WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk

Journal article


Zheng, Hou-Feng, Tobias, Jon H., Duncan, Emma, Evans, David M., Eriksson, Joel, Paternoster, Lavinia, Yerges-Armstrong, Laura M., Lehtimäki, Terho, Bergström, Ulrica, Kähönen, Mika, Leo, Paul J., Raitakari, Olli, Laaksonen, Marika, Nicholson, Geoffrey C., Viikari, Jorma, Ladouceur, Martin, Lehtimäki, Leo-Pekka, Medina-Gomez, Carolina, Rivadeneira, Fernando, ... Lorentzon, Mattias. (2012) WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk. PLoS Genetics. 8(7), pp. 1 - 13. https://doi.org/10.1371/journal.pgen.1002745
AuthorsZheng, Hou-Feng, Tobias, Jon H., Duncan, Emma, Evans, David M., Eriksson, Joel, Paternoster, Lavinia, Yerges-Armstrong, Laura M., Lehtimäki, Terho, Bergström, Ulrica, Kähönen, Mika, Leo, Paul J., Raitakari, Olli, Laaksonen, Marika, Nicholson, Geoffrey C., Viikari, Jorma, Ladouceur, Martin, Lehtimäki, Leo-Pekka, Medina-Gomez, Carolina, Rivadeneira, Fernando, Prince, Richard L., Sievanen, Harri, Leslie, William D., Mellström, Dan, Eisman, John A., Movérare-Skrtic, Sofia, Goltzman, David, Hanley, David A., Jones, Graeme, St. Pourcain, Beate, Xiao, Yongjun, Timpson, Nicholas J., Smith, George Davey, Reid, Ian R., Ring, Susan M., Sambrook, Philip N., Karlsson, Magnus, Dennison, Elaine M., Kemp, John P., Danoy, Patrick, Sayers, Adrian, Wilson, Scott G., Nethander, Maria, McCloskey, Eugene, Vandenput, Liesbeth, Eastell, Richard, Liu, Jeff, Spector, Tim, Mitchell, Braxton D., Streeten, Elizabeth A., Brommage, Robert, Pettersson-Kymmer, Ulrika, Brown, Matthew A., Ohlsson, Claes, Richards, J. Brent and Lorentzon, Mattias
Abstract

We aimed to identify genetic variants associated with cortical bone thickness (CBT) and bone mineral density (BMD) by performing two separate genome-wide association study (GWAS) meta-analyses for CBT in 3 cohorts comprising 5,878 European subjects and for BMD in 5 cohorts comprising 5,672 individuals. We then assessed selected single-nucleotide polymorphisms (SNPs) for osteoporotic fracture in 2,023 cases and 3,740 controls. Association with CBT and forearm BMD was tested for ∼2.5 million SNPs in each cohort separately, and results were meta-analyzed using fixed effect meta-analysis. We identified a missense SNP (Thr>Ile; rs2707466) located in the WNT16 gene (7q31), associated with CBT (effect size of −0.11 standard deviations [SD] per C allele, P = 6.2×10−9). This SNP, as well as another nonsynonymous SNP rs2908004 (Gly>Arg), also had genome-wide significant association with forearm BMD (−0.14 SD per C allele, P = 2.3×10−12, and −0.16 SD per G allele, P = 1.2×10−15, respectively). Four genome-wide significant SNPs arising from BMD meta-analysis were tested for association with forearm fracture. SNP rs7776725 in FAM3C, a gene adjacent to WNT16, was associated with a genome-wide significant increased risk of forearm fracture (OR = 1.33, P = 7.3×10−9), with genome-wide suggestive signals from the two missense variants in WNT16 (rs2908004: OR = 1.22, P = 4.9×10−6 and rs2707466: OR = 1.22, P = 7.2×10−6). We next generated a homozygous mouse with targeted disruption of Wnt16. Female Wnt16−/− mice had 27% (P<0.001) thinner cortical bones at the femur midshaft, and bone strength measures were reduced between 43%–61% (6.5×10−13

Year2012
JournalPLoS Genetics
Journal citation8 (7), pp. 1 - 13
PublisherPublic Library of Science
ISSN1553-7390
Digital Object Identifier (DOI)https://doi.org/10.1371/journal.pgen.1002745
Scopus EID2-s2.0-84863888921
Open accessOpen access
Page range1 - 13
Research GroupMary MacKillop Institute for Health Research
Publisher's version
License
Place of publicationUnited States of America
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Sundh, Daniel, Nilsson, A. G., Nilsson, Martin, Johansson, L., Mellström, Dan and Lorentzon, Mattias. (2017) Increased cortical porosity in women with hip fracture. Journal of Internal Medicine. 281(5), pp. 496 - 506. https://doi.org/10.1111/joim.12587
Low serum iron is associated with high serum intact FGF23 in elderly men: The Swedish MrOS study
Lewerin, Catharina, Ljunggren, Östen, Nilsson-Ehle, Herman, Karlsson, Magnus K., Herlitz, Hans, Lorentzon, Mattias, Ohlsson, Claes and Mellström, Dan. (2017) Low serum iron is associated with high serum intact FGF23 in elderly men: The Swedish MrOS study. Bone. 98, pp. 1 - 8. https://doi.org/10.1016/j.bone.2017.02.005
Low-frequency synonymous coding variation in CYP2R1 has large effects on vitamin d levels and risk of multiple sclerosis
Manousaki, Despoina, Dudding, Tom, Haworth, Simon, Hsu, Yi-Hsiang, Liu, Chiang-Ti, Medina-Gómez, Carolina, Voortman, Trudy, van der Velde, Nathalie, Melhus, Håkan, Robinson-Cohen, Cassianne, Cousminer, Diana L., Nethander, Maria, Vandenput, Liesbeth, Noordam, Raymond, Forgetta, Vincenzo, Greenwood, Celia M. T., Biggs, Mary L., Psaty, Bruce M., Rotter, Jerome I., ... Richards, J. Brent. (2017) Low-frequency synonymous coding variation in CYP2R1 has large effects on vitamin d levels and risk of multiple sclerosis. American Journal of Human Genetics. 101(2), pp. 227 - 238. https://doi.org/10.1016/j.ajhg.2017.06.014
Type 2 diabetes mellitus is associated with better bone microarchitecture but lower bone material strength and poorer physical function in elderly women: A population-based study
Nilsson, Anna G., Sundh, Daniel, Johansson, Lisa, Nilsson, Martin, Mellström, Dan, Rudäng, Robert, Zoulakis, Michail, Wallander, Märit, Darelid, Anna and Lorentzon, Mattias. (2017) Type 2 diabetes mellitus is associated with better bone microarchitecture but lower bone material strength and poorer physical function in elderly women: A population-based study. Journal of Bone and Mineral Research. 32(5), pp. 1062 - 1071. https://doi.org/10.1002/jbmr.3057
Bone mass development from childhood into young adulthood in patients with childhood-onset inflammatory bowel disease
Sigurdsson, Gudmundur Vignir, Schmidt, Susanne, Mellström, Dan, Ohlsson, Claes, Kindblom, Jenny M., Lorentzon, Mattias and Saalman, Robert. (2017) Bone mass development from childhood into young adulthood in patients with childhood-onset inflammatory bowel disease. Inflammatory Bowel Diseases. 23(12), pp. 2215 - 2226. https://doi.org/10.1097/MIB.0000000000001277
Genetic variants associated with circulating parathyroid hormone
Robinson-Cohen, Cassianne, Lutsey, Pamela L., Kleber, Marcus E., Nielson, Carrie M., Mitchell, Braxton D., Bis, Joshua C., Eny, Karen M., Portas, Laura, Eriksson, Joel, Lorentzon, Mattias, Koller, Daniel L., Milaneschi, Yuri, Teumer, Alexander, Pilz, Stefan, Nethander, Maria, Selvin, Elizabeth, Tang, Weihong, Weng, Lu-Chen, Wong, Hoi Suen, ... Kestenbaum, Bryan. (2017) Genetic variants associated with circulating parathyroid hormone. Journal of the American Society of Nephrology. 28(5), pp. 1553 - 1565. https://doi.org/10.1681/ASN.2016010069
Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis
Eriksson, Joel, Haring, Robin, Grarup, Niels, Vandenput, Liesbeth, Wallaschofski, Henri, Lorentzen, Erik, Hansen, Torben, Mellström, Dan, Pedersen, Oluf, Nauck, Matthias, Lorentzon, Mattias, Husemoen, Lise Lotte Nystrup, Völzke, Henry, Karlsson, Magnus, Baumeister, Sebastian E., Linneberg, Allan and Ohlsson, Claes. (2017) Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis. PLoS ONE. 12(4), pp. 1 - 15. https://doi.org/10.1371/journal.pone.0176277
Romosozumab or alendronate for fracture prevention in women with osteoporosis
Saag, Kenneth G., Petersen, Jeffrey, Brandi, Maria Luisa, Karaplis, Andrew C., Lorentzon, Mattias, Thomas, Thierry A., Maddox, Judy, Fan, Michelle, Meisner, Paul D. and Grauer, Andreas. (2017) Romosozumab or alendronate for fracture prevention in women with osteoporosis. New England Journal of Medicine. 377(15), pp. 1417 - 1427. https://doi.org/10.1056/NEJMoa1708322
Low serum DHEAS predicts increased fracture risk in older men: The MrOS Sweden study
