Transferring principles of solid-state and Laplace NMR to the field of in vivo brain MRI
Journal article
Joao P. de Almeida Martins, Chantal M. W. Tax, Filip Szczepankiewicz, Derek K. Jones, Carl-Fredrik Westin and Daniel Topgaard. (2020). Transferring principles of solid-state and Laplace NMR to the field of in vivo brain MRI. Magnetic Resonance. 1(1), pp. 27-43. https://doi.org/10.5194/mr-1-27-2020
Authors | Joao P. de Almeida Martins, Chantal M. W. Tax, Filip Szczepankiewicz, Derek K. Jones, Carl-Fredrik Westin and Daniel Topgaard |
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Abstract | Magnetic resonance imaging (MRI) is the primary method for noninvasive investigations of the human brain in health, disease, and development but yields data that are difficult to interpret whenever the millimeter-scale voxels contain multiple microscopic tissue environments with different chemical and structural properties. We propose a novel MRI framework to quantify the microscopic heterogeneity of the living human brain as spatially resolved five-dimensional relaxation–diffusion distributions by augmenting a conventional diffusion-weighted imaging sequence with signal encoding principles from multidimensional solid-state nuclear magnetic resonance (NMR) spectroscopy, relaxation–diffusion correlation methods from Laplace NMR of porous media, and Monte Carlo data inversion. The high dimensionality of the distribution space allows resolution of multiple microscopic environments within each heterogeneous voxel as well as their individual characterization with novel statistical measures that combine the chemical sensitivity of the relaxation rates with the link between microstructure and the anisotropic diffusivity of tissue water. The proposed framework is demonstrated on a healthy volunteer using both exhaustive and clinically viable acquisition protocols. |
Year | 2020 |
Journal | Magnetic Resonance |
Journal citation | 1 (1), pp. 27-43 |
Publisher | Copernicus GmbH |
ISSN | 2699-0016 |
Digital Object Identifier (DOI) | https://doi.org/10.5194/mr-1-27-2020 |
Open access | Published as ‘gold’ (paid) open access |
Publisher's version | License File Access Level Open |
Publication process dates | |
Deposited | 16 Apr 2021 |
https://acuresearchbank.acu.edu.au/item/8vx2z/transferring-principles-of-solid-state-and-laplace-nmr-to-the-field-of-in-vivo-brain-mri
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Publisher's version
OA_de_Almeida_Martins_2020_Transferring_principles_of_solid_state_and.pdf | |
License: CC BY 4.0 | |
File access level: Open |
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