The use of doubly labeled milk protein to measure postprandial muscle protein synthesis rates in vivo in humans

Journal article


Burd, N., Cermak, N., Kouw, Imre W. K., Gorissen, Stefan H. M., Gijsen, Annemie P. and Van Loon, Luc. (2014) The use of doubly labeled milk protein to measure postprandial muscle protein synthesis rates in vivo in humans. Journal of Applied Physiology. 117(11), pp. 1363 - 1370. https://doi.org/10.1152/japplphysiol.00411.2014
AuthorsBurd, N., Cermak, N., Kouw, Imre W. K., Gorissen, Stefan H. M., Gijsen, Annemie P. and Van Loon, Luc
Abstract

We aimed to determine the impact of precursor pool dilution on the assessment of postprandial myofibrillar protein synthesis rates (MPS). A Holstein dairy cow was infused with large amounts of L-[1-13C]phenylalanine and L-[1-13C]leucine, and the milk was collected and fractionated. The enrichment levels in the casein were 38.7 and 9.3 mole percent excess, respectively. In a subsequent human experiment, 11 older men (age: 71 ± 1 y, body mass index: 26 ± 0.1 kg·m−2) received a primed constant infusion of L-[ring-2H5]phenylalanine and L-[1-13C]leucine. Blood and muscle samples were collected before and after the ingestion of 20-g doubly labeled casein to assess postprandial MPS based on the 1) constant tracer infusion of L-[ring-2H5]phenylalanine, 2) ingestion of intrinsically L-[1-13C]phenylalanine-labeled casein, and 3) constant infusion of L-[1-13C]leucine in combination with the ingestion of intrinsically L-[1-13C]leucine-labeled casein. Postprandial MPS was increased (P < 0.05) after protein ingestion (∼70% above postabsorptive values) based on the L-[1-13C]leucine tracer. There was no significant stimulation of postprandial MPS (∼27% above postabsorptive values) when the calculated fractional synthesis rate was based on the L-[ring-2H5]phenylalanine (P = 0.2). Comparisons of postprandial MPS based on the primed continuous infusion of L-[1-13C]leucine or the ingestion of intrinsically L-[1-13C]phenylalanine-labeled casein protein demonstrated differences compared with the primed continuous infusion of L-[ring-2H5]phenylalanine (P > 0.05). Our findings confirm that the postprandial MPS assessed using the primed continuous tracer infusion approach may differ if tracer steady-state conditions in the precursor pools are perturbed. The use of intrinsically doubly labeled protein provides a method to study the metabolic fate of the ingested protein and the subsequent postprandial MPS response.

Keywordsdietary protein; nutrition; stable isotopes; hypertrophy
Year2014
JournalJournal of Applied Physiology
Journal citation117 (11), pp. 1363 - 1370
PublisherAmerican Physiological Society
ISSN8750-7587
Digital Object Identifier (DOI)https://doi.org/10.1152/japplphysiol.00411.2014
Scopus EID2-s2.0-84914125523
Page range1363 - 1370
Research GroupMary MacKillop Institute for Health Research
Place of publicationUnited States
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Trommelen, Jorn, Fuchs, Cas J., Beelen, M, Lenaerts, Kaatje, Jeukendrup, A. E., Cermak, N. and Van Loon, Luc. (2017) Fructose and sucrose intake increase exogenous carbohydrate oxidation during exercise. Nutrients. 9(2), pp. 1 - 12. https://doi.org/10.3390/nu9020167
Protein ingestion before sleep increases overnight muscle protein synthesis rates in healthy older men: A randomized controlled trial
Kouw, Imre W.K., Holwerda, Andrew M., Trommelen, Jorn, Kramer, Irene Fleur, Bastiaanse, Jacqueline, Halson, Shona, Wodzig, Will K.W.H., Verdijk, Lex B. and Van Loon, Luc. (2017) Protein ingestion before sleep increases overnight muscle protein synthesis rates in healthy older men: A randomized controlled trial. The Journal of Nutrition. 147(12), pp. 2252 - 2261. https://doi.org/10.3945/jn.117.254532
Habituation to low or high protein intake does not modulate basal or postprandial muscle protein synthesis rates: a randomized trial
