Glucocorticoid-induced insulin resistance in men is associated with suppressed undercarboxylated osteocalcin

Journal article


Parker, Lewan, Lin, Xuzhu, Garnham, Andrew, McConell, Glenn, Stepto, Nigel K., Hare, David L., Byrnes, Elizabeth, Ebeling, Peter R., Seeman, Ego, Brennan-Speranza, Tara C. and Levinger, Itamar. (2019). Glucocorticoid-induced insulin resistance in men is associated with suppressed undercarboxylated osteocalcin. Journal of Bone and Mineral Research. 34(1), pp. 49-58. https://doi.org/10.1002/jbmr.3574
AuthorsParker, Lewan, Lin, Xuzhu, Garnham, Andrew, McConell, Glenn, Stepto, Nigel K., Hare, David L., Byrnes, Elizabeth, Ebeling, Peter R., Seeman, Ego, Brennan-Speranza, Tara C. and Levinger, Itamar
Abstract

In mice, glucocorticoid‐induced insulin resistance occurs largely through impaired osteoblast function and decreased circulating undercarboxylated osteocalcin (ucOC). Whether these mechanisms contribute to glucocorticoid‐induced insulin resistance in humans has yet to be established. In addition, the effects of glucocorticoids on the exercise‐induced increase in circulating ucOC and insulin sensitivity are also unknown. We hypothesized that acute glucocorticoid treatment would lead to basal and postexercise insulin resistance in part through decreased circulating ucOC and ucOC‐mediated skeletal muscle protein signaling. Nine healthy men completed two separate cycling sessions 12 hours after ingesting either glucocorticoid (20 mg prednisolone) or placebo (20 mg Avicel). The homeostatic model assessment was used to assess basal insulin sensitivity and a 2‐hour euglycemic–hyperinsulinemic clamp was commenced 3 hours after exercise to assess postexercise insulin sensitivity. Serum ucOC and skeletal muscle protein signaling were measured. Single‐dose glucocorticoid ingestion increased fasting glucose (27%, p  < 0.01) and insulin (83%, p  < 0.01), and decreased basal insulin sensitivity (−47%, p  < 0.01). Glucocorticoids reduced insulin sensitivity after cycling exercise (−34%, p  < 0.01), reduced muscle GPRC6A protein content (16%, p  < 0.05), and attenuated protein phosphorylation of mTORSer2481, AktSer374, and AS160Thr642 (59%, 61%, and 50%, respectively; all p s < 0.05). Serum ucOC decreased (−24%, p  < 0.01) which correlated with lower basal insulin sensitivity (r  = 0.54, p  = 0.02), lower insulin sensitivity after exercise (r  = 0.72, p  < 0.05), and attenuated muscle protein signaling (r  = 0.48–0.71, p  < 0.05). Glucocorticoid‐induced basal and postexercise insulin resistance in humans is associated with the suppression of circulating ucOC and ucOC‐linked protein signaling in skeletal muscle. Whether ucOC treatment can offset glucocorticoid‐induced insulin resistance in human subjects requires further investigation. © 2018 American Society for Bone and Mineral Research.

Keywordsglucocorticoid metabolism; anti-inflammation; glycemic control; high-intensity interval exercise; insulin signaling
Year2019
JournalJournal of Bone and Mineral Research
Journal citation34 (1), pp. 49-58
PublisherJohn Wiley & Sons
ISSN0884-0431
Digital Object Identifier (DOI)https://doi.org/10.1002/jbmr.3574
Scopus EID2-s2.0-85053517542
Open accessPublished as green open access
Page range49-58
FunderVictoria University
National Heart Foundation of Australia
Deakin University
Collaborative Research Networks (CRN), Australian Government
Research GroupMary MacKillop Institute for Health Research
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Open
Publisher's version
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File Access Level
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Output statusPublished
Publication dates
Online17 Sep 2018
Publication process dates
Accepted08 Aug 2018
Grant ID100040
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Wang, Xiao-Fang, Ghasem-Zadeh, Ali, Zhou, Bin, Guo, X. Edward, Zhang, Zhendong and Seeman, Ego. (2019). Dimorphism in axial and appendicular dimensions, cortical and trabecular microstructure and matrix mineral density in Chinese and Caucasian women. Bone. 128, pp. 1 - 7. https://doi.org/10.1016/j.bone.2019.115039
Adding marrow adiposity and cortical porosity to femoral neck areal bone mineral density improves the discrimination of women with nonvertebral fractures from controls
Zebaze, Roger M., Osima, Marit, Bui, Minh Q., Lukic, Marko, Wang, Xiaofang, Ghasem-Zadeh, Ali, Eriksen, Erik F., Vais, Angela, Shore-Lorenti, Catherine, Ebeling, Peter R., Seeman, Ego and Bjørnerem, Ashild. (2019). Adding marrow adiposity and cortical porosity to femoral neck areal bone mineral density improves the discrimination of women with nonvertebral fractures from controls. Journal of Bone and Mineral Research. 34(8), pp. 1451 - 1460. https://doi.org/10.1002/jbmr.3721
Increased cortical porosity and reduced trabecular density are not necessarily synonymous with bone loss and microstructural deterioration
