Predicting alcohol dependence from multi-site brain structural measures

Journal article


Hahn, Sage, Mackey, Scott, Cousijn, Janna, Foxe, John J., Heinz, Andreas, Hester, Robert, Hutchinson, Kent, Kiefer, Falk, Korucuoglu, Ozlem, Lett, Tristram, Li, Chiang-Shan R., London, Edythe, Lorenzetti, Valentina, Maartje, Luijten, Momenan, Reza, Orr, Catherine, Paulus, Martin, Schmaal, Lianne, Sinha, Rajita, ... Garavan, Hugh. (2020). Predicting alcohol dependence from multi-site brain structural measures. Human Brain Mapping. pp. 1-11. https://doi.org/10.1002/hbm.25248
AuthorsHahn, Sage, Mackey, Scott, Cousijn, Janna, Foxe, John J., Heinz, Andreas, Hester, Robert, Hutchinson, Kent, Kiefer, Falk, Korucuoglu, Ozlem, Lett, Tristram, Li, Chiang-Shan R., London, Edythe, Lorenzetti, Valentina, Maartje, Luijten, Momenan, Reza, Orr, Catherine, Paulus, Martin, Schmaal, Lianne, Sinha, Rajita, Sjoerds, Zsuzsika, Stein, Dan J., Stein, Elliot, van Holst, Ruth J., Veltman, Dick, Walter, Henrik, Wiers, Reinout W., Yucel, Murat, Thompson, Paul M., Conrod, Patricia, Allgaier, Nicholas and Garavan, Hugh
Abstract

To identify neuroimaging biomarkers of alcohol dependence (AD) from structural magnetic resonance imaging, it may be useful to develop classification models that are explicitly generalizable to unseen sites and populations. This problem was explored in a mega-analysis of previously published datasets from 2,034 AD and comparison participants spanning 27 sites curated by the ENIGMA Addiction Working Group. Data were grouped into a training set used for internal validation including 1,652 participants (692 AD, 24 sites), and a test set used for external validation with 382 participants (146 AD, 3 sites). An exploratory data analysis was first conducted, followed by an evolutionary search based feature selection to site generalizable and high performing subsets of brain measurements. Exploratory data analysis revealed that inclusion of case- and control-only sites led to the inadvertent learning of site-effects. Cross validation methods that do not properly account for site can drastically overestimate results. Evolutionary-based feature selection leveraging leave-one-site-out cross-validation, to combat unintentional learning, identified cortical thickness in the left superior frontal gyrus and right lateral orbitofrontal cortex, cortical surface area in the right transverse temporal gyrus, and left putamen volume as final features. Ridge regression restricted to these features yielded a test-set area under the receiver operating characteristic curve of 0.768. These findings evaluate strategies for handling multi-site data with varied underlying class distributions and identify potential biomarkers for individuals with current AD.

Keywordsaddiction; alcohol dependence; genetic algorithm; machine learning; multi-site; prediction; structural MRI
Year2020
JournalHuman Brain Mapping
Journal citationpp. 1-11
PublisherJohn Wiley & Sons
ISSN1065-9471
Digital Object Identifier (DOI)https://doi.org/10.1002/hbm.25248
Scopus EID2-s2.0-85092600277
Open accessPublished as ‘gold’ (paid) open access
Research or scholarlyResearch
Page range1-11
Publisher's version
License
File Access Level
Open
Output statusPublished
Publication dates
Online16 Oct 2020
Publication process dates
Accepted06 Oct 2020
Deposited12 Jul 2021
Permalink -

https://acuresearchbank.acu.edu.au/item/8w5v2/predicting-alcohol-dependence-from-multi-site-brain-structural-measures

Download files


Publisher's version
  • 78
    total views
  • 16
    total downloads
  • 2
    views this month
  • 1
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Daily cannabidiol administration for 10 weeks modulates hippocampal and amygdalar resting-state functional connectivity in cannabis users : A fMRI open-label clinical trial
Lorenzetti, Valentina, McTavish, Eugene, Broyd, Samantha, van Hell, Hendrika, Ganella, Eleni, Kottaram, Akhil Raja, Beale, Camilla, Martin, Jennifer, Galettis, Peter, Solowij, Nadia and Greenwood, Lisa-Marie. (2023). Daily cannabidiol administration for 10 weeks modulates hippocampal and amygdalar resting-state functional connectivity in cannabis users : A fMRI open-label clinical trial. Cannabis and Cannabinoid Research. pp. 1-14. https://doi.org/10.1089/can.2022.0336
Brain volumes in alcohol use disorder : Do females and males differ? A whole-brain magnetic resonance imaging mega-analysis
Maggioni, Eleonora, Rossetti, Maria G., Allen, Nicholas B., Batalla, Albert, Bellani, Marcella, Chye, Yann, Cousijn, Janna, Goudriaan, Anna E., Hester, Robert, Hutchison, Kent, Li, Chiang-Shan R., Martin-Santos, Rocio, Momenan, Reza, Sinha, Rajita, Schmaal, Lianne, Solowij, Nadia, Suo, Chao, van Holst, Ruth J., Veltman, Dick J., ... Lorenzetti, Valentina. (2023). Brain volumes in alcohol use disorder : Do females and males differ? A whole-brain magnetic resonance imaging mega-analysis. Human Brain Mapping. 44, p. 4652–4666. https://doi.org/10.1002/hbm.26404
Transcultural aspects of cannabis use : A descriptive overview of cannabis use across cultures
Rafei, Parnian, Englund, Amir, Lorenzetti, Valentina, Elkholy, Hussien, Potenza, Marc N. and Baldacchino, Alex. (2023). Transcultural aspects of cannabis use : A descriptive overview of cannabis use across cultures. Current Addiction Reports. 10, p. 458–471. https://doi.org/10.1007/s40429-023-00500-8
Do mindfulness-based interventions change brain function in people with substance dependence? A systematic review of the fMRI evidence
