Electrophysiological correlates of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism

Journal article

Roy, Nikita, Barry, Robert J., Fernandez, Francesca E., Lim, Chai K., Al-Dabbas, Mahmoud A., Karamacoska, Diana, Broyd, Samantha J., Solowij, Nadia, Chiu, Christine L. and Steiner, Genevieve Z.. (2020). Electrophysiological correlates of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism. Scientific Reports. 10(1), p. 17915. https://doi.org/10.1038/s41598-020-74780-9
AuthorsRoy, Nikita, Barry, Robert J., Fernandez, Francesca E., Lim, Chai K., Al-Dabbas, Mahmoud A., Karamacoska, Diana, Broyd, Samantha J., Solowij, Nadia, Chiu, Christine L. and Steiner, Genevieve Z.
Abstract

The brain-derived neurotrophic factor (BDNF) protein is essential for neuronal development. Val66Met (rs6265) is a functional polymorphism at codon 66 of the BDNF gene that affects neuroplasticity and has been associated with cognition, brain structure and function. The aim of this study was to clarify the relationship between BDNF Val66Met polymorphism and neuronal oscillatory activity, using the electroencephalogram (EEG), in a normative cohort. Neurotypical (N = 92) young adults were genotyped for the BDNF Val66Met polymorphism and had eyes open resting-state EEG recorded for four minutes. Focal increases in right fronto-parietal delta, and decreases in alpha-1 and right hemispheric alpha-2 amplitudes were observed for the Met/Met genotype group compared to Val/Val and Val/Met groups. Stronger frontal topographies were demonstrated for beta-1 and beta-2 in the Val/Met group versus the Val/Val group. Findings highlight BDNF Val66Met genotypic differences in EEG spectral amplitudes, with increased cortical excitability implications for Met allele carriers.

Year2020
JournalScientific Reports
Journal citation10 (1), p. 17915
PublisherNature Publishing Group
ISSN2045-2322
Digital Object Identifier (DOI)https://doi.org/10.1038/s41598-020-74780-9
Scopus EID2-s2.0-85093099276
Open accessPublished as ‘gold’ (paid) open access
Research or scholarlyResearch
Page range1-11
FunderNational Health and Medical Research Council (NHMRC)
Australian Research Council (ARC)
Publisher's version
License
File Access Level
Open
Output statusPublished
Publication dates
Online21 Oct 2020
Publication process dates
Accepted25 Aug 2020
Deposited30 Jul 2021
ARC Funded ResearchThis output has been funded, wholly or partially, under the Australian Research Council Act 2001
Grant IDNHMRC/1102532
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