Zebaze, Roger M., Atkinson, Elizabeth J., Peng, Yu, Bui, Minh, Ghasem-Zadeh, Ali, Khosla, Sundeep and Seeman, Ego. (2019). Increased cortical porosity and reduced trabecular density are not necessarily synonymous with bone loss and microstructural deterioration. JBMR Plus. 3(4), pp. 1 - 7. https://doi.org/10.1002/jbm4.10078
Menopause and age-related bone loss
Isales, Carlos M. and Seeman, Ego. (2019). Menopause and age-related bone loss. In In J. P. Bilezikian (Ed.). Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism pp. 155 - 161 Wiley-Blackwell. https://doi.org/10.1002/9781119266594.ch21
Antiresorptive and anabolic agents in the prevention and reversal of bone fragility
Seeman, Ego and Martin, T. J.. (2019). Antiresorptive and anabolic agents in the prevention and reversal of bone fragility. Nature Reviews Rheumatology. 15(4), pp. 225 - 236. https://doi.org/10.1038/s41584-019-0172-3
Exercise and GLUT4 in human subcutaneous adipose tissue
Flores-Opazo, Marcelo, Boland, Eva, Garnham, Andrew, Murphy, Robyn M., McGee, Sean L. and Hargreaves, Mark. (2018). Exercise and GLUT4 in human subcutaneous adipose tissue. Physiological Reports. 6(22), pp. 1 - 8. https://doi.org/10.14814/phy2.13918
The influence of cortical porosity on the strength of bone during growth and advancing age
Ramchand, S. K. and Seeman, Ego. (2018). The influence of cortical porosity on the strength of bone during growth and advancing age. Current Osteoporosis Reports. 16(5), pp. 561 - 572. https://doi.org/10.1007/s11914-018-0478-0
ACE I/D gene variant predicts ACE enzyme content in blood but not the ACE, UCP2, and UCP3 protein content in human skeletal muscle in the GeneSMART study
Yan, Xu, Dvir, Noam, Jacques, Macsue, Cavalcante, Luiz, Papadimitriou, Ioannis D., Munson, Fiona, Kuang, Jujiao, Garnham, Andrew, Landen, Shanie, Li, Jia, O'Keefe, Lannie, Tirosh, Oren, Bishop, David, Voisin, Sarah and Eynon, Nir. (2018). ACE I/D gene variant predicts ACE enzyme content in blood but not the ACE, UCP2, and UCP3 protein content in human skeletal muscle in the GeneSMART study. Journal of Applied Physiology. 125(3), pp. 923 - 930. https://doi.org/10.1152/japplphysiol.00344.2018
No evidence of direct association between GLUT4 and glycogen in human skeletal muscle
Murphy, Robyn M., Flores-Opazo, Marcelo, Frankish, Barnaby P., Garnham, Andrew, Stapleton, David and Hargreaves, Mark. (2018). No evidence of direct association between GLUT4 and glycogen in human skeletal muscle. Physiological Reports. 6(21), pp. 1 - 5. https://doi.org/10.14814/phy2.13917
Mechanical loading of the femoral neck in human locomotion
Kersh, M. E., Martelli, Saulo, Zebaze, Roger M., Seeman, Ego and Pandy, Marcus. (2018). Mechanical loading of the femoral neck in human locomotion. Journal of Bone and Mineral Research. 33(11), pp. 1999 - 2006. https://doi.org/10.1002/jbmr.3529
Sexual dimorphism in cortical and trabecular bone microstructure appears during puberty in chinese children
Cheuk, Ka Yee, Wang, Xiao-Fang, Wang, Ji, Zhang, Zhendong, Yu, Fiona Wai Ping, Tam, Elisa Man Shan, Hung, Vivian Wing Yin, Lee, Wayne Yuk Wai, Ghasem-Zadeh, Ali, Zebaze, Roger, Zhu, Tracy Y., Guo, X. Edward, Cheng, Jack Chun Yiu, Lam, Tsz Ping and Seeman, Ego. (2018). Sexual dimorphism in cortical and trabecular bone microstructure appears during puberty in chinese children. Journal of Bone and Mineral Research. 33(11), pp. 1948 - 1955. https://doi.org/10.1002/jbmr.3551
Cortical matrix mineral density measured noninvasively in pre- and postmenopausal women and a woman with vitamin d–dependent rickets
Chiang, Cherie Y., Zebaze, Roger, Wang, Xiao-Fang, Ghasem-Zadeh, Ali, Zajac, Jeffrey D. and Seeman, Ego. (2018). Cortical matrix mineral density measured noninvasively in pre- and postmenopausal women and a woman with vitamin d–dependent rickets. Journal of Bone and Mineral Research. 33(7), pp. 1312 - 1317. https://doi.org/10.1002/jbmr.3415
Systemic mastocytosis identified in two women developing fragility fractures during lactation
Zhu, J. J., Mahendran, D., Lee, M.H., Seah, J., Fourlanos, S., Varadarajan, S., Ghasem-Zadeh, Ali, MacIsaac, Richard and Seeman, Ego. (2018). Systemic mastocytosis identified in two women developing fragility fractures during lactation. Osteoporosis International. 29(7), pp. 1671 - 1674. https://doi.org/10.1007/s00198-018-4498-5
The material and structural basis of the growth-related gain and age-related loss of bone strength
Seeman, Ego. (2018). The material and structural basis of the growth-related gain and age-related loss of bone strength. In In N. C. Harvey and C. Cooper (Ed.). Osteoporosis: A Lifecourse Epidemiology Approach to Skeletal Health pp. 105 - 122 CRC Press. https://doi.org/10.1201/9781351234627-9
An even distribution of protein intake daily promotes protein adequacy but does not influence nutritional status in institutionalized elderly
