Interindividual variation in fornix microstructure and macrostructure is related to visual discrimination accuracy for scenes but not faces
Postans, Mark, Hodgetts, Carl J., Mundy, Matthew E., Jones, Derek Kenton, Lawrence, Andrew D. and Graham, Kim S.. (2014) Interindividual variation in fornix microstructure and macrostructure is related to visual discrimination accuracy for scenes but not faces. Journal of Neuroscience. 34(36), pp. 12121 - 12126. https://doi.org/10.1523/JNEUROSCI.0026-14.2014
|Authors||Postans, Mark, Hodgetts, Carl J., Mundy, Matthew E., Jones, Derek Kenton, Lawrence, Andrew D. and Graham, Kim S.|
Transection of the nonhuman primate fornix has been shown to impair learning of configurations of spatial features and object-in-scene memory. Although damage to the human fornix also results in memory impairment, it is not known whether there is a preferential involvement of this white-matter tract in spatial learning, as implied by animal studies. Diffusion-weighted MR images were obtained from healthy participants who had completed versions of a task in which they made rapid same/different discriminations to two categories of highly visually similar stimuli: ( 1 ) virtual reality scene pairs; and ( 2 ) face pairs. Diffusion-MRI measures of white-matter microstructure [fractional anisotropy ( FA ) and mean diffusivity ( MD )] and macrostructure ( tissue volume fraction, f ) were then extracted from the fornix of each participant, which had been reconstructed using a deterministic tractography protocol. Fornix MD and fmeasures correlated with scene, but not face, discrimination accuracy in both discrimination tasks. A complementary voxelwise analysis using tract-based spatial statistics suggested the crus of the fornix as a focus for this relationship. These findings extend previous reports of spatial learning impairments after fornix transection in nonhuman primates, critically highlighting the fornix as a source of interindividual variation in scene discrimination in humans.
|Keywords||discrimination learning; fornix; hippocampus; scene discrimination; tractography|
|Journal||Journal of Neuroscience|
|Journal citation||34 (36), pp. 12121 - 12126|
|Publisher||Society for Neuroscience|
|Digital Object Identifier (DOI)||https://doi.org/10.1523/JNEUROSCI.0026-14.2014|
|Open access||Open access|
|Page range||12121 - 12126|
|Research Group||School of Philosophy|
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
|Place of publication||United States|
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