Low serum 25-hydroxyvitamin D is associated with increased risk of the development of the metabolic syndrome at five years : Results from a national, population-based prospective study (The Australian Diabetes, Obesity and Lifestyle Study : AusDiab)
Journal article
Gagnon, Claudia, Lu, Zhong, Magliano, Dianna, Dunstan, David, Shaw, Jonathan, Zimmet, Paul, Sikaris, Ken, Ebeling, Peter and Daly, Robin. (2012). Low serum 25-hydroxyvitamin D is associated with increased risk of the development of the metabolic syndrome at five years : Results from a national, population-based prospective study (The Australian Diabetes, Obesity and Lifestyle Study : AusDiab). The Journal of Clinical Endocrinology and Metabolism. 97(6), pp. 1953 - 1961. https://doi.org/10.1210/jc.2011-3187
| Authors | Gagnon, Claudia, Lu, Zhong, Magliano, Dianna, Dunstan, David, Shaw, Jonathan, Zimmet, Paul, Sikaris, Ken, Ebeling, Peter and Daly, Robin |
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| Abstract | Context: Serum 25-hydroxyvitamin D [25(OH)D] concentration has been inversely associated with the prevalence of metabolic syndrome (MetS), but the relationship between 25(OH)D and incident MetS remains unclear. Objective: We evaluated the prospective association between 25(OH)D, MetS, and its components in a large population-based cohort of adults aged 25 yr or older. Design: We used baseline (1999–2000) and 5-yr follow-up data of the Australian Diabetes, Obesity, and Lifestyle Study (AusDiab). Participants: Of the 11,247 adults evaluated at baseline, 6,537 returned for follow-up. We studied those without MetS at baseline and with complete data (n = 4164; mean age 50 yr; 58% women; 92% Europids). Outcome Measures: We report the associations between baseline 25(OH)D and 5-yr MetS incidence and its components, adjusted for age, sex, ethnicity, season, latitude, smoking, family history of type 2 diabetes, physical activity, education, kidney function, waist circumference (WC), and baseline MetS components. Results: A total of 528 incident cases (12.7%) of MetS developed over 5 yr. Compared with those in the highest quintile of 25(OH)D (≥34 ng/ml), MetS risk was significantly higher in people with 25(OH)D in the first ( < 18 ng/ml) and second (18–23 ng/ml) quintiles; odds ratio (95% confidence interval) = 1.41 (1.02–1.95) and 1.74 (1.28–2.37), respectively. Serum 25(OH)D was inversely associated with 5-yr WC (P < 0.001), triglycerides (P < 0.01), fasting glucose (P < 0.01), and homeostasis model assessment for insulin resistance (P < 0.001) but not with 2-h plasma glucose (P = 0.29), high-density lipoprotein cholesterol (P = 0.70), or blood pressure (P = 0.46). Conclusions: In Australian adults, lower 25(OH)D concentrations were associated with increased MetS risk and higher WC, serum triglyceride, fasting glucose, and insulin resistance at 5 yr. Vitamin D supplementation studies are required to establish whether the link between vitamin D deficiency and MetS is causal. |
| Year | 2012 |
| Journal | The Journal of Clinical Endocrinology and Metabolism |
| Journal citation | 97 (6), pp. 1953 - 1961 |
| ISSN | 0021-972X |
| Digital Object Identifier (DOI) | https://doi.org/10.1210/jc.2011-3187 |
| Page range | 1953 - 1961 |
| Research Group | Mary MacKillop Institute for Health Research |
| Publisher's version | File Access Level Controlled |
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