Tieland, Michael, Beelen, Janne, Laan, Anna C. M., Poon, Shirley, de Groot, Lisette C. P. G. M., Seeman, Ego, Wang, Xiaofang and Iuliano, Sandra. (2018). An even distribution of protein intake daily promotes protein adequacy but does not influence nutritional status in institutionalized elderly. Journal of the American Medical Directors Association (JAMDA): long-term care: management, applied research and clinical issues. 19(1), pp. 33 - 39. https://doi.org/10.1016/j.jamda.2017.07.007
The diagnostic threshold for osteoporosis impedes fracture prevention in women at high risk for fracture: A registry-based cohort study
Leslie, William D., Seeman, Ego, Morin, Suzanne N., Lix, Lisa and Majumdar, S. R.. (2018). The diagnostic threshold for osteoporosis impedes fracture prevention in women at high risk for fracture: A registry-based cohort study. Bone. 114, pp. 298 - 303. https://doi.org/10.1016/j.bone.2018.07.004
Acute HIIE elicits similar changes in human skeletal muscle mitochondrial H2O2 release, respiration, and cell signaling as endurance exercise even with less work
Trewin, Adam J., Parker, Lewan, Shaw, Christopher S., Hiam, Danielle S., Garnham, Andrew, Levinger, Itamar, McConell, Glenn K. and Stepto, Nigel K.. (2018). Acute HIIE elicits similar changes in human skeletal muscle mitochondrial H2O2 release, respiration, and cell signaling as endurance exercise even with less work. American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 315(5), pp. R1003 - R1016. https://doi.org/10.1152/ajpregu.00096.2018
Advances and unmet needs in the therapeutics of bone fragility
Ramchand, S. K. and Seeman, Ego. (2018). Advances and unmet needs in the therapeutics of bone fragility. Frontiers in Endocrinology. 9, pp. 1 - 10. https://doi.org/10.3389/fendo.2018.00505
Menopause-related appendicular bone loss is mainly cortical and results in increased cortical porosity
Bjørnerem, Ashild, Wang, Xiaofang, Bui, Q. M., Ghasem-Zadeh, Ali, Hopper, John, Zebaze, Roger M. and Seeman, Ego. (2018). Menopause-related appendicular bone loss is mainly cortical and results in increased cortical porosity. Journal of Bone and Mineral Research. 33(4), pp. 598 - 605. https://doi.org/10.1002/jbmr.3333
Four days of simulated shift work reduces insulin sensitivity in humans
Bescos, Raul, Boden, Michael J., Jackson, Melinda L., Trewin, Adam J., Marin, Evelyn C., Levinger, Itamar, Garnham, Andrew, Hiam, Andrew, Falcao-Tebas, Filippe, Conte, F., Owens, Julie A., Kennaway, David J. and McConell, Glenn K.. (2018). Four days of simulated shift work reduces insulin sensitivity in humans. Acta Physiologica. 223(2), pp. 1 - 13. https://doi.org/10.1111/apha.13039
Increased cortical porosity is associated with daily, not weekly, administration of equivalent doses of teriparatide
Zebaze, Roger, Takao-Kawabata, Ryoko, Peng, Yu, Zadeh, Ali Ghasem, Hirano, Kyoko, Yamane, Hiroshi, Takakura, Aya, Isogai, Yukihiro, Ishizuya, Toshinori and Seeman, Ego. (2017). Increased cortical porosity is associated with daily, not weekly, administration of equivalent doses of teriparatide. Bone. 99, pp. 80 - 84. https://doi.org/10.1016/j.bone.2017.03.042
Dairy food supplementation may reduce malnutrition risk in institutionalised elderly
Iuliano, Sandra, Poon, Shirley, Wang, Xiaofang, Bui, Minh and Seeman, Ego. (2017). Dairy food supplementation may reduce malnutrition risk in institutionalised elderly. British Journal of Nutrition. 117(1), pp. 142 - 147. https://doi.org/10.1017/S000711451600461X
Overview of bone microstructure, and treatment of bone fragility in chronic kidney disease
Seeman, Ego. (2017). Overview of bone microstructure, and treatment of bone fragility in chronic kidney disease. Nephrology. 22(Suppl 2), pp. 34 - 35. https://doi.org/10.1111/nep.13024
Serum 25-hydroxyvitamin d insufficiency in search of a bone disease
Shah, Sonali, Chiang, Cherie, Sikaris, Ken, Lu, Zhong, Bui, Minh, Zebaze, Roger and Seeman, Ego. (2017). Serum 25-hydroxyvitamin d insufficiency in search of a bone disease. The Journal of Clinical Endocrinology and Metabolism. 102(7), pp. 2321 - 2328. https://doi.org/10.1210/jc.2016-3189
Irreversible deterioration of cortical and trabecular microstructure associated with breastfeeding
Bjørnerem, Åshild, Ghasem-Zadeh, Ali, Wang, Xiaofang, Bui, Minh, Walker, Susan P., Zebaze, Roger and Seeman, Ego. (2017). Irreversible deterioration of cortical and trabecular microstructure associated with breastfeeding. Journal of Bone and Mineral Research. 32(4), pp. 681 - 687. https://doi.org/10.1002/jbmr.3018
Striated muscle activator of rho signalling (STARS) is reduced in ageing human skeletal muscle and targeted by mir-628-5p
Russell, Andrew, Wallace, M. A., Kalanon, M., Zacharewicz, Evelyn, Gatta, P. A.D., Garnham, Andrew and Lamon, Séverine. (2017). Striated muscle activator of rho signalling (STARS) is reduced in ageing human skeletal muscle and targeted by mir-628-5p. Acta Physiologica. 220(2), pp. 263 - 274. https://doi.org/10.1111/apha.12819
Premenopausal women with early breast cancer treated with estradiol suppression have severely deteriorated bone microstructure
