Voluntary physical activity protects against olanzapine-induced hyperglycemia
Journal article
Shamshoum, Hesham, McKie, Greg L., Medak, Kyle D., Ashworth, Kristen E., Kemp, Bruce E. and Wright, David C.. (2021). Voluntary physical activity protects against olanzapine-induced hyperglycemia. Journal of Applied Physiology. 130(2), pp. 466-478. https://doi.org/10.1152/japplphysiol.00876.2020
Authors | Shamshoum, Hesham, McKie, Greg L., Medak, Kyle D., Ashworth, Kristen E., Kemp, Bruce E. and Wright, David C. |
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Abstract | Olanzapine (OLZ) is used in the treatment of schizophrenia and a growing number of “off-label” conditions. Although effective in reducing psychoses, OLZ causes rapid impairments in glucose and lipid homeostasis. The purpose of this study was to investigate if voluntary physical activity via wheel running (VWR) would protect against the acute metabolic side effects of OLZ. Male C57BL/6J mice remained sedentary or were provided with running wheels overnight, before treatment with OLZ either at the beginning of the light cycle, or 7 or 24 h following the cessation of VWR. Prior VWR protected against OLZ-induced hyperglycemia immediately and 7 h following a bout of overnight wheel running. Protection against, hyperglycemia immediately following VWR was associated with increased insulin tolerance and an attenuated OLZ-induced increase in the serum glucagon:insulin ratio. The protective effect of VWR against OLZ-induced increases in hyperglycemia and glucagon:insulin ratio was maintained in high-fat fed, and AMPK β1-deficient mice, models which display a potentiated OLZ-induced increase in blood glucose. Repeated OLZ treatment did not impair VWR performance and protection against the acute effects of OLZ on blood glucose was present after 1 wk of daily OLZ treatment in mice given access to running wheels. In contrast to the effects on glucose metabolism, VWR, for the most part, did not impact OLZ-induced perturbations in lipolysis, liver triglyceride accumulation, or whole body substrate oxidation. Collectively, our findings demonstrate the efficacy of voluntary physical activity as an approach to protect against OLZ-induced impairments in glucose metabolism. |
Keywords | antipsychotic; glucose; insulin; mice; physical activity |
Year | 2021 |
Journal | Journal of Applied Physiology |
Journal citation | 130 (2), pp. 466-478 |
Publisher | American Physiological Society |
ISSN | 8750-7587 |
Digital Object Identifier (DOI) | https://doi.org/10.1152/japplphysiol.00876.2020 |
Scopus EID | 2-s2.0-85102213073 |
Open access | Published as green open access |
Research or scholarly | Research |
Page range | 466-478 |
Funder | Australian Research Council (ARC) |
National Health and Medical Research Council (NHMRC) | |
Author's accepted manuscript | License All rights reserved File Access Level Open |
Publisher's version | License All rights reserved File Access Level Controlled |
Output status | Published |
Publication dates | |
Online | 18 Feb 2021 |
01 Feb 2021 | |
Publication process dates | |
Accepted | 22 Dec 2020 |
Deposited | 01 Jul 2021 |
ARC Funded Research | This output has been funded, wholly or partially, under the Australian Research Council Act 2001 |
Grant ID | ARC/170101196 |
NHMRC/1085460 |
https://acuresearchbank.acu.edu.au/item/8w4wx/voluntary-physical-activity-protects-against-olanzapine-induced-hyperglycemia
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Author's accepted manuscript
AM_Shamshoum_2021_Voluntary_physical_activity_protects_against_olanzapine.pdf | |
License: All rights reserved | |
File access level: Open |
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