Recurrence of bilateral atypical femoral fractures associated with the sequential use of teriparatide and denosumab: A case report

Journal article

Ramchand, S. K., Chiang, C. Y., Zebaze, R. M. and Seeman, Ego. (2016). Recurrence of bilateral atypical femoral fractures associated with the sequential use of teriparatide and denosumab: A case report. Osteoporosis International. 27(2), pp. 821 - 825. https://doi.org/10.1007/s00198-015-3354-0

Authors	Ramchand, S. K., Chiang, C. Y., Zebaze, R. M. and Seeman, Ego
Abstract	We report that a postmenopausal woman with osteoporosis developed bilateral incomplete atypical femoral fractures (AFFs) after seven years of bisphosphonate therapy. Cessation of the bisphosphonate and treatment with teriparatide was associated with near complete radiological resolution of the AFFs. After 12 months without treatment, denosumab was commenced to prevent structural deterioration. Six months later she developed recurrent bilateral AFFs. This case highlights the management dilemma in patients with ongoing bone loss but prone to stress fractures associated with antiresorptive therapy. Stopping the antiresorptive is recommended but structural decay will recur predisposing to fragility fractures. If the antiresorptive is continued, bone material composition will be further compromised predisposing to atypical fractures. Teriparatide may assist healing of stress fractures and improvement in bone matrix composition. Later antiresosrptive therapy to preserve bone microstructure may compromise material composition.
Keywords	atypical femoral fractures; denosumab; osteoporosis; teriparatide
Year	2016
Journal	Osteoporosis International
Journal citation	27 (2), pp. 821 - 825
Publisher	Springer-Verlag London Ltd
ISSN	0937-941X
Digital Object Identifier (DOI)	https://doi.org/10.1007/s00198-015-3354-0
Page range	821 - 825
Research Group	Institute for Health and Ageing
Publisher's version	File Access Level Controlled
Place of publication	Germany

Permalink -

https://acuresearchbank.acu.edu.au/item/87zzv/recurrence-of-bilateral-atypical-femoral-fractures-associated-with-the-sequential-use-of-teriparatide-and-denosumab-a-case-report

Restricted files

Publisher's version

(1 files)

123
total views
0
total downloads
0
views this month
0
downloads this month

These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Bone Remodeling and Modeling : Cellular Targets for Antiresorptive and Anabolic Treatments, Including Approaches Through the Parathyroid Hormone (PTH)/PTH-Related Protein Pathway

Martin, T. John and Seeman, Ego. (2023). Bone Remodeling and Modeling : Cellular Targets for Antiresorptive and Anabolic Treatments, Including Approaches Through the Parathyroid Hormone (PTH)/PTH-Related Protein Pathway. Neurospine. 20(4), pp. 1097-1109. https://doi.org/10.14245/ns.2346966.483

Bone microarchitecture and estimated failure load are deteriorated whether patients with chronic kidney disease have normal bone mineral density, osteopenia or osteoporosis

Ghasem-Zadeh, Ali, Bui, Minh, Seeman, Ego, Boyd, Steven K., Iuliano, Sandra, Jaipurwala, Rizwan, Mount, Peter F., Toussaint, Nigel D. and Chiang, Cherie. (2022). Bone microarchitecture and estimated failure load are deteriorated whether patients with chronic kidney disease have normal bone mineral density, osteopenia or osteoporosis. Bone. 154, p. Article 116260. https://doi.org/10.1016/j.bone.2021.116260

The effect of denosumab and alendronate on trabecular plate and rod microstructure at the distal tibia and radius : A post-hoc HR-pQCT study

Hu, Yizhong, Chines, Arkadi, Shi, Yifei, Seeman, Ego and Guo, X. Edward. (2022). The effect of denosumab and alendronate on trabecular plate and rod microstructure at the distal tibia and radius : A post-hoc HR-pQCT study. Bone. 154, p. 116187. https://doi.org/10.1016/j.bone.2021.116187

Sex differences in recovery of quality of life 12 months post-fracture in community-dwelling older adults : Analyses of the Australian arm of the International Costs and Utilities Related to Osteoporotic Fractures Study (AusICUROS)