Gorissen, Stefan H.M., Horstman, Astrid M.H., Franssen, Rinske, Kouw, Imre W.K., Wall, Benjamin T., Burd, N., de Groot, Lisette C.P.G.M. and Loon, Luc Van. (2017) Habituation to low or high protein intake does not modulate basal or postprandial muscle protein synthesis rates: a randomized trial. American Journal of Clinical Nutrition. 105(2), pp. 332 - 342. https://doi.org/10.3945/ajcn.115.129924
Sodium nitrate ingestion increases skeletal muscle nitrate content in humans
Nyakayiru, Jean, Kouw, Imre W.K., Cermak, N, Senden, Joan M., Van Loon, Luc and Verdijk, Lex B.. (2017) Sodium nitrate ingestion increases skeletal muscle nitrate content in humans. Journal of Applied Physiology. 123(3), pp. 637 - 644. https://doi.org/10.1152/japplphysiol.01036.2016
Intramyocellular lipid content and lipogenic gene expression responses following a single bout of resistance type exercise differ between young and older men
Tsintzas, Kostas, Stephens, F. B., Snijders, Tim, Wall, Benjamin T., Cooper, Scott, Mallinson, Joanne, Verdijk, Lex B. and Van Loon, Luc. (2017) Intramyocellular lipid content and lipogenic gene expression responses following a single bout of resistance type exercise differ between young and older men. Experimental Gerontology. 93, pp. 36 - 45. https://doi.org/10.1016/j.exger.2017.03.018
Commentaries on Viewpoint: A time for exercise: the exercise window
Boule, Normand G., Terada, Tasuku, Francois, Monique E., Hawley, John, Cotter, James D., Kruse, Nicholas T., McDonald, Matthew W., Olver, T D., Paoli, Antonio, Sacchetti, Massimo, Di Luigi, Luigi, van Dijk, Jan W., Van Loon, Luc, Yardley, Jane E., DiPietro, Loretta, Gribok, Andrei and Rumpler, William. (2017) Commentaries on Viewpoint: A time for exercise: the exercise window. Journal of Applied Physiology. 122(1), pp. 210 - 213. https://doi.org/10.1152/japplphysiol.00938.2016
No effect of acute and 6-day nitrate supplementation on VO2 and time-trial performance in highly trained cyclists
Nyakayiru, Jean, Jonvik, Kristin L., Pinckaers, Philippe J.M., Senden, Joan M., Van Loon, Luc and Verdijk, Lex B.. (2017) No effect of acute and 6-day nitrate supplementation on VO2 and time-trial performance in highly trained cyclists. International Journal of Sport Nutrition and Exercise Metabolism. 27(1), pp. 11 - 17. https://doi.org/10.1123/ijsnem.2016-0034
Food ingestion in an upright sitting position increases postprandial amino acid availability when compared with food ingestion in a lying down position
Holwerda, Andrew M., Lenaerts, Kaatje, Bierau, Jörgen, Wodzig, Will K.W.H. and Van Loon, Luc. (2017) Food ingestion in an upright sitting position increases postprandial amino acid availability when compared with food ingestion in a lying down position. Applied Physiology, Nutrition and Metabolism. 42(7), pp. 738 - 743. https://doi.org/10.1139/apnm-2016-0522
Beetroot juice supplementation improves high-intensity intermittent type exercise performance in trained soccer players
Nyakayiru, Jean, Jonvik, Kristin L., Trommelen, Jorn, Pinckaers, Philippe J.M., Senden, Joan M., Van Loon, Luc and Verdijk, Lex B.. (2017) Beetroot juice supplementation improves high-intensity intermittent type exercise performance in trained soccer players. Nutrients. 9(3), pp. 1 - 10. https://doi.org/10.3390/nu9030314
Seasonal variation in vitamin d status in elite athletes: a longitudinal study
Backx, E. M.P., van der Avoort, Cindy van, Tieland, Michael, Maase, K., Kies, A. K., Van Loon, Luc, de Groot, Lisette C.P.G.M. and Mensink, M.. (2017) Seasonal variation in vitamin d status in elite athletes: a longitudinal study. International Journal of Sport Nutrition and Exercise Metabolism. 27(1), pp. 6 - 10. https://doi.org/10.1123/ijsnem.2016-0177
Glycemic control during consecutive days with prolongedwalking exercise in individuals with type 1 diabetes mellitus
van Dijk, Jan Willem, Eijsvogels, Thijs M., Nyakayiru, Jean, Schreuder, Tim H. A., Hopman, Maria T., Thijssen, Dick H. and Van Loon, Lucas. (2016) Glycemic control during consecutive days with prolongedwalking exercise in individuals with type 1 diabetes mellitus. Diabetes Research and Clinical Practice. 117, pp. 74 - 81. https://doi.org/10.1016/j.diabres.2016.04.053
May bed rest cause greater muscle loss than limb immobilization?