Ohlsson, Claes, Nethander, Maria, Kindmark, Andreas, Ljunggren, Östen, Lorentzon, Mattias, Rosengren, Björn E., Karlsson, Magnus K., Mellström, Dan and Vandenput, Liesbeth. (2017) Low serum DHEAS predicts increased fracture risk in older men: The MrOS Sweden study. Journal of Bone and Mineral Research. 32(8), pp. 1607 - 1614. https://doi.org/10.1002/jbmr.3123
Current physical activity is independently associated with cortical bone size and bone strength in elderly Swedish women
Nilsson, Martin, Sundh, Daniel, Mellström, Dan and Lorentzon, Mattias. (2017) Current physical activity is independently associated with cortical bone size and bone strength in elderly Swedish women. Journal of Bone and Mineral Research. 32(3), pp. 473 - 485. https://doi.org/10.1002/jbmr.3006
Which measuring site in ankylosing spondylitis is best to detect bone loss and what predicts the decline: results from a 5-year prospective study
Deminger, Anna, Klingberg, Eva, Lorentzon, Mattias, Geijer, Mats, Göthlin, Jan, Hedberg, Martin, Rehnberg, Eva, Carlsten, Hans, Jacobsson, Lennart T. and Forsblad-d'Elia, Helena. (2017) Which measuring site in ankylosing spondylitis is best to detect bone loss and what predicts the decline: results from a 5-year prospective study. Arthritis Research and Therapy. 19(1), pp. 1 - 12. https://doi.org/10.1186/s13075-017-1480-0
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
Justice, Anne E., Winkler, Thomas W., Feitosa, Mary F., Graff, Misa, Fisher, Virginia A., Young, Kristin L., Barata, Llilda, Deng, Xuan, Czajkowski, Jacek, Hadley, David, Ngwa, Julius S., Ahluwalia, Tarunveer S., Chu, Audrey Y., Heard-Costa, Nancy L., Lim, Elise, Perez, Jeremiah, Eicher, John D., Kutalik, Zoltán, Xue, Luting, ... Lorentzon, Mattias. (2017) Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nature Communications. 8(1), pp. 1 - 19. https://doi.org/10.1038/ncomms14977
Characteristics of prevalent vertebral fractures predict new fractures in elderly men
Karlsson, Magnus K., Kherad, Mehrsa, Hasserius, Ralph, Nilsson, Jan-Åke, Redlund-Johnell, Inga, Ohlsson, Claes, Lorentzon, Mattias, Mellström, Dan and Rosengren, Björn E.. (2016) Characteristics of prevalent vertebral fractures predict new fractures in elderly men. Journal of Bone and Joint Surgery: American Volume. 98(5), pp. 379 - 385. https://doi.org/10.2106/JBJS.15.00328
A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
Ried, Janina S., Jeff, Janina, Chu, Audrey Y., Bragg-Gresham, Jennifer L., van Dongen, Jenny, Huffman, Jennifer E., Ahluwalia, Tarunveer S., Cadby, Gemma, Eklund, Niina, Eriksson, Joel, Esko, Tõnu, Feitosa, Mary F., Goel, Anuj, Gorski, Mathias, Hayward, Caroline, Heard-Costa, Nancy L., Jackson, Anne U., Jokinen, Eero, Kanoni, Stavroula, ... Loos, Ruth J. F.. (2016) A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape. Nature Communications. 7(1), pp. 1 - 11. https://doi.org/10.1038/ncomms13357
Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits
Teumer, Alexander, Qi, bin Qi, Nethander, Maria, Aschard, Hugues, Bandinelli, Stefania, Beekman, Marian, Berndt, Sonja I., Bidlingmaier, Martin, Broer, Linda, Cappola, Anne, Ceda, Gian Paolo, Chanock, Stephen J., Chen, Ming-Huei, Chen, Tai C., Chen, Yii-Der, Chung, Jonathan, Del Greco Miglianico, Fabiola, Eriksson, Joel, Ferrucci, Luigi, ... Lorentzon, Mattias. (2016) Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits. Aging Cell. 15(5), pp. 811 - 824. https://doi.org/10.1111/acel.12490
Determinants of microstructural, dimensional and bone mineral changes postpartum in Swedish women
Brembeck, Peter, Winkvist, Anna, Ohlsson, Claes, Lorentzon, Mattias and Augustin, Hanna. (2016) Determinants of microstructural, dimensional and bone mineral changes postpartum in Swedish women. The British Journal of Nutrition. 116(10), pp. 1736 - 1744. https://doi.org/10.1017/S0007114516003998
Fall risk assessment predicts fall-related injury, hip fracture, and head injury in older adults
Nilsson, , Eriksson, Joel, Larsson, Berit A. M., Odén, Anders, Johansson, Helena and Lorentzon, Mattias. (2016) Fall risk assessment predicts fall-related injury, hip fracture, and head injury in older adults. Journal of the American Geriatrics Society. 64(11), pp. 2242 - 2250. https://doi.org/10.1111/jgs.14439
Bone material strength is associated with areal BMD but not with prevalent fractures in older women
Rudäng, R., Zoulakis, M., Sundh, D., Brisby, H., Diez-Perez, Aldolfo, Johansson, L., Mellström, Dan, Darelid, A. and Lorentzon, Mattias. (2016) Bone material strength is associated with areal BMD but not with prevalent fractures in older women. Osteoporosis International. 27(4), pp. 1585 - 1592. https://doi.org/10.1007/s00198-015-3419-0
High serum SHBG predicts incident vertebral fractures in elderly men
Vandenput, Liesbeth, Mellström, Dan, Kindmark, Andreas, Johansson, Helena, Lorentzon, Mattias, Leung, Jason, Redlund-Johnell, Inga, Rosengren, Björn E., Karlsson, Magnus K., Wang, Yi-Xiang, Kwok, Timothy and Ohlsson, Claes. (2016) High serum SHBG predicts incident vertebral fractures in elderly men. Journal of Bone and Mineral Research. 31(3), pp. 683 - 689. https://doi.org/10.1002/jbmr.2718
Effectiveness of a minimal resource fracture liaison service
Axelsson, K. F., Jacobsson, R., Lund, D. and Lorentzon, Mattias. (2016) Effectiveness of a minimal resource fracture liaison service. Osteoporosis International. 27(11), pp. 3165 - 3175. https://doi.org/10.1007/s00198-016-3643-2
High plasma osteocalcin is associated with low blood haemoglobin in elderly men: The MrOS Sweden Study
Lewerin, C., Johansson, Helena, Karlsson, Magnus K., Lorentzon, Mattias, Lerner, Ulf H., Kindblom, J. M., Ohlsson, Claes, Smith, Ulf and Mellström, Dan. (2016) High plasma osteocalcin is associated with low blood haemoglobin in elderly men: The MrOS Sweden Study. Journal of Internal Medicine. 280(4), pp. 398 - 406. https://doi.org/10.1111/joim.12505
Non-hip and non-vertebral fractures: the neglected fracture sites
Holloway, Kara, Henry, Margaret, Brennan-Olsen, Sharon, Bucki-Smith, Gosia, Nicholson, Geoffrey Charles, Korn, S., Sanders, Kerrie, Pasco, Julie and Kotowicz, Mark. (2016) Non-hip and non-vertebral fractures: the neglected fracture sites. Osteoporosis International. 27(3), pp. 905 - 913. https://doi.org/10.1007/s00198-015-3322-8
Low serum vitamin D is associated with higher cortical porosity in elderly men
Sundh, D., Mellström, Dan, Ljunggren, Östen, Karlsson, Magnus K., Ohlsson, Claes, Nilsson, M., Nilsson, A. G. and Lorentzon, Mattias. (2016) Low serum vitamin D is associated with higher cortical porosity in elderly men. Journal of Internal Medicine. 280(5), pp. 496 - 508. https://doi.org/10.1111/joim.12514
The association between anxiety and falls: A meta-analysis
Hallford, David John, Nicholson, Geoffrey Charles, Sanders, Kerrie and McCabe, Marita Patricia. (2016) The association between anxiety and falls: A meta-analysis. Journal of Gerontology: Psychological Sciences. 00(00), pp. 1 - 13. https://doi.org/10.1093/geronb/gbv160
Novel genetic variants associated with increased vertebral volumetric BMD, reduced vertebral fracture risk, and increased expression of SLC1A3 and EPHB2
Nielson, Carrie M., Liu, Ching-Ti, Smith, Albert V., Ackert-Bicknell, Cheryl L., Reppe, Sjur, Jakobsdottir, Johanna, Wassel, Christina, Register, Thomas C., Oei, Ling, Alonso, Nerea, Oei, Edwin H., Parimi, Neeta, Samelson, Elizabeth J., Nalls, Mike A., Zmuda, Joseph, Lang, Thomas, Bouxsein, Mary, Latourelle, Jeanne, Claussnitzer, Melina, ... Hsu, Yi-Hsiang. (2016) Novel genetic variants associated with increased vertebral volumetric BMD, reduced vertebral fracture risk, and increased expression of SLC1A3 and EPHB2. Journal of Bone and Mineral Research. 31(12), pp. 2085 - 2097. https://doi.org/10.1002/jbmr.2913
Anxiety Disorders and falls among older adults
