Stable isotope approaches to study muscle mass outcomes in clinical populations

Journal article


Chapple, Lee-Anne S., Dirks, Marlou L. and Kouw, Imre W. K.. (2021). Stable isotope approaches to study muscle mass outcomes in clinical populations. Clinical Nutrition Open Science. 36, pp. 98-108. https://doi.org/10.1016/j.nutos.2021.01.004
AuthorsChapple, Lee-Anne S., Dirks, Marlou L. and Kouw, Imre W. K.
Abstract

Both low muscle mass and muscle loss are associated with reduced physical function, mobility, independence, and quality of life, and are characteristic of a number of clinical conditions including diabetes, cardiovascular disease (CVD), chronic obstructive pulmonary disease (COPD), and critical illness. The accurate measurement of muscle mass is critical to assess the efficacy of an intervention or therapy. Stable isotope amino acid approaches can be used to quantify specific aspects of whole-body and muscle protein turnover, including synthesis and breakdown, which play distinctive roles in muscle mass maintenance in direct response to therapies. This review aims to elucidate whether acute responses measured using stable isotope amino acid tracers relate to changes in muscle mass in vulnerable clinical populations. Experimental studies quantifying whole-body protein synthesis and breakdown rates in clinical populations have been conducted to determine the response to nutritional interventions or to compare disease with health; however, these studies show limited potential to translate to expected muscle mass outcomes. In addition, clinical studies that have assessed both muscle mass and acute changes in whole-body or muscle protein turnover are lacking. We argue that the assessment of both muscle protein synthesis and breakdown rates, or simply limb net balance, obtains the most complete picture in relation to muscle-specific outcomes. While stable isotope amino acid tracer experiments provide meaningful mechanistic insight into the acute response to clinical interventions, they should be combined with, and/or followed-up by, longer-term studies incorporating measurements of muscle mass to ascertain the impact of an intervention on muscle mass maintenance in clinical populations.

Keywordsstable isotope tracers; amino acid; protein metabolism; muscle mass
Year2021
JournalClinical Nutrition Open Science
Journal citation36, pp. 98-108
PublisherElsevier Ltd
ISSN2667-2685
Digital Object Identifier (DOI)https://doi.org/10.1016/j.nutos.2021.01.004
Scopus EID2-s2.0-85102819695
Open accessPublished as ‘gold’ (paid) open access
Research or scholarlyResearch
Page range98-108
Publisher's version
License
File Access Level
Open
Output statusPublished
Publication dates
Online01 Mar 2021
Publication process dates
Accepted19 Jan 2021
Deposited14 Mar 2022
Permalink -

https://acuresearchbank.acu.edu.au/item/8x896/stable-isotope-approaches-to-study-muscle-mass-outcomes-in-clinical-populations

Download files


Publisher's version
OA_Chapple_2021_Stable_isotope_approaches_to_study_muscle.pdf
License: CC BY-NC-ND 4.0
File access level: Open

  • 26
    total views
  • 8
    total downloads
  • 2
    views this month
  • 1
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