Lorenzetti, Valentina, Gaillard, Alexandra, Beyer, Emillie, Kowalczyk, Magdalena, Kamboj, Sunjeev K., Manning, Victoria and Gleeson, John Francis Martin. (2023). Do mindfulness-based interventions change brain function in people with substance dependence? A systematic review of the fMRI evidence. BMC Psychiatry. 23(1), p. Article 407. https://doi.org/10.1186/s12888-023-04789-7
Cognitive training and remediation interventions for substance use disorders : A Delphi consensus study
Verdejo-Garcia, Antonio, Rezapour, Tara, Giddens, Emily, Khojasteh Zonoozi, Arash, Rafei, Parnian, Berry, Jamie, Caracuel, Alfonso, Copersino, Marc L., Field, Matt, Garland, Eric L., Lorenzetti, Valentina, Malloy-Diniz, Leandro, Manning, Victoria, Marceau, Ely M., Pennington, David L., Strickland, Justin C., Wiers, Reinout, Fairhead, Rahia, Anderson, Alexandra, ... Ekhtiari, Hamed. (2023). Cognitive training and remediation interventions for substance use disorders : A Delphi consensus study. Addiction. 118(5), pp. 935-951. https://doi.org/10.1111/add.16109
Motivational and myopic mechanisms underlying dopamine medication-induced impulsive-compulsive behaviors in Parkinson's disease
Dawson, Andrew, Ortelli, Paola, Carter, Adrian, Ferrazzoli, Davide, Dissanayaka, Nadeeka N., Evans, Andrew, Chye, Yann, Lorenzetti, Valentina, Frazzitta, Giuseppe and Yucel, Murat. (2023). Motivational and myopic mechanisms underlying dopamine medication-induced impulsive-compulsive behaviors in Parkinson's disease. Frontiers in Behavioral Neuroscience. 16, p. Article 949406. https://doi.org/10.3389/fnbeh.2022.949406
Measuring white matter microstructure in 1,457 cannabis users and 1,441 controls : A systematic review of diffusion-weighted MRI studies
Robinson, Emily Anne, Gleeson, John, Arun, Arush Honnedevasthana, Clemente, Adam, Gaillard, Alexandra, Rossetti, Maria Gloria, Brambilla, Paolo, Bellani, Marcella, Crisanti, Camilla, Curran, Valerie H. and Lorenzetti, Valentina. (2023). Measuring white matter microstructure in 1,457 cannabis users and 1,441 controls : A systematic review of diffusion-weighted MRI studies. Frontiers in Neuroimaging. 2, p. Article 1129587. https://doi.org/10.3389/fnimg.2023.1129587
Effects of cannabinoids on resting state functional brain connectivity : A systematic review
Lorenzetti, Valentina, Gaillard, Alexandra, Thomson, Diny, Englund, Amir and Freeman, Tom P.. (2023). Effects of cannabinoids on resting state functional brain connectivity : A systematic review. Neuroscience and Biobehavioral Reviews. 145, p. Article 105014. https://doi.org/10.1016/j.neubiorev.2022.105014
Using the standard THC unit to regulate THC content in legal cannabis markets [Commentary]
Freeman, Tom P. and Lorenzetti, Valentina. (2023). Using the standard THC unit to regulate THC content in legal cannabis markets [Commentary]. Addiction. 118(6), pp. 1007-1009. https://doi.org/10.1111/add.16183
Brain structural covariance network differences in adults with alcohol dependence and heavy-drinking adolescents
Ottino-Gonzalez, Jonatan, Garavan, Hugh, Albaugh, Matthew D., Cao, Zhipeng, Cupertino, Renata B., Schwab, Nathan, Spechler, Philip A., Allen, Nicholas, Artiges, Eric, Banaschewski, Tobias, Bokde, Arun L. W., Burke Quinlan, Erin, Brühl, Rüdiger, Orr, Catherine, Cousijn, Janna, Desrivieres, Sylvane, Flor, Herta, Foxe, John J., Fröhner, Juliane H., ... Mackey, Scott. (2022). Brain structural covariance network differences in adults with alcohol dependence and heavy-drinking adolescents. Addiction. 117(5), pp. 1312-1325. https://doi.org/10.1111/add.15772
Different frequency of Heschl’s gyrus duplication patterns in neuropsychiatric disorders : An MRI study in bipolar and major depressive disorders
Takahashi, Tsutomu, Sasabayashi, Daiki, Yücel, Murat, Whittle, Sarah, Lorenzetti, Valentina, Walterfang, Mark, Suzuki, Michio, Pantelis, Christos, Malhi, Gin S. and Allen, Nicholas B.. (2022). Different frequency of Heschl’s gyrus duplication patterns in neuropsychiatric disorders : An MRI study in bipolar and major depressive disorders. Frontiers in Human Neuroscience. 16, p. Article 917270. https://doi.org/10.3389/fnhum.2022.917270
Focused attention meditation in healthy adults : A systematic review and meta-analysis of cross-sectional functional MRI studies
Ganesan, Saampras, Beyer, Emillie, Moffat, Bradford, Van Dam, Nicholas T., Lorenzetti, Valentina and Zalesky, Andrew. (2022). Focused attention meditation in healthy adults : A systematic review and meta-analysis of cross-sectional functional MRI studies. Neuroscience and Biobehavioral Reviews. 141, p. Article 104846. https://doi.org/10.1016/j.neubiorev.2022.104846
The International Cannabis Toolkit (iCannToolkit) : A multidisciplinary expert consensus on minimum standards for measuring cannabis use
Lorenzetti, Valentina, Hindocha, Chandni, Petrilli, Kat, Griffiths, Paul, Brown, Jamie, Castillo-Carniglia, Álvaro, Caulkins, Jonathan P., Englund, Amir, ElSohly, Mahmoud A., Gage, Suzanne H., Groshkova, Teodora, Gual, Antoni, Hammond, David, Lawn, Will, López-Pelayo, Hugo, Manthey, Jakob, Mokrysz, Claire, Pacula, Rosalie Liccardo, van Laar, Margriet, ... Freeman, Tom P.. (2022). The International Cannabis Toolkit (iCannToolkit) : A multidisciplinary expert consensus on minimum standards for measuring cannabis use. Addiction. 117(6), pp. 1510-1517. https://doi.org/10.1111/add.15702