Holloway, Kara L., Williams, L. J., Brennan-Olsen, Sharon L., Morse, Amelia G., Kotowicz, Mark A., Nicholson, Geoffrey Charles and Pasco, Julie A.. (2016) Anxiety Disorders and falls among older adults. Journal of Affective Disorders. 205, pp. 20 - 27. https://doi.org/10.1016/j.jad.2016.06.052
A Meta-Analysis of Trabecular Bone Score in Fracture Risk Prediction and Its Relationship to FRAX
McCloskey, Eugene, Oden, Anders, Harvey, Nicholas C., Leslie, William, Hans, D., Johansson, Helena, Barkmann, Reinhard, Boutroy, Stephanie, Brown, J. P., Chapurlat, Roland D., Elders, Petra J. M., Fujita, Yuki, Glüer, Claus C., Goltzman, David, Iki, Masayuki, Karlsson, M. K., Kindmark, Andreas, Kotowicz, Mark, Kurumatani, Norio, ... Kanis, John A.. (2016) A Meta-Analysis of Trabecular Bone Score in Fracture Risk Prediction and Its Relationship to FRAX. Journal of Bone and Mineral Research. 31(5), pp. 940 - 948. https://doi.org/10.1002/jbmr.2734
Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels
Kilpeläinen, Tuomas O., Martin Carli, Jayne F., Skowronski, Alicja A., Sun, Qi, Kriebel, Jennifer, Feitosa, Mary F., Hedman, Åsa K., Drong, Alexander W., Hayes, James E., Zhao, Jinghua H., Pers, Tune H., Schick, Ursula M., Grarup, Niels, Kutalik, Zoltán, Trompet, Stella, Mangino, Massimo, Kristiansson, Kati, Beekman, Marian, Lyytikäinen, Leo-Pekka, ... Lorentzon, Mattias. (2016) Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels. Nature Communications. 7(1), pp. 1 - 14. https://doi.org/10.1038/ncomms10494
A high amount of local adipose tissue Is associated with high cortical porosity and low bone material strength in older women
Sundh, Daniel, Rudäng, Robert, Zoulakis, Michail, Nilsson, Anna G., Darelid, Anna and Lorentzon, Mattias. (2016) A high amount of local adipose tissue Is associated with high cortical porosity and low bone material strength in older women. Journal of Bone and Mineral Research. 31(4), pp. 749 - 757. https://doi.org/10.1002/jbmr.2747
Low-level cadmium exposure is associated with decreased bone mineral density and increased risk of incident fractures in elderly men: The MrOS Sweden study
Wallin, Maria, Barregard, Lars, Sallsten, Gerd, Lundh, Thomas, Karlsson, Magnus K., Lorentzon, Mattias, Ohlsson, Claes and Mellström, Dan. (2016) Low-level cadmium exposure is associated with decreased bone mineral density and increased risk of incident fractures in elderly men: The MrOS Sweden study. Journal of Bone and Mineral Research. 31(4), pp. 732 - 741. https://doi.org/10.1002/jbmr.2743
Hydroxysteroid (17 beta)-dehydrogenase 1–deficient female mice present with normal puberty onset but are severely subfertile due to a defect in luteinization and progesterone production
Hakkarainen, Janne, Jokela, Heli, Pakarinen, Pirjo, Heikelä, Hanna, Kätkänaho, Laura, Vandenput, Liesbeth, Ohlsson, Claes, Zhang, Fu-Ping and Poutanen, Matti. (2015) Hydroxysteroid (17 beta)-dehydrogenase 1–deficient female mice present with normal puberty onset but are severely subfertile due to a defect in luteinization and progesterone production. The FASEB Journal. 29(9), pp. 3806 - 3816. https://doi.org/10.1096/fj.14-269035
Osteoporosis: The evolution of a diagnosis
Lorentzon, Mattias and Cummings, Steven R.. (2015) Osteoporosis: The evolution of a diagnosis. Journal of Internal Medicine. 277(6), pp. 650 - 661. https://doi.org/10.1111/joim.12369
New genetic loci link adipose and insulin biology to body fat distribution
Shungin, Dmitry, Winkler, Thomas W., Croteau-Chonka, Damien C., Ferreira, Teresa, Locke, Adam E., Mägi, Reedik, Strawbridge, Rona J., Pers, Tune H., Fischer, Krista, Justice, Anne E., Workalemahu, Tsegaselassie, Wu, Joseph M. W., Buchkovich, Martin L., Heard-Costa, Nancy L., Roman, Tamara S., Drong, Alexander W., Song, Ci, Gustafsson, Stefan, Day, Felix R., ... Lorentzon, Mattias. (2015) New genetic loci link adipose and insulin biology to body fat distribution. Nature. 518, pp. 187 - 196. https://doi.org/10.1038/nature14132
Identification of a novel FGFRL1 MicroRNA target site polymorphism for bone mineral density in meta-analyses of genome-wide association studies
Niu, Tianhua, Liu, Ning, Zhao, Ming, Xie, Guie, Zhang, Lei, Li, Jian, Pei, Yu-Fang, Shen, Hui, Fu, Xiaoying, He, Hao, Lu, Shan, Chen, Xiang-Ding, Tan, Li-Jun, Yang, Tie-Lin, Guo, Yan, Leo, Paul, Duncan, Emma, Shen, Jie, Guo, Yan-Fang, ... Deng, Hong-Wen. (2015) Identification of a novel FGFRL1 MicroRNA target site polymorphism for bone mineral density in meta-analyses of genome-wide association studies. Human Molecular Genetics. https://doi.org/10.1093/hmg/ddv144
Lower urinary symptoms are associated with low levels of serum serotonin, high levels of adinopectin and fasting glucose, and benign prostatic enlargement
Haghsheno, Mohammad-Ali, Mellstrom, Dan, Peeker, Ralph, Hammarsten, Jan, Lorentzon, Mattias, Sundh, Valter, Karlsson, Magnus, Ohlsson, Claes and Damber, Jan-Erik. (2015) Lower urinary symptoms are associated with low levels of serum serotonin, high levels of adinopectin and fasting glucose, and benign prostatic enlargement. Scandinavian Journal of Urology. 49(2), pp. 155 - 161. https://doi.org/10.3109/21681805.2014.936495
Measurement of a comprehensive sex steroid profile in rodent serum by high-sensitive gas chromatography-tandem mass spectrometry
Nilsson, Maria E., Vandenput, Liesbeth, Tivesten, Åsa, Norlén, Anna-Karin, Lagerquist, Marie K., Windahl, Sara H., Börjesson, Anna E., Farman, Helen H., Poutannen, Matti, Benrick, Anna, Maliqueo, Manuel, Stener-Victorin, Elisabet, Ryberg, Henrik and Ohlsson, Claes. (2015) Measurement of a comprehensive sex steroid profile in rodent serum by high-sensitive gas chromatography-tandem mass spectrometry. Endocrinology. 156(7), pp. 2492 - 2502. https://doi.org/10.1210/en.2014-1890
The number and characteristics of prevalent vertebral fractures in elderly men are associated with low bone mass and osteoporosis
Kherad, M., Mellström, Dan, Rosengren, Björn E., Hasserius, R., Nilsson, J.-Å., Redlund-Johnell, Inga, Ohlsson, Claes, Lorentzon, Mattias and Karlsson, Magnus K.. (2015) The number and characteristics of prevalent vertebral fractures in elderly men are associated with low bone mass and osteoporosis. The Bone and Joint Journal. 97-B(8), pp. 1106 - 1110. https://doi.org/10.1302/0301-620X.97B8.35032
Changes in cortical volumetric bone mineral density and thickness, and trabecular thickness in lactating women postpartum
Brembeck, P., Lorentzon, Mattias, Ohlsson, Claes, Winkvist, A. and Augustin, H.. (2015) Changes in cortical volumetric bone mineral density and thickness, and trabecular thickness in lactating women postpartum. Journal of Clinical Endocrinology and Metabolism. 100(2), pp. 535 - 543. https://doi.org/10.1210/jc.2014-2825
Determinants of rural practice : Positive interaction between rural background and rural undergraduate training
Kondalsamy-Chennakes, Srinivas, Eley, Diann, Ranmuthugala, Geetha, Chater, Alan, Toombs, Maree, Darshan, Deepak and Nicholson, Geoff. (2015) Determinants of rural practice : Positive interaction between rural background and rural undergraduate training. Medical Journal of Australia. https://doi.org/10.5694/mja14.00236
Changes in quality of life associated with fragility fractures : Australian arm of the International Cost and Utility Related to Osteoporotic Fractures Study (AusICUROS)
Abimanyi-Ochom, J., Watts, Jennifer, Borgstrom, F., Nicholson, Geoffrey, Shore-Lorenti, Catherine, Stuart, Amanda, Zhang, Y., Luliano, S., Seeman, Ego, Prince, Richard, March, Lyn, Winzenberg, T., Laslett, Laura, Duque, Gustavo, Ebeling, P. and Sanders, K. M.. (2015) Changes in quality of life associated with fragility fractures : Australian arm of the International Cost and Utility Related to Osteoporotic Fractures Study (AusICUROS). Osteoporosis International. 26(6), pp. 1781 - 1790. https://doi.org/10.1007/s00198-015-3088-z
