Limbic white matter microstructure plasticity reflects recovery from depression
Journal article
Bracht, Tobias, Jones, Derek Kenton, Müller, Thomas J., Wiest, Roland and Walther, Sebastian. (2015). Limbic white matter microstructure plasticity reflects recovery from depression. Journal of Affective Disorders. 170, pp. 143 - 149. https://doi.org/10.1016/j.jad.2014.08.031
Authors | Bracht, Tobias, Jones, Derek Kenton, Müller, Thomas J., Wiest, Roland and Walther, Sebastian |
---|---|
Abstract | Background White matter microstructure alterations of limbic and reward pathways have been reported repeatedly for depressive episodes in major depressive disorder (MDD) and bipolar disorder (BD). However, findings during remission are equivocal. It was the aim of this study to investigate if white matter microstructure changes during the time course of clinical remission. Methods Fifteen depressed patients (11 MDD, 4 BD) underwent diffusion-weighted MRI both during depression, and during remission following successful antidepressive treatment (average time interval between scans=6 months). Fractional anisotropy (FA) was sampled along reconstructions of the supero-lateral medial forebrain bundle (slMFB), the cingulum bundle (CB), the uncinate fasciculus (UF), the parahippocampal cingulum (PHC) and the fornix. Repeated measures ANCOVAs controlling for the effect of age were calculated for each tract. Results There was a significant main effect of time (inter-scan interval) for mean-FA for the right CB and for the left PHC. For both pathways there was a significant time×age interaction. In the right CB, FA increased in younger patients, while FA decreased in older patients. In the left PHC, a reverse pattern was seen. FA changes in the right CB correlated positively with symptom reductions. Mean-FA of UF, slMFB and fornix did not change between the two time points. Limitations All patients were medicated, sample size, and lack of control group. Conclusions Right CB and left PHC undergo age-dependent plastic changes during the course of remission and may serve as a state marker in depression. UF, slMFB and FO microstructure remains stable. |
Keywords | Major depressive disorder; Bipolar disorder; Remission; Reward system; Neuroplasticity; Diffusion tensor imaging |
Year | 2015 |
Journal | Journal of Affective Disorders |
Journal citation | 170, pp. 143 - 149 |
Publisher | Elsevier |
ISSN | 0165-0327 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.jad.2014.08.031 |
Scopus EID | 2-s2.0-84907943912 |
Page range | 143 - 149 |
Publisher's version | File Access Level Controlled |
Place of publication | Netherlands |
https://acuresearchbank.acu.edu.au/item/8q03w/limbic-white-matter-microstructure-plasticity-reflects-recovery-from-depression
Restricted files
Publisher's version
178
total views0
total downloads0
views this month0
downloads this month