Brain anatomical alterations in young cannabis users : Is it all hype? A meta-analysis of structural neuroimaging studies
Lorenzetti, Valentina, Kowalczyk, Magdalena, Duehlmeyer, Leonie, Greenwood, Lisa-Marie, Chye, Yann, Yücel, Murat, Whittle, Sarah and Roberts, Carl A.. (2022). Brain anatomical alterations in young cannabis users : Is it all hype? A meta-analysis of structural neuroimaging studies. Cannabis and Cannabinoid Research. 8(1), pp. 184-196. https://doi.org/10.1089/can.2021.0099
Is resting-state functional connectivity altered in regular cannabis users? A systematic review of the literature
Thomson, Hannah, Labuschagne, Izelle, Greenwood, Lisa-Marie, Robinson, Emily, Sehl, Hannah, Suo, Chao and Lorenzetti, Valentina. (2022). Is resting-state functional connectivity altered in regular cannabis users? A systematic review of the literature. Psychopharmacology. 239, pp. 1191-1209. https://doi.org/10.1007/s00213-021-05938-0
How do cannabis users mentally travel in time? Evidence from an fMRI study of episodic future thinking
Rafei, Parnian, Rezapour, Tara, Batouli, Seyed Amir Hossein, Verdejo-Garcia, Antonio, Lorenzetti, Valentina and Hatami, Javad. (2022). How do cannabis users mentally travel in time? Evidence from an fMRI study of episodic future thinking. Psychopharmacology. 239(5), pp. 1441-1457. https://doi.org/10.1007/s00213-021-06002-7
The iCannToolkit : A tool to embrace measurement of medicinal and non-medicinal cannabis use across licit, illicit and cross-cultural settings
Lorenzetti, Valentina, Hindocha, Chandni, Petrilli, Katherine, Griffiths, Paul, Brown, Jamie, Castillo-Carniglia, Álvaro, Caulkins, Jonathan P., Englund, Amir, ElSohly, Mahmoud A., Gage, Suzanne H., Groshkova, Teodora, Gual, Antoni, Hammond, David, Lawn, Will, López-Pelayo, Hugo, Manthey, Jakob, Mokrysz, Claire, Pacula, Rosalie Liccardo, van Laar, Margriet, ... Freeman, Tom P.. (2022). The iCannToolkit : A tool to embrace measurement of medicinal and non-medicinal cannabis use across licit, illicit and cross-cultural settings. Addiction. 117(6), pp. 1523-1525. https://doi.org/10.1111/add.15855
Reproducibility in the absence of selective reporting : An illustration from large-scale brain asymmetry research
Kong, Xiang-Zhen, ENIGMA Laterality Working Group, Francks, Clyde and Lorenzetti, Valentina*. (2022). Reproducibility in the absence of selective reporting : An illustration from large-scale brain asymmetry research. Human Brain Mapping. 43(1), pp. 244-254. https://doi.org/10.1002/hbm.25154
Resting-state neuroimaging in social anxiety disorder : A systematic review
Mizzi, Simone, Pedersen, Mangor, Lorenzetti, Valentina, Heinrichs, Markus and Labuschagne, Izelle. (2022). Resting-state neuroimaging in social anxiety disorder : A systematic review. Molecular Psychiatry. 27(1), pp. 164-179. https://doi.org/10.1038/s41380-021-01154-6
How do substance use disorders compare to other psychiatric conditions on structural brain abnormalities? A cross-disorder meta-analytic comparison using the ENIGMA consortium findings
Navarri, Xavier, Afzali, Mohammad H., Lavoie, Jacob, Sinha, Rajita, Stein, Dan J., Momenan, Reza, Veltman, Dick J., Korucuoglu, Ozlem, Sjoerds, Zsuzsika, van Holst, Ruth J., Hester, Rob, Orr, Catherine, Cousijn, Janna, Yucel, Murat, Lorenzetti, Valentina, Wiers, Reinout, Jahanshad, Neda, Glahn, David C., Thompson, Paul M., ... Conrod, Patricia J.. (2022). How do substance use disorders compare to other psychiatric conditions on structural brain abnormalities? A cross-disorder meta-analytic comparison using the ENIGMA consortium findings. Human Brain Mapping. 43(1), pp. 399-413. https://doi.org/10.1002/hbm.25114
Standard units for cannabis dose : Why is it important to standardize cannabis dose for drug policy and how can we enhance its place on the public health agenda?
López-Pelayo, Hugo, Matrai, Silvia, Balcells-Olivero, Mercè, Campeny, Eugènia, Braddick, Fleur, Bossong, Matthijs G., Cruz, Olga S., Deluca, Paolo, Dom, Geert, Feingold, Daniel, Freeman, Tom P., Guzman, Pablo, Hindocha, Chandni, Kelly, Brian C., Liebregts, Nienke, Lorenzetti, Valentina, Manthey, Jakob, Matias, João, Oliveras, Clara, ... Gual, Antoni. (2021). Standard units for cannabis dose : Why is it important to standardize cannabis dose for drug policy and how can we enhance its place on the public health agenda? International Journal of Drug Policy. 97, p. Article 103350. https://doi.org/10.1016/j.drugpo.2021.103350
A standard THC unit for reporting of health research on cannabis and cannabinoids
Freeman, Tom P. and Lorenzetti, Valentina. (2021). A standard THC unit for reporting of health research on cannabis and cannabinoids. The Lancet Psychiatry. 8(11), pp. 944-946. https://doi.org/10.1016/S2215-0366(21)00355-2
Brain imaging and substance use disorders : Focus on white matter microstructural integrity
Rossetti, Maria Gloria, Crisanti, Camilla, Brambilla, Paolo and Lorenzetti, Valentina. (2021). Brain imaging and substance use disorders : Focus on white matter microstructural integrity. In In Della Sala, Sergio (Ed.). Encyclopedia of behavioral neuroscience ; volume 1 pp. 652-673 Elsevier Science. https://doi.org/10.1016/B978-0-12-819641-0.00117-1
Dipendenza da alcol e sostanze
Rossetti, Maria Gloria, Crisanti, Camilla, Brambilla, Paolo and Lorenzetti, Valentina. (2021). Dipendenza da alcol e sostanze. In In Brambilla, Paolo (Ed.). Neuroscienze psichiatriche e computazionali pp. 272-285 Edizioni Minerva Medica.