Ramchand, Sabashini K., Seeman, Ego, Wang, Xiao-Fang, Ghasem-Zadeh, Ali, Francis, Prudence A., Ponnusamy, Evangeline J., Bardin, Michele S., Bui, Minh, Zebaze, Roger, Zajac, Jeffrey D. and Grossmann, Mathis. (2017). Premenopausal women with early breast cancer treated with estradiol suppression have severely deteriorated bone microstructure. Bone. 103, pp. 131 - 135. https://doi.org/10.1016/j.bone.2017.06.024
Actin alpha cardiac muscle 1 gene expression is upregulated in the skeletal muscle of men undergoing androgen deprivation therapy for prostate cancer
Cheung, Ada S., Rooy, Casey D., Levinger, Itamar, Rana, Kesha, Clarke, Michele V., How, Jackie M., Garnham, Andrew, McLean, Catriona, Zajac, J. D., Davey, Rachel A. and Grossmann, M.. (2017). Actin alpha cardiac muscle 1 gene expression is upregulated in the skeletal muscle of men undergoing androgen deprivation therapy for prostate cancer. The Journal of Steroid Biochemistry and Molecular Biology. 174, pp. 56 - 64. https://doi.org/10.1016/j.jsbmb.2017.07.029
Quantifying sex, race, and age specific differences in bone microstructure requires measurement of anatomically equivalent regions
Ghasem-Zadeh, Ali, Burghardt, Andrew, Wang, Xiao-Fang, Iuliano, Sandra, Bonaretti, Serena, Bui, Minh, Zebaze, Roger and Seeman, Ego. (2017). Quantifying sex, race, and age specific differences in bone microstructure requires measurement of anatomically equivalent regions. Bone. 101, pp. 206 - 213. https://doi.org/10.1016/j.bone.2017.05.010
Abaloparatide is an anabolic, but does it spare resorption?
Martin, T. John and Seeman, Ego. (2017). Abaloparatide is an anabolic, but does it spare resorption? Journal of Bone and Mineral Research. 32(1), pp. 11 - 16. https://doi.org/10.1001/jama.2016.11136
The effect of acute and short term glucocorticoid administration on exercise capacity and metabolism
Tacey, Alexander, Parker, Lewan, Garnham, Andrew, Brennan-Speranza, Tara C. and Levinger, Itamar. (2017). The effect of acute and short term glucocorticoid administration on exercise capacity and metabolism. Journal of Science and Medicine in Sport. 20(6), pp. 543 - 548. https://doi.org/10.1016/j.jsams.2016.10.016
Atraumatic tears of the ligamentum teres are more frequent in professional ballet dancers than a sporting population
Mayes, Susan, Ferris, April-Rose, Smith, Peter, Garnham, Andrew and Cook, Jill. (2016). Atraumatic tears of the ligamentum teres are more frequent in professional ballet dancers than a sporting population. Skeletal Radiology. 45(7), pp. 959 - 967. https://doi.org/10.1007/s00256-016-2379-6
Challenges in the use of cross-sectional data to quantify growth and deterioration of bone structure during advancing age
Ghasem-Zadeh, Ali and Seeman, Ego. (2016). Challenges in the use of cross-sectional data to quantify growth and deterioration of bone structure during advancing age. Journal of Clinical Densitometry. 20(1), pp. 5 - 7. https://doi.org/10.1016/j.jocd.2016.08.006
A single dose of prednisolone as a modulator of undercarboxylated osteocalcin and insulin sensitivity post-exercise in healthy young men: A study protocol
Levinger, Itamar, Brennan-Speranza, Tara C., Stepto, Nigel K., Jerums, George, Parker, Lewan, McConell, Glenn K., Anderson, Mitchell, Garnham, Andrew, Hare, David L., Ebeling, Peter R. and Seeman, Ego. (2016). A single dose of prednisolone as a modulator of undercarboxylated osteocalcin and insulin sensitivity post-exercise in healthy young men: A study protocol. JMIR Research Protocols. 5(2), pp. 1 - 7. https://doi.org/10.2196/resprot.5119
Professional ballet dancers have a similar prevalence of articular cartilage defects compared to age- and sex-matched non-dancing athletes
Mayes, Susan, Ferris, April-Rose, Smith, Peter, Garnham, Andrew and Cook, Jill. (2016). Professional ballet dancers have a similar prevalence of articular cartilage defects compared to age- and sex-matched non-dancing athletes. Clinical Rheumatology. 35(12), pp. 3037 - 3043. https://doi.org/10.1007/s10067-016-3389-4
A randomised controlled trial of low-dose aspirin for the prevention of fractures in healthy older people: Protocol for the ASPREE-Fracture substudy
Barker, Anna L., McNeil, John J., Seeman, Ego, Ward, Stephanie A., Sanders, Kerrie M., Khosla, Sundeep, Cumming, Robert G., Pasco, Julie A., Bohensky, Megan A., Ebeling, Peter E., Woods, Robyn L., Lockery, Jessica E., Wolfe, Rory, Talevski, Jason and ASPREE Investigator Group. (2016). A randomised controlled trial of low-dose aspirin for the prevention of fractures in healthy older people: Protocol for the ASPREE-Fracture substudy. Injury Prevention. 22(4), pp. 297-301. https://doi.org/10.1136/injuryprev-2015-041655
No effect of acute beetroot juice ingestion on oxygen consumption, glucose kinetics, or skeletal muscle metabolism during submaximal exercise in males
Betteridge, Scott, Bescós, Raúl, Martorell, Miquel, Pons, Antoni, Garnham, Andrew, Stathis, Christos C. and Mcconell, Glenn. (2016). No effect of acute beetroot juice ingestion on oxygen consumption, glucose kinetics, or skeletal muscle metabolism during submaximal exercise in males. Journal of Applied Physiology. 120(4), pp. 391 - 398. https://doi.org/10.1152/japplphysiol.00658.2015