Sleep duration and disturbances were associated with testosterone level, muscle mass, and muscle strength - A cross-sectional study in 1274 older men
Auyeung, Tung Wai, Kwok, Tung Wai, Leung, Jason, Shun Wah Lee, Jenny, Ohlsson, Claes, Vandenput, Liesbeth, Wing, Yun Kwok and Woo, Jean. (2015) Sleep duration and disturbances were associated with testosterone level, muscle mass, and muscle strength - A cross-sectional study in 1274 older men. Journal of the American Medical Directors Association (JAMDA). 16(7), pp. 630.e1 - 630.e6. https://doi.org/10.1016/j.jamda.2015.04.006
Limited clinical utility of a genetic risk score for the prediction of fracture risk in elderly subjects
Eriksson, Joel, Evans, Daniel S., Nielson, Carrie M., Shen, Jian, Srikanth, Priya, Hochberg, Marc, McWeeney, Shannon, Cawthon, Peggy M., Wilmot, Beth, Zmuda, Joseph, Tranah, Greg, Mirel, Daniel B., Challa, Sashi, Mooney, Michael, Crenshaw, Andrew, Karlsson, Magnus, Mellström, Dan, Vandenput, Liesbeth, Orwoll, Eric and Ohlsson, Claes. (2015) Limited clinical utility of a genetic risk score for the prediction of fracture risk in elderly subjects. Journal of Bone and Mineral Research. 30(1), pp. 184 - 194. https://doi.org/10.1002/jbmr.2314
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption
Cornelis, Marilyn C., Byrne, Enda M., Esko, Tonu, Nalls, Michael A., Ganna, Andrea, Paynter, Nina, Monda, Keri L., Amin, Najaf, Fischer, Krista, Renstrom, Frida, Ngwa, Julius S., Huikari, Ville, Cavadino, Alana, Nolte, Ilja M., Teumer, Alexander, Yu, Kai, Marques-Vidal, Pedro Manuel, Rawal, Rajesh, Manichaikul, Ani, ... UK Brain Expression Consortium (UKBEC). (2015) Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. Molecular Psychiatry. 20(5), pp. 647 - 656. https://doi.org/10.1038/mp.2014.107
Low clinical relevance of a prevalent vertebral fracture in elderly men - the MrOs Sweden study
Kherad, Mehrsa, Rosengren, Björn E., Hasserius, Ralph, Nilsson, Jan-Åke, Redlund-Johnell, Inga, Ohlsson, Claes, Lorentzon, Mattias, Mellström, Dan and Karlsson, Magnus K.. (2015) Low clinical relevance of a prevalent vertebral fracture in elderly men - the MrOs Sweden study. The Spine Journal. 15(2), pp. 281 - 289. https://doi.org/10.1016/j.spinee.2014.09.016
Increased cortical porosity in older men with fracture
Sundh, Daniel, Mellström, Dan, Nilsson, Martin, Karlsson, Magnus, Ohlsson, Claes and Lorentzon, Mattias. (2015) Increased cortical porosity in older men with fracture. Journal of Bone and Mineral Research. 30(9), pp. 1692 - 1700. https://doi.org/10.1002/jbmr.2509
Bone turnover markers predict bone mass development in young adult men: A five-year longitudinal study
Darelid, Anna, Nilsson, Martin, Kindblom, Jenny M., Mellström, Dan, Ohlsson, Claes and Lorentzon, Mattias. (2015) Bone turnover markers predict bone mass development in young adult men: A five-year longitudinal study. Journal of Clinical Endocrinology and Metabolism. 100(4), pp. 1460 - 1468. https://doi.org/10.1210/jc.2014-3947
High serum adiponectin is associated with low blood haemoglobin in elderly men: The Swedish MrOS study
Lewerin, C., Johansson, Helena, Lerner, Ulf H., Karlsson, Magnus K., Lorentzon, Mattias, Barrett-Connor, Elizabeth, Smith, Ulf, Ohlsson, Claes and Mellström, Dan. (2015) High serum adiponectin is associated with low blood haemoglobin in elderly men: The Swedish MrOS study. Journal of Internal Medicine. 278(1), pp. 68 - 76. https://doi.org/10.1111/joim.12340
Is the Swedish FRAX model appropriate for Swedish immigrants?
Johansson, Helena, Oden, Anders, Lorentzon, Mattias, McCloskey, Eugene V., Kanis, John A., Harvey, Nicholas C., Karlsson, M. K. and Mellström, Dan. (2015) Is the Swedish FRAX model appropriate for Swedish immigrants? Osteoporosis International. 26(11), pp. 2617 - 2622. https://doi.org/10.1007/s00198-015-3180-4
Association of vitamin D status with arterial blood pressure and hypertension risk: A mendelian randomisation study
Vimaleswaran, Karani S., Cavadino, Alana, Berry, Diane J., Jorde, Rolf, Dieffenbach, Aida Karina, Lu, Chen, Alves, Alexessander Couto, Heerspink, Hiddo J. Lambers, Tikkanen, Emmi, Eriksson, Joel, Wong, Andrew, Mangino, Massimo, Jablonski, Kathleen A., Nolte, Ilja M., Houston, Denise K., Ahluwalia, Tarunveer Singh, van der Most, Peter J., Pasko, Dorota, Zgaga, Lina, ... Hyppönen, Elina. (2014) Association of vitamin D status with arterial blood pressure and hypertension risk: A mendelian randomisation study. The Lancet Diabetes & Endocrinology. 2(9), pp. 719 - 729. https://doi.org/10.1016/S2213-8587(14)70113-5
Genome-wide association study for radiographic vertebral fractures: A potential role for the 16q24 BMD locus
Oei, Ling, Estrada, Karol, Duncan, Emma L., Christiansen, Claus, Liu, Ching-Ti, Langdahl, Bente L., Obermayer-Pietsch, Barbara, Riancho, José A., Prince, Richard L., van Schoor, Natasja M., McCloskey, Eugene, Hsu, Yi-Hsiang, Evangelou, Evangelos, Ntzani, Evangelia, Evans, David M., Alonso, Nerea, Husted, Lise B., Valero, Carmen, Hernandez, Jose L., ... Rivadeneira, Fernando. (2014) Genome-wide association study for radiographic vertebral fractures: A potential role for the 16q24 BMD locus. Bone. 59, pp. 20 - 27. https://doi.org/10.1016/j.bone.2013.10.015
Exercise during growth and young adulthood is independently associated with cortical bone size and strength in old Swedish men
Nilsson, Martin, Sundh, Daniel, Ohlsson, Claes, Karlsson, Magnus, Mellström, Dan and Lorentzon, Mattias. (2014) Exercise during growth and young adulthood is independently associated with cortical bone size and strength in old Swedish men. Journal of Bone and Mineral Research. 29(8), pp. 1795 - 1804. https://doi.org/10.1002/jbmr.2212
Efficacy and safety of oral methazolamide in patients with type 2 diabetes: A 24-week, placebo-controlled, double-blind study
Simpson, Richard W., Nicholson, Geoffrey C., Proietto, Joseph, Sarah, Alana, Sanders, Kerrie M., Phillips, Gabrielle, Chambers, Jo, MacGinley, Rob, Orford, Neil, Walder, Ken, Krippner, Guy, Skoff, Kathy and Wacher, Vincent J.. (2014) Efficacy and safety of oral methazolamide in patients with type 2 diabetes: A 24-week, placebo-controlled, double-blind study. Diabetes Care. 37(11), pp. 3121 - 3123. https://doi.org/10.2337/dc14-1038
Defining the role of common variation in the genomic and biological architecture of adult human height
Wood, Andrew R., Esko, Tonu, Yang, Jian, Vedantam, Sailaya, Pers, Tune H., Gustafsson, Stefan, Chu, Audrey Y., Estrada, Karol, Luan, Jian'an, Kutalik, Zoltán, Amin, Najaf, Buchkovich, Martin L., Croteau-Chonka, Damien C., Day, Felix R., Duan, Yanan, Fall, Tove, Fehrmann, Rudolf, Ferreira, Teresa, Jackson, Anne U., ... Lorentzon, Mattias. (2014) Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics. 46(11), pp. 1173 - 1186. https://doi.org/10.1038/ng.3097
Fracture risk among older men: Osteopenia and osteoporosis defined using cut-points derived from female versus male reference data
Pasco, Julie A., Lane, Steven E., Brennan, Sharon L., Timney, Elizabeth N., Bucki-Smith, Gosia, Dobbins, Amelia Grace, Nicholson, Geoffrey Charles and Kotowicz, Mark A.. (2014) Fracture risk among older men: Osteopenia and osteoporosis defined using cut-points derived from female versus male reference data. Osteoporosis International. 25(3), pp. 857 - 862. https://doi.org/10.1007/s00198-013-2561-9
Serum estradiol levels are inversely associated with cortical porosity in older men
Vandenput, Liesbeth, Lorentzon, Mattias, Sundh, Daniel, Nilsson, Maria E., Karlsson, Magnus K., Mellström, Dan and Ohlsson, Claes. (2014) Serum estradiol levels are inversely associated with cortical porosity in older men. Journal of Clinical Endocrinology and Metabolism. 99(7), pp. E1322 - E1326. https://doi.org/10.1210/jc.2014-1319
International and ethnic variability of falls in older men