Cannabis, cannabinoids, and brain morphology : A review of the evidence
Chye, Yann, Kirkham, Rebecca, Lorenzetti, Valentina, McTavish, Eugene, Solowij, Nadia and Yücel, Murat. (2021). Cannabis, cannabinoids, and brain morphology : A review of the evidence. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 6(6), pp. 627-635. https://doi.org/10.1016/j.bpsc.2020.07.009
Supporting future cannabis policy – developing a standard joint unit : A brief back-casting exercise
López-Pelayo, Hugo, Matrai, Silvia, Balcells-Olivero, Mercè, Campeny, Eugènia, Braddick, Fleur, Bossong, Matthijs G., Cruz, Olga S., Deluca, Paolo, Dom, Geert, Feingold, Daniel, Freeman, Tom P., Guzman, Pablo, Hindocha, Chandni, Kelly, Brian C., Liebregts, Nienke, Lorenzetti, Valentina, Manthey, Jakob, Matias, João, Oliveras, Clara, ... Gual, Antoni. (2021). Supporting future cannabis policy – developing a standard joint unit : A brief back-casting exercise. Frontiers in Psychiatry. 12, p. Article: 675033. https://doi.org/10.3389/fpsyt.2021.675033
Mapping cortical and subcortical asymmetries in substance dependence : Findings from the ENIGMA Addiction Working Group
Cao, Zhipeng, Ottino-Gonzalez, Jonatan, Cupertino, Renata B., Schwab, Nathan, Hoke, Colin, Catherine, Orr, Cousijn, Janna, Dagher, Alain, Foxe, John J., Goudriaan, Anna E., Hester, Robert, Hutchison, Kent, Li, Chiang-Shan R., London, Edythe D., Lorenzetti, Valentina, Luijten, Maartje, Martin-Santos, Rocio, Momenan, Reza, Paulus, Martin P., ... Garavan, Hugh. (2021). Mapping cortical and subcortical asymmetries in substance dependence : Findings from the ENIGMA Addiction Working Group. Addiction Biology. 26, p. Article e13010. https://doi.org/10.1111/adb.13010
Patterns of brain function associated with cannabis cue-reactivity in regular cannabis users : A systematic review of fMRI studies
Sehl, Hannah, Terrett, Gill, Greenwood, Lisa-Marie, Kowalczyk, Magdalena, Thomson, Hannah, Poudel, Govinda, Manning, Victoria and Lorenzetti, Valentina. (2021). Patterns of brain function associated with cannabis cue-reactivity in regular cannabis users : A systematic review of fMRI studies. Psychopharmacology. 238(10), pp. 2709-2728. https://doi.org/10.1007/s00213-021-05973-x
Sex differences in the neuroanatomy of alcohol dependence : Hippocampus and amygdala subregions in a sample of 966 people from the ENIGMA Addiction Working Group
Grace, Sally, Rossetti, Maria Gloria, Allen, Nicholas, Batalla, Albert, Bellani, Marcella, Brambilla, Paolo, Chye, Yann, Cousijn, Janna, Goudriaan, Anna E., Hester, Robert, Hutchison, Kent, Labuschagne, Izelle, Momenan, Reza, Martin-Santos, Rocio, Rendell, Peter, Solowij, Nadia, Sinha, Rajita, Li, Chiang-shan Ray, Schmaal, Lianne, ... Lorenzetti, Valentina. (2021). Sex differences in the neuroanatomy of alcohol dependence : Hippocampus and amygdala subregions in a sample of 966 people from the ENIGMA Addiction Working Group. Translational Psychiatry. 11(1), p. Article 156. https://doi.org/10.1038/s41398-021-01204-1
Sex and dependence related neuroanatomical differences in regular cannabis users : Findings from the ENIGMA Addiction Working Group
Rossetti, Maria Gloria, Mackey, Scott, Patalay, Praveetha, Allen, Nicholas B., Batalla, Albert, Bellani, Marcella, Chye, Yann, Conrod, Patricia, Cousijn, Janna, Garavan, Hugh, Goudriaan, Anna E., Hester, Robert, Martin-Santos, Rocio, Solowij, Nadia, Suo, Chao, Thompson, Paul M., Yücel, Murat, Brambilla, Paolo and Lorenzetti, Valentina. (2021). Sex and dependence related neuroanatomical differences in regular cannabis users : Findings from the ENIGMA Addiction Working Group. Translational Psychiatry. 11(1), p. Article 272. https://doi.org/10.1038/s41398-021-01382-y
Investigating the residual effects of chronic cannabis use and abstinence on verbal and visuospatial learning
Lorenzetti, Valentina, Takagi, Michael, van Dalen, Yvonne, Yücel, Murat and Solowij, Nadia. (2021). Investigating the residual effects of chronic cannabis use and abstinence on verbal and visuospatial learning. Frontiers in Psychiatry. 12, p. Article 663701. https://doi.org/10.3389/fpsyt.2021.663701
Gender-related neuroanatomical differences in alcohol dependence : Findings from the ENIGMA Addiction Working Group
Rossetti, Maria Gloria, Patalay, Praveetha, Mackey, Scott, Allen, Nicholas B., Batalla, Albert, Bellani, Marcella, Chye, Yann, Cousijn, Janna, Goudriaan, Anna E., Hester, Robert, Hutchison, Kent, Li, Chiang-Shan R., Martin-Santos, Rocio, Momenan, Reza, Sinha, Rajita, Schmaal, Lianne, Sjoerds, Zsuzsika, Solowij, Nadia, Suo, Chao, ... Lorenzetti, Valentina. (2021). Gender-related neuroanatomical differences in alcohol dependence : Findings from the ENIGMA Addiction Working Group. NeuroImage: Clinical. 30, p. Article 102636. https://doi.org/10.1016/j.nicl.2021.102636
Do comorbid personality disorders in cocaine dependence exacerbate neuroanatomical alterations? A structural neuroimaging study
Roberts, Carl A., Lorenzetti, Valentina, Albein-Urios, Natalia, Kowalczyk, Magdalena A., Martinez-Gonzalez, Jose M. and Verdejo-Garcia, Antonio. (2021). Do comorbid personality disorders in cocaine dependence exacerbate neuroanatomical alterations? A structural neuroimaging study. Progress in Neuropsychopharmacology and Biological Psychiatry. 110, p. 110298. https://doi.org/10.1016/j.pnpbp.2021.110298
Moving forwards with the standard THC unit [Commentary]
Freeman, Tom and Lorenzetti, Valentina. (2020). Moving forwards with the standard THC unit [Commentary] John Wiley & Sons Ltd. https://doi.org/10.1111/add.15107
Mapping and mitigating the health risks of legalizing recreational cannabis use : A call for synergy between research and policy
Hoch, Eva and Lorenzetti, Valentina. (2020). Mapping and mitigating the health risks of legalizing recreational cannabis use : A call for synergy between research and policy. World Psychiatry. 19(2), pp. 189-191. https://doi.org/10.1002/wps.20738