Dirks, Marlou L., Backx, E. M. P., Wall, Benjamin T., Verdijk, Lex B. and van Loon, Luc. (2016) May bed rest cause greater muscle loss than limb immobilization? Acta Physiologica. 218(1), pp. 10 - 12. https://doi.org/10.1111/apha.12699
Both basal and post-prandial muscle protein synthesis rates, following the ingestion of a leucine-enriched whey protein supplement, are not impaired in sarcopenic older males
Kramer, Irene Fleur, Verdijk, Lex B., Hamer, Henrike M., Verlaan, Sjors, Luiking, Yvette C., Kouw, Imre W. K., Senden, Joan M., van Kranenburg, Janneau, Gijsen, Annemarie P., Bierau, Jörgen, Poeze, Martijn and van Loon, Luc J. C.. (2016) Both basal and post-prandial muscle protein synthesis rates, following the ingestion of a leucine-enriched whey protein supplement, are not impaired in sarcopenic older males. Clinical Nutrition. 36, pp. 1440 - 1449. https://doi.org/10.1016/j.clnu.2016.09.023
Hyperoxia increases arterial oxygen pressure during exercise in type 2 diabetes patients: A feasibility study
Rozenberg, Robert, Mankowski, Robert T., van Loon, Luc, Langendonk, Janneke G., Sijbrands, Eric J. G., van den Meiracker, Anton H., Stam, Henk J. and Praet, Stephan F. E.. (2016) Hyperoxia increases arterial oxygen pressure during exercise in type 2 diabetes patients: A feasibility study. European Journal of Medical Research. 21(1), pp. 1 - 8. https://doi.org/10.1186/s40001-015-0194-5
Resistance Exercise Augments Postprandial Overnight Muscle Protein Synthesis Rates
Trommelen, Jorn, Holwerda, Andrew M., Kouw, Imre W. K., Langer, Henning, Halson, Shona L., Rollo, Ian, Verdijk, Lex B. and Van Loon, Luc J.C.. (2016) Resistance Exercise Augments Postprandial Overnight Muscle Protein Synthesis Rates. Medicine and Science in Sports and Exercise. 48(12), pp. 2517 - 2525. https://doi.org/10.1249/MSS.0000000000001045
Cardiac Troponin T and i Release after a 30-km Run
Klinkenberg, Lieke J. J., Luyten, Peter, Van Der Linden, Noreen, Urgel, Kim, Snijders, Daniëlle P. C., Knackstedt, Christian, Dennert, Robert, Kietselaer, Bastiaan L. J. H., Mingels, Alma M. A., Cardinaels, Eline P. M., Peeters, Frederique E. C. M., Van Suijlen, Jeroen D. E., Kate, Joop Ten, Marsch, Elke, Theelen, Thomas L., Sluimer, Judith C., Wouters, Kristiaan, Bekers, Otto, Bekkers, Sebastiaan C. A. M., ... Meex, Steven J. R.. (2016) Cardiac Troponin T and i Release after a 30-km Run. American Journal of Cardiology. 118(2), pp. 281 - 287. https://doi.org/10.1016/j.amjcard.2016.04.030
Prognostic value of basal high-sensitive cardiac troponin levels on mortality in the general population
van der Linden, Noreen, Klinkenberg, Lieke J. J., Bekers, Otto, van Loon, Luc, Van Dieijen-Visser, Marja P., Zeegers, Maurice P. and Meex, Steven J. R.. (2016) Prognostic value of basal high-sensitive cardiac troponin levels on mortality in the general population. Medicine. https://doi.org/10.1097/MD.0000000000005703
Short-term muscle disuse lowers myofibrillar protein synthesis rates and induces anabolic resistance to protein ingestion
Wall, Benjamin T., Dirks, Marlou L., Snijders, Tim, Willem van Dijk, Jan, Fritsch, Mario, Verdijk, Lex B. and Van Loon, Luc. (2016) Short-term muscle disuse lowers myofibrillar protein synthesis rates and induces anabolic resistance to protein ingestion. American Journal of Physiology - Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.00227.2015
Impact of diet composition on blood glucose regulation
Russell, Wendy R., Baka, Athanasia, Bjorck, Inger, Delzenne, Nathalie, Gao, Dan, Griffiths, Helen R., Hadjilucas, Ellie, Juvonen, Kristiina, Lahtinen, Sampo, Lansink, Mirian, van Loon, Luc, Mykkanen, Hannu, Ostman, Elin, Riccardi, Gabrielle, Vinoy, Sophie and Weickert, Martin O.. (2016) Impact of diet composition on blood glucose regulation. Critical Reviews in Food Science and Nutrition. 56(4), pp. 541 - 590. https://doi.org/10.1080/10408398.2013.792772
