Treatment of osteoporosis and osteoarthritis in the oldest old
Journal article
Fuggle, Nicholas, Laslop, Andrea, Rizzoli, René, Al-Daghri, Nasser, Alokail, Majed, Bałkowiec-Iskra, Ewa, Beaudart, Charlotte, Bruyère, Olivier, Botto-van Bemden, Angie, Burlet, Nansa, Cavalier, Etienne, Cerreta, Francesca, Chandran, Manju, Cherubini, Antonio, da Silva Rosa, Mario Miguel Coelho, Conaghan, Philip, Cortet, Bernard, Jentoft, Alfonso Cruz, Curtis, Elizabeth M., ... Harvey, Nicholas C.. (2025). Treatment of osteoporosis and osteoarthritis in the oldest old. Drugs. 85(3), pp. 343-360. https://doi.org/10.1007/s40265-024-02138-w
Authors | Fuggle, Nicholas, Laslop, Andrea, Rizzoli, René, Al-Daghri, Nasser, Alokail, Majed, Bałkowiec-Iskra, Ewa, Beaudart, Charlotte, Bruyère, Olivier, Botto-van Bemden, Angie, Burlet, Nansa, Cavalier, Etienne, Cerreta, Francesca, Chandran, Manju, Cherubini, Antonio, da Silva Rosa, Mario Miguel Coelho, Conaghan, Philip, Cortet, Bernard, Jentoft, Alfonso Cruz, Curtis, Elizabeth M., D’Amelio, Patrizia, Dawson-Hughes, Bess, Dennison, Elaine M., Hiligsmann, Mickaël, Kaufman, Jean-Marc, Maggi, Stefania, Matijevic, Radmila, McCloskey, Eugene, Messina, Daniel, Pinto, Daniel, Yerro, María Concepción Prieto, Radermecker, Régis Pierre, Rolland, Yves, Torre, Carla, Veronese, Nicola, Kanis, John A., Cooper, Cyrus, Reginster, Jean-Yves and Harvey, Nicholas C. |
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Abstract | Osteoporosis and osteoarthritis are key diseases of musculoskeletal ageing and are increasing in prevalence and burden with the progressively ageing population worldwide. These conditions are thus particularly common in ‘the oldest old’, and there are complexities of managing them within the context of extensive multimorbidity, physical and mental disability, and polypharmacy, the rates for all of which are high in this population. In this narrative review, we explore the epidemiology of osteoporosis and osteoarthritis in the oldest old before examining trials and real-world data relating to the pharmacological treatment of these diseases in older adults, including anti-resorptives and bone-forming agents in osteoporosis and symptomatic slow-acting drugs for osteoarthritis, paracetamol, and non-steroidal anti-inflammatory drugs in osteoarthritis, recognising that the oldest old are usually excluded from clinical trials. We then review the potential benefits of nutritional interventions and exercise therapy before highlighting the health economic benefits of interventions for osteoporosis and osteoarthritis. The high prevalence of risk factors for both disease and adverse events associated with treatment in the oldest old mean that careful attention must be paid to the potential benefits of intervention (including fracture risk reduction and improvements in osteoarthritis pain and function) versus the potential harms and adverse effects. Further direct evidence relating to such interventions is urgently needed from future research. |
Year | 2025 |
Journal | Drugs |
Journal citation | 85 (3), pp. 343-360 |
Publisher | Adis International Ltd. |
ISSN | 0012-6667 |
Digital Object Identifier (DOI) | https://doi.org/10.1007/s40265-024-02138-w |
PubMed ID | 39969778 |
Scopus EID | 2-s2.0-85218139899 |
PubMed Central ID | PMC11891106 |
Open access | Published as ‘gold’ (paid) open access |
Page range | 343-360 |
Funder | European Society for Clinical and Economic Aspects of Osteoporosis (ESCEO) |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 19 Feb 2025 |
Publication process dates | |
Accepted | 01 Dec 2024 |
Deposited | 04 Jun 2025 |
Additional information | © The Author(s) 2025. This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/. |
https://acuresearchbank.acu.edu.au/item/91yv8/treatment-of-osteoporosis-and-osteoarthritis-in-the-oldest-old
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License: CC BY-NC 4.0 | |
File access level: Open |
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