‘Standard THC units’ : A proposal to standardize dose across all cannabis products and methods of administration
Freeman, Tom P. and Lorenzetti, Valentina. (2020). ‘Standard THC units’ : A proposal to standardize dose across all cannabis products and methods of administration. Addiction. 115(7), pp. 1207-1216. https://doi.org/10.1111/add.14842
Neuroanatomical alterations in people with high and low cannabis dependence
Lorenzetti, Valentina, Chye, Yann, Suo, Chao, Walterfang, Mark, Lubman, Dan I., Takagi, Michael, Whittle, Sarah, Verdejo-Garcia, Antonio, Cousijn, Janna, Pantelis, Christos, Seal, Marc, Fornito, Alex, Yücel, Murat and Solowij, Nadia. (2020). Neuroanatomical alterations in people with high and low cannabis dependence. Australian and New Zealand Journal of Psychiatry. 54(1), pp. 68-75. https://doi.org/10.1177/0004867419859077
Young adults with higher motives and expectancies of regular cannabis use show poorer psychosocial functioning
Amiet, Danielle, Youssef, George J., Hagg, Lauryn J., Lorenzetti, Valentina, Parkes, Linden, Solowij, Nadia and Yücel, Murat. (2020). Young adults with higher motives and expectancies of regular cannabis use show poorer psychosocial functioning. Frontiers in Psychiatry. 11, p. 599365. https://doi.org/10.3389/fpsyt.2020.599365
Unpacking common and distinct neuroanatomical alterations in cocaine dependent versus pathological gambling
Irizar, Patricia, Albein-Urios, Natalia, Martínez-González, José Miguel, Verdejo-Garcia, Antonio and Lorenzetti, Valentina. (2020). Unpacking common and distinct neuroanatomical alterations in cocaine dependent versus pathological gambling. European Neuropsychopharmacology. 33, pp. 81-88. https://doi.org/10.1016/j.euroneuro.2020.01.019
Pineal gland volume in major depressive and bipolar disorders
Takahashi, Tsutomu, Sasabayashi, Daiki, Yücel, Murat, Whittle, Sarah, Lorenzetti, Valentina, Walterfang, Mark, Suzuki, Michio, Pantelis, Christos, Malhi, Gin S. and Allen, Nicholas B.. (2020). Pineal gland volume in major depressive and bipolar disorders. Frontiers in Psychiatry. 11, p. 450. https://doi.org/10.3389/fpsyt.2020.00450
Neural correlates of symptom severity in obsessive-compulsive disorder using magnetization transfer and diffusion tensor imaging
Maleki, Suzan, Chye, Yann, Zhang, Xiaoliu, Parkes, Linden, Chamberlain, Samuel R., Fontenelle, Leonardo F., Braganza, Leah, Youssef, George, Lorenzetti, Valentina, Harrison, Ben J., Yücel, Murat and Suo, Chao. (2020). Neural correlates of symptom severity in obsessive-compulsive disorder using magnetization transfer and diffusion tensor imaging. Psychiatry Research: Neuroimaging. 298, p. Article 111046. https://doi.org/10.1016/j.pscychresns.2020.111046
Brain-derived neurotrophic factor association with amygdala response in major depressive disorder
Lorenzetti, Valentina, Costafreda, Sergi G., Rimmer, Rachael M., Rasenick, Mark M., Marangell, Lauren B. and Fu, Cynthia H. Y.. (2020). Brain-derived neurotrophic factor association with amygdala response in major depressive disorder. Journal of Affective Disorders. 267, pp. 103-106. https://doi.org/10.1016/j.jad.2020.01.159
Adolescent cannabis use, cognition, brain health and educational outcomes : A review of the evidence
Lorenzetti, Valentina, Hoch, Eva and Hall, Wayne. (2020). Adolescent cannabis use, cognition, brain health and educational outcomes : A review of the evidence. European Neuropsychopharmacology. 36, pp. 169-180. https://doi.org/10.1016/j.euroneuro.2020.03.012
Accuracy of automated amygdala MRI segmentation approaches in Huntington's disease in the IMAGE-HD cohort
Alexander, Bonnie, Georgiou-Karistianis, Nellie, Beare, Richard, Ahveninen, Lotta M., Lorenzetti, Valentina, Stout, Julie C. and Glikmann-Johnston, Yifat. (2020). Accuracy of automated amygdala MRI segmentation approaches in Huntington's disease in the IMAGE-HD cohort. Human Brain Mapping. 41(7), pp. 1875-1888. https://doi.org/10.1002/hbm.24918
Subcortical surface morphometry in substance dependence : An ENIGMA addiction working group study
Chye, Yann, Mackey, Scott, Gutman, Boris A., Ching, Christopher R. K., Batalla, Albert, Blaine, Sara, Brooks, Samantha, Caparelli, Elisabeth C., Cousijn, Janna, Dagher, Alain, Foxe, John J., Goudriaan, Anna E., Hester, Robert, Hutchison, Kent, Jahanshad, Neda, Kaag, Anne M., Korucuoglu, Ozlem, Li, Chiang-Shan R., London, Edythe D., ... Garavan, Hugh. (2020). Subcortical surface morphometry in substance dependence : An ENIGMA addiction working group study. Addiction Biology. 25(6), p. e12830. https://doi.org/10.1111/adb.12830
Cannabis use and mental health : Risks and benefits [Editorial]
Hall, Wayne, Hoch, Eva and Lorenzetti, Valentina. (2019). Cannabis use and mental health : Risks and benefits [Editorial]. European Archives of Psychiatry and Clinical Neuroscience. 269, pp. 1-3. https://doi.org/10.1007/s00406-019-00986-2
Neuroanatomical alterations in people with high and low cannabis dependence
Lorenzetti, Valentina, Chye, Yann, Suo, Chao, Walterfang, Mark, Lubman, Dan I., Takagi, Michael, Whittle, Sarah, Verdejo-Garcia, Antonio, Cousijn, Janna, Pantelis, Christos, Seal, Marc, Fornito, Alex, Yücel, Murat and Solowij, Nadia. (2019). Neuroanatomical alterations in people with high and low cannabis dependence. Australian and New Zealand Journal of Psychiatry. 54(1), pp. 68-75. https://doi.org/10.1177/0004867419859077
A roadmap for integrating neuroscience into addiction treatment : A consensus of the neuroscience interest group of the international society of addiction medicine
Verdejo-Garcia, Antonio, Lorenzetti, Valentina, Manning, Victoria, Piercy, Hugh, Bruno, Raimondo, Hester, Rob, Pennington, David, Tolomeo, Serenella, Arunogiri, Shalini, Bates, Marsha E., Bowden-Jones, Henrietta, Campanella, Salvatore, Daughters, Stacey B., Kouimtsidis, Christos, Lubman, Dan I., Meyerhoff, Dieter J., Ralph, Annaketurah, Rezapour, Tara, Tavakoli, Hosna, ... Ekhtiari, Hamed. (2019). A roadmap for integrating neuroscience into addiction treatment : A consensus of the neuroscience interest group of the international society of addiction medicine. Frontiers in Psychiatry. 10, p. Article 877. https://doi.org/10.3389/fpsyt.2019.00877