No differences in muscle protein synthesis rates following ingestion of wheat protein, milk protein, and their protein blend in healthy, young males
Pinckaers, Philippe J. M., Kouw, Imre W. K., Hendriks, Floris K., van Kranenburg, Janneau M. X., de Groot, Lisette C. P. G. M., Verdijk, Lex B., Snijders, Tim and van Loon, Luc J. C.. (2021). No differences in muscle protein synthesis rates following ingestion of wheat protein, milk protein, and their protein blend in healthy, young males. British Journal of Nutrition. 126(12), pp. 1832-1842. https://doi.org/10.1017/S0007114521000635
Protein type, protein dose, and age modulate dietary protein digestion and phenylalanine absorption kinetics and plasma phenylalanine availability in humans
Gorissen, Stefan H. M., Trommelen, Jorn, Kouw, Imre W. K., Holwerda, Andrew M., Pennings, Bart, Groen, Bart B. L., Wall, Benjamin T., Churchward-Venne, Tyler A., Horstman, Astrid M. H., Koopman, René, Burd, Nicholas A., Fuchs, Cas J., Dirks, Marlou L., Res, Peter T., Senden, Joan M. G., Steijns, Jan M. J. M., de Groot, Lisette C. P. G. M., Verdijk, Lex B. and van Loon, Luc J. C.. (2020). Protein type, protein dose, and age modulate dietary protein digestion and phenylalanine absorption kinetics and plasma phenylalanine availability in humans. The Journal of Nutrition. 150(8), pp. 2041-2050. https://doi.org/10.1093/jn/nxaa024
Postexercise cooling impairs muscle protein synthesis rates in recreational athletes
Fuchs, Cas J., Kouw, Imre W. K., Churchward-Venne, Tyler A., Smeets, Joey S. J., Senden, Joan M., Lichtenbelt, Wouter D. van Marken, Verdijk, Lex B. and van Loon, Luc J. C.. (2020). Postexercise cooling impairs muscle protein synthesis rates in recreational athletes. The Journal of Physiology. 598(4), pp. 755-772. https://doi.org/10.1113/JP278996
Intermittent versus continuous enteral nutrition attenuates increases in insulin and leptin during short-term bed rest
Gonzalez, Javier T., Dirks, Marlou L., Holwerda, Andrew M., Kouw, Imre W. K. and van Loon, Luc J. C.. (2020). Intermittent versus continuous enteral nutrition attenuates increases in insulin and leptin during short-term bed rest. European Journal of Applied Physiology. 120, pp. 2083-2094. https://doi.org/10.1007/s00421-020-04431-4
During hospitalization, older patients at risk for malnutrition consume <0.65 grams of protein per kilogram body weight per day
Weijzen, Michelle E. G., Kouw, Imre W. K., Geerlings, Phil, Verdijk, Lex B. and van Loon, Luc J. C.. (2020). During hospitalization, older patients at risk for malnutrition consume <0.65 grams of protein per kilogram body weight per day. Nutrition in Clinical Practice. 35(4), pp. 655-663. https://doi.org/10.1002/ncp.10542
The muscle protein synthetic response to whey protein ingestion is greater in middle-aged women when compared with men
Horstman, Astrid M. H., Kouw, Imre W. K., van Dijk, Jan-Willem, Hamer, Henrike M., Groen, Bart B. L., van Kranenburg, Janneau, Gorissen, Stefan H. M. and van Loon, Luc J. C.. (2019). The muscle protein synthetic response to whey protein ingestion is greater in middle-aged women when compared with men. The Journal of Clinical Endocrinology and Metabolism. 104(4), pp. 994 - 1004. https://doi.org/10.1210/jc.2018-01734
The impact of pre-sleep protein ingestion on the skeletal muscle adaptive response to exercise in humans: An update
Snijders, Tim, Trommelen, Jorn, Kouw, Imre W. K., Holwerda, Andrew M., Verdijk, Lex B. and van Loon, Luc J. C.. (2019). The impact of pre-sleep protein ingestion on the skeletal muscle adaptive response to exercise in humans: An update. Frontiers in Nutrition. 6, pp. 1 - 8. https://doi.org/10.3389/fnut.2019.00017
Dietary feeding pattern does not modulate the loss of muscle mass or the decline in metabolic health during short-term bed rest
Dirks, Marlou L., Smeets, Joey S. J., Holwerda, Andrew M., Kouw, Imre W. K., Marzuca-Nassr, Gabriel N., Gijsen, Annemie P., Holloway, Graham P., Verdijk, Lex B. and van Loon, Luc J. C.. (2019). Dietary feeding pattern does not modulate the loss of muscle mass or the decline in metabolic health during short-term bed rest. American Journal of Physiology - Endocrinology and Metabolism. 316(3), pp. 536 - 545. https://doi.org/10.1152/ajpendo.00378.2018
