Epigenetic regulation in schizophrenia : Focus on methylation and histone modifications in human studies

Journal article

Delphin, Natasha, Aust, Caitlin, Griffiths, Lyn and Fernandez, Francesca. (2024). Epigenetic regulation in schizophrenia : Focus on methylation and histone modifications in human studies. Genes. 15(3), p. Article 272. https://doi.org/10.3390/genes15030272
AuthorsDelphin, Natasha, Aust, Caitlin, Griffiths, Lyn and Fernandez, Francesca
Abstract

Despite extensive research over the last few decades, the etiology of schizophrenia (SZ) remains unclear. SZ is a pathological disorder that is highly debilitating and deeply affects the lifestyle and minds of those affected. Several factors (one or in combination) have been reported as contributors to SZ pathogenesis, including neurodevelopmental, environmental, genetic and epigenetic factors. Deoxyribonucleic acid (DNA) methylation and post-translational modification (PTM) of histone proteins are potentially contributing epigenetic processes involved in transcriptional activity, chromatin folding, cell division and apoptotic processes, and DNA damage and repair. After establishing a summary of epigenetic processes in the context of schizophrenia, this review aims to highlight the current understanding of the role of DNA methylation and histone PTMs in this disorder and their potential roles in schizophrenia pathophysiology and pathogenesis.

Keywordsepigenetic; methylation; histone; schizophrenia; post-translational modification; genes
Year2024
JournalGenes
Journal citation15 (3), p. Article 272
PublisherMultidisciplinary Digital Publishing Institute (MDPI AG)
ISSN2073-4425
Digital Object Identifier (DOI)https://doi.org/10.3390/genes15030272
PubMed ID38540331
Scopus EID2-s2.0-85188670101
PubMed Central IDPMC10970389
Open accessPublished as ‘gold’ (paid) open access
Page range1-16
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License
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Open
Output statusPublished
Publication dates
Online21 Feb 2024
Publication process dates
Accepted19 Feb 2024
Deposited02 Jul 2025
Additional information

© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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