The Martin Vigorimeter Represents a Reliable and More Practical Tool Than the Jamar Dynamometer to Assess Handgrip Strength in the Geriatric Patient
Sipers, Walther M. W. H., Verdijk, Lex B., Sipers, Simone J. E., Schols, Jos M. G. A. and Van Loon, Luc. (2016) The Martin Vigorimeter Represents a Reliable and More Practical Tool Than the Jamar Dynamometer to Assess Handgrip Strength in the Geriatric Patient. Journal of the American Medical Directors Association. 17(5), pp. 1 - 7. https://doi.org/10.1016/j.jamda.2016.02.026
Resistance training increases skeletal muscle capillarization in healthy older men
Verdijk, Lex B., Snijders, Tim, Holloway, Tanya M., Van Kranenburg, Janneau and van Loon, Luc. (2016) Resistance training increases skeletal muscle capillarization in healthy older men. Medicine and Science in Sports and Exercise. 48(11), pp. 2157 - 2164. https://doi.org/10.1249/MSS.0000000000001019
Physical activity performed in the evening increases the overnight muscle protein synthetic response to presleep protein ingestion in older men
Holwerda, Andrew M., Kouw, Imre W. K., Trommelen, Jorn, Halson, Shona L., Wodzig, Will K. W. H., Verdijk, Lex B. and van Loon, Luc J. C.. (2016) Physical activity performed in the evening increases the overnight muscle protein synthetic response to presleep protein ingestion in older men. Journal of Nutrition. 146(7), pp. 1307 - 1314. https://doi.org/10.3945/jn.116.230086
Habitual Dietary Nitrate Intake in Highly Trained Athletes
Jonvik, Kristin L., Nyakayiru, Jean, Willem van Dijk, Jan, Wardenaar, Floris C., Van Loon, Lucas and Verdijk, Lex B.. (2016) Habitual Dietary Nitrate Intake in Highly Trained Athletes. International Journal of Sport Nutrition and Exercise Metabolism. https://doi.org/10.1123/ijsnem.2016-0239
Protein intake and lean body mass preservation during energy intake restriction in overweight older adults
Backx, E. M. P., Tieland, Michael, Borgonjen-Van Den Berg, Karin J., Claessen, P. R., Van Loon, Lucas and de Groot, Lisette C.P.G.M.. (2016) Protein intake and lean body mass preservation during energy intake restriction in overweight older adults. International Journal of Obesity. https://doi.org/10.1038/ijo.2015.182
Changes in myonuclear domain size do not precede muscle hypertrophy during prolonged resistance-type exercise training
Snijders, Tim, Smeets, Joey S. J., Van Kranenburg, Janneau, Kies, A. K., Van Loon, Lucas and Verdijk, Lex B.. (2016) Changes in myonuclear domain size do not precede muscle hypertrophy during prolonged resistance-type exercise training. Acta Physiologica. https://doi.org/10.1111/apha.12609
Resistance Exercise Augments Postprandial Overnight Muscle Protein Synthesis Rates
Trommelen, Jorn, Holwerda, Andrew M., Kouw, Imre W. K., Langer, Henning, Halson, Shona L., Verdijk, Lex B. and van Loon, Luc J. C.. (2016) Resistance Exercise Augments Postprandial Overnight Muscle Protein Synthesis Rates. Medicine and Science in Sports and Exercise. 48(12), pp. 2517 - 2525. https://doi.org/10.1249/MSS.0000000000001045
Presleep protein ingestion does not compromise the muscle protein synthetic response to protein ingested the following morning
Wall, Benjamin T., Burd, Nicholas A., Franssen, Rinske, Gorissen, Stefan H. M., Snijders, Tim, Senden, Joan M., Gijsen, Annemie P. and van Loon, Luc. (2016) Presleep protein ingestion does not compromise the muscle protein synthetic response to protein ingested the following morning. American Journal of Physiology - Endocrinology and Metabolism. 311(6), pp. 964 - 973. https://doi.org/10.1152/ajpendo.00325.2016
May bed rest cause greater muscle loss than limb immobilization?