Talevski, J, Sanders, K. M., Watts, J. J., Nicholson, G. C., Seeman, E., Iuliano, S., Prince, R., March, L., Winzenberg, T., Duque, G., Ebeling, P. R., Borgström, F., Kanis, J. A., Stuart, A. L., Beauchamp, A. and Brennan-Olsen, S. L.. (2022). Sex differences in recovery of quality of life 12 months post-fracture in community-dwelling older adults : Analyses of the Australian arm of the International Costs and Utilities Related to Osteoporotic Fractures Study (AusICUROS). Osteoporosis International. 33(1), pp. 67-75. https://doi.org/10.1007/s00198-021-06058-3

Bilateral atypical femoral fractures during denosumab therapy in a patient with adult-onset hypophosphatasia

Warren, Annabelle M., Ebeling, Peter R., Grill, Vivian, Seeman, Ego and Sztal-Mazer, Shoshana. (2021). Bilateral atypical femoral fractures during denosumab therapy in a patient with adult-onset hypophosphatasia. Endocrinology, Diabetes & Metabolism. 2021(1), pp. 1-5. https://doi.org/10.1530/EDM-21-0096

Physiological and pharmacological roles of PTH and PTHrP in bone using their shared receptor, PTH1R

Martin, T. John, Sims, Natalie A. and Seeman, Ego. (2021). Physiological and pharmacological roles of PTH and PTHrP in bone using their shared receptor, PTH1R. Endocrine Reviews. 42(4), pp. 383-406. https://doi.org/10.1210/endrev/bnab005

Recovery of quality of life is associated with lower mortality 5-year post-fracture : the Australian arm of the International Costs and Utilities Related to Osteoporotic Fractures Study (AusICUROS)

Talevski, Jason, Sanders, Kerrie M., Vogrin, Sara, Duque, Gustavo, Beauchamp, Alison, Seeman, Ego, Iuliano, Sandra, Svedbom, Axel, Borgström, Fredrik, Kanis, John A., Stuart, Amanda L. and Brennan-Olsen, Sharon L.. (2021). Recovery of quality of life is associated with lower mortality 5-year post-fracture : the Australian arm of the International Costs and Utilities Related to Osteoporotic Fractures Study (AusICUROS). Archives of Osteoporosis. 16, p. Article 112. https://doi.org/10.1007/s11657-021-00981-y

Heterogeneity in microstructural deterioration following spinal cord injury

Ghasem-Zadeh, Ali, Galea, Mary P., Nunn, Andrew, Panisset, Maya, Wang, Xiao-Fang, Iuliano, Sandra, Boyd, Steven K., Forwood, Mark R. and Seeman, Ego. (2021). Heterogeneity in microstructural deterioration following spinal cord injury. Bone. 142, p. 115778. https://doi.org/10.1016/j.bone.2020.115778

High cortico-trabecular transitional zone porosity and reduced trabecular density in men and women with stress fractures

Zendeli, Afrodite, Bui, Minh, Fischer, Lukas, Ghasem-Zadeh, Ali, Schima, Wolfgang and Seeman, Ego. (2021). High cortico-trabecular transitional zone porosity and reduced trabecular density in men and women with stress fractures. Journal of Clinical Sleep Medicine. 10(5), pp. 1-10. https://doi.org/10.3390/jcm10051123

Cost-effectiveness of treatment of women aged 70 years and older with both osteopenia and microstructural deterioration

Liew, Danny, Chapurlat, R. D., Sornay-Rendu, E., Lespessailles, Eric, Peng, Yu and Seeman, Ego. (2021). Cost-effectiveness of treatment of women aged 70 years and older with both osteopenia and microstructural deterioration. Bone. 142, p. 115682. https://doi.org/10.1016/j.bone.2020.115682

Reduced bone modeling and unbalanced bone remodeling : Targets for antiresorptive and anabolic therapy

Ramchand, Sabashini and Seeman, Ego. (2020). Reduced bone modeling and unbalanced bone remodeling : Targets for antiresorptive and anabolic therapy. In In Stern, Paula H. (Ed.). Bone regulators and osteoporosis therapy pp. 423-450 Springer Nature Switzerland AG. https://doi.org/10.1007/164_2020_354

Differing effects of zoledronic acid on bone microarchitecture and bone mineral density in men receiving androgen deprivation therapy : A randomized controlled trial

Cheung, Ada S., Hoermann, Rudolf, Ghasem-Zadeh, Ali, Tinson, Alistair J., Ly, Vivian, Milevski, Stefan V., Joon, Daryl Lim, Zajac, Jeffrey D., Seeman, Ego and Grossmann, Mathis. (2020). Differing effects of zoledronic acid on bone microarchitecture and bone mineral density in men receiving androgen deprivation therapy : A randomized controlled trial. Journal of Bone and Mineral Research. 35(10), pp. 1871-1880. https://doi.org/10.1002/jbmr.4106