Karlsson, Magnus L., Ribom, Eva L., Nilsson, J.-Å., Karlsson, Caroline, Cöster, Maria, Vonschewelov, Thord, Mallmin, Hans, Ljunggren, Östen, Ohlsson, Claes, Mellström, Dan, Lorentzon, Mattias, Leung, Ping C., Lau, Edith, Cauley, Jane A., Barrett-Connor, Elizabeth, Stefanick, Marcia L., Orwoll, Eric and Rosengren, Björn E.. (2014) International and ethnic variability of falls in older men. Scandinavian Journal of Public Health. 42(2), pp. 194 - 200. https://doi.org/10.1177/1403494813510789
Musculoskeletal deterioration in men accompanies increases in body fat
Pasco, Julie A., Gould, Haslinda, Brennan, Sharon L., Nicholson, Geoffrey Charles and Kotowicz, Mark A.. (2014) Musculoskeletal deterioration in men accompanies increases in body fat. Obesity. 22(3), pp. 863 - 867. https://doi.org/10.1002/oby.20496
Serum estradiol associates with blood hemoglobin in elderly men: The MrOS Sweden study
Lewerin, Catharina, Nilsson-Ehle, Herman, Jacobsson, Stefan, Johansson, Helena, Sundh, Valter, Karlsson, Magnus K., Lorentzon, Mattias, Barrett-Connor, Elizabeth, Vandenput, Liesbeth, Ohlsson, Claes and Mellström, Dan. (2014) Serum estradiol associates with blood hemoglobin in elderly men: The MrOS Sweden study. Journal of Clinical Endocrinology and Metabolism. 99(7), pp. 2549 - 2556. https://doi.org/10.1210/jc.2013-4111
Total and appendicular lean mass reference ranges for Australian men and women: The Geelong Osteoporosis Study
Gould, Haslinda, Brennan, Sharon L., Kotowicz, Mark A., Nicholson, Geoffrey Charles and Pasco, Julie A.. (2014) Total and appendicular lean mass reference ranges for Australian men and women: The Geelong Osteoporosis Study. Calcified Tissue International. 94(4), pp. 363 - 372. https://doi.org/10.1007/s00223-013-9830-7
Genome-wide association studies on serum sex steroid levels
Vandenput, Liesbeth and Ohlsson, Claes. (2014) Genome-wide association studies on serum sex steroid levels. Molecular and Cellular Endocrinology. 382(1), pp. 758 - 766. https://doi.org/10.1016/j.mce.2013.03.009
Low holotranscobalamin and cobalamins predict incident fractures in elderly men: The MrOS Sweden
Lewerin, C. Lewerin, Nilsson-Ehle, H., Jacobsson, S., Johansson, Helena, Sundh, V., Karlsson, Magnus, Ljunggren, Östen, Lorentzon, Mattias, Kanis, John A., Lerner, Ulf H., Cummings, Steven R., Ohlsson, Claes and Mellström, Dan. (2014) Low holotranscobalamin and cobalamins predict incident fractures in elderly men: The MrOS Sweden. Osteoporosis International. 25(1), pp. 131 - 140. https://doi.org/10.1007/s00198-013-2527-y
A 6-year exercise program improves skeletal traits without affecting fracture risk: A prospective controlled study in 2621 children
Detter, Fredrik, Rosengren, Björn E., Dencker, Magnus, Lorentzon, Mattias, Nilsson, Jan‐Åke and Karlsson, Magnus K.. (2014) A 6-year exercise program improves skeletal traits without affecting fracture risk: A prospective controlled study in 2621 children. Journal of Bone and Mineral Research. 29(6), pp. 1325 - 1336. https://doi.org/10.1002/jbmr.2168
Investigating the predictive ability of gait speed and quadriceps strength for incident falls in community-dwelling older women at high risk of fracture
Scott, David, Stuart, Amanda, Kay, Deborah, Ebeling, Peter, Nicholson, Geoffrey and Sanders, Kerrie. (2014) Investigating the predictive ability of gait speed and quadriceps strength for incident falls in community-dwelling older women at high risk of fracture. Archives of Gerontology and Geriatrics. 58(3), pp. 308 - 313. https://doi.org/10.1016/j.archger.2013.11.004
Undercarboxylated osteocalcin, muscle strength and indices of bone health in older women
Levinger, Itamar, Scott, David, Nicholson, Geoffrey, Stuart, Amanda, Duque, Gustavo, McCorquodale, Thomas, Herrmann, Markus, Ebeling, Peter and Sanders, Kerrie. (2014) Undercarboxylated osteocalcin, muscle strength and indices of bone health in older women. Bone. 64, pp. 8 - 12. https://doi.org/10.1016/j.bone.2014.03.008
Genetic determinants of heel bone properties: Genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium
Moayyeri, Alireza, Hsu, Yi-Hsiang, Karasik, David, Estrada, Karol, Xiao, Su-Mei, Nielson, Carrie, Srikanth, Priya, Giroux, Sylvie, Wilson, Scott G., Zheng, Hou-Feng, Smith, Albert V., Pye, Stephen R., Leo, Paul J., Teumer, Alexander, Hwang, Joo-Yeon, Ohlsson, Claes, McGuigan, Fiona, Minster, Ryan L., Hayward, Caroline, ... Kaptoge, Stephen K.. (2014) Genetic determinants of heel bone properties: Genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium. Human Molecular Genetics. 23(11), pp. 3054 - 3068. https://doi.org/10.1093/hmg/ddt675
Does bone resorption stimulate periosteal expansion? A cross-sectional analysis of β-C-telopeptides of type i collagen (CTX), genetic markers of the RANKL pathway, and periosteal circumference as measured by pQCT
Kemp, John P., Sayers, Adrian, Paternoster, Lavinia, Evans, David M., Deere, Kevin, St. Pourcain, Beate, Timpson, Nicholas J., Ring, Susan M., Lorentzon, Mattias, Lehtimäki, Terho, Eriksson, Joel, Kähönen, Mika, Raitakari, Olli, Laaksonen, Marika, Sievänen, Harri, Viikari, Jorma, Lyytikäinen, Leo-Pekka, Smith, George Davey, Fraser, William D., ... Tobias, Jon H.. (2014) Does bone resorption stimulate periosteal expansion? A cross-sectional analysis of β-C-telopeptides of type i collagen (CTX), genetic markers of the RANKL pathway, and periosteal circumference as measured by pQCT. Journal of Bone and Mineral Research. 29(4), pp. 1015 - 1024. https://doi.org/10.1002/jbmr.2093
Dehydroepiandrosterone and its sulfate predict the 5-year risk of coronary heart disease events in elderly men
Tivesten, Åsa, Vandenput, Liesbeth, Carlzon, Daniel, Nilsson, Maria, Karlsson, Magnus K., Ljunggren, Östen, Barrett-Connor, Elizabeth, Mellström, Dan and Ohlsson, Claes. (2014) Dehydroepiandrosterone and its sulfate predict the 5-year risk of coronary heart disease events in elderly men. Journal of the American College of Cardiology. 64(17), pp. 1801 - 1810. https://doi.org/10.1016/j.jacc.2014.05.076
A systematic review: Identifying the prevalence rates of psychiatric disorder in Australia''s Indigenous populations
Black, Emma B., Ranmuthugala, Geetha, Kondalsamy-Chennakesavan, Srinivas, Toombs, Maree R., Nicholson, Geoffrey C. and Kisely, Steve. (2014) A systematic review: Identifying the prevalence rates of psychiatric disorder in Australia''s Indigenous populations. Australian and New Zealand Journal of Psychiatry. 115(5), pp. 518 - 524. https://doi.org/10.1177/0004867415569802
Genetics of endocrine disorders in the era of genome-wide association studies
Vandenput, Liesbeth and Ohlsson, Claes. (2014) Genetics of endocrine disorders in the era of genome-wide association studies. Molecular and Cellular Endocrinology. 382(1), pp. 725 - 725. https://doi.org/10.1016/j.mce.2013.06.031
Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels
Kwan, Johnny S. H., Hsu, Yi-Hsiang, Cheung, Ching-Lung, Dupuis, Josée, Saint-Pierre, Aude, Eriksson, Joel, Handelman, Samuel K., Aragaki, Aaron K., Karasik, David, Pramstaller, Peter P., Kooperberg, Charles, Lacroix, Andrea Z., Larson, Martin G., Lau, Kam-Shing, Lorentzon, Mattias, Pichler, Irene, Sham, Pak Chung, Taliun, Daniel, Vandenput, Liesbeth, ... Kung, Annie Wai Chee. (2014) Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels. Human Molecular Genetics. 23(24), pp. 6684 - 6693. https://doi.org/10.1093/hmg/ddu386
Genetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure
Paternoster, Lavinia, Lorentzon, Mattias, Lehtimäki, Terho, Eriksson, Joel, Kähönen, Mika, Raitakari, Olli, Laaksonen, Marika, Sievänen, Harri, Viikari, Jorma, Lyytikäinen, Leo-Pekka, Mellström, Dan, Karlsson, Magnus, Ljunggren, Östen, Grundberg, Elin, Kemp, John P., Sayers, Adrian, Nethander, Maria, Evans, David M., Vandenput, Liesbeth, ... Ohlsson, Claes. (2013) Genetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure. PLoS Genetics. 9(2), pp. 1 - 15. https://doi.org/10.1371/journal.pgen.1003247
Is high dose Vitamin D harmful?