Glucose-loading reduces bone remodeling in women and osteoblast function in vitro
Levinger, Itamar, Seeman, Ego, Jerums, George, McConell, Glenn K., Rybchyn, Mark S., Cassar, Samantha, Byrnes, Elizabeth, Selig, Steve, Mason, Rebecca S., Ebeling, Peter R. and Brennan-Speranza, Tara C.. (2016). Glucose-loading reduces bone remodeling in women and osteoblast function in vitro. Physiological Reports. 4(3), pp. 1 - 10. https://doi.org/10.14814/phy2.12700
Recurrence of bilateral atypical femoral fractures associated with the sequential use of teriparatide and denosumab: A case report
Ramchand, S. K., Chiang, C. Y., Zebaze, R. M. and Seeman, Ego. (2016). Recurrence of bilateral atypical femoral fractures associated with the sequential use of teriparatide and denosumab: A case report. Osteoporosis International. 27(2), pp. 821 - 825. https://doi.org/10.1007/s00198-015-3354-0
Muscle atrophy in patients with Type 2 Diabetes Mellitus: Roles of inflammatory pathways, physical activity and exercise
Perry, Ben D., Caldow, Marissa K., Brennan-Speranza, Tara C., Sbaraglia, Melissa, Jerums, George, Garnham, Andrew, Wong, Chiew, Levinger, Pazit, ul Haq, Muhammad Asrar, Hare, David L., Price, S. Russ and Levinger, Itamar. (2016). Muscle atrophy in patients with Type 2 Diabetes Mellitus: Roles of inflammatory pathways, physical activity and exercise. Exercise Immunology Review. 22, pp. 94 - 108.
The effects of muscle contraction and recombinant osteocalcin on insulin sensitivity ex vivo
Levinger, Itamar, Lin, X, Zhang, X., Brennan-Speranza, T C., Volpato, B, Hayes, A., Jeru, G, Seeman, Ego and Mcconell, Glenn K.. (2016). The effects of muscle contraction and recombinant osteocalcin on insulin sensitivity ex vivo. Osteoporosis International. 27(2), pp. 653 - 663. https://doi.org/10.1007/s00198-015-3273-0
Challenges in the acquisition and analysis of bone microstructure during growth
Seeman, Ego and Ghasem-Zadeh, Ali. (2016). Challenges in the acquisition and analysis of bone microstructure during growth. Journal of Bone and Mineral Research. 31(12), pp. 2239 - 2241. https://doi.org/10.1002/jbmr.3015
Similar prevalence of acetabular labral tear in professional ballet dancers and sporting participants
Mayes, Susan, Ferris, April-Rose, Smith, Peter W. F., Garnham, Andrew and Cook, Jill. (2016). Similar prevalence of acetabular labral tear in professional ballet dancers and sporting participants. Clinical Journal of Sport Medicine. 26(4), pp. 307 - 313. https://doi.org/10.1097/JSM.0000000000000257
Bone remodeling markers: So easy to measure, so difficult to interpret
Seeman, E. and Nguyen, T. V.. (2016). Bone remodeling markers: So easy to measure, so difficult to interpret. Osteoporosis International. 27, pp. 33 - 35. https://doi.org/10.1007/s00198-015-3374-9
Denosumab reduces cortical porosity of the proximal femoral shaft in postmenopausal women with osteoporosis
Zebaze, Roger M., Libanati, Cesar, McClung, Michael R., Zanchetta, Jose Ruben, Kendler, David L., Høiseth, Arne, Wang, Andrea, Ghasem-Zadeh, Ali and Seeman, Ego. (2016). Denosumab reduces cortical porosity of the proximal femoral shaft in postmenopausal women with osteoporosis. Journal of Bone and Mineral Research. 31(10), pp. 1827 - 1834. https://doi.org/10.1002/jbmr.2855
Erythropoietin does not enhance skeletal muscle protein synthesis following exercise in young and older adults
Lamon, Séverine, Zacharewicz, Evelyn, Arentson-Lantz, Emily, Della Gatta, Paul A., Ghobrial, Lobna, Gerlinger-Romero, Frederico, Garnham, Andrew, Paddon-Jones, Douglas and Russell, Aaron P.. (2016). Erythropoietin does not enhance skeletal muscle protein synthesis following exercise in young and older adults. Frontiers in Physiology. 7, pp. 1 - 9. https://doi.org/10.3389/fphys.2016.00292
Osteoporosis: Treat or let die twice more likely
Nguyen, Tuan V. and Seeman, Ego. (2015). Osteoporosis: Treat or let die twice more likely. Journal of Bone and Mineral Research. 30(9), pp. 1551 - 1552. https://doi.org/10.1002/jbmr.2601/pdf
Cortical bone: A challenging geography
Zebaze, Roger and Seeman, Ego. (2015). Cortical bone: A challenging geography. Journal of Bone and Mineral Research. 30(1), pp. 24 - 29. https://doi.org/10.1002/jbmr.2419
Regional heterogeneity in the configuration of the intracortical canals of the femoral shaft
Perilli, Egon, Bala, Yohann, Zebaze, Roger M., Reynolds, Karen J. and Seeman, Ego. (2015). Regional heterogeneity in the configuration of the intracortical canals of the femoral shaft. Calcified Tissue International. 97(4), pp. 327 - 335. https://doi.org/10.1007/s00223-015-0014-5
Changes in quality of life associated with fragility fractures : Australian arm of the International Cost and Utility Related to Osteoporotic Fractures Study (AusICUROS)