Deterioration of cortical and trabecular microstructure identifies women with osteopenia or normal bone mineral density at imminent and long-term risk for fragility fracture : A prospective study

Chapurlat, Roland, Bui, Minh, Sornay-Rendu, Elisabeth, Zebaze, Roger, Delmas, Pierre D., Liew, Danny, Lespessailles, Eric and Seeman, Ego. (2020). Deterioration of cortical and trabecular microstructure identifies women with osteopenia or normal bone mineral density at imminent and long-term risk for fragility fracture : A prospective study. Journal of Bone and Mineral Research. 35(6), pp. 833-844. https://doi.org/10.1002/jbmr.3924

Osteocalcin and its forms across the lifespan in adult men

Smith, Cassandra, Voisin, Sarah, Al Saedi, Ahmed, Phu, Steven, Brennan-Speranza, Tara C., Parker, Lewan, Eynon, Nir, Hiam, Danielle S., Yan, Xu, Scott, David, Blekkenhorst, Lauren C., Lewis, Joshua R., Seeman, Ego, Byrnes, Elizabeth, Flicker, Leon, Duque, Gustavo, Yeap, Bu B. and Levinger, Itamar. (2020). Osteocalcin and its forms across the lifespan in adult men. Bone. 130, pp. 1 - 6. https://doi.org/10.1016/j.bone.2019.115085

Modeling and remodeling : The cellular machinery responsible for bone's material and structural strength during growth, aging, and drug therapy

Seeman, Ego. (2019). Modeling and remodeling : The cellular machinery responsible for bone's material and structural strength during growth, aging, and drug therapy. In In Bilezikian, John P., Martin, T. John, Clemens, Thomas L. and Rosen, Clifford J. (Ed.). Principles of bone biology ; volume 1 pp. 245-274 Academic Press. https://doi.org/10.1016/B978-0-12-814841-9.00011-7

The cost of osteoporosis, osteopenia, and associated fractures in Australia in 2017

Tatangelo, Gemma, Watts, Jennifer J., Lim, Karen, Connaughton, Catherine, Abimanyi-Ochom, Julie, Borgström, Fredrik, Nicholson, Geoff C., Shore-Lorenti, Catherine, Stuart, Amanda L., Iuliano-Burns, Sandra, Seeman, Ego, Prince, Richard L., March, Lyn, Cross, Marita, Winzenberg, Tania, Laslett, Laura L., Duque, Gustavo, Ebeling, Peter R. and Sanders, Kerrie M.. (2019). The cost of osteoporosis, osteopenia, and associated fractures in Australia in 2017. Journal of Bone and Mineral Research. 34(4), pp. 616 - 625. https://doi.org/10.1002/jbmr.3640

Skeletal growth: A major determinant of bone's structural diversity in women and men

Seeman, Ego. (2019). Skeletal growth: A major determinant of bone's structural diversity in women and men. In In J. P. Bilezikian (Ed.). Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism pp. 123 - 130 Wiley-Blackwell. https://doi.org/10.1002/9781119266594.ch16

Fat from dairy foods and 'meat' consumed within recommended levels is associated with favourable serum cholesterol levels in institutionalised older adults

Liu, Yusi, Poon, Shirley, Seeman, Ego, Hare, David L., Bui, Minh Q. and Iuliano, Sandra. (2019). Fat from dairy foods and 'meat' consumed within recommended levels is associated with favourable serum cholesterol levels in institutionalised older adults. Journal of Nutritional Science. 8(e10), pp. 1 - 8. https://doi.org/10.1017/jns.2019.5

Dimorphism in axial and appendicular dimensions, cortical and trabecular microstructure and matrix mineral density in Chinese and Caucasian women

Wang, Xiao-Fang, Ghasem-Zadeh, Ali, Zhou, Bin, Guo, X. Edward, Zhang, Zhendong and Seeman, Ego. (2019). Dimorphism in axial and appendicular dimensions, cortical and trabecular microstructure and matrix mineral density in Chinese and Caucasian women. Bone. 128, pp. 1 - 7. https://doi.org/10.1016/j.bone.2019.115039

