Analytical considerations and plans to standardize or harmonize assays for the reference bone turnover markers PINP and β-CTX in blood
Journal article
Bhattoa, Harjit P., Cavalier, Etienne, Eastell, Richard, Heijboer, Annemieke C., Jørgensen, Niklas R., Makris, Konstantinos, Ulmer, Candice Z., Kanis, John A., Cooper, Cyrus, Silverman, Stuart L. and Vasikaran, Samuel D.. (2021). Analytical considerations and plans to standardize or harmonize assays for the reference bone turnover markers PINP and β-CTX in blood. Clinica Chimica Acta. 515, pp. 16-20. https://doi.org/10.1016/j.cca.2020.12.023
Authors | Bhattoa, Harjit P., Cavalier, Etienne, Eastell, Richard, Heijboer, Annemieke C., Jørgensen, Niklas R., Makris, Konstantinos, Ulmer, Candice Z., Kanis, John A., Cooper, Cyrus, Silverman, Stuart L. and Vasikaran, Samuel D. |
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Abstract | Procollagen type I N-propeptide (PINP) and the C-terminal telopeptide of type I collagen (β-CTX) in blood have been designated as reference bone turnover markers in osteoporosis by the International Osteoporosis Foundation (IOF) and International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). The IFCC Committee on Bone Metabolism (C-BM) has examined current commercial assays and performed a multicentre study to examine the agreement between assays for PINP and β-CTX in serum and plasma. The results of these studies will inform our work towards the harmonization of PINP assays and the standardization of β-CTX assays in blood, with the development of common calibrators and reference measurement procedures in collaboration with the reagent manufacturing industry. Successful achievement of these goals will help develop universally acceptable practice guidelines for the management of osteoporosis with the inclusion of common reference intervals and treatment targets for PINP and β-CTX. |
Keywords | procollagen type I N-propeptide; PINP; C-terminal telopeptide of type I collagen; β-CTX; bone turnover markers; bone formation; bone resorption; standardization; harmonization |
Year | 2021 |
Journal | Clinica Chimica Acta |
Journal citation | 515, pp. 16-20 |
Publisher | Elsevier B.V. |
ISSN | 0009-8981 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.cca.2020.12.023 |
Scopus EID | 2-s2.0-85099205225 |
Research or scholarly | Research |
Page range | 16-20 |
Author's accepted manuscript | License File Access Level Open |
Publisher's version | License All rights reserved File Access Level Controlled |
Output status | Published |
Publication dates | |
Online | 28 Dec 2020 |
Publication process dates | |
Accepted | 18 Dec 2020 |
Deposited | 23 Jun 2021 |
https://acuresearchbank.acu.edu.au/item/8w445/analytical-considerations-and-plans-to-standardize-or-harmonize-assays-for-the-reference-bone-turnover-markers-pinp-and-ctx-in-blood
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AM_Bhattoa_2021_Analytical_considerations_and_plans_to_standardize.pdf | |
License: CC BY-NC-ND | |
File access level: Open |
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