom to know the difference : Strategy-situation fit in emotion regulation in daily life is associated with well-being
Haines, Simon J., Gleeson, John, Kuppens, Peter, Hollenstein, Tom, Ciarrochi, Joseph, Labuschagne, Izelle, Grace, Caitlin and Koval, Peter. (2016). The wisdom to know the difference : Strategy-situation fit in emotion regulation in daily life is associated with well-being. Psychological Science. 27(12), pp. 1651-1659. https://doi.org/10.1177/0956797616669086
Improving research standards to restore trust in intranasal oxytocin
Carson, Dean S., Yuan, Hsiangkuo and Labuschagne, Izelle. (2016). Improving research standards to restore trust in intranasal oxytocin. Biological Psychiatry. 79(8), pp. e53 - e54. https://doi.org/10.1016/j.biopsych.2015.08.031
Effects of oxytocin and genetic variants on brain and behaviour : Implications for treatment in schizophrenia
Bartholomeusz, Cali, Ganella, Eleni, Labuschagne, Izelle, Bousman, Chad and Pantelis, Christos. (2015). Effects of oxytocin and genetic variants on brain and behaviour : Implications for treatment in schizophrenia. Schizophrenia Research. 168(3), pp. 614 - 627. https://doi.org/10.1016/j.schres.2015.06.007
Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder
Gorka, Stephanie M., Fitzgerald, Daniel A., Labuschagne, Izelle, Hosanagar, Avinash, Wood, Amanda G., Nathan, Pradeep J. and Phan, K. Luan. (2015). Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder. Neuropsychopharmacology. 40(2), pp. 278 - 286. https://doi.org/10.1038/npp.2014.168
Detection of motor changes in huntington's disease using dynamic causal modeling
Minkova, Lora, Scheller, Elisa, Peter, Jessica, Abdulkadir, Ahmed, Kaller, Christoph P., Roos, Raymund A. C., Dürr, Alexandra, Leavitt, Blair R., Tabrizi, Sarah J., Kloppel, Stefan, Coleman, Allison J., Decolongon, J., Fan, M., Koren, T., Jauffret, Céline, Justo, Damian, Lehericy, Stephane, Nigaud, Kevin, Valabrègue, Romain, ... Mills, J.. (2015). Detection of motor changes in huntington's disease using dynamic causal modeling. Frontiers in Human Neuroscience. 9, pp. 1 - 13. https://doi.org/10.3389/fnhum.2015.00634
Compensation in preclinical Huntington's disease: Evidence from the track-on hd study
Kloppel, Stefan, Gregory, Sarah, Scheller, Elisa, Minkova, Lora, Razi, Adeel, Durr, Alexandra, Roos, Raymund A. C., Leavitt, Blair R., Papoutsi, Marina, Landwehrmeyer, G. Bernhard, Reilmann, Ralf, Borowsky, Beth, Johnson, Hans, Mills, James A., Owen, Gail N., Stout, Julie C., Scahill, Rachael I., Long, Jeffrey D., Rees, Geraint, ... Orth, M.. (2015). Compensation in preclinical Huntington's disease: Evidence from the track-on hd study. EBioMedicine. 2(10), pp. 1420 - 1429. https://doi.org/10.1016/j.ebiom.2015.08.002
Neuropsychiatry and white matter microstructure in Huntington's Disease
Gregory, Sarah L., Scahill, Rachael I., Seunarine, Kiran K., Stopford, Cheryl, Zhang, Hui, Zhang, Jiaying, Orth, Michael, Dürr, Alexandra, Roos, Raymund A. C., Langbehn, Douglas R., Long, Jeffrey D., Johnson, Hans, Rees, Geraint, Tabrizi, Sarah J., Craufurd, David I. O., Campbell, C., Campbell, Melissa, Labuschagne, Izelle, Milchman, C., ... Campbell, Colin. (2015). Neuropsychiatry and white matter microstructure in Huntington's Disease. Journal of Huntington's Disease. 4(3), pp. 239 - 249. https://doi.org/10.3233/JHD-150160
Differential effects of social stress on laboratory-based decision-making are related to both impulsive personality traits and gender