Adding marrow adiposity and cortical porosity to femoral neck areal bone mineral density improves the discrimination of women with nonvertebral fractures from controls

Zebaze, Roger M., Osima, Marit, Bui, Minh Q., Lukic, Marko, Wang, Xiaofang, Ghasem-Zadeh, Ali, Eriksen, Erik F., Vais, Angela, Shore-Lorenti, Catherine, Ebeling, Peter R., Seeman, Ego and Bjørnerem, Ashild. (2019). Adding marrow adiposity and cortical porosity to femoral neck areal bone mineral density improves the discrimination of women with nonvertebral fractures from controls. Journal of Bone and Mineral Research. 34(8), pp. 1451 - 1460. https://doi.org/10.1002/jbmr.3721

Increased cortical porosity and reduced trabecular density are not necessarily synonymous with bone loss and microstructural deterioration

Zebaze, Roger M., Atkinson, Elizabeth J., Peng, Yu, Bui, Minh, Ghasem-Zadeh, Ali, Khosla, Sundeep and Seeman, Ego. (2019). Increased cortical porosity and reduced trabecular density are not necessarily synonymous with bone loss and microstructural deterioration. JBMR Plus. 3(4), pp. 1 - 7. https://doi.org/10.1002/jbm4.10078

Glucocorticoid-induced insulin resistance in men is associated with suppressed undercarboxylated osteocalcin

Parker, Lewan, Lin, Xuzhu, Garnham, Andrew, McConell, Glenn, Stepto, Nigel K., Hare, David L., Byrnes, Elizabeth, Ebeling, Peter R., Seeman, Ego, Brennan-Speranza, Tara C. and Levinger, Itamar. (2019). Glucocorticoid-induced insulin resistance in men is associated with suppressed undercarboxylated osteocalcin. Journal of Bone and Mineral Research. 34(1), pp. 49-58. https://doi.org/10.1002/jbmr.3574

Menopause and age-related bone loss

Isales, Carlos M. and Seeman, Ego. (2019). Menopause and age-related bone loss. In In J. P. Bilezikian (Ed.). Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism pp. 155 - 161 Wiley-Blackwell. https://doi.org/10.1002/9781119266594.ch21

Antiresorptive and anabolic agents in the prevention and reversal of bone fragility

Seeman, Ego and Martin, T. J.. (2019). Antiresorptive and anabolic agents in the prevention and reversal of bone fragility. Nature Reviews Rheumatology. 15(4), pp. 225 - 236. https://doi.org/10.1038/s41584-019-0172-3

The influence of cortical porosity on the strength of bone during growth and advancing age

Ramchand, S. K. and Seeman, Ego. (2018). The influence of cortical porosity on the strength of bone during growth and advancing age. Current Osteoporosis Reports. 16(5), pp. 561 - 572. https://doi.org/10.1007/s11914-018-0478-0

Mechanical loading of the femoral neck in human locomotion

Kersh, M. E., Martelli, Saulo, Zebaze, Roger M., Seeman, Ego and Pandy, Marcus. (2018). Mechanical loading of the femoral neck in human locomotion. Journal of Bone and Mineral Research. 33(11), pp. 1999 - 2006. https://doi.org/10.1002/jbmr.3529

Sexual dimorphism in cortical and trabecular bone microstructure appears during puberty in chinese children

Cheuk, Ka Yee, Wang, Xiao-Fang, Wang, Ji, Zhang, Zhendong, Yu, Fiona Wai Ping, Tam, Elisa Man Shan, Hung, Vivian Wing Yin, Lee, Wayne Yuk Wai, Ghasem-Zadeh, Ali, Zebaze, Roger, Zhu, Tracy Y., Guo, X. Edward, Cheng, Jack Chun Yiu, Lam, Tsz Ping and Seeman, Ego. (2018). Sexual dimorphism in cortical and trabecular bone microstructure appears during puberty in chinese children. Journal of Bone and Mineral Research. 33(11), pp. 1948 - 1955. https://doi.org/10.1002/jbmr.3551

Cortical matrix mineral density measured noninvasively in pre- and postmenopausal women and a woman with vitamin d–dependent rickets

Chiang, Cherie Y., Zebaze, Roger, Wang, Xiao-Fang, Ghasem-Zadeh, Ali, Zajac, Jeffrey D. and Seeman, Ego. (2018). Cortical matrix mineral density measured noninvasively in pre- and postmenopausal women and a woman with vitamin d–dependent rickets. Journal of Bone and Mineral Research. 33(7), pp. 1312 - 1317. https://doi.org/10.1002/jbmr.3415

