Neural correlates of symptom severity in obsessive-compulsive disorder using magnetization transfer and diffusion tensor imaging
Journal article
Maleki, Suzan, Chye, Yann, Zhang, Xiaoliu, Parkes, Linden, Chamberlain, Samuel R., Fontenelle, Leonardo F., Braganza, Leah, Youssef, George, Lorenzetti, Valentina, Harrison, Ben J., Yücel, Murat and Suo, Chao. (2020). Neural correlates of symptom severity in obsessive-compulsive disorder using magnetization transfer and diffusion tensor imaging. Psychiatry Research: Neuroimaging. 298, p. Article 111046. https://doi.org/10.1016/j.pscychresns.2020.111046
Authors | Maleki, Suzan, Chye, Yann, Zhang, Xiaoliu, Parkes, Linden, Chamberlain, Samuel R., Fontenelle, Leonardo F., Braganza, Leah, Youssef, George, Lorenzetti, Valentina, Harrison, Ben J., Yücel, Murat and Suo, Chao |
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Abstract | Recent neuroimaging studies in OCD have reported structural alterations in the brain, not limited to frontostriatal regions. While Diffusion Tensor Imaging (DTI) is typically used to interrogate WM microstructure in OCD, additional imaging metric, such as Magnetization Transfer Imaging (MTI), allows for further identification of subtle but important structural changes across both GM and WM. In this study, both MTI and DTI were utilised to investigate the structural integrity of the brain, in OCD in relation to healthy controls. 38 adult OCD patients were recruited, along with 41 age- and gender-matched controls. Structural T1, MTI and DTI data were collected. Case-control differences in Magnetization Transfer Ratio (MTR) and DTI metrics (FA, MD) were examined, along with MTR/DTI-related associations with symptom severity in patients. No significant group differences were found across MTR, FA, and MD. However, OCD symptom severity was positively correlated with MTR in a distributed network of brain regions, including the striatum, cingulate, orbitofrontal area and insula. Within the same regions, OCD symptoms were also positively correlated with FA in WM, and negatively correlated with MD in GM. These results indicate a greater degree of myelination in certain cortical and subcortical regions in the more severe cases of OCD. |
Keywords | magnetization transfer imaging; obsessive-compulsive disorder; diffusion tensor imaging; MTI; OCD; DTI |
Year | 2020 |
Journal | Psychiatry Research: Neuroimaging |
Journal citation | 298, p. Article 111046 |
Publisher | Elsevier B.V. |
ISSN | 0925-4927 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.pscychresns.2020.111046 |
PubMed ID | 32106018 |
Scopus EID | 2-s2.0-85079833644 |
PubMed Central ID | PMC7100004 |
Open access | Published as green open access |
Page range | 1-8 |
Funder | National Health and Medical Research Council (NHMRC) |
Australian Research Council (ARC) | |
Department of Industry, Innovation and Science (DIIS), Australian Government | |
David Winston Turner Endowment Fund | |
Wilson Foundation | |
Wellcome Trust | |
Conselho Nacional de Desenvolvimento Científico e Tecnológico | |
Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro | |
Author's accepted manuscript | License File Access Level Open |
Publisher's version | License All rights reserved File Access Level Controlled |
Output status | Published |
Publication dates | |
Online | 11 Feb 2020 |
Publication process dates | |
Accepted | 04 Feb 2020 |
ARC Funded Research | This output has been funded, wholly or partially, under the Australian Research Council Act 2001 |
Grant ID | NHMRC/1117188 |
110049/Z/15/Z | |
308237/2014-5 | |
203590 |
https://acuresearchbank.acu.edu.au/item/8w590/neural-correlates-of-symptom-severity-in-obsessive-compulsive-disorder-using-magnetization-transfer-and-diffusion-tensor-imaging
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AM_Maleki_2020_Neural_correlates_of_symptom_severity_in.pdf | |
License: CC BY-NC-ND 4.0 | |
File access level: Open |
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