Impact of incident myocardial infarction on the risk of venous thromboembolism: The Tromsø Study
Journal article
Rinde, L. B., Lind, C., Smabrekke, B., Njølstad, I., Mathiesen, E. B., Wilsgaard, T., Løchen, Maja-Lisa, Hald, E. M., Vik, A., Braekkan, Sigrid K. and Hansen, J.-B.. (2016). Impact of incident myocardial infarction on the risk of venous thromboembolism: The Tromsø Study. Journal of Thrombosis and Haemostasis. 14(6), pp. 1183 - 1191. https://doi.org/10.1111/jth.13329
Authors | Rinde, L. B., Lind, C., Smabrekke, B., Njølstad, I., Mathiesen, E. B., Wilsgaard, T., Løchen, Maja-Lisa, Hald, E. M., Vik, A., Braekkan, Sigrid K. and Hansen, J.-B. |
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Abstract | Background: Recent studies have demonstrated an association between venous thromboembolism (VTE) and arterial thrombotic diseases. Objectives: To study the association between incident myocardial infarction (MI) and VTE in a prospective population-based cohort. Methods: Study participants (n = 29 506) were recruited from three surveys of the Tromsø Study (conducted in 1994–1995, 2001–2002, and 2007–2008) and followed up to 2010. All incident MI and VTE events during follow-up were recorded. Cox regression models with age as the time scale and MI as a time-dependent variable were used to calculate hazard ratios (HRs) of VTE adjusted for sex, body mass index, blood pressure, diabetes mellitus, HDL cholesterol, smoking, physical activity, and education level. Results: During a median follow-up of 15.7 years, 1853 participants experienced an MI and 699 experienced a VTE. MI was associated with a 51% increased risk of VTE (HR 1.51; 95% confidence interval [CI] 1.08–2.10) and a 72% increased risk of pulmonary embolism (PE) (HR 1.72; 95% CI 1.07–2.75), but not significantly associated with the risk of deep vein thrombosis (DVT) (HR 1.36; 95% CI 0.86–2.15). The highest risk estimates for PE were observed during the first 6 months after the MI (HR 8.49; 95% CI 4.00–18.77). MI explained 6.2% of the PEs in the population (population attributable risk) and 78.5% of the PE risk in MI patients (attributable risk). Conclusions: Our findings indicate that MI is associated with a transient increased VTE risk, independently of traditional atherosclerotic risk factors. The risk estimates were particularly high for PE. |
Keywords | epidemiology; myocardial infarction; pulmonary embolism; risk factors; venous thromboembolism |
Year | 2016 |
Journal | Journal of Thrombosis and Haemostasis |
Journal citation | 14 (6), pp. 1183 - 1191 |
Publisher | Wiley-Blackwell Publishing Ltd. |
ISSN | 1538-7933 |
Digital Object Identifier (DOI) | https://doi.org/10.1111/jth.13329 |
Scopus EID | 2-s2.0-84974707524 |
Page range | 1183 - 1191 |
Research Group | Mary MacKillop Institute for Health Research |
Publisher's version | File Access Level Controlled |
Place of publication | United Kingdom |
https://acuresearchbank.acu.edu.au/item/88y14/impact-of-incident-myocardial-infarction-on-the-risk-of-venous-thromboembolism-the-troms-study
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