Wise, Richard J., Phung, Alissa L., Labuschagne, Izelle and Stout, Julie C.. (2015). Differential effects of social stress on laboratory-based decision-making are related to both impulsive personality traits and gender. Cognition and Emotion. 29, pp. 1475 - 1485. https://doi.org/10.1080/02699931.2014.989815
Safety, tolerability, and efficacy of PBT2 in Huntington's disease: A phase 2, randomised, double-blind, placebo-controlled trial
Angus, D., Herd, C., Stone, C., Stout, Julie, Wieler, Marguerite, Reilmann, Ralf, Ritchie, C. W., Dorsey, Earl Ray, Helles, K., Kayson, Elise, Oakes, David, Rosas, Herminia Diana, Vaughan, Carr J., Panegyres, Peter K., Ames, David J., Goh, Anita, Agarwal, Pinky, Churchyard, Andrew, Murathodizic, M., ... Targum, S.. (2015). Safety, tolerability, and efficacy of PBT2 in Huntington's disease: A phase 2, randomised, double-blind, placebo-controlled trial. Lancet Neurology. 14(1), pp. 39 - 47. https://doi.org/10.1016/S1474-4422(14)70262-5
The impact of occipital lobe cortical thickness on cognitive task performance : An investigation in Huntington's Disease
Johnson, Eileanoir, Rees, Elin, Labuschagne, Izelle, Durr, Alexandra, Leavitt, Blair, Roos, Raymund, Reilmann, Ralf, Johnson, Hans, Hobbs, Nicola, Langbehn, Douglas, Stout, Julie, Tabrizi, Sarah and Scahill, Rachael. (2015). The impact of occipital lobe cortical thickness on cognitive task performance : An investigation in Huntington's Disease. Neuropsychologia. 79, pp. 138 - 146. https://doi.org/10.1016/j.neuropsychologia.2015.10.033
Modulation of resting-state amygdala-frontal functional connectivity by oxytocin in generalized social anxiety disorder
Dodhia, Sonam, Hosanagar, Avinash, Fitzgerald, Daniel A., Labuschagne, Izelle, Wood, Amanda G., Nathan, Pradeep J. and Phan, Kinhluan Luan. (2014). Modulation of resting-state amygdala-frontal functional connectivity by oxytocin in generalized social anxiety disorder. Neuropsychopharmacology. 39(9), pp. 2061 - 2069. https://doi.org/10.1038/npp.2014.53
Using theories of delusion formation to explain abnormal beliefs in Body Dysmorphic Disorder (BDD)
Rossell, Susan L., Labuschagne, Izelle, Dunai, Judith, Kyrios, Michael and Castle, David. (2014). Using theories of delusion formation to explain abnormal beliefs in Body Dysmorphic Disorder (BDD). Psychiatry Research. 215(3), pp. 599 - 605. https://doi.org/10.1016/j.psychres.2013.12.030
The potential of composite cognitive scores for tracking progression in Huntington's disease.
Jones, Rebecca D., Stout, Julie C., Labuschagne, Izelle, Say, Miranda Julia, Justo, Damian, Coleman, Allison J., Dumas, Eve M., Hart, Ellen P., Owen, Gail N., Durr, Alexandra, Leavitt, Blair R., Roos, Raymund A. C., O'Regan, Alison M., Langbehn, Doug R., Tabrizi, Sarah J. and Frost, Chris D.. (2014). The potential of composite cognitive scores for tracking progression in Huntington's disease. Journal of Huntington's Disease. 3(2), pp. 197 - 207. https://doi.org/10.3233/JHD-140101
The cognitive burden in Huntington's disease: Pathology, phenotype and mechanisms of compensation
Papoutsi, Marina, Labuschagne, Izelle, Tabrizi, Sarah J. and Stout, Julie C.. (2014). The cognitive burden in Huntington's disease: Pathology, phenotype and mechanisms of compensation. Movement Disorders Society. 29(5), pp. 673 - 683. https://doi.org/10.1002/mds.25864
A comparison of executive function in Body Dysmorphic Disorder (BDD) and Obsessive-Compulsive Disorder (OCD)
Labuschagne, Izelle, Rossell, Susan, Dunai, Judith, Castle, David and Kyrios, Michael. (2013). A comparison of executive function in Body Dysmorphic Disorder (BDD) and Obsessive-Compulsive Disorder (OCD). Journal of Obsessive-Compulsive and Related Disorders. 2(3), pp. 257 - 262. https://doi.org/10.1016/j.jocrd.2013.05.003
