Effects of progressive resistance training and weight loss versus weight loss alone on inflammatory and endothelial biomarkers in older adults with type 2 diabetes
Journal article
Miller, Eiliza G., Sethi, Parneet, Nowson, Carol, Dunstan, David and Daly, Rob. (2017). Effects of progressive resistance training and weight loss versus weight loss alone on inflammatory and endothelial biomarkers in older adults with type 2 diabetes. European Journal of Applied Physiology. 117(8), pp. 1669 - 1678. https://doi.org/10.1007/s00421-017-3657-2
Authors | Miller, Eiliza G., Sethi, Parneet, Nowson, Carol, Dunstan, David and Daly, Rob |
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Abstract | Purpose Type 2 diabetes has been associated with an increase in inflammatory and endothelial biomarkers, which are associated with an increased risk of cardiovascular disease and diabetes-related complications. This study examined the effects of high-intensity progressive resistance training (PRT) with moderate weight loss (WL) versus WL alone on inflammatory and endothelial biomarkers in older overweight adults with type 2 diabetes. Methods This was a 12-month randomized controlled trial in which 36 inactive, overweight adults aged 60–80 years with poorly controlled type 2 diabetes were randomized to 6 months of supervised PRT + WL or stretching (sham) exercise plus WL followed by 6 months of home-training without dietary modification. Fasted blood samples were collected at baseline and subsequent 3-month intervals with the following inflammatory [interleukin (IL)-10, IL-6, tumor necrosis factor (TNF)-α, adiponectin] and endothelial markers [resistin and intercellular adhesion molecule (ICAM)-1)] assessed. Results No significant within-group changes or between-group differences were detected for any inflammatory or endothelial biomarker following the 6-month supervised exercise and WL phase. There was a greater reduction in IL-10 at 9 months in the PRT + WL relative to WL group (P = 0.033). There was also a greater reduction in TNF-α at 9 and 12 months in the PRT + WL relative to WL group (P = 0.026 and P = 0.024, respectively). Serum adiponectin increased in the PRT + WL relative to WL group after 12 months (P = 0.036). All results were adjusted for baseline values, age, weight, sex, diabetes duration, medication use and any change in medication. Conclusions Long-term participation in PRT, independent of change in weight, can result in some improvements in certain inflammatory markers in older overweight adults with type 2 diabetes. |
Year | 2017 |
Journal | European Journal of Applied Physiology |
Journal citation | 117 (8), pp. 1669 - 1678 |
Publisher | Springer |
ISSN | 1439-6319 |
Digital Object Identifier (DOI) | https://doi.org/10.1007/s00421-017-3657-2 |
Scopus EID | 2-s2.0-85020411203 |
Page range | 1669 - 1678 |
Research Group | Mary MacKillop Institute for Health Research |
Publisher's version | File Access Level Controlled |
Place of publication | Germany |
Editors | H. Westerblad and K.R. Westerterp |
https://acuresearchbank.acu.edu.au/item/855y6/effects-of-progressive-resistance-training-and-weight-loss-versus-weight-loss-alone-on-inflammatory-and-endothelial-biomarkers-in-older-adults-with-type-2-diabetes
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