Epigenetic regulation in schizophrenia : Focus on methylation and histone modifications in human studies
Journal article
Delphin, Natasha, Aust, Caitlin, Griffiths, Lyn and Fernandez, Francesca. (2024). Epigenetic regulation in schizophrenia : Focus on methylation and histone modifications in human studies. Genes. 15(3), p. Article 272. https://doi.org/10.3390/genes15030272
Authors | Delphin, Natasha, Aust, Caitlin, Griffiths, Lyn and Fernandez, Francesca |
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Abstract | Despite extensive research over the last few decades, the etiology of schizophrenia (SZ) remains unclear. SZ is a pathological disorder that is highly debilitating and deeply affects the lifestyle and minds of those affected. Several factors (one or in combination) have been reported as contributors to SZ pathogenesis, including neurodevelopmental, environmental, genetic and epigenetic factors. Deoxyribonucleic acid (DNA) methylation and post-translational modification (PTM) of histone proteins are potentially contributing epigenetic processes involved in transcriptional activity, chromatin folding, cell division and apoptotic processes, and DNA damage and repair. After establishing a summary of epigenetic processes in the context of schizophrenia, this review aims to highlight the current understanding of the role of DNA methylation and histone PTMs in this disorder and their potential roles in schizophrenia pathophysiology and pathogenesis. |
Keywords | epigenetic; methylation; histone; schizophrenia; post-translational modification; genes |
Year | 2024 |
Journal | Genes |
Journal citation | 15 (3), p. Article 272 |
Publisher | Multidisciplinary Digital Publishing Institute (MDPI AG) |
ISSN | 2073-4425 |
Digital Object Identifier (DOI) | https://doi.org/10.3390/genes15030272 |
PubMed ID | 38540331 |
Scopus EID | 2-s2.0-85188670101 |
PubMed Central ID | PMC10970389 |
Open access | Published as ‘gold’ (paid) open access |
Page range | 1-16 |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 21 Feb 2024 |
Publication process dates | |
Accepted | 19 Feb 2024 |
Deposited | 02 Jul 2025 |
Additional information | © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
https://acuresearchbank.acu.edu.au/item/92003/epigenetic-regulation-in-schizophrenia-focus-on-methylation-and-histone-modifications-in-human-studies
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Publisher's version
OA_Delphin_2024_Epigenetic_regulation_in_schizophrenia_Focus_on.pdf | |
License: CC BY 4.0 | |
File access level: Open |
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