Sanders, Kerrie, Nicholson, Geoffrey and Ebeling, Peter. (2013) Is high dose Vitamin D harmful? Calcified Tissue International. 92(2), pp. 191 - 206. https://doi.org/10.1007/s00223-012-9679-1
Impact of denosumab on the peripheral skeleton of postmenopausal women with osteoporosis: Bone density, mass, and strength of the radius, and wrist fracture
Simon, James A., Recknor, Christopher, Moffett, Alfred H., Adachi, Jonathan D., Franek, Edward, Lewiecki, E. Michael, McClung, Michael R., Mautalen, Carlos A., Ragi-Eis, Sergio, Nicholson, Geoffrey Charles, Muschitz, Christian, Nuti, Ranuccio, Torring, Ove, Wang, Andrea and Libanati, Cesar. (2013) Impact of denosumab on the peripheral skeleton of postmenopausal women with osteoporosis: Bone density, mass, and strength of the radius, and wrist fracture. Menopause. 20(2), pp. 130 - 137. https://doi.org/10.1097/gme.0b013e318267f909
Calcaneal ultrasound reference ranges for Australian men and women: The Geelong Osteoporosis Study
Gould, Haslinda, Brennan, Sharon L., Nicholson, Geoffrey Charles, Kotowicz, Mark A., Henry, Margaret J. and Pasco, Julie A.. (2013) Calcaneal ultrasound reference ranges for Australian men and women: The Geelong Osteoporosis Study. Osteoporosis International. 24(4), pp. 1369 - 1377. https://doi.org/10.1007/s00198-012-2082-y
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
Berndt, Sonja I., Gustafsson, Stefan, Mägi, Reedik, Ganna, Andrea, Wheeler, Eleanor, Feitosa, Mary F., Justice, Anne E., Monda, Keri L., Croteau-Chonka, Damien C., Day, Felix R., Esko, Tonu, Fall, Tove, Ferreira, Teresa, Gentilini, Davide, Jackson, Anne U., Luan, Jianan, Randall, Joshua C., Vedantam, Sailaja, Willer, Cristen J., ... Lorentzon, Mattias. (2013) Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nature Genetics. 45, pp. 501 - 512. https://doi.org/10.1038/ng.2606
Comparisons of immunoassay and mass spectrometry measurements of serum estradiol levels and their influence on clinical association studies in men
Ohlsson, Claes, Nilsson, Maria E., Tivesten, Åsa, Ryberg, Henrik, Mellström, Dan, Karlsson, Magnus K., Ljunggren, Östen, Labrie, Fernand, Orwoll, Eric S., Lee, David M., Pye, Stephen R., O'Neill, Terence W., Finn, Joseph D., Adams, Judith E., Ward, Kate A., Boonen, Steven, Bartfai, Gyorgy, Casanueva, Felipe F., Forti, Gianni, ... EMAS Study Group. (2013) Comparisons of immunoassay and mass spectrometry measurements of serum estradiol levels and their influence on clinical association studies in men. Journal of Clinical Endocrinology and Metabolism. 98(6), pp. e1097 - e1102. https://doi.org/10.1210/jc.2012-3861
Associations between measures of adiposity over 10 years and patella cartilage in population-based asymptomatic women
Gunardi, A. J., Brennan, Sharon L., Wang, Yuanyuan, Cicuttini, Flavia M., Pasco, Julie A., Kotowicz, Mark A., Nicholson, Geoffrey Charles and Wluka, Anita E.. (2013) Associations between measures of adiposity over 10 years and patella cartilage in population-based asymptomatic women. International Journal of Obesity. 37(12), pp. 1586 - 1589. https://doi.org/10.1038/ijo.2013.42
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders
Hoed, Marcel den, Eijgelsheim, Mark, Esko, Tonu, Brundel, Bianca J.J.M., Peal, David S., Evans, David M., Nolte, Ilja M., Segrè, Ayellet V., Hólm, Hilma, Handsaker, Robert E., Westra, Harm-Jan, Johnson, Toby, Isaacs, Aaron, Yang, Jian, Lundby, Alicia, Zhao, Jing Hua, Kim, Young Jin, Go, Min Jin, Almgren, Peter, ... Lorentzon, Mattias. (2013) Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nature Genetics. 45(6), pp. 621 - 631. https://doi.org/10.1038/ng.2610
The role of IGF-1 for fracture risk in men
Vandenput, Liesbeth, Sjögren, Klara, Svensson, Johan and Ohlsson, Claes. (2012) The role of IGF-1 for fracture risk in men. Frontiers in Endocrinology. 3, pp. 1 - 3. https://doi.org/10.3389/fendo.2012.00051
Low serum vitamin D is associated with increased mortality in elderly men: MrOS Sweden
Johansson, Helena Johansson, Oden, Anders, Kanis, John A., McCloskey, Eugene, Lorentzon, Mattias, Ljunggren, Östen, Karlsson, Magnus, Thorsby, P. M., Tivesten, A., Barrett-Connor, Elizabeth, Ohlsson, Claes and Mellström, Dan. (2012) Low serum vitamin D is associated with increased mortality in elderly men: MrOS Sweden. Osteoporosis International. 23(3), pp. 991 - 999. https://doi.org/10.1007/s00198-011-1809-5
Sex steroids and bone health in men
Ohlsson, Claes, Börjesson, Anna E. and Vandenput, Liesbeth. (2012) Sex steroids and bone health in men. BoneKEy Reports. 1(2), pp. 1 - 7. https://doi.org/10.1038/bonekey.2012.3
Cross-sectional analysis of association between socioeconomic status and utilization of primary total hip joint replacements 2006-7: Australian Orthopaedic Association National Joint Replacement Registry
Brennan, Sharon L., Stanford, Tyman, Wluka, Anita E., Henry, Margaret J., Page, Richard S., Graves, Stephen E., Kotowicz, Mark A., Nicholson, Geoffrey Charles and Pasco, Julie A.. (2012) Cross-sectional analysis of association between socioeconomic status and utilization of primary total hip joint replacements 2006-7: Australian Orthopaedic Association National Joint Replacement Registry. BMC Musculoskeletal Disorders. 13(63), pp. 63 - 69. https://doi.org/10.1186/1471-2474-13-63
Endogenous parathyroid hormone is associated with reduced cartilage volume in vivo in a population-based sample of adult women
Brennan, Sharon L., Cicuttini, Flavia M., Nicholson, Geoffrey Charles, Pasco, Julie A., Kotowicz, Mark A. and Wluka, Anita E.. (2012) Endogenous parathyroid hormone is associated with reduced cartilage volume in vivo in a population-based sample of adult women. Annals of the Rheumatic Diseases. 71(6), pp. 1000 - 1003. https://doi.org/10.1136/annrheumdis-2011-200957
High serum adiponectin predicts incident fractures in elderly men: Osteoporotic fractures in men (MrOS) Sweden
Johansson, Helena, Oden, Anders, Lerner, Ulf H., Jutberger, Hans, Lorentzon, Mattias, Barrett-Connor, Elizabeth, Karlsson, Magnus, Ljunggren, Östen, Smith, Ulf, McCloskey, Eugene, Kanis, John A., Ohlsson, Claes and Mellstrom, Dan. (2012) High serum adiponectin predicts incident fractures in elderly men: Osteoporotic fractures in men (MrOS) Sweden. Journal of Bone and Mineral Research. 27(6), pp. 1390 - 1396. https://doi.org/10.1002/jbmr.1591
Dietary selenium and major depression: A nested case-control study
Pasco, Julie A., Jacka, Felice N., Willia, Lana J., Evans-Cleverdon, Melinda, Brennan, Sharon L., Kotowicz, Mark A., Nicholson, Geoffrey Charles, Ball, Madeleine J. and Berk, Michael. (2012) Dietary selenium and major depression: A nested case-control study. Complementary Therapies in Medicine. 20(3), pp. 119 - 123. https://doi.org/10.1016/j.ctim.2011.12.008
Social determinants of bone densitometry uptake for osteoporosis risk in patients aged 50yr and older: A systematic review