Abimanyi-Ochom, J., Watts, Jennifer, Borgstrom, F., Nicholson, Geoffrey, Shore-Lorenti, Catherine, Stuart, Amanda, Zhang, Y., Luliano, S., Seeman, Ego, Prince, Richard, March, Lyn, Winzenberg, T., Laslett, Laura, Duque, Gustavo, Ebeling, P. and Sanders, K. M.. (2015). Changes in quality of life associated with fragility fractures : Australian arm of the International Cost and Utility Related to Osteoporotic Fractures Study (AusICUROS). Osteoporosis International. 26(6), pp. 1781 - 1790. https://doi.org/10.1007/s00198-015-3088-z
The effects of knee injury on skeletal muscle function, Na+-ATPase content, and isoform abundance
Perry, Ben D., Levinger, P, Morris, Hayden G., Petersen, Aaron C., Garnham, Andrew, Levinger, Itamar and McKenna, Michael J.. (2015). The effects of knee injury on skeletal muscle function, Na+-ATPase content, and isoform abundance. Physiological Reports. 3(2), pp. 1 - 14. https://doi.org/10.14814/phy2.12294
Genetic and environmental variances of bone microarchitecture and bone remodeling markers: A twin study
Bjornerem, Ashild, Bui, Q Minh, Wang, Xiaofang, Ghasem-Zadeh, Ali, Hopper, John L., Zebaze, Roger M. and Seeman, Ego. (2015). Genetic and environmental variances of bone microarchitecture and bone remodeling markers: A twin study. Journal of Bone and Mineral Research. 30(3), pp. 516 - 524. https://doi.org/10.1002/jbmr.2365
Bones material constituents and their contribution to bone strength in health, disease, and treatment
Bala, Y. and Seeman, Ego. (2015). Bones material constituents and their contribution to bone strength in health, disease, and treatment. Calcified Tissue International. 97(3), pp. 308 - 326. https://doi.org/10.1007/s00223-015-9971-y
A. Michael Parfitt: Enlightened scholar and revered mentor: May 10, 1930-May 18, 2015
Manolagas, Stavros C., Compston, Juliet, Rao, Sudhaker and Seeman, Ego. (2015). A. Michael Parfitt: Enlightened scholar and revered mentor: May 10, 1930-May 18, 2015. Journal of Bone and Mineral Research. 30(8), pp. 1349 - 1355. https://doi.org/10.1002/jbmr.2576
Co-administration of antiresorptive and anabolic agents: A missed opportunity
Seeman, Ego and Martin, T. John. (2015). Co-administration of antiresorptive and anabolic agents: A missed opportunity. Journal of Bone and Mineral Research. 30(5), pp. 753 - 764. https://doi.org/10.1002/jbmr.2496
The ABC of writing a grant proposal
Seeman, Ego. (2015). The ABC of writing a grant proposal. Osteoporosis International. 26(6), pp. 1665 - 1666. https://doi.org/10.1007/s00198-015-3085-2
Growth and age-related abnormalities in cortical structure and fracture risk
Seeman, Ego. (2015). Growth and age-related abnormalities in cortical structure and fracture risk. Endocrinology and Metabolism. 30(4), pp. 419 - 428. https://doi.org/10.3803/EnM.2015.30.4.419
Identification of MicroRNAs linked to regulators of muscle protein synthesis and regeneration in young and old skeletal muscle
Zacharewicz, Evelyn, Della Gatta, P. A., Reynolds, John, Garnham, Andrew, Crowley, Tamsyn, Russell, Andrew and Lamon, Séverine. (2014). Identification of MicroRNAs linked to regulators of muscle protein synthesis and regeneration in young and old skeletal muscle. PLoS ONE. 9(12), pp. 1 - 25. https://doi.org/10.1371/journal.pone.0114009
Ageing has no effect on the regulation of the ubiquitin proteasome-related genes and proteins following resistance exercise
Stefanetti, Renae J., Zacharewicz, Evelyn, Della Gatta, Paul A., Garnham, Andrew, Russell, Aaron P. and Lamon, Séverine. (2014). Ageing has no effect on the regulation of the ubiquitin proteasome-related genes and proteins following resistance exercise. Frontiers in Physiology. 5, pp. 1 - 10. https://doi.org/10.3389/fphys.2014.00030
High-resolution in vivo imaging of bone and joints: a window to microarchitecture
Geusens, P., Geusens, P., Chapurlat, Roland D., Chapurlat, Roland D., Schett, G., Ghasem-Zadeh, Ali, Ghasem-Zadeh, Ali, Seeman, Ego, De Jong, J. and Van Den Bergh, J.. (2014). High-resolution in vivo imaging of bone and joints: a window to microarchitecture. Nature Reviews Rheumatology. 10(5), pp. 304 - 313. https://doi.org/10.1038/nrrheum.2014.23
Effect of exercise training on skeletal muscle cytokine expression in the elderly
Della Gatta, Paul A., Garnham, Andrew P., Peake, Jonathan M. and Cameron-Smith, David. (2014). Effect of exercise training on skeletal muscle cytokine expression in the elderly. Brain, Behavior, and Immunity. 39, pp. 80 - 86. https://doi.org/10.1016/j.bbi.2014.01.006
A new method of segmentation of compact-appearing, transitional and trabecular compartments and quantification of cortical porosity from high resolution peripheral quantitative computed tomographic images
Zebaze, Roger M., Ghasem-Zadeh, Ali, Mbala, A. and Seeman, Ego. (2013). A new method of segmentation of compact-appearing, transitional and trabecular compartments and quantification of cortical porosity from high resolution peripheral quantitative computed tomographic images. Bone. 54(1), pp. 8 - 20. https://doi.org/10.1016/j.bone.2013.01.007
Teriparatide improves bone quality and healing of atypical femoral fractures associated with bisphosphonate therapy