Protein intake falls below 0.6 g.kg-1d-1 in healthy, older patients admitted for elective hip of knee arthroplasty
Weijzen, M. E. G., Kouw, Imre W. K., Verschuren, A. A. J., Muyters, R., Geurts, Jan A. P., Emans, P. J., Geerlings, P., Verdijk, Lex B. and Van Loon, Luc J. C.. (2019). Protein intake falls below 0.6 g.kg-1d-1 in healthy, older patients admitted for elective hip of knee arthroplasty. Journal of Nutrition, Health and Aging. 23(3), pp. 299 - 305. https://doi.org/10.1007/s12603-019-1157-2
One week of hospitalization following elective hip surgery induces substantial muscle atrophy in older patients
Kouw, Imre W. K., Groen, Bart B. L., Smeets, Joey S. J., Kramer, Irene Fleur, van Kranenburg, Janneau M. X., Nilwik, Rachél, Geurts, Jan A. P., ten Broeke, René H. M., Poeze, Martijn, van Loon, Luc J. C. and Verdijk, Lex B.. (2019). One week of hospitalization following elective hip surgery induces substantial muscle atrophy in older patients. Journal of the American Medical Directors Association (JAMDA): long-term care: management, applied research and clinical issues. 20(1), pp. 35 - 42. https://doi.org/10.1016/j.jamda.2018.06.018
Basal and postprandial myofibrillar protein synthesis rates do not differ between lean and obese middle-aged men
Kouw, Imre W. K., van Dijk, Jan Willem, Horstman, Astrid M. H., Kramer, Irene Fleur, Goessens, Joy P. B., van Dielen, Francois M. H., Verdijk, Lex B. and van Loon, Luc J. C.. (2019). Basal and postprandial myofibrillar protein synthesis rates do not differ between lean and obese middle-aged men. The Journal of Nutrition. 149(9), pp. 1533 - 1542. https://doi.org/10.1093/jn/nxz104
Protein ingestion before sleep increases overnight muscle protein synthesis rates in healthy older men: A randomized controlled trial
Kouw, Imre W.K., Holwerda, Andrew M., Trommelen, Jorn, Kramer, Irene Fleur, Bastiaanse, Jacqueline, Halson, Shona, Wodzig, Will K.W.H., Verdijk, Lex B. and Van Loon, Luc. (2017). Protein ingestion before sleep increases overnight muscle protein synthesis rates in healthy older men: A randomized controlled trial. The Journal of Nutrition. 147(12), pp. 2252 - 2261. https://doi.org/10.3945/jn.117.254532
Habituation to low or high protein intake does not modulate basal or postprandial muscle protein synthesis rates: a randomized trial
Gorissen, Stefan H.M., Horstman, Astrid M.H., Franssen, Rinske, Kouw, Imre W.K., Wall, Benjamin T., Burd, N., de Groot, Lisette C.P.G.M. and Loon, Luc Van. (2017). Habituation to low or high protein intake does not modulate basal or postprandial muscle protein synthesis rates: a randomized trial. American Journal of Clinical Nutrition. 105(2), pp. 332 - 342. https://doi.org/10.3945/ajcn.115.129924
Sodium nitrate ingestion increases skeletal muscle nitrate content in humans
Nyakayiru, Jean, Kouw, Imre W.K., Cermak, N, Senden, Joan M., Van Loon, Luc and Verdijk, Lex B.. (2017). Sodium nitrate ingestion increases skeletal muscle nitrate content in humans. Journal of Applied Physiology. 123(3), pp. 637 - 644. https://doi.org/10.1152/japplphysiol.01036.2016
Both basal and post-prandial muscle protein synthesis rates, following the ingestion of a leucine-enriched whey protein supplement, are not impaired in sarcopenic older males
Kramer, Irene Fleur, Verdijk, Lex B., Hamer, Henrike M., Verlaan, Sjors, Luiking, Yvette C., Kouw, Imre W. K., Senden, Joan M., van Kranenburg, Janneau, Gijsen, Annemarie P., Bierau, Jörgen, Poeze, Martijn and van Loon, Luc J. C.. (2016). Both basal and post-prandial muscle protein synthesis rates, following the ingestion of a leucine-enriched whey protein supplement, are not impaired in sarcopenic older males. Clinical Nutrition. 36, pp. 1440 - 1449. https://doi.org/10.1016/j.clnu.2016.09.023
Physical activity performed in the evening increases the overnight muscle protein synthetic response to presleep protein ingestion in older men