Dirks, Marlou L., Backx, E. M. P., Wall, Benjamin T., Verdijk, Lex B. and Van Loon, Lucas. (2016) May bed rest cause greater muscle loss than limb immobilization? Acta Physiologica. 218(1), pp. 10 - 12. https://doi.org/10.1111/apha.12699
Diurnal rhythm of cardiac troponin: Consequences for the diagnosis of acute myocardial infarction
Klinkenberg, Lieke J. J., Wildi, Karin, Van Der Linden, Noreen, Kouw, Imre W. K., Niens, Marijke, Twerenbold, Raphael, Gimenez, Maria Rubini, Puelacher, Christian, Neuhaus, Jean Daniel, Hillinger, Petra, Nestelberger, Thomas, Boeddinghaus, Jasper, Grimm, Karin, Sabti, Zaid, Bons, Judith A. P., Van Suijlen, Jeroen D. E., Tan, Frans E. S., Kate, Joop Ten, Bekers, Otto, ... Meex, Steven J. R.. (2016) Diurnal rhythm of cardiac troponin: Consequences for the diagnosis of acute myocardial infarction. Clinical Chemistry. 62(12), pp. 1602 - 1611. https://doi.org/10.1373/clinchem.2016.257485
Expression of protocadherin gamma in skeletal muscle tissue is associated with age and muscle weakness
Hangelbroek, Roland W. J., Fazelzadeh, Parastoo, Tieland, Michael, Boekschoten, Mark V., Hooiveld, Guido J. E. J., van Duynhoven, John P. M., Timmons, James A., Verdijk, Lex B., de Groot, Lisette C. P. G. M., Van Loon, Luc and Müller, Michael. (2016) Expression of protocadherin gamma in skeletal muscle tissue is associated with age and muscle weakness. Journal Cachexia Sarcopenia Muscle. 7(5), pp. 604 - 614. https://doi.org/10.1002/jcsm.12099
The impact of 1-year vitamin D supplementation on vitamin D status in athletes: A dose-response study
Backx, E. M. P., Tieland, Michael, Maase, K., Kies, A. K., Mensink, M., Van Loon, Luc and de Groot, Lisette C. P. G. M.. (2016) The impact of 1-year vitamin D supplementation on vitamin D status in athletes: A dose-response study. European Journal of Clinical Nutrition. 70(9), pp. 1009 - 1014. https://doi.org/10.1038/ejcn.2016.133
Sodium nitrate co-ingestion with protein does not augment postprandial muscle protein synthesis rates in older, type 2 diabetes patients
Kouw, Imre W. K., Cermak, Naomi M., Burd, Nicholas A., Churchward-Venne, Tyler A., Senden, Joan M., Gijsen, Annemie P. and van Loon, Luc J. C.. (2016) Sodium nitrate co-ingestion with protein does not augment postprandial muscle protein synthesis rates in older, type 2 diabetes patients. American Journal of Physiology - Endocrinology and Metabolism. 311(2), pp. 325 - 334. https://doi.org/10.1152/ajpendo.00122.2016
Recommendations for the conduct of clinical trials for drugs to treat or prevent sarcopenia
Reginster, Jean Yves, Cooper, Cyrus, Rizzoli, Rene, Kanis, John A., Appelboom, Geoff, Bautmans, Ivan, Bischoff-Ferrari, Heike A., Boers, Maarten, Brandi, Maria Luisa, Bruyère, Olivier, Cherubini, Antonio, Flamion, Bruno, Fielding, Roger A., Gasparik, Andrea Ildiko, Van Loon, Lucas, McCloskey, Eugene, Mitlak, Bruce, Pilotto, Alberto, Reiter-Niesert, Suzanne, ... Cruz-Jentoft, Alfonso J.. (2016) Recommendations for the conduct of clinical trials for drugs to treat or prevent sarcopenia. Aging Clinical and Experimental Research. https://doi.org/10.1007/s40520-015-0517-y
Postprandial protein handling is not impaired in type 2 diabetes patients when compared with normoglycemic controls