Oxytocin enhances resting-state connectivity between amygdala and medial frontal cortex
Sripada, Chandra, Phan, Kinhluan, Labuschagne, Izelle, Welsh, Robert, Nathan, Pradeep and Wood, Amanda. (2013). Oxytocin enhances resting-state connectivity between amygdala and medial frontal cortex. International Journal of Neuropsychopharmacology (print). 16(2), pp. 255 - 260. https://doi.org/10.1017/S1461145712000533
Emotional face recognition deficits and medication effects in pre-manifest through stage-II Huntington's disease
Labuschagne, Izelle, Jones, Rebecca, Callaghan, Jenny, Whitehead, Daisy, Dumas, Eve, Say, Miranda, Hart, Ellen, Justo, Damian, Coleman, Allison, Dar Santos, Rachelle, Frost, Chris, Craufurd, David, Trabrizi, Sarah and Stout, Julie. (2013). Emotional face recognition deficits and medication effects in pre-manifest through stage-II Huntington's disease. Psychiatry Research. 207(1-2), pp. 118 - 126. https://doi.org/10.1016/j.psychres.2012.09.022
Emotional face recognition deficits and medication effects in pre-manifest through stage-II Huntington's disease
Labuschagne, Izelle, Jones, Rebecca, Callaghan, Jenny, Whitehead, Daisy, Dumas, Eve, Say, Miranda, Hart, Ellen, Justo, Damian, Coleman, Allison, Dar Santos, Rachelle, Frost, Chris, Craufurd, David, Tabrizi, Sarah and Stout, Julie. (2013). Emotional face recognition deficits and medication effects in pre-manifest through stage-II Huntington's disease. Psychiatry Research. 207(1-2), pp. 118 - 126. https://doi.org/10.1016/j.psychres.2012.09.022
Oxytocin enhances resting-state connectivity between amygdala and medial frontal cortex
Sripada, Chandra, Phan, Kinhluan, Labuschagne, Izelle, Welsh, Robert, Nathan, Pradeep and Wood, Amanda. (2013). Oxytocin enhances resting-state connectivity between amygdala and medial frontal cortex. International Journal of Neuropsychopharmacology. 16(2), pp. 255 - 260. https://doi.org/10.1017/S1461145712000533
Visual working memory impairment in premanifest gene-carriers and early Huntington's Disease
Dumas, Eve M., Say, Miranda Julia, Jones, Rebecca D., Labuschagne, Izelle, O'Regan, Alison M., Hart, Ellen P., van den Bogaard, Simon J. A., Queller, Sarah, Justo, Damian, Coleman, Allison J., dar Santos, Rachelle C., Durr, Alexandra, Leavitt, Blair R., Tabrizi, Sarah J., Roos, Raymund A. C. and Stout, Julie C.. (2012). Visual working memory impairment in premanifest gene-carriers and early Huntington's Disease. Journal of Huntington's Disease. 1(1), pp. 97 - 106. https://doi.org/10.3233/JHD-2012-120010
Evaluation of longitudinal 12 and 24 month cognitive outcomes in premanifest and early Huntington's disease
Stout, Julie, Jones, Rebecca, Labuschagne, Izelle, O'Regan, Alison, Say, Miranda, Dumas, Eve, Queller, Sarah, Justo, Damian, Dar Santos, Rachelle, Coleman, Allison, Hart, Ellen, Durr, Alexandra, Leavitt, Blair, Roos, Raymund, Langbehn, Doug, Tabrizi, Sarah J. and Frost, Chris. (2012). Evaluation of longitudinal 12 and 24 month cognitive outcomes in premanifest and early Huntington's disease. Journal of Neurology, Neurosurgery and Psychiatry. 83(7), pp. 687 - 694. https://doi.org/10.1136/jnnp-2011-301940
Medial frontal hyperactivity to sad faces in generalized social anxiety disorder and modulation by oxytocin