Systemic mastocytosis identified in two women developing fragility fractures during lactation

Zhu, J. J., Mahendran, D., Lee, M.H., Seah, J., Fourlanos, S., Varadarajan, S., Ghasem-Zadeh, Ali, MacIsaac, Richard and Seeman, Ego. (2018). Systemic mastocytosis identified in two women developing fragility fractures during lactation. Osteoporosis International. 29(7), pp. 1671 - 1674. https://doi.org/10.1007/s00198-018-4498-5

The material and structural basis of the growth-related gain and age-related loss of bone strength

Seeman, Ego. (2018). The material and structural basis of the growth-related gain and age-related loss of bone strength. In In N. C. Harvey and C. Cooper (Ed.). Osteoporosis: A Lifecourse Epidemiology Approach to Skeletal Health pp. 105 - 122 CRC Press. https://doi.org/10.1201/9781351234627-9

An even distribution of protein intake daily promotes protein adequacy but does not influence nutritional status in institutionalized elderly

Tieland, Michael, Beelen, Janne, Laan, Anna C. M., Poon, Shirley, de Groot, Lisette C. P. G. M., Seeman, Ego, Wang, Xiaofang and Iuliano, Sandra. (2018). An even distribution of protein intake daily promotes protein adequacy but does not influence nutritional status in institutionalized elderly. Journal of the American Medical Directors Association (JAMDA): long-term care: management, applied research and clinical issues. 19(1), pp. 33 - 39. https://doi.org/10.1016/j.jamda.2017.07.007

The diagnostic threshold for osteoporosis impedes fracture prevention in women at high risk for fracture: A registry-based cohort study

Leslie, William D., Seeman, Ego, Morin, Suzanne N., Lix, Lisa and Majumdar, S. R.. (2018). The diagnostic threshold for osteoporosis impedes fracture prevention in women at high risk for fracture: A registry-based cohort study. Bone. 114, pp. 298 - 303. https://doi.org/10.1016/j.bone.2018.07.004

Advances and unmet needs in the therapeutics of bone fragility

Ramchand, S. K. and Seeman, Ego. (2018). Advances and unmet needs in the therapeutics of bone fragility. Frontiers in Endocrinology. 9, pp. 1 - 10. https://doi.org/10.3389/fendo.2018.00505

Menopause-related appendicular bone loss is mainly cortical and results in increased cortical porosity

Bjørnerem, Ashild, Wang, Xiaofang, Bui, Q. M., Ghasem-Zadeh, Ali, Hopper, John, Zebaze, Roger M. and Seeman, Ego. (2018). Menopause-related appendicular bone loss is mainly cortical and results in increased cortical porosity. Journal of Bone and Mineral Research. 33(4), pp. 598 - 605. https://doi.org/10.1002/jbmr.3333

Increased cortical porosity is associated with daily, not weekly, administration of equivalent doses of teriparatide

Zebaze, Roger, Takao-Kawabata, Ryoko, Peng, Yu, Zadeh, Ali Ghasem, Hirano, Kyoko, Yamane, Hiroshi, Takakura, Aya, Isogai, Yukihiro, Ishizuya, Toshinori and Seeman, Ego. (2017). Increased cortical porosity is associated with daily, not weekly, administration of equivalent doses of teriparatide. Bone. 99, pp. 80 - 84. https://doi.org/10.1016/j.bone.2017.03.042

Dairy food supplementation may reduce malnutrition risk in institutionalised elderly

Iuliano, Sandra, Poon, Shirley, Wang, Xiaofang, Bui, Minh and Seeman, Ego. (2017). Dairy food supplementation may reduce malnutrition risk in institutionalised elderly. British Journal of Nutrition. 117(1), pp. 142 - 147. https://doi.org/10.1017/S000711451600461X

Overview of bone microstructure, and treatment of bone fragility in chronic kidney disease

Seeman, Ego. (2017). Overview of bone microstructure, and treatment of bone fragility in chronic kidney disease. Nephrology. 22(Suppl 2), pp. 34 - 35. https://doi.org/10.1111/nep.13024