Defining compulsive behavior
Luigjes, Judy, Lorenzetti, Valentina, de Haan, Sanneke, Youssef, George J., Murawski, Carsten, Sjoerds, Zsuzsika, van den Brink, Wim, Denys, Damiaan, Fontenelle, Leonardo F. and Yücel, Murat. (2019). Defining compulsive behavior. Neuropsychology Review. 29(1), pp. 4-13. https://doi.org/10.1007/s11065-019-09404-9
Transdiagnostic variations in impulsivity and compulsivity in obsessive-compulsive disorder and gambling disorder correlate with effective connectivity in cortical-striatal-thalamic-cortical circuits
Parkes, Linden, Tiego, Jeggan, Aquino, Kevin, Braganza, Leah, Chamberlain, Samuel R., Fontenelle, Leonardo F., Harrison, Ben J., Lorenzetti, Valentina, Paton, Bryan, Razi, Adeel, Fornito, Alex and Yücel, Murat. (2019). Transdiagnostic variations in impulsivity and compulsivity in obsessive-compulsive disorder and gambling disorder correlate with effective connectivity in cortical-striatal-thalamic-cortical circuits. NeuroImage. 202, p. 116070. https://doi.org/10.1016/j.neuroimage.2019.116070
Does regular cannabis use affect neuroanatomy? An updated systematic review and meta-analysis of structural neuroimaging studies
Lorenzetti, Valentina, Chye, Yann, Silva, Pedro, Solowij, Nadia and Roberts, Carl A.. (2019). Does regular cannabis use affect neuroanatomy? An updated systematic review and meta-analysis of structural neuroimaging studies. European Archives of Psychiatry and Clinical Neuroscience. 269(1), pp. 59 - 71. https://doi.org/10.1007/s00406-019-00979-1
Mega-analysis of gray matter volume in substance dependence: General and substance-specific regional effects
Mackey, Scott, Allgaier, Nicholas, Chaarani, Bader, Spechler, Philip, Orr, Catherine, Bunn, Janice, Allen, Nicholas B., Alia-Klein, Nelly, Batalla, Albert, Blaine, Sara K., Brooks, Samantha, Caparelli, Elisabeth C., Chye, Yann Ying, Cousijn, Janna, Dagher, Alain, Desrivieres, Sylvane, Feldstein-Ewing, Sarah W., Foxe, John J., Goldstein, Rita Z., ... Garavan, Hugh. (2019). Mega-analysis of gray matter volume in substance dependence: General and substance-specific regional effects. American Journal of Psychiatry. 176(2), pp. 119 - 128. https://doi.org/10.1176/appi.ajp.2018.17040415
From socioeconomic disadvantage to obesity: The mediating role of psychological distress and emotional eating
Spinosa, Jade, Christiansen, Paul, Dickson, Joanne M., Lorenzetti, Valentina and Hardman, Charlotte A.. (2019). From socioeconomic disadvantage to obesity: The mediating role of psychological distress and emotional eating. Obesity. 27(4), pp. 559 - 564. https://doi.org/10.1002/oby.22402
Impulsivity and body fat accumulation are linked to cortical and subcortical brain volumes among adolescents and adults
Kakoschke, Naomi, Lorenzetti, Valentina, Caeyenberghs, Karen and Verdejo-García, Antonio. (2019). Impulsivity and body fat accumulation are linked to cortical and subcortical brain volumes among adolescents and adults. Scientific Reports. 9(1), pp. 1 - 11. https://doi.org/10.1038/s41598-019-38846-7
Alteration to hippocampal volume and shape confined to cannabis dependence: A multi-site study
Chye, Yann, Lorenzetti, Valentina, Suo, Chao, Batalla, Albert, Cousijn, Janna, Goudriaan, Anna E., Jenkinson, Mark, Martin-Santos, Rocio, Whittle, Sarah, Yücel, Murat and Solowij, Nadia. (2019). Alteration to hippocampal volume and shape confined to cannabis dependence: A multi-site study. Addiction Biology. 24(4), pp. 822 - 834. https://doi.org/10.1111/adb.12652
Cortical surface morphology in long-term cannabis users: A multi-site MRI study
Chye, Yann, Suo, Chao, Lorenzetti, Valentina, Batalla, Albert, Cousijn, Janna, Goudriaan, Anna E., Martin-Santos, Rocio, Whittle, Sarah, Solowij, Nadia and Yücel, Murat. (2019). Cortical surface morphology in long-term cannabis users: A multi-site MRI study. European Neuropsychopharmacology. 29(2), pp. 257 - 265. https://doi.org/10.1016/j.euroneuro.2018.11.1110
Reduced amygdala volumes are related to motor and cognitive signs in Huntington's disease: The IMAGE-HD study
Ahveninen, Lotta M., Stout, Julie C., Georgiou-Karistianis, Nellie, Lorenzetti, Valentina and Glikmann-Johnston, Yifat. (2018). Reduced amygdala volumes are related to motor and cognitive signs in Huntington's disease: The IMAGE-HD study. NeuroImage: Clinical. 18, pp. 881 - 887. https://doi.org/10.1016/j.nicl.2018.03.027
The anticipation and outcome phases of reward and loss processing: A neuroimaging meta-analysis of the monetary incentive delay task
Oldham, Stuart, Murawski, Carsten, Fornito, Alex, Youssef, George J., Yücel, Murat and Lorenzetti, Valentina. (2018). The anticipation and outcome phases of reward and loss processing: A neuroimaging meta-analysis of the monetary incentive delay task. Human Brain Mapping. 39(8), pp. 3398 - 3418. https://doi.org/10.1002/hbm.24184
Exploring the association of legalisation status of cannabis with problematic cannabis use and impulsivity in the USA
Destrée, Louise, Amiet, Danielle, Carter, Adrian, Lee, Rico, Lorenzetti, Valentina, Segrave, Rebecca, Youssef, George, Solowij, Nadia and Yücel, Murat. (2018). Exploring the association of legalisation status of cannabis with problematic cannabis use and impulsivity in the USA. Drugs in Context. 7, pp. 1 - 5. https://doi.org/10.7573/dic.212541
Emotion regulation using virtual environments and real-time fMRI neurofeedback
Lorenzetti, Valentina, Melo, Bruno, Basílio, Rodrigo, Suo, Chao, Yücel, Murat, Tierra-Criollo, Carlos J. and Moll, Jorge. (2018). Emotion regulation using virtual environments and real-time fMRI neurofeedback. Frontiers in Neurology. 9, pp. 1 - 15. https://doi.org/10.3389/fneur.2018.00390
Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA consortium