Kouw, Imre W. K., Gorissen, Stefan H. M., Burd, Nicholas A., Cermak, Naomi M., Gijsen, Annemie P., van Kranenburg, Janneau and van Loon, Luc J. C.. (2015) Postprandial protein handling is not impaired in type 2 diabetes patients when compared with normoglycemic controls. Journal of Clinical Endocrinology and Metabolism. 100(8), pp. 3103 - 3111. https://doi.org/10.1210/jc.2015-1234
Hypoxia induces a prothrombotic state independently of the physical activity
Ninivaggi, Marisa, De Laat, Marieke, Lancé, Marcus M. D., Kicken, Cécile H., Pelkmans, Leonie, Bloemen, Saartje, Dirks, Marlou L., Van Loon, Luc, Govers-Riemslag, José W. P., Lindhout, Theo, Konings, Joke and De Laat, Bas. (2015) Hypoxia induces a prothrombotic state independently of the physical activity. PLoS ONE. 10(10), pp. 1 - 14. https://doi.org/10.1371/journal.pone.0141797
Prolonged adaptation to a low or high protein diet does not modulate basal muscle protein synthesis rates: A substudy
Hursel, Rick, Martens, Eveline A. P., Gonnissen, Hanne K. J., Hamer, Henrike M., Senden, Joan M., Van Loon, Luc and Westerterp-Plantenga, Margriet S.. (2015) Prolonged adaptation to a low or high protein diet does not modulate basal muscle protein synthesis rates: A substudy. PLoS ONE. 10(9), pp. 1 - 15. https://doi.org/10.1371/journal.pone.0137183
Can elite athletes benefit from dietary nitrate supplementation?
Jonvik, Kristin L., Nyakayiru, Jean, Van Loon, Luc and Verdijk, Lex B.. (2015) Can elite athletes benefit from dietary nitrate supplementation? Journal of Applied Physiology. 119(6), pp. 759 - 761. https://doi.org/10.1152/japplphysiol.00232.2015
Exercise strategies to optimize glycemic control in type 2 diabetes: A continuing glucose monitoring perspective
van Dijk, Jan Willem and Van Loon, Luc. (2015) Exercise strategies to optimize glycemic control in type 2 diabetes: A continuing glucose monitoring perspective. Diabetes Spectrum. 28(1), pp. 24 - 31. https://doi.org/10.2337/diaspect.28.1.24
A single dose of sodium nitrate does not improve oral glucose tolerance in patients with type 2 diabetes mellitus
Cermak, Naomi M., Hansen, Dominique, Kouw, Imre W. K., van Dijk, Jan-Willem, Blackwell, James R., Jones, Andrew M., Gibala, Martin J. and van Loon, Luc J. C.. (2015) A single dose of sodium nitrate does not improve oral glucose tolerance in patients with type 2 diabetes mellitus. Nutrition Research. 35(8), pp. 674 - 680. https://doi.org/10.1016/j.nutres.2015.05.017
Aging is accompanied by a blunted muscle protein synthetic response to protein ingestion
Wall, Benjamin T., Gorissen, Stefan H. M., Pennings, Bart, Koopman, René, Groen, Bart B. L., Verdijk, Lex B. and Van Loon, Luc. (2015) Aging is accompanied by a blunted muscle protein synthetic response to protein ingestion. PLoS ONE. 10(11), pp. 1 - 13. https://doi.org/10.1371/journal.pone.0140903
Impact of the macronutrient composition of a nutritional supplement on muscle protein synthesis rates in older men: A randomized, double blind, controlled trial
Kramer, Irene Fleur, Verdijk, Lex B., Hamer, Henrike M., Verlaan, Sjors, Luiking, Yvette C., Kouw, Imre W. K., Senden, Joan M., van Kranenburg, Janneau, Gijsen, Annemie P., Poeze, Martijn and van Loon, Luc J. C.. (2015) Impact of the macronutrient composition of a nutritional supplement on muscle protein synthesis rates in older men: A randomized, double blind, controlled trial. Journal of Clinical Endocrinology and Metabolism. 100(11), pp. 4124 - 4132. https://doi.org/10.1210/jc.2015-2352