Serum 25-hydroxyvitamin d insufficiency in search of a bone disease

Shah, Sonali, Chiang, Cherie, Sikaris, Ken, Lu, Zhong, Bui, Minh, Zebaze, Roger and Seeman, Ego. (2017). Serum 25-hydroxyvitamin d insufficiency in search of a bone disease. The Journal of Clinical Endocrinology and Metabolism. 102(7), pp. 2321 - 2328. https://doi.org/10.1210/jc.2016-3189

Irreversible deterioration of cortical and trabecular microstructure associated with breastfeeding

Bjørnerem, Åshild, Ghasem-Zadeh, Ali, Wang, Xiaofang, Bui, Minh, Walker, Susan P., Zebaze, Roger and Seeman, Ego. (2017). Irreversible deterioration of cortical and trabecular microstructure associated with breastfeeding. Journal of Bone and Mineral Research. 32(4), pp. 681 - 687. https://doi.org/10.1002/jbmr.3018

Premenopausal women with early breast cancer treated with estradiol suppression have severely deteriorated bone microstructure

Ramchand, Sabashini K., Seeman, Ego, Wang, Xiao-Fang, Ghasem-Zadeh, Ali, Francis, Prudence A., Ponnusamy, Evangeline J., Bardin, Michele S., Bui, Minh, Zebaze, Roger, Zajac, Jeffrey D. and Grossmann, Mathis. (2017). Premenopausal women with early breast cancer treated with estradiol suppression have severely deteriorated bone microstructure. Bone. 103, pp. 131 - 135. https://doi.org/10.1016/j.bone.2017.06.024

Quantifying sex, race, and age specific differences in bone microstructure requires measurement of anatomically equivalent regions

Ghasem-Zadeh, Ali, Burghardt, Andrew, Wang, Xiao-Fang, Iuliano, Sandra, Bonaretti, Serena, Bui, Minh, Zebaze, Roger and Seeman, Ego. (2017). Quantifying sex, race, and age specific differences in bone microstructure requires measurement of anatomically equivalent regions. Bone. 101, pp. 206 - 213. https://doi.org/10.1016/j.bone.2017.05.010

Abaloparatide is an anabolic, but does it spare resorption?

Martin, T. John and Seeman, Ego. (2017). Abaloparatide is an anabolic, but does it spare resorption? Journal of Bone and Mineral Research. 32(1), pp. 11 - 16. https://doi.org/10.1001/jama.2016.11136

Method and system for image analysis

Zebaze, Roger, Mackie, Eleanor Jean, Bohte, Anne, Mbala, Aloys, Ghasemzadeh, Ali and Seeman, Ego. (2016). Method and system for image analysis US009378566B2

Challenges in the use of cross-sectional data to quantify growth and deterioration of bone structure during advancing age

Ghasem-Zadeh, Ali and Seeman, Ego. (2016). Challenges in the use of cross-sectional data to quantify growth and deterioration of bone structure during advancing age. Journal of Clinical Densitometry. 20(1), pp. 5 - 7. https://doi.org/10.1016/j.jocd.2016.08.006

A single dose of prednisolone as a modulator of undercarboxylated osteocalcin and insulin sensitivity post-exercise in healthy young men: A study protocol

Levinger, Itamar, Brennan-Speranza, Tara C., Stepto, Nigel K., Jerums, George, Parker, Lewan, McConell, Glenn K., Anderson, Mitchell, Garnham, Andrew, Hare, David L., Ebeling, Peter R. and Seeman, Ego. (2016). A single dose of prednisolone as a modulator of undercarboxylated osteocalcin and insulin sensitivity post-exercise in healthy young men: A study protocol. JMIR Research Protocols. 5(2), pp. 1 - 7. https://doi.org/10.2196/resprot.5119

A randomised controlled trial of low-dose aspirin for the prevention of fractures in healthy older people: Protocol for the ASPREE-Fracture substudy

Barker, Anna L., McNeil, John J., Seeman, Ego, Ward, Stephanie A., Sanders, Kerrie M., Khosla, Sundeep, Cumming, Robert G., Pasco, Julie A., Bohensky, Megan A., Ebeling, Peter E., Woods, Robyn L., Lockery, Jessica E., Wolfe, Rory, Talevski, Jason and ASPREE Investigator Group. (2016). A randomised controlled trial of low-dose aspirin for the prevention of fractures in healthy older people: Protocol for the ASPREE-Fracture substudy. Injury Prevention. 22(4), pp. 297-301. https://doi.org/10.1136/injuryprev-2015-041655

Glucose-loading reduces bone remodeling in women and osteoblast function in vitro

