Electrophysiological correlates of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism
Journal article
Roy, Nikita, Barry, Robert J., Fernandez, Francesca E., Lim, Chai K., Al-Dabbas, Mahmoud A., Karamacoska, Diana, Broyd, Samantha J., Solowij, Nadia, Chiu, Christine L. and Steiner, Genevieve Z.. (2020). Electrophysiological correlates of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism. Scientific Reports. 10(1), p. 17915. https://doi.org/10.1038/s41598-020-74780-9
Authors | Roy, Nikita, Barry, Robert J., Fernandez, Francesca E., Lim, Chai K., Al-Dabbas, Mahmoud A., Karamacoska, Diana, Broyd, Samantha J., Solowij, Nadia, Chiu, Christine L. and Steiner, Genevieve Z. |
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Abstract | The brain-derived neurotrophic factor (BDNF) protein is essential for neuronal development. Val66Met (rs6265) is a functional polymorphism at codon 66 of the BDNF gene that affects neuroplasticity and has been associated with cognition, brain structure and function. The aim of this study was to clarify the relationship between BDNF Val66Met polymorphism and neuronal oscillatory activity, using the electroencephalogram (EEG), in a normative cohort. Neurotypical (N = 92) young adults were genotyped for the BDNF Val66Met polymorphism and had eyes open resting-state EEG recorded for four minutes. Focal increases in right fronto-parietal delta, and decreases in alpha-1 and right hemispheric alpha-2 amplitudes were observed for the Met/Met genotype group compared to Val/Val and Val/Met groups. Stronger frontal topographies were demonstrated for beta-1 and beta-2 in the Val/Met group versus the Val/Val group. Findings highlight BDNF Val66Met genotypic differences in EEG spectral amplitudes, with increased cortical excitability implications for Met allele carriers. |
Year | 2020 |
Journal | Scientific Reports |
Journal citation | 10 (1), p. 17915 |
Publisher | Nature Publishing Group |
ISSN | 2045-2322 |
Digital Object Identifier (DOI) | https://doi.org/10.1038/s41598-020-74780-9 |
Scopus EID | 2-s2.0-85093099276 |
Open access | Published as ‘gold’ (paid) open access |
Research or scholarly | Research |
Page range | 1-11 |
Funder | National Health and Medical Research Council (NHMRC) |
Australian Research Council (ARC) | |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 21 Oct 2020 |
Publication process dates | |
Accepted | 25 Aug 2020 |
Deposited | 30 Jul 2021 |
ARC Funded Research | This output has been funded, wholly or partially, under the Australian Research Council Act 2001 |
Grant ID | NHMRC/1102532 |
https://acuresearchbank.acu.edu.au/item/8w70y/electrophysiological-correlates-of-the-brain-derived-neurotrophic-factor-bdnf-val66met-polymorphism
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Publisher's version
OA_Roy_2020_Electrophysiological_correlates_of_the_brain_derived.pdf | |
License: CC BY 4.0 | |
File access level: Open |
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