Holwerda, Andrew M., Kouw, Imre W. K., Trommelen, Jorn, Halson, Shona L., Wodzig, Will K. W. H., Verdijk, Lex B. and van Loon, Luc J. C.. (2016). Physical activity performed in the evening increases the overnight muscle protein synthetic response to presleep protein ingestion in older men. Journal of Nutrition. 146(7), pp. 1307 - 1314. https://doi.org/10.3945/jn.116.230086
Resistance exercise augments postprandial overnight muscle protein synthesis rates
Trommelen, Jorn, Holwerda, Andrew M., Kouw, Imre W. K., Langer, Henning, Halson, Shona L., Verdijk, Lex B. and van Loon, Luc J. C.. (2016). Resistance exercise augments postprandial overnight muscle protein synthesis rates. Medicine and Science in Sports and Exercise. 48(12), pp. 2517-2525. https://doi.org/10.1249/MSS.0000000000001045
Diurnal rhythm of cardiac troponin: Consequences for the diagnosis of acute myocardial infarction
Klinkenberg, Lieke J. J., Wildi, Karin, Van Der Linden, Noreen, Kouw, Imre W. K., Niens, Marijke, Twerenbold, Raphael, Gimenez, Maria Rubini, Puelacher, Christian, Neuhaus, Jean Daniel, Hillinger, Petra, Nestelberger, Thomas, Boeddinghaus, Jasper, Grimm, Karin, Sabti, Zaid, Bons, Judith A. P., Van Suijlen, Jeroen D. E., Tan, Frans E. S., Kate, Joop Ten, Bekers, Otto, ... Meex, Steven J. R.. (2016). Diurnal rhythm of cardiac troponin: Consequences for the diagnosis of acute myocardial infarction. Clinical Chemistry. 62(12), pp. 1602 - 1611. https://doi.org/10.1373/clinchem.2016.257485
Sodium nitrate co-ingestion with protein does not augment postprandial muscle protein synthesis rates in older, type 2 diabetes patients
Kouw, Imre W. K., Cermak, Naomi M., Burd, Nicholas A., Churchward-Venne, Tyler A., Senden, Joan M., Gijsen, Annemie P. and van Loon, Luc J. C.. (2016). Sodium nitrate co-ingestion with protein does not augment postprandial muscle protein synthesis rates in older, type 2 diabetes patients. American Journal of Physiology - Endocrinology and Metabolism. 311(2), pp. 325 - 334. https://doi.org/10.1152/ajpendo.00122.2016
Postprandial protein handling is not impaired in type 2 diabetes patients when compared with normoglycemic controls
Kouw, Imre W. K., Gorissen, Stefan H. M., Burd, Nicholas A., Cermak, Naomi M., Gijsen, Annemie P., van Kranenburg, Janneau and van Loon, Luc J. C.. (2015). Postprandial protein handling is not impaired in type 2 diabetes patients when compared with normoglycemic controls. The Journal of Clinical Endocrinology and Metabolism. 100(8), pp. 3103 - 3111. https://doi.org/10.1210/jc.2015-1234
A single dose of sodium nitrate does not improve oral glucose tolerance in patients with type 2 diabetes mellitus
Cermak, Naomi M., Hansen, Dominique, Kouw, Imre W. K., van Dijk, Jan-Willem, Blackwell, James R., Jones, Andrew M., Gibala, Martin J. and van Loon, Luc J. C.. (2015). A single dose of sodium nitrate does not improve oral glucose tolerance in patients with type 2 diabetes mellitus. Nutrition Research. 35(8), pp. 674 - 680. https://doi.org/10.1016/j.nutres.2015.05.017
Impact of the macronutrient composition of a nutritional supplement on muscle protein synthesis rates in older men: A randomized, double blind, controlled trial
Kramer, Irene Fleur, Verdijk, Lex B., Hamer, Henrike M., Verlaan, Sjors, Luiking, Yvette C., Kouw, Imre W. K., Senden, Joan M., van Kranenburg, Janneau, Gijsen, Annemie P., Poeze, Martijn and van Loon, Luc J. C.. (2015). Impact of the macronutrient composition of a nutritional supplement on muscle protein synthesis rates in older men: A randomized, double blind, controlled trial. The Journal of Clinical Endocrinology and Metabolism. 100(11), pp. 4124 - 4132. https://doi.org/10.1210/jc.2015-2352
The use of doubly labeled milk protein to measure postprandial muscle protein synthesis rates in vivo in humans
Burd, N., Cermak, N., Kouw, Imre W. K., Gorissen, Stefan H. M., Gijsen, Annemie P. and Van Loon, Luc. (2014). The use of doubly labeled milk protein to measure postprandial muscle protein synthesis rates in vivo in humans. Journal of Applied Physiology. 117(11), pp. 1363 - 1370. https://doi.org/10.1152/japplphysiol.00411.2014