Levinger, Itamar, Seeman, Ego, Jerums, George, McConell, Glenn K., Rybchyn, Mark S., Cassar, Samantha, Byrnes, Elizabeth, Selig, Steve, Mason, Rebecca S., Ebeling, Peter R. and Brennan-Speranza, Tara C.. (2016). Glucose-loading reduces bone remodeling in women and osteoblast function in vitro. Physiological Reports. 4(3), pp. 1 - 10. https://doi.org/10.14814/phy2.12700

The effects of muscle contraction and recombinant osteocalcin on insulin sensitivity ex vivo

Levinger, Itamar, Lin, X, Zhang, X., Brennan-Speranza, T C., Volpato, B, Hayes, A., Jeru, G, Seeman, Ego and Mcconell, Glenn K.. (2016). The effects of muscle contraction and recombinant osteocalcin on insulin sensitivity ex vivo. Osteoporosis International. 27(2), pp. 653 - 663. https://doi.org/10.1007/s00198-015-3273-0

Challenges in the acquisition and analysis of bone microstructure during growth

Seeman, Ego and Ghasem-Zadeh, Ali. (2016). Challenges in the acquisition and analysis of bone microstructure during growth. Journal of Bone and Mineral Research. 31(12), pp. 2239 - 2241. https://doi.org/10.1002/jbmr.3015

Bone remodeling markers: So easy to measure, so difficult to interpret

Seeman, E. and Nguyen, T. V.. (2016). Bone remodeling markers: So easy to measure, so difficult to interpret. Osteoporosis International. 27, pp. 33 - 35. https://doi.org/10.1007/s00198-015-3374-9

Denosumab reduces cortical porosity of the proximal femoral shaft in postmenopausal women with osteoporosis

Zebaze, Roger M., Libanati, Cesar, McClung, Michael R., Zanchetta, Jose Ruben, Kendler, David L., Høiseth, Arne, Wang, Andrea, Ghasem-Zadeh, Ali and Seeman, Ego. (2016). Denosumab reduces cortical porosity of the proximal femoral shaft in postmenopausal women with osteoporosis. Journal of Bone and Mineral Research. 31(10), pp. 1827 - 1834. https://doi.org/10.1002/jbmr.2855

Analysis method and system

Zebaze, R., Seeman, Ego, Ghasemzadeh, Ali, Bohte, Anne, Mackie, Eleanor Jean and Mbala, Aloys. (2015). Analysis method and system AU2015203523

Osteoporosis: Treat or let die twice more likely

Nguyen, Tuan V. and Seeman, Ego. (2015). Osteoporosis: Treat or let die twice more likely. Journal of Bone and Mineral Research. 30(9), pp. 1551 - 1552. https://doi.org/10.1002/jbmr.2601/pdf

Cortical bone: A challenging geography

Zebaze, Roger and Seeman, Ego. (2015). Cortical bone: A challenging geography. Journal of Bone and Mineral Research. 30(1), pp. 24 - 29. https://doi.org/10.1002/jbmr.2419

Regional heterogeneity in the configuration of the intracortical canals of the femoral shaft

Perilli, Egon, Bala, Yohann, Zebaze, Roger M., Reynolds, Karen J. and Seeman, Ego. (2015). Regional heterogeneity in the configuration of the intracortical canals of the femoral shaft. Calcified Tissue International. 97(4), pp. 327 - 335. https://doi.org/10.1007/s00223-015-0014-5

Changes in quality of life associated with fragility fractures : Australian arm of the International Cost and Utility Related to Osteoporotic Fractures Study (AusICUROS)

Abimanyi-Ochom, J., Watts, Jennifer, Borgstrom, F., Nicholson, Geoffrey, Shore-Lorenti, Catherine, Stuart, Amanda, Zhang, Y., Luliano, S., Seeman, Ego, Prince, Richard, March, Lyn, Winzenberg, T., Laslett, Laura, Duque, Gustavo, Ebeling, P. and Sanders, K. M.. (2015). Changes in quality of life associated with fragility fractures : Australian arm of the International Cost and Utility Related to Osteoporotic Fractures Study (AusICUROS). Osteoporosis International. 26(6), pp. 1781 - 1790. https://doi.org/10.1007/s00198-015-3088-z

Genetic and environmental variances of bone microarchitecture and bone remodeling markers: A twin study