Chiang, Cherie Ying, Zebaze, Roger M.D., Ghasem-Zadeh, Ali, Iuliano-Burns, Sandra, Hardidge, Andrew and Seeman, Ego. (2013). Teriparatide improves bone quality and healing of atypical femoral fractures associated with bisphosphonate therapy. Bone. 52(1), pp. 360 - 365. https://doi.org/10.1016/j.bone.2012.10.006
Effect of exercise on the skeletal muscle proteome in patients with type 2 diabetes
Hussey, Sophie E., Sharoff, Carrie G., Garnham, Andrew, Yi, Zhengping, Bowen, Benjamin P., Mandarino, Lawrence J. and Hargreaves, Mark. (2013). Effect of exercise on the skeletal muscle proteome in patients with type 2 diabetes. Medicine and Science in Sports and Exercise. 45(6), pp. 1069 - 1076. https://doi.org/10.1249/MSS.0b013e3182814917
Preexercise aminoacidemia and muscle protein synthesis after resistance exercise
Burke, Louise, Hawley, John, Ross, M, Moore, Daniel, Phillips, S, Slater, G, Stellingwerff, T, Tipton, K, Garnham, A and Coffey, Vernon. (2012). Preexercise aminoacidemia and muscle protein synthesis after resistance exercise. Medicine and Science in Sports and Exercise. 44(10), pp. 1968 - 1977. https://doi.org/10.1249/MSS.0b013e31825d28fa
Early inflammatory and myogenic responses to resistance exercise in the elderly
Mathers, Jessica L., Farnfield, Michelle M., Garnham, Andrew P., Caldow, Marissa K., Cameron-Smith, David and Peake, Jonathan M.. (2012). Early inflammatory and myogenic responses to resistance exercise in the elderly. Muscle & Nerve. 46(3), pp. 407 - 412. https://doi.org/10.1002/mus.23317
Evaluation of the MAIIA dipstick test to detect recombinant human erythropoietin in plasma
Ashenden, Michael, Sharpe, Ken, Garnham, Andrew and Gore, Christopher J.. (2012). Evaluation of the MAIIA dipstick test to detect recombinant human erythropoietin in plasma. Journal of Pharmaceutical and Biomedical Analysis. 67-68, pp. 123 - 128. https://doi.org/10.1016/j.jpba.2012.04.025
Activation of mTOR signalling in young and old human skeletal muscle in response to combined resistance exercise and whey protein ingestion
Farnfield, Michelle M., Breen, Leigh, Carey, Kate A., Garnham, Andrew and Cameron-Smith, David. (2012). Activation of mTOR signalling in young and old human skeletal muscle in response to combined resistance exercise and whey protein ingestion. Applied Physiology, Nutrition and Metabolism. 37(1), pp. 21 - 30. https://doi.org/10.1139/H11-132
Predictors of new and severe vertebral fractures: Results from the HoRIZoN Pivotal Fracture Trial
Wustrack, R., Seeman, Ego, Bucci-Rechtweg, C. and Burch, S.. (2012). Predictors of new and severe vertebral fractures: Results from the HoRIZoN Pivotal Fracture Trial. Osteoporosis International. 23(1), pp. 53 - 58. https://doi.org/10.1007/s00198-011-1664-4
Low muscle glycogen concentration does not suppress the anabolic response to resistance exercise
Camera, Donny, West, D, Burd, N, Phillips, S, Garnham, A, Hawley, John and Coffey, Vernon. (2012). Low muscle glycogen concentration does not suppress the anabolic response to resistance exercise. Journal of Applied Physiology. 113(2), pp. 206 - 214. https://doi.org/10.1152/japplphysiol.00395.2012
Nutrient provision increases signalling and protein synthesis in human skeletal muscle after repeated sprints
Coffey, Vernon, Moore, Daniel, Burd, N, Rerecich, T, Stellingwerff, T, Garnham, A, Phillips, S and Hawley, John. (2011). Nutrient provision increases signalling and protein synthesis in human skeletal muscle after repeated sprints. European Journal of Applied Physiology. 111(7), pp. 1473 - 1483. https://doi.org/10.1007/s00421-010-1768-0
The effect of acute exercise on undercarboxylated osteocalcin in obese men
Levinger, Itamar, Zebaze, Roger M., Jeru, G., Hare, David L., Selig, Steve and Seeman, Ego. (2011). The effect of acute exercise on undercarboxylated osteocalcin in obese men. Osteoporosis International. 22(5), pp. 1621 - 1626. https://doi.org/10.1007/s00198-010-1370-7
Impact of resistance exercise training on interleukin-6 and JAK/STAT in young men
Trenerry, Marissa K., Della Gatta, Paul A., Larsen, Amy E., Garnham, Andrew P. and Cameron-Smith, David. (2011). Impact of resistance exercise training on interleukin-6 and JAK/STAT in young men. Muscle & Nerve. 43(3), pp. 385 - 392. https://doi.org/10.1002/mus.21875
Impact of resistance exercise training on interleukin-6 and JAK/STAT in young men
Trenerry, Melissa K., Della Gatta, Paul A., Larson, Amy E. and Garnham, Andrew P.. (2011). Impact of resistance exercise training on interleukin-6 and JAK/STAT in young men. Muscle & Nerve. 43(3), pp. 385 - 392. https://doi.org/10.1002/mus.21875
Vitamin D status and musculoskeletal health in adolescent male ballet dancers a pilot study
Ducher, Gaele, Kukuljan, Sonja, Hill, B., Garnham, Andrew P., Nowson, Carol A., Kimlin, M. G. and Cook, Jill. (2011). Vitamin D status and musculoskeletal health in adolescent male ballet dancers a pilot study. Journal of Dance Medicine and Science. 15(3), pp. 99 - 107.