Labuschagne, Izelle, Phan, K. Luan, Wood, Amanda, Angstadt, Mike, Chua, Phyllis, Heinrichs, Markus, Stout, Julie C., Nathan, Pradeep J. and Pradeep,. (2012). Medial frontal hyperactivity to sad faces in generalized social anxiety disorder and modulation by oxytocin. International Journal of Neuropsychopharmacology (print). 15(7), pp. 883 - 896. https://doi.org/10.1017/S1461145711001489
Evaluation of longitudinal 12 and 24 month cognitive outcomes in premanifest and early Huntington's disease
Stout, Julie, Jones, Rebecca, Labuschagne, Izelle, O'Regan, Alison, Say, Miranda, Dumas, Eve, Queller, Sarah, Justo, Damian, Dar Santos, Rachelle, Coleman, Allison, Hart, Ellen, Durr, Alexandra, Leavitt, Blair, Roos, Raymund, Langbehn, Douglas, Tabrizi, Sarah J. and Frost, Chris. (2012). Evaluation of longitudinal 12 and 24 month cognitive outcomes in premanifest and early Huntington's disease. Journal of Neurology, Neurosurgery and Psychiatry. 83(7), pp. 687 - 694. https://doi.org/10.1136/jnnp-2011-301940
What the cognitive deficits in body dysmorphic disorder tell us about the underlying neurobiology: An investigation of three cases
Labuschagne, Izelle, Castle, David and Rossell, Susan L.. (2011). What the cognitive deficits in body dysmorphic disorder tell us about the underlying neurobiology: An investigation of three cases. International Journal of Cognitive Therapy. 4(1), pp. 21 - 33. https://doi.org/10.1521/ijct.2011.4.1.21
Oxytocin attenuates amygdala reactivity to fear in generalized social anxiety disorder
Labuschagne, Izelle, Phan, K. Luan, Wood, Amanda G., Angstadt, Mike, Chua, Phyllis, Heinrichs, Markus, Stout, Julie C. and Nathan, Pradeep. (2010). Oxytocin attenuates amygdala reactivity to fear in generalized social anxiety disorder. Neuropsychopharmacology. 35(12), pp. 2403 - 2413. https://doi.org/10.1038/npp.2010.123
Augmenting serotonin neurotransmission with citalopram modulates emotional expression decoding but not structural encoding of moderate intensity sad facial emotional stimuli: An event-related potential (ERP) investigation
Labuschagne, Izelle, Croft, Rodney, Phan, K. Luan and Nathan, Pradeep. (2010). Augmenting serotonin neurotransmission with citalopram modulates emotional expression decoding but not structural encoding of moderate intensity sad facial emotional stimuli: An event-related potential (ERP) investigation. Journal of Psychopharmacology. 24(8), pp. 1153 - 1164. https://doi.org/10.1177/0269881108097878
Executive function in body dysmorphic disorder
Dunai, Judith, Labuschagne, Izelle, Castle, David J., Kyrios, Michael and Rossell, Susan. (2010). Executive function in body dysmorphic disorder. Psychological Medicine. 40(9), pp. 1541 - 1548. https://doi.org/10.1017/S003329170999198X
An examination of delusional thinking and cognitive styles in body dysmorphic disorder
Labuschagne, Izelle, Castle, David J., Dunai, Judith, Kyrios, Michael and Rossell, Susan. (2010). An examination of delusional thinking and cognitive styles in body dysmorphic disorder. Australian and New Zealand Journal of Psychiatry. 44(8), pp. 706 - 712. https://doi.org/10.3109/00048671003671007
Evidence for modulation of facial emotional processing bias during emotional expression decoding by serotonergic and noradrenergic antidepressants: An event-related potential (ERP) study
Kerestes, Rebecca, Labuschagne, Izelle, Croft, Rodney, O'Neill, Barry, Bhagwagar, Zubin M., Phan, K Luan and Nathan, Pradeep. (2009). Evidence for modulation of facial emotional processing bias during emotional expression decoding by serotonergic and noradrenergic antidepressants: An event-related potential (ERP) study. Psychopharmacology. 202(4), pp. 621 - 634. https://doi.org/10.1007/s00213-008-1340-3