Kong, Xiang-Zhen, Mathias, Samuel R., Guadalupe, Tulio, ENIGMA Laterality Working Group,, Glahn, David C., Franke, Barbara, Crivello, Fabrice, Tzourio-Mazoyer, Nathalie, Fisher, Simon E., Thompson, Paul M., Francks, Clyde, Lorenzetti, Valentina and ENIGMA Laterality Working Group. (2018). Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA consortium. Proceedings of the National Academy of Sciences of USA. 115(22), pp. E5154 - E5163. https://doi.org/10.1073/pnas.1718418115
A systematic review and meta-analysis of the neural correlates of psychological therapies in major depression
Sankar, Anjali, Melin, Alice, Lorenzetti, Valentina, Horton, Paul, Costafreda, Sergi G. and Fu, Cynthia H. Y.. (2018). A systematic review and meta-analysis of the neural correlates of psychological therapies in major depression. Psychiatry Research: Neuroimaging. 279, pp. 31 - 39. https://doi.org/10.1016/j.pscychresns.2018.07.002
A transdiagnostic dimensional approach towards a neuropsychological assessment for addiction: an international Delphi consensus study
Yucel, Murat, Oldenhof, Erin, Ahmed, Serge H., Belin, David, Billieux, Joel, Bowden-Jones, Henrietta, Carter, Adrian, Chamberlain, Samuel R., Clark, Luke, Connor, Jason P., Daglish, Mark, Dom, Geert, Dannon, Pinhas, Duka, Theodora, Fernandez-Serrano, Maria Jose, Field, Matt, Franken, Ingmar, Goldstein, Rita Z., Gonzalez, Raul, ... Verdejo-Garcia, Antonio. (2018). A transdiagnostic dimensional approach towards a neuropsychological assessment for addiction: an international Delphi consensus study. Addiction. 114(6), pp. 1095 - 1109. https://doi.org/10.1111/add.14424
Unpacking the role of self-reported compulsivity and impulsivity in obsessive-compulsive disorder
Prochazkova, Luisa, Parkes, Linden, Dawson, Andrew, Youssef, George J., Ferreira, Gabriela M., Lorenzetti, Valentina, Segrave, Rebecca A., Fontenelle, Leonardo F. and Yücel, Murat. (2018). Unpacking the role of self-reported compulsivity and impulsivity in obsessive-compulsive disorder. CNS Spectrums. 23(1), pp. 51 - 58. https://doi.org/10.1017/S1092852917000244
Neuroscience in gambling policy and treatment: an interdisciplinary perspective
Murat Yucel, Adrian Carter, Amy R Allen, Bernard Balleine, Luke Clark, Nicki A Dowling, Sally M Gainsbury, Anna E Goudriaan, Jon Grant, Alan Hayes, David Hodgins, Ruth van Holst, Ralph Lattimore, Charles Livingstone, Valentina Lorenzetti, Dan Lubman, Carsten Murawski, Linden Parkes, Nancy Petry, ... Wayne Hall. (2017). Neuroscience in gambling policy and treatment: an interdisciplinary perspective. The Lancet Psychiatry. 4(6), pp. 501-506. https://doi.org/10.1016/S2215-0366(16)30369-8
Orbitofrontal and caudate volumes in cannabis users: A multi-site mega-analysis comparing dependent versus non-dependent users
Chye, Yann, Solowij, Nadia, Suo, Chao, Batalla, Albert, Cousijn, Janna, Goudriaan, Anna E., Martin-Santos, Rocio, Whittle, Sarah, Lorenzetti, Valentina and Yücel, Murat. (2017). Orbitofrontal and caudate volumes in cannabis users: A multi-site mega-analysis comparing dependent versus non-dependent users. Psychopharmacology. 234(13), pp. 1985 - 1995. https://doi.org/10.1007/s00213-017-4606-9
Cannabis-related hippocampal volumetric abnormalities specific to subregions in dependent users
Chye, Yann, Suo, Chao, Yücel, Murat, den Ouden, Lauren, Solowij, Nadia and Lorenzetti, Valentina. (2017). Cannabis-related hippocampal volumetric abnormalities specific to subregions in dependent users. Psychopharmacology. 234(14), pp. 2149 - 2157. https://doi.org/10.1007/s00213-017-4620-y
A psychometric validation study of the Impulsive-Compulsive Behaviours Checklist: A transdiagnostic tool for addictive and compulsive behaviours
Guo, Karen, Youssef, George J., Dawson, Andrew, Parkes, Linden, Oostermeijer, Sanne, López-Solà, Clara, Lorenzetti, Valentina, Greenwood, Christopher, Fontenelle, Leonardo F. and Yücel, Murat. (2017). A psychometric validation study of the Impulsive-Compulsive Behaviours Checklist: A transdiagnostic tool for addictive and compulsive behaviours. Addictive Behaviors. 67, pp. 26 - 33. https://doi.org/10.1016/j.addbeh.2016.11.021
Longitudinal study of hippocampal volumes in heavy cannabis users
Koenders, L., Lorenzetti, Valentina, de Haan, L., Suo, C., Vingerhoets, W. A. M., van den Brink, W., Wiers, R. W., Meijer, C. J., MacHielsen, M. W. J., Goudriaan, Anna E., Veltman, D. J., Yücel, Murat and Cousijn, Janna. (2017). Longitudinal study of hippocampal volumes in heavy cannabis users. Journal of Psychopharmacology. 31(8), pp. 1027 - 1034. https://doi.org/10.1177/0269881117718380
Role of orbitofrontal sulcogyral pattern on lifetime cannabis use and depressive symptoms
Chye, Yann, Solowij, Nadia, Ganella, Eleni P., Suo, Chao, Yücel, Murat, Batalla, Albert, Cousijn, Janna, Goudriaan, Anna E., Martin-Santos, Rocio, Whittle, Sarah, Bartholomeusz, Cali F. and Lorenzetti, Valentina. (2017). Role of orbitofrontal sulcogyral pattern on lifetime cannabis use and depressive symptoms. Progress in Neuropsychopharmacology and Biological Psychiatry. 79, pp. 392 - 400. https://doi.org/10.1016/j.pnpbp.2017.07.017
Investigating the role of anticipatory reward and habit strength in obsessive-compulsive disorder
Ferreira, Gabriela M., Yücel, Murat, Dawson, Andrew, Lorenzetti, Valentina and Fontenelle, Leonardo F.. (2017). Investigating the role of anticipatory reward and habit strength in obsessive-compulsive disorder. CNS Spectrums. 22(3), pp. 295 - 304. https://doi.org/10.1017/S1092852916000535
Neuroimaging of the human brain in adolescent substance users
Takagi, Michael, Youssef, George and Lorenzetti, Valentina. (2016). Neuroimaging of the human brain in adolescent substance users. In In De Micheli, Denise, Andrade, André Luiz Monezi, da Silva, Eroy Aparecida and de Souza Formigoni, Maria Lucia Oliveira (Ed.). Drug abuse in adolescence : Neurobiological, cognitive, and psychological issues pp. 69-99 Springer. https://doi.org/10.1007/978-3-319-17795-3_6
Cannabis use disorders and altered brain morphology : Where is the evidence?
