Strong diffusion gradients allow the separation of intra- and extra-axonal gradient-echo signals in the human brain
Journal article
Kleban, Elena, Tax, Chantal M. W., Rudrapatna, Umesh S., Jones, Derek K. and Bowtell, Richard. (2020). Strong diffusion gradients allow the separation of intra- and extra-axonal gradient-echo signals in the human brain. NeuroImage. 217, pp. 1-14. https://doi.org/10.1016/j.neuroimage.2020.116793
Authors | Kleban, Elena, Tax, Chantal M. W., Rudrapatna, Umesh S., Jones, Derek K. and Bowtell, Richard |
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Abstract | The quantification of brain white matter properties is a key area of application of Magnetic Resonance Imaging (MRI), with much effort focused on using MR techniques to quantify tissue microstructure. While diffusion MRI probes white matter (WM) microstructure by characterising the sensitivity of Brownian motion of water molecules to anisotropic structures, susceptibility-based techniques probe the tissue microstructure by observing the effect of interaction between the tissue and the magnetic field. Here, we unify these two complementary approaches by combining ultra-strong (300 mT=m) gradients with a novel Diffusion-Filtered Asymmetric Spin Echo (D-FASE) technique. Using D-FASE we can separately assess the evolution of the intra- and extra-axonal signals under the action of susceptibility effects, revealing differences in the behaviour in different fibre tracts. We observed that the effective relaxation rate of the ASE signal in the corpus callosum decreases with increasing bvalue in all subjects (from 17.1 ± 0.7 s-¹ at b = 0 s/mm² to 14.6 ± 0.7 s-¹ at b = 4800 s/mm²), while this dependence on b in the corticospinal tract is less pronounced (from 12.0 ± 1.1 s-¹ at b = 0 s/mm² to 10.7 ± 0.5 s-¹ at b = 4800 s/mm²). Voxelwise analysis of the signal evolution with respect to b-factor and acquisition delay using a microscopic model demonstrated differences in gradient echo signal evolution between the intra- and extra-axonal pools. |
Keywords | MRI contrast mechanisms; white matter; myelin; microstructure |
Year | 2020 |
Journal | NeuroImage |
Journal citation | 217, pp. 1-14 |
Publisher | Elsevier B.V. |
ISSN | 1053-8119 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.neuroimage.2020.116793 |
Scopus EID | 2-s2.0-85085004127 |
Open access | Published as ‘gold’ (paid) open access |
Research or scholarly | Research |
Page range | 1-14 |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 23 Apr 2020 |
Publication process dates | |
Accepted | 19 Mar 2020 |
Deposited | 07 May 2021 |
https://acuresearchbank.acu.edu.au/item/8vzqx/strong-diffusion-gradients-allow-the-separation-of-intra-and-extra-axonal-gradient-echo-signals-in-the-human-brain
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Publisher's version
OA_Kleban_2020_Strong_diffusion_gradients_allow_the_separation.pdf | |
License: CC BY-NC-ND 4.0 | |
File access level: Open |
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