Post-prandial protein handling: You are what you just ate
Groen, Bart B. L., Horstman, Astrid M. H., Hamer, Henrike M., De Haan, Michiel, Van Kranenburg, Janneau, Bierau, Jörgen, Poeze, Martijn, Wodzig, Will K. W. H., Rasmussen, Blake B. and van Loon, Luc. (2015) Post-prandial protein handling: You are what you just ate. PLoS ONE. 10(11), pp. 1 - 22. https://doi.org/10.1371/journal.pone.0141582
Dietary Protein as a Trigger for Metabolic Adaptation
Van Loon, Luc. (2014) Dietary Protein as a Trigger for Metabolic Adaptation. In In R. J. Maughan (Ed.). The Encyclopaedia of Sports Medicine: An IOC Medical Commission Publication pp. 147 - 155 Wiley-Blackwell.
The effect of a six-month resistance-type exercise training program on the course of high sensitive cardiac troponin T levels in (pre)frail elderly
Van Der Linden, Noreen, Tieland, Michael, Klinkenberg, Lieke J. J., Verdijk, Lex B., de Groot, Lisette C. P. G. M., Van Loon, Lucas, Van Dieijen-Visser, Marja P. and Meex, Steven J. R.. (2014) The effect of a six-month resistance-type exercise training program on the course of high sensitive cardiac troponin T levels in (pre)frail elderly. International Journal of Cardiology. 175(2), pp. 374 - 375. https://doi.org/10.1016/j.ijcard.2014.05.017
The role of amino acids in skeletal muscle adaptation to exercise
Aguirre, Nick, Van Loon, Lucas and Baar, Keith. (2013) The role of amino acids in skeletal muscle adaptation to exercise. In In E. Isolauri, P.M. Sherman and W. A. Walker (Ed.). Nestle Nutrition Institute workshop series pp. 85 - 102 S. Karger AG. https://doi.org/10.1159/000350261
Disturbed energy metabolism and muscular dystrophy caused by pure creatine deficiency are reversible by creatine intake
Nabuurs, C. I., Choe, C. U., Veltien, A., Kan, H. E., Van Loon, Luc, Rodenburg, R. J. T., Matschke, J., Wieringa, B., Kemp, G. J., Isbrandt, D. and Heerschap, A.. (2013) Disturbed energy metabolism and muscular dystrophy caused by pure creatine deficiency are reversible by creatine intake. Journal of Physiology. 591(2), pp. 571 - 592. https://doi.org/10.1113/jphysiol.2012.241760
Elderly men and women benefit equally from prolonged resistance-type exercise training
Leenders, Marika, Verdijk, Lex B., van der Hoeven, Letty, Van Kranenburg, Janneau, Nilwik, Rachel and Van Loon, Luc. (2013) Elderly men and women benefit equally from prolonged resistance-type exercise training. Journals of Gerontology: Series A Biological Sciences and Medical Sciences. 68(7), pp. 769 - 779. https://doi.org/10.1093/gerona/gls241
Validity and Reliability of Tools to Measure Muscle Mass, Strength, and Physical Performance in Community-Dwelling Older People: A Systematic Review
Mijnarends, Donja M., Meijers, Judith M. M., Halfens, Ruud J. G., Borg, Sovianne Ter, Luiking, Yvette C., Verlaan, Sjors, Schoberer, Daniela, Cruz-Jentoft, Alfonso J., Van Loon, Luc and Schols, Jos M. G. A.. (2013) Validity and Reliability of Tools to Measure Muscle Mass, Strength, and Physical Performance in Community-Dwelling Older People: A Systematic Review. Journal of the American Medical Directors Association. 14(3), pp. 170 - 178. https://doi.org/10.1016/j.jamda.2012.10.009