Lorenzetti, Valentina, Batalla, Albert and Cousijn, Janna. (2016). Cannabis use disorders and altered brain morphology : Where is the evidence? Current Addiction Reports. 3(2), pp. 189-198. https://doi.org/10.1007/s40429-016-0102-2
The neurobiology of cannabis use disorders: A call for evidence
Valentina Lorenzetti, Janna Cousijn, Nadia Solowij, Hugh Garavan, Chao Suo, Murat Yucel and Antonio Verdejo-Garcia. (2016). The neurobiology of cannabis use disorders: A call for evidence. Frontiers in Behavioral Neuroscience. 10, pp. 1-3. https://doi.org/10.3389/fnbeh.2016.00086
Olfactory sulcus morphology in patients with current and past major depression
Takahashi, Tsutomu, Nishikawa, Yumiko, Yücel, Murat, Whittle, Sarah, Lorenzetti, Valentina, Walterfang, Mark, Sasabayashi, Daiki, Suzuki, Michio, Pantelis, Christos and Allen, Nicholas B.. (2016). Olfactory sulcus morphology in patients with current and past major depression. Psychiatry Research: Neuroimaging. 255, pp. 60 - 65. https://doi.org/10.1016/j.pscychresns.2016.07.008
Genetic imaging consortium for addiction medicine: From neuroimaging to genes
Mackey, Scott, Kan, Kees-Jan, Chaarani, Bader, Alia-Klein, Nelly, Batalla, Albert, Brooks, Samantha, Cousijn, Janna, Dagher, Alain, de Ruiter, Michiel, Desrivieres, Sylvane, Feldstein Ewing, Sarah W., Goldstein, Rita Z., Goudriaan, Anna E., Heitzeg, Mary M., Hutchison, Kent, Li, Chiang-Shan R., London, Edythe D., Lorenzetti, Valentina, Luijten, Maartje, ... Conrod, Patricia. (2016). Genetic imaging consortium for addiction medicine: From neuroimaging to genes. In Neuroscience for addiction medicine: From prevention to rehabilitation - methods and interventions pp. 203 - 223 Elsevier. https://doi.org/10.1016/bs.pbr.2015.07.026
Adolescent cannabis use: What is the evidence for functional brain alteration?
Lorenzetti, Valentina, Alonso-Lana, Silvia, Youssef, G. J., Verdejo-Garcia, Antonio, Suo, Chao, Cousijn, Janna, Takagi, Michael, Yucel, Murat and Solowij, Nadia. (2016). Adolescent cannabis use: What is the evidence for functional brain alteration? Current Pharmaceutical Design. 22(42), pp. 6353 - 6365. https://doi.org/10.2174/1381612822666160805155922
The role of cannabinoids in neuroanatomic alterations in cannabis users
Lorenzetti, Valentina, Solowij, Nadia and Yücel, Murat. (2016). The role of cannabinoids in neuroanatomic alterations in cannabis users. Biological Psychiatry. 79(7), pp. e17 - e31. https://doi.org/10.1016/j.biopsych.2015.11.013
Hippocampal harms, protection and recovery following regular cannabis use
Yücel, Murat, Lorenzetti, Valentina, Suo, C., Zalesky, Andrew, Fornito, Alex, Takagi, Michael J., Lubman, Dan I. and Solowij, Nadia. (2016). Hippocampal harms, protection and recovery following regular cannabis use. Translational Psychiatry. 6(1), pp. 1 - 7. https://doi.org/10.1038/tp.2015.201
An MRI study of white matter tract integrity in regular cannabis users: Effects of cannabis use and age
Jakabek, David, Yucel, Murat, Lorenzetti, Valentina and Solowij, Nadia. (2016). An MRI study of white matter tract integrity in regular cannabis users: Effects of cannabis use and age. Psychopharmacology. 233(19-20), pp. 3627 - 3637. https://doi.org/10.1007/s00213-016-4398-3
Gross morphological brain changes with chronic, heavy cannabis use
Lorenzetti, Valentina, Solowij, Nadia, Whittle, Sarah, Fornito, Alex, Lubman, Dan I., Pantelis, Christos and Yücel, Murat. (2015). Gross morphological brain changes with chronic, heavy cannabis use. British Journal of Psychiatry. 206(1), pp. 77 - 78. https://doi.org/10.1192/bjp.bp.114.151407
Cortico-limbic network abnormalities in individuals with current and past major depressive disorder
Klauser, Paul, Fornito, Alex, Lorenzetti, Valentina, Davey, Christopher G., Dwyer, Dominic B., Allen, Nicholas B. and Yücel, Murat. (2015). Cortico-limbic network abnormalities in individuals with current and past major depressive disorder. Journal of Affective Disorders. 173, pp. 45 - 52. https://doi.org/10.1016/j.jad.2014.10.041
The association between regular cannabis exposure and alterations of human brain morphology: An updated review of the literature
Lorenzetti, Valentina, Solowij, Nadia, Fornito, Alex, Lubman, Dan Ian and Yücel, Murat. (2014). The association between regular cannabis exposure and alterations of human brain morphology: An updated review of the literature. Current Pharmaceutical Design. 20(13), pp. 2138 - 2167. https://doi.org/10.2174/13816128113199990435
The neural cascade of olfactory processing: A combined fMRI-EEG study
Masaoka, Yuri, Harding, Ian H., Koiwa, Nobuyoshi, Yoshida, Masaki, Harrison, Ben J., Lorenzetti, Valentina, Ida, Masahiro, Izumizaki, Masahiko, Pantelis, Christos and Homma, Ikuo. (2014). The neural cascade of olfactory processing: A combined fMRI-EEG study. Respiratory Physiology & Neurobiology. 204, pp. 71 - 77. https://doi.org/10.1016/j.resp.2014.06.008
Human amygdala volume is predicted by common DNA variation in the stathmin and serotonin transporter genes
Stjepanović, D., Lorenzetti, Valentina, Yücel, Murat, Hawi, Z. and Bellgrove, M. A.. (2013). Human amygdala volume is predicted by common DNA variation in the stathmin and serotonin transporter genes. Translational Psychiatry. 3(7), pp. 1 - 7. https://doi.org/10.1038/tp.2013.41
Alteration to hippocampal shape in cannabis users with and without schizophrenia
Solowij, Nadia, Walterfang, Mark, Lubman, Dan I., Whittle, Sarah, Lorenzetti, Valentina, Styner, Martin, Velakoulis, Dennis, Pantelis, Christos and Yucel, Murat. (2013). Alteration to hippocampal shape in cannabis users with and without schizophrenia. Schizophrenia Research. 143(1), pp. 179 - 184. https://doi.org/10.1016/j.schres.2012.10.040