Measuring compartmental T2-orientational dependence in human brain white matter using a tiltable RF coil and diffusion-T2 correlation MRI
Journal article
Tax, Chantal M. W., Kleban, Elena, Chamberland, Maxime, Baraković, Muhamed, Rudrapatna, Umesh and Jones, Derek K.. (2021). Measuring compartmental T2-orientational dependence in human brain white matter using a tiltable RF coil and diffusion-T2 correlation MRI. NeuroImage. 236, p. Article 117967. https://doi.org/10.1016/j.neuroimage.2021.117967
Authors | Tax, Chantal M. W., Kleban, Elena, Chamberland, Maxime, Baraković, Muhamed, Rudrapatna, Umesh and Jones, Derek K. |
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Abstract | The anisotropy of brain white matter microstructure manifests itself in orientational-dependence of various MRI contrasts, and can result in significant quantification biases if ignored. Understanding the origins of this orientation-dependence could enhance the interpretation of MRI signal changes in development, ageing and disease and ultimately improve clinical diagnosis. Using a novel experimental setup, this work studies the contributions of the intra- and extra-axonal water to the orientation-dependence of one of the most clinically-studied parameters, apparent transverse relaxation . Specifically, a tiltable receive coil is interfaced with an ultra-strong gradient MRI scanner to acquire multidimensional MRI data with an unprecedented range of acquisition parameters. Using this setup, compartmental can be disentangled based on differences in diffusional-anisotropy, and its orientation-dependence further elucidated by re-orienting the head with respect to the main magnetic field . A dependence of (compartmental) on the fibre orientation w.r.t. was observed, and further quantified using characteristic representations for susceptibility- and magic angle effects. Across white matter, anisotropy effects were dominated by the extra-axonal water signal, while the intra-axonal water signal decay varied less with fibre-orientation. Moreover, the results suggest that the stronger extra-axonal orientation-dependence is dominated by magnetic susceptibility effects (presumably from the myelin sheath) while the weaker intra-axonal orientation-dependence may be driven by a combination of microstructural effects. Even though the current design of the tiltable coil only offers a modest range of angles, the results demonstrate an overall effect of tilt and serve as a proof-of-concept motivating further hardware development to facilitate experiments that explore orientational anisotropy. These observations have the potential to lead to white matter microstructural models with increased compartmental sensitivity to disease, and can have direct consequences for longitudinal and group-wise - and diffusion-MRI data analysis, where the effect of head-orientation in the scanner is commonly ignored. |
Keywords | diffusion MRI; microstructure; 𝑇2 relaxation; directional anisotropy; myelin susceptibility |
Year | 2021 |
Journal | NeuroImage |
Journal citation | 236, p. Article 117967 |
Publisher | Elsevier Inc. |
ISSN | 1053-8119 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.neuroimage.2021.117967 |
Scopus EID | 2-s2.0-85104913897 |
Research or scholarly | Research |
Page range | 1-18 |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 29 Apr 2021 |
Publication process dates | |
Accepted | 08 Mar 2021 |
Deposited | 03 Sep 2021 |
https://acuresearchbank.acu.edu.au/item/8wv31/measuring-compartmental-t2-orientational-dependence-in-human-brain-white-matter-using-a-tiltable-rf-coil-and-diffusion-t2-correlation-mri
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Publisher's version
OA_Tax_2021_Measuring_compartmental_T2_orientational_dependence_in.pdf | |
License: CC BY 4.0 | |
File access level: Open |
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