Brennan, Sharon, Wluka, Anita, Gould, Haslinda, Nicholson, Geoffrey, Leslie, William, Ebeling, Peter, Oldenburg, Brian, Kotowicz, Mark and Pasco, Julie. (2012) Social determinants of bone densitometry uptake for osteoporosis risk in patients aged 50yr and older: A systematic review. Journal of Clinical Densitometry. 15(2), pp. 165 - 175. https://doi.org/10.1016/j.jocd.2011.12.005
Utilisation of primary total knee joint replacements across socioeconomic status in the Barwon Statistical Division, Australia, 2006-2007: A cross-sectional study
Brennan, Sharon L., Stanford, Tyman, Wluka, Anita, Page, Richard S., Graves, Stephen E., Kotowicz, Mark A., Nicholson, Geoffrey Charles and Pasco, Julie A.. (2012) Utilisation of primary total knee joint replacements across socioeconomic status in the Barwon Statistical Division, Australia, 2006-2007: A cross-sectional study. BMJ Open. 2(5), pp. 1 - 6. https://doi.org/10.1136/bmjopen-2012-001310
Sex steroids and bone health in older Chinese men
Woo, J., Kwok, T., Leung, J. C. S., Ohlsson, C., Vandenput, L. and Leung, P. C.. (2012) Sex steroids and bone health in older Chinese men. Osteoporosis International. 23(5), pp. 1553 - 1562. https://doi.org/10.1007/s00198-011-1552-y
The epidemiology of the first wave of H1N1 influenza pandemic in Australia: A population-based study
Pasco, Julie A., Nicholson, Geoffrey Charles, Brennan, Sharon L., Bennett, Kathy E., Dobbins, Amelia Grace and Athan, Eugene. (2012) The epidemiology of the first wave of H1N1 influenza pandemic in Australia: A population-based study. The Open Public Health Journal. 5, pp. 80 - 85. https://doi.org/10.2174/1874944501205010080
Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus
Medina-Gomez, Carolina, Kemp, John P., Estrada, Karol, Eriksson, Joel, Liu, Jeff, Reppe, Sjur, Evans, David M., Heppe, Denise H. M., Vandenput, Liesbeth, Herrera, Lizbeth, Ring, Susan M., Kruithof, Claudia J., Timpson, Nicholas J., Zillikens, M. Carola, Olstad, Ole K., Zheng, Hou-Feng, Richards, J. Brent, St. Pourcain, Beate, Hofman, Albert, ... Rivadeneira, Fernando. (2012) Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus. PLoS Genetics. 8(7), pp. 1 - 14. https://doi.org/10.1371/journal.pgen.1002718
Prevalence of obesity and the relationship between the body mass index and body fat: Cross-sectional, population-based data
Pasco, Julie A., Nicholson, Geoffrey C., Brennan, Sharon L. and Kotowicz, Mark A.. (2012) Prevalence of obesity and the relationship between the body mass index and body fat: Cross-sectional, population-based data. PLoS ONE. 7(1), pp. 1 - 7. https://doi.org/10.1371/journal.pone.0029580
Incident hip fracture and social disadvantage in an Australian population aged 50 years or greater
Brennan, Sharon, Henry, Margaret, Kotowicz, Mark, Nicholson, Geoffrey, Zhang, Yu and Pasco, Julie. (2011) Incident hip fracture and social disadvantage in an Australian population aged 50 years or greater. Bone. 48(3), pp. 607 - 610. https://doi.org/10.1016/j.bone.2010.10.175
Fracture risk score and absolute risk of fracture
Henry, Margaret, Pasco, Julie, Merriman, Elizabeth, Zhang, Yu, Sanders, Kerrie, Kotowicz, Mark and Nicholson, Geoffrey. (2011) Fracture risk score and absolute risk of fracture. Radiology. 259(2), pp. 495 - 501. https://doi.org/10.1148/radiol.10101406
Changes in hip fracture rates in southeastern Australia spanning the period 1994-2007
Pasco, Julie, Brennan, Sharon, Henry, Margaret, Nicholson, Geoffrey, Sanders, Kerrie, Zhang, Yu and Kotowicz, Mark. (2011) Changes in hip fracture rates in southeastern Australia spanning the period 1994-2007. Journal of Bone and Mineral Research. 26(7), pp. 1648 - 1654. https://doi.org/10.1002/jbmr.393
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile
Kilpeläinen, Tuomas O., Zillikens, M. Carola, Stančákova, Alena, Finucane, Francis M., Ried, Janina S., Langenberg, Claudia, Zhang, Weihua, Beckmann, Jacques S., Luan, Jian'an, Vandenput, Liesbeth, Styrkarsdottir, Unnur, Zhou, Yanhua, Smith, Albert V., Zhao, Jing-Hua, Amin, Najaf, Vedantam, Sailaja, Shin, So-Youn, Haritunians, Talin, Fu, Mao, ... Loos, Ruth J. F.. (2011) Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nature Genetics. 43(8), pp. 753 - 760. https://doi.org/10.1038/ng.866
Genetic determinants of serum testosterone concentrations in men
Ohlsson, Claes, Wallaschofski, Henri, Lunetta, Kathryn L., Stolk, Lisette, Perry, John R. B., Koster, Annemarie, Petersen, Ann-Kristin, Eriksson, Joel, Lehtima¨ki, Terho, Huhtaniemi, Ilpo T., Hammond, Geoffrey L., Maggio, Marcello, Coviello, Andrea D., Ferrucci, Luigi, Heier, Margit, Hofman, Albert, Holliday, Kate L., Jansson, John-Olov, Kahonen, Mika, ... Melzer, David. (2011) Genetic determinants of serum testosterone concentrations in men. PLoS Genetics. 7(10), pp. 1 - 11. https://doi.org/10.1371/journal.pgen.1002313
Independent and combined effects of calcium-vitamin D3 and exercise on bone structure and strength in older men: An 18-month factorial design randomized controlled trial
Kukuljan, Sonja, Nowson, Caryl, Sanders, Kerrie, Nicholson, Geoffrey, Seibel, Markus, Salmon, Jo and Daly, Robin. (2011) Independent and combined effects of calcium-vitamin D3 and exercise on bone structure and strength in older men: An 18-month factorial design randomized controlled trial. Journal of Clinical Endocrinology and Metabolism. 96(4), pp. 955 - 963. https://doi.org/10.1210/jc.2010-2284
Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms
Zhai, Guangju, Teumer, Alexander, Stolk, Lisette, Perry, John R. B., Vandenput, Liesbeth, Coviello, Andrea D., Koster, Annemarie, Bell, Jordana T., Bhasin, Shalender, Eriksson, Joel, Ernst, Florian, Ferrucci, Luigi, Frayling, Timothy M., Glass, Daniel, Grundberg, Elin, Haring, Robin, Hedman, Åsa K., Hofman, Albert, Kiel, Douglas P., ... MuTHER Consortium. (2011) Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms. PLoS Genetics. 7(4), pp. 1 - 10. https://doi.org/10.1371/journal.pgen.1002025
Low DHEAS levels are associated with depressive symptoms in elderly Chinese men: results from a large study
Wong, Samuel Y. S., Leung, Jason, Kwok, Timothy, Ohlsson, Claes, Vandenput, Liesbeth, Leung, Ping C. and Woo, Jean. (2011) Low DHEAS levels are associated with depressive symptoms in elderly Chinese men: results from a large study. Asian Journal of Andrology. 13(6), pp. 898 - 902. https://doi.org/10.1038/aja.2011.116
Paracetamol (acetaminophen) use, fracture and bone mineral density
Williams, Lana, Pasco, Julie, Henry, Margaret, Sanders, Kerrie, Nicholson, Geoffrey, Kotowicz, Mark and Berk, Michael. (2011) Paracetamol (acetaminophen) use, fracture and bone mineral density. Bone. 48(6), pp. 1277 - 1281. https://doi.org/10.1016/j.bone.2011.03.435
