Bone microarchitecture in ankylosing spondylitis and the association with bone mineral density, fractures, and syndesmophytes
Klingberg, Eva, Lorentzon, Mattias, Göthlin, Jan, Mellström, Dan, Geijer, Mats, Ohlsson, Claes, Atkinson, Elizabeth J., Khosla, Sundeep, Carlsten, Hans and Forsblad-d’Elia, Helena. (2013). Bone microarchitecture in ankylosing spondylitis and the association with bone mineral density, fractures, and syndesmophytes. Arthritis Research and Therapy. 15, pp. 1-11. https://doi.org/10.1186/ar4368
|Authors||Klingberg, Eva, Lorentzon, Mattias, Göthlin, Jan, Mellström, Dan, Geijer, Mats, Ohlsson, Claes, Atkinson, Elizabeth J., Khosla, Sundeep, Carlsten, Hans and Forsblad-d’Elia, Helena|
When compared with age-matched AS controls, patients with vertebral fractures had lower lumbar cortical vBMD (-22%; P = 0.019), lower cortical cross-sectional area in radius (-28.3%; P = 0.001) and tibia (-24.0%; P = 0.013), and thinner cortical bone in radius (-28.3%; P = 0.001) and tibia (-26.9%; P = 0.016).
mSASSS correlated negatively with trabecular vBMD in lumbar spine (rS = -0.620; P < 0.001), radius (rS = -0.400; p = 0.001) and tibia (rS = -0.475; p < 0.001) and also with trabecular thickness in radius (rS = -0.528; P < 0.001) and tibia (rS = -0.488; P < 0.001).
Adjusted for age, syndesmophytes were significantly associated with decreasing trabecular vBMD, but increasing cortical vBMD in lumbar spine, but not with increasing cortical thickness or density in peripheral bone. Estimated lumbar vBMD by DXA correlated with trabecular vBMD measured by QCT (rS = 0.636; P < 0.001).
|Journal||Arthritis Research and Therapy|
|Journal citation||15, pp. 1-11|
|Digital Object Identifier (DOI)||https://doi.org/10.1186/ar4368|
|Open access||Published as ‘gold’ (paid) open access|
File Access Level
|Online||05 Nov 2013|
|Publication process dates|
|Accepted||15 Oct 2013|
|Deposited||08 Apr 2021|
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