Bjornerem, Ashild, Bui, Q Minh, Wang, Xiaofang, Ghasem-Zadeh, Ali, Hopper, John L., Zebaze, Roger M. and Seeman, Ego. (2015). Genetic and environmental variances of bone microarchitecture and bone remodeling markers: A twin study. Journal of Bone and Mineral Research. 30(3), pp. 516 - 524. https://doi.org/10.1002/jbmr.2365

Bones material constituents and their contribution to bone strength in health, disease, and treatment

Bala, Y. and Seeman, Ego. (2015). Bones material constituents and their contribution to bone strength in health, disease, and treatment. Calcified Tissue International. 97(3), pp. 308 - 326. https://doi.org/10.1007/s00223-015-9971-y

A. Michael Parfitt: Enlightened scholar and revered mentor: May 10, 1930-May 18, 2015

Manolagas, Stavros C., Compston, Juliet, Rao, Sudhaker and Seeman, Ego. (2015). A. Michael Parfitt: Enlightened scholar and revered mentor: May 10, 1930-May 18, 2015. Journal of Bone and Mineral Research. 30(8), pp. 1349 - 1355. https://doi.org/10.1002/jbmr.2576

Co-administration of antiresorptive and anabolic agents: A missed opportunity

Seeman, Ego and Martin, T. John. (2015). Co-administration of antiresorptive and anabolic agents: A missed opportunity. Journal of Bone and Mineral Research. 30(5), pp. 753 - 764. https://doi.org/10.1002/jbmr.2496

The ABC of writing a grant proposal

Seeman, Ego. (2015). The ABC of writing a grant proposal. Osteoporosis International. 26(6), pp. 1665 - 1666. https://doi.org/10.1007/s00198-015-3085-2

Growth and age-related abnormalities in cortical structure and fracture risk

Seeman, Ego. (2015). Growth and age-related abnormalities in cortical structure and fracture risk. Endocrinology and Metabolism. 30(4), pp. 419 - 428. https://doi.org/10.3803/EnM.2015.30.4.419

High-resolution in vivo imaging of bone and joints: a window to microarchitecture

Geusens, P., Geusens, P., Chapurlat, Roland D., Chapurlat, Roland D., Schett, G., Ghasem-Zadeh, Ali, Ghasem-Zadeh, Ali, Seeman, Ego, De Jong, J. and Van Den Bergh, J.. (2014). High-resolution in vivo imaging of bone and joints: a window to microarchitecture. Nature Reviews Rheumatology. 10(5), pp. 304 - 313. https://doi.org/10.1038/nrrheum.2014.23

A new method of segmentation of compact-appearing, transitional and trabecular compartments and quantification of cortical porosity from high resolution peripheral quantitative computed tomographic images

Zebaze, Roger M., Ghasem-Zadeh, Ali, Mbala, A. and Seeman, Ego. (2013). A new method of segmentation of compact-appearing, transitional and trabecular compartments and quantification of cortical porosity from high resolution peripheral quantitative computed tomographic images. Bone. 54(1), pp. 8 - 20. https://doi.org/10.1016/j.bone.2013.01.007

Teriparatide improves bone quality and healing of atypical femoral fractures associated with bisphosphonate therapy

Chiang, Cherie Ying, Zebaze, Roger M.D., Ghasem-Zadeh, Ali, Iuliano-Burns, Sandra, Hardidge, Andrew and Seeman, Ego. (2013). Teriparatide improves bone quality and healing of atypical femoral fractures associated with bisphosphonate therapy. Bone. 52(1), pp. 360 - 365. https://doi.org/10.1016/j.bone.2012.10.006

Predictors of new and severe vertebral fractures: Results from the HoRIZoN Pivotal Fracture Trial

Wustrack, R., Seeman, Ego, Bucci-Rechtweg, C. and Burch, S.. (2012). Predictors of new and severe vertebral fractures: Results from the HoRIZoN Pivotal Fracture Trial. Osteoporosis International. 23(1), pp. 53 - 58. https://doi.org/10.1007/s00198-011-1664-4

The effect of acute exercise on undercarboxylated osteocalcin in obese men

Levinger, Itamar, Zebaze, Roger M., Jeru, G., Hare, David L., Selig, Steve and Seeman, Ego. (2011). The effect of acute exercise on undercarboxylated osteocalcin in obese men. Osteoporosis International. 22(5), pp. 1621 - 1626. https://doi.org/10.1007/s00198-010-1370-7