Area-based socioeconomic status and mood disorders: Cross-sectional evidence from a cohort of randomly selected adult women
Williams, Lana, Brennan, Sharon, Henry, Margaret, Berk, Michael, Jacka, Felice, Nicholson, Geoffrey, Kotowicz, Mark and Pasco, Julie. (2011) Area-based socioeconomic status and mood disorders: Cross-sectional evidence from a cohort of randomly selected adult women. Maturitas. 69(2), pp. 173 - 178. https://doi.org/10.1016/j.maturitas.2011.03.015
Older men with low serum IGF-1 have an increased risk of incident fractures: The MrOS Sweden study
Ohlsson, Claes, Mellström, Dan, Carlzon, Daniel, Orwoll, Eric, Ljunggren, Östen, Karlsson, Magnus K. and Vandenput, Liesbeth. (2011) Older men with low serum IGF-1 have an increased risk of incident fractures: The MrOS Sweden study. Journal of Bone and Mineral Research. 26(4), pp. 865 - 872. https://doi.org/10.1002/jbmr.281
Low bone mineral density is associated with increased mortality in elderly men: MrOS Sweden
Johansson, Helena, Oden, Anders, Kanis, John A., McCloskey, Eugene V., Lorentzon, Mattias, Ljunggren, Östen, Karlsson, Magnus K., Orwoll, E., Tivesten, A., Ohlsson, Claes and Mellström, Dan. (2011) Low bone mineral density is associated with increased mortality in elderly men: MrOS Sweden. Osteoporosis International. 22(5), pp. 1411 - 1418. https://doi.org/10.1007/s00198-010-1331-1
Testosterone but not estradiol level is positively related to muscle strength and physical performance independent of muscle mass: a cross-sectional study in 1489 older men
Auyeung, Tung Wai, Shun Wah Lee, Jenny, Kwok, Timothy, Leung, Jason, Ohlsson, Claes, Vandenput, Liesbeth, Leung, Ping Ching and Woo, Jean. (2011) Testosterone but not estradiol level is positively related to muscle strength and physical performance independent of muscle mass: a cross-sectional study in 1489 older men. European Journal of Endocrinology. 164(5), pp. 811 - 817. https://doi.org/10.1530/EJE-10-0952
Annual high-dose vitamin D3 and mental well-being: Randomised controlled trial
Sanders, Kerrie, Stuart, Amanda, Williamson, Elizabeth, Jacka, Felice, Dodd, Seetal, Nicholson, Geoff and Berk, Michael. (2011) Annual high-dose vitamin D3 and mental well-being: Randomised controlled trial. British Journal of Psychiatry. 198(5), pp. 357 - 364. https://doi.org/10.1192/bjp.bp.110.087544
High serum testosterone is associated with reduced risk of cardiovascular events in elderly men - The MrOS (Osteoporotic Fractures in Men) study in Sweden
Ohlsson, Claes, Barrett-Connor, Elizabeth, Bhasin, Shalender, Orwoll, Eric, Labrie, Fernand, Karlsson, Magnus K., Ljunggren, Östen, Vandenput, Liesbeth, Mellström, Dan and Tivesten, Åsa. (2011) High serum testosterone is associated with reduced risk of cardiovascular events in elderly men - The MrOS (Osteoporotic Fractures in Men) study in Sweden. Journal of the American College of Cardiology. 58(16), pp. 1674 - 1681. https://doi.org/10.1016/j.jacc.2011.07.019
Bone mineral density is cross sectionally associated with cartilage volume in healthy, asymptomatic adult females: Geelong Osteoporosis Study
Brennan, Sharon, Pasco, Julie, Cicuttini, Flavia, Henry, Margaret, Kotowicz, Mark, Nicholson, Geoffrey and Wluka, Anita. (2011) Bone mineral density is cross sectionally associated with cartilage volume in healthy, asymptomatic adult females: Geelong Osteoporosis Study. Bone. 49(4), pp. 839 - 844. https://doi.org/10.1016/j.bone.2011.06.015
Habitual physical activity and the risk for depressive and anxiety disorders among older men and women
Pasco, Julie, Williams, Lana, Jacka, Felice, Henry, Margaret, Coulson, Carolyn, Brennan, Sharon, Leslie, Eva, Nicholson, Geoffrey, Kotowicz, Mark and Berk, Michael. (2011) Habitual physical activity and the risk for depressive and anxiety disorders among older men and women. International Psychogeriatrics. 23(2), pp. 292 - 298. https://doi.org/10.1017/S1041610210001833
Annual feedback is an effective tool for a sustained increase in calcium intake among older women
Sanders, Kerrie, Stuart, Amanda L., Kotowicz, Mark and Nicholson, Geoff. (2010) Annual feedback is an effective tool for a sustained increase in calcium intake among older women. Nutrients. 2(9), pp. 1018 - 1025. https://doi.org/10.3390/nu2091018
Patterns of alcohol use and associated physical and lifestyle characteristics according to new Australian guidelines
Coulson, Carolyn E., Williams, Lana J., Henry, Margaret, Berk, Michael, Lubman, Dan, Brennan-Olsen, Sharon, Nicholson, Geoff, Kotowicz, Mark, Korn, S and Pasco, Julie. (2010) Patterns of alcohol use and associated physical and lifestyle characteristics according to new Australian guidelines. Australian and New Zealand Journal of Psychiatry. 44(10), pp. 946 - 951. https://doi.org/10.3109/00048674.2010.495051
Socioeconomic status, obesity and lifestyle in men: The Geelong Osteoporosis Study
Brennan-Olsen, Sharon, Henry, Margaret, Nicholson, Geoff, Kotowicz, Mark and Pasco, Julie. (2010) Socioeconomic status, obesity and lifestyle in men: The Geelong Osteoporosis Study. Journal of Men's Health. 7(1), pp. 31 - 41. https://doi.org/10.1016/j.jomh.2009.10.004
Does an increase in body mass index over 10 years affect knee structure in a population-based cohort study of adult women?
Brennan-Olsen, Sharon, Cicuttini, Flavia, Pasco, Julie, Henry, Margaret, Wang, Yuanyuan, Kotowicz, Mark, Nicholson, Geoff and Wluka, Anita. (2010) Does an increase in body mass index over 10 years affect knee structure in a population-based cohort study of adult women? Arthritis Research and Therapy. 12(4), pp. 1 - 7. https://doi.org/10.1186/ar3078
Smoking predicts incident fractures in elderly men: Mr OS Sweden
Jutberger, Hans, Lorentzon, Mattias, Barrett-Connor, Elizabeth, Johansson, Helena, Kanis, John, Ljunggren, Östen, Karlsson, Magnus, Rosengren, Björn E., Redlund-Johnell, Inga, Orwoll, E, Ohlsson, Claes and Mellström, Dan. (2010) Smoking predicts incident fractures in elderly men: Mr OS Sweden. Journal of Bone and Mineral Research. 25(5), pp. 1010 - 1016. https://doi.org/10.1359/jbmr.091112
Annual high-dose oral vitamin D and falls and fractures in older women: A randomized controlled trial
Sanders, Kerrie, Stuart, Amanda L., Williamson, Elizabeth J., Simpson, Julie A., Kotowicz, Mark, Young, Doris and Nicholson, Geoff. (2010) Annual high-dose oral vitamin D and falls and fractures in older women: A randomized controlled trial. JAMA: Journal of the American Medical Association. 303(18), pp. 1815 - 1822. https://doi.org/10.1001/jama.2010.594
Socioeconomic status and bone mineral density in a population-based sample of men
Brennan-Olsen, Sharon, Henry, Margaret, Wluka, Anita, Nicholson, Geoff, Kotowicz, Mark and Pasco, Julie. (2010) Socioeconomic status and bone mineral density in a population-based sample of men. Bone. 46(4), pp. 993 - 999. https://doi.org/10.1016/j.bone.2009.12.029