Teriparatide therapy for osteonecrosis of the jaw REPLY
Cheung, Ada S. and Seeman, Ego. (2011). Teriparatide therapy for osteonecrosis of the jaw REPLY. New England Journal of Medicine. 364, pp. 1081 - 1082. https://doi.org/10.1056/NEJMc1100730
Current markers of the Athlete Blood Passport do not flag microdose EPO doping
Ashenden, Michael, Gough, Clare E., Garnham, Andrew, Gore, Christopher J. and Sharpe, Ken. (2011). Current markers of the Athlete Blood Passport do not flag microdose EPO doping. European Journal of Applied Physiology. 111(9), pp. 2307 - 2314. https://doi.org/10.1007/s00421-011-1867-6
Exercise training increases adipose tissue GLUT4 expression in patients with type 2 diabetes
Hussey, Sophie E., McGee, S. L., Garnham, Andrew, Wentworth, John M., Jeukendrup, A. E. and Hargreaves, M.. (2011). Exercise training increases adipose tissue GLUT4 expression in patients with type 2 diabetes. Diabetes, Obesity and Metabolism. 13(10), pp. 959 - 962. https://doi.org/10.1111/j.1463-1326.2011.01426.x
Acute signalling responses to intense endurance training commenced with low or normal muscle glycogen : Experimental Physiology-Research Paper
Yeo, W, McGee, S, Carey, A, Paton, C, Garnham, A, Hargreaves, M and Hawley, John. (2010). Acute signalling responses to intense endurance training commenced with low or normal muscle glycogen : Experimental Physiology-Research Paper. Experimental Physiology. 95(2), pp. 351 - 358. https://doi.org/10.1113/expphysiol.2009.049353
Cytokine responses to carbohydrate ingestion during recovery from exercise-induced muscle injury
Ross, M, Halson, Shona, Suzuki, K, Garnham, A, Hawley, John, Cameron-Smith, David and Peake, J. (2010). Cytokine responses to carbohydrate ingestion during recovery from exercise-induced muscle injury. Journal of Interferon and Cytokine Research. 30(5), pp. 329 - 337. https://doi.org/10.1089/jir.2009.0079
Effect of consecutive repeated sprint and resistance exercise bouts on acute adaptive responses in human skeletal muscle
Coffey, Vernon Glenn, Jemiolo, Bozena, Edge, Johann, Garnham, Andrew P., Trappe, Scott W. and Hawley, John Alan. (2009). Effect of consecutive repeated sprint and resistance exercise bouts on acute adaptive responses in human skeletal muscle. American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 297(5), pp. 1441 - 1451. https://doi.org/10.1152/ajpregu.00351.2009
Festschrift to honor Professor Pierre D. Delmas
Seeman, E., Lindsay, R. and Kanis, J. A.. (2009). Festschrift to honor Professor Pierre D. Delmas. Osteoporosis International. 20(Supplement 3), pp. S231 - S233. https://doi.org/10.1007/s00198-008-0811-z
Consecutive bouts of diverse contractile activity alter acute responses in human skeletal muscle
Coffey, Vernon Glenn, Pilegaard, Henriette, Garnham, Andrew P., O'Brien, Brendan J. and Hawley, John Alan. (2009). Consecutive bouts of diverse contractile activity alter acute responses in human skeletal muscle. Journal of Applied Physiology. 106(4), pp. 1187 - 1197. https://doi.org/10.1152/japplphysiol.91221.2008
Skeletal muscle adaptation and performance responses to once a day versus twice every second day endurance training regimens
Yeo, Wee Kian, Paton, Carl D., Garnham, Andrew P., Burke, Louise M., Carey, Andrew L. and Hawley, John Alan. (2008). Skeletal muscle adaptation and performance responses to once a day versus twice every second day endurance training regimens. Journal of Applied Physiology. 105(5), pp. 1462 - 1470. https://doi.org/10.1152/japplphysiol.90882.2008
Fat adaptation followed by carbohydrate restoration increases AMPK activity in skeletal muscle from trained humans
Yeo, Wee Kian, Lessard, Sarah J., Chen, Zhi-Ping, Garnham, Andrew P., Burke, Louise, Rivas, Donato A., Kemp, Bruce Ernest and Hawley, John Alan. (2008). Fat adaptation followed by carbohydrate restoration increases AMPK activity in skeletal muscle from trained humans. Journal of Applied Physiology. 105(5), pp. 1519 - 1526. https://doi.org/10.1152/japplphysiol.90540.2008
Bone fragility in men - Where are we?
Seeman, Ego, Bianchi, Georges, Khosla, Sundeep, Kanis, John and Orwoll, E. (2006). Bone fragility in men - Where are we? Osteoporosis International. 17(11), pp. 1577 - 1583. https://doi.org/10.1007/s00198-006-0160-8