Substantial differences between organ and muscle specific tracer incorporation rates in a lactating dairy cow
Burd, N, Hamer, Henrike M., Pennings, Bart, Pellikaan, Wilbert F., Senden, Joan M., Gijsen, Annemie P. and Van Loon, Luc. (2013) Substantial differences between organ and muscle specific tracer incorporation rates in a lactating dairy cow. PLoS ONE. 8(6), pp. 1 - 10. https://doi.org/10.1371/journal.pone.0068109
Effect of antioxidant supplementation on exercise-induced cardiac troponin release in cyclists: A randomized trial
Klinkenberg, Lieke J. J., Res, Peter T., Haenen, Guido R., Bast, Aalt, Van Loon, Luc, Van Dieijen-Visser, Marja P. and Meex, Steven J. R.. (2013) Effect of antioxidant supplementation on exercise-induced cardiac troponin release in cyclists: A randomized trial. PLoS ONE. 8(11), pp. 1 - 6. https://doi.org/10.1371/journal.pone.0079280
Strong link between basal and exercise-induced cardiac troponin T levels: Do both reflect risk?
Klinkenberg, Lieke J. J., Res, Peter T., Van Loon, Lucas, Van Dieijen-Visser, Marja P. and Meex, Steven J. R.. (2012) Strong link between basal and exercise-induced cardiac troponin T levels: Do both reflect risk? International Journal of Cardiology. 158(1), pp. 129 - 131. https://doi.org/10.1016/j.ijcard.2012.04.050
The single biopsy approach is reliable for the measurement of muscle protein synthesis rates in vivo in older men
Burd, N., Pennings, Bart, Groen, Bart B. L., Gijsen, Annemie P., Senden, Joan M. and Van Loon, Luc. (2012) The single biopsy approach is reliable for the measurement of muscle protein synthesis rates in vivo in older men. Journal of Applied Physiology. 113(6), pp. 896 - 902. https://doi.org/10.1152/japplphysiol.00513.2012
Inspanningstherapie bij type 2 diabetes: is dagelijkse inspanning noodzakelijk om glycemische controle te optimaliseren?
van Dijk, Jan W., Tummers, Kyra, Stehouwer, Coen D.A., Hartgens, Fred and van Loon, Luc. (2012) Inspanningstherapie bij type 2 diabetes: is dagelijkse inspanning noodzakelijk om glycemische controle te optimaliseren? Nederlands Tijdschrift voor Diabetologie. 10(2), pp. 60 - 61. https://doi.org/10.1007/s12467-012-0021-3
Protein Supplementation Improves Physical Performance in Frail Elderly People: A Randomized, Double-Blind, Placebo-Controlled Trial
Tieland, Michael, De Rest, Ondine Van, Dirks, Marlou L., Van Der Zwalu, Nikita L., Mensink, Marco, Van Loon, Luc and de Groot, Lisette C. P. G. M.. (2012) Protein Supplementation Improves Physical Performance in Frail Elderly People: A Randomized, Double-Blind, Placebo-Controlled Trial. Journal of the American Medical Directors Association. 13(8), pp. 720 - 726. https://doi.org/10.1016/j.jamda.2012.07.005
Exercise-Induced splanchnic hypoperfusion results in gut dysfunction in healthy men
Wijck, Kim V., Lenaerts, Kaatje, Van Loon, Luc, Peters, Wilbert H. M., Buurman, Wim A. and Dejong, Cornelis H. C.. (2011) Exercise-Induced splanchnic hypoperfusion results in gut dysfunction in healthy men. PLoS ONE. 6(7), pp. 1 - 10. https://doi.org/10.1371/journal.pone.0022366
Nutritional strategies to promote postexercise recovery
Beelen, M, Burke, Louise, Gibala, M and van Loon, Luc. (2010) Nutritional strategies to promote postexercise recovery. International Journal of Sport Nutrition and Exercise Metabolism. 20(6), pp. 515 - 532. https://doi.org/10.1123/ijsnem.20.6.515