Sex- and age-related differences in autistic behaviours in children with neurofibromatosis type 1

Journal article

Chisholm, Anita K., Lami, Francesca, Haebich, Kristina M., Ure, Alex, Brignell, Amanda, Maloof, Tiba, Pride, Natalie A., Walsh, Karin S., Maier, Alice, Rouel, Melissa, Granader, Yael, Barton, Belinda, Darke, Hayley, Fuelscher, Ian, Dabscheck, Gabriel, Anderson, Vicki A., Williams, Katrina, North, Kathryn N. and Payne, Jonathan M.. (2022). Sex- and age-related differences in autistic behaviours in children with neurofibromatosis type 1. Journal of Autism and Developmental Disorders. 53, p. 2835–2850. https://doi.org/10.1007/s10803-022-05571-6
AuthorsChisholm, Anita K., Lami, Francesca, Haebich, Kristina M., Ure, Alex, Brignell, Amanda, Maloof, Tiba, Pride, Natalie A., Walsh, Karin S., Maier, Alice, Rouel, Melissa, Granader, Yael, Barton, Belinda, Darke, Hayley, Fuelscher, Ian, Dabscheck, Gabriel, Anderson, Vicki A., Williams, Katrina, North, Kathryn N. and Payne, Jonathan M.
Abstract

This study investigated sex and age differences in autistic behaviours in children with neurofibromatosis type 1 (NF1) who scored within the clinical range on the Social Responsiveness Scale - Second Edition (T score ≥ 60). Thirty-four males and 28 females (3–16 years) were assessed with the Autism Diagnostic Observation Schedule - Second Edition and Autism Diagnostic Interview - Revised. Across both measures, males exhibited greater social communication deficits relative to females. Age-related abatement of social communication difficulties was observed for males but not females. Conversely, no sex differences were found for restricted/repetitive behaviours, which were stable over time for both males and females. The findings are discussed within the context of broader neurodevelopmental considerations that are common in NF1.

Keywordsneurofibromatosis type 1; autism; autistic; sex differences; age-related differences; children
Year2022
JournalJournal of Autism and Developmental Disorders
Journal citation53, p. 2835–2850
PublisherSpringer
ISSN0162-3257
Digital Object Identifier (DOI)https://doi.org/10.1007/s10803-022-05571-6
PubMed ID35445370
Scopus EID2-s2.0-85129624551
Web address (URL)https://link.springer.com/article/10.1007/s10803-022-05571-6
Research or scholarlyResearch
Page range2835–2850
Publisher's version
License
All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online20 Apr 2022
Publication process dates
Accepted10 Apr 2022
Deposited13 Mar 2023
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