Bone microarchitecture in ankylosing spondylitis and the association with bone mineral density, fractures, and syndesmophytes
Journal article
Klingberg, Eva, Lorentzon, Mattias, Göthlin, Jan, Mellström, Dan, Geijer, Mats, Ohlsson, Claes, Atkinson, Elizabeth J., Khosla, Sundeep, Carlsten, Hans and Forsblad-d’Elia, Helena. (2013). Bone microarchitecture in ankylosing spondylitis and the association with bone mineral density, fractures, and syndesmophytes. Arthritis Research and Therapy. 15, pp. 1-11. https://doi.org/10.1186/ar4368
Authors | Klingberg, Eva, Lorentzon, Mattias, Göthlin, Jan, Mellström, Dan, Geijer, Mats, Ohlsson, Claes, Atkinson, Elizabeth J., Khosla, Sundeep, Carlsten, Hans and Forsblad-d’Elia, Helena |
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Abstract | Introduction Methods Results When compared with age-matched AS controls, patients with vertebral fractures had lower lumbar cortical vBMD (-22%; P = 0.019), lower cortical cross-sectional area in radius (-28.3%; P = 0.001) and tibia (-24.0%; P = 0.013), and thinner cortical bone in radius (-28.3%; P = 0.001) and tibia (-26.9%; P = 0.016). mSASSS correlated negatively with trabecular vBMD in lumbar spine (rS = -0.620; P < 0.001), radius (rS = -0.400; p = 0.001) and tibia (rS = -0.475; p < 0.001) and also with trabecular thickness in radius (rS = -0.528; P < 0.001) and tibia (rS = -0.488; P < 0.001). Adjusted for age, syndesmophytes were significantly associated with decreasing trabecular vBMD, but increasing cortical vBMD in lumbar spine, but not with increasing cortical thickness or density in peripheral bone. Estimated lumbar vBMD by DXA correlated with trabecular vBMD measured by QCT (rS = 0.636; P < 0.001). Conclusions |
Year | 2013 |
Journal | Arthritis Research and Therapy |
Journal citation | 15, pp. 1-11 |
Publisher | BioMed Central |
ISSN | 1478-6354 |
Digital Object Identifier (DOI) | https://doi.org/10.1186/ar4368 |
Scopus EID | 2-s2.0-84887076729 |
Open access | Published as ‘gold’ (paid) open access |
Page range | 1-11 |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 05 Nov 2013 |
Publication process dates | |
Accepted | 15 Oct 2013 |
Deposited | 08 Apr 2021 |
https://acuresearchbank.acu.edu.au/item/8v998/bone-microarchitecture-in-ankylosing-spondylitis-and-the-association-with-bone-mineral-density-fractures-and-syndesmophytes
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OA_Klingberg_2013_Bone_microarchitecture_in_ankylosing_spondylitis_and.pdf | |
License: CC BY 2.0 | |
File access level: Open |
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