From ACE inhibitors/ARBs to ARNIs in coronary artery disease and heart failure (part 2/5)
Journal article
Leong, Darryl P., McMurray, John J. V., Joseph, Philip G. and Yusuf, Salim. (2019). From ACE inhibitors/ARBs to ARNIs in coronary artery disease and heart failure (part 2/5). Journal of the American College of Cardiology. 74(5), pp. 683 - 698. https://doi.org/10.1016/j.jacc.2019.04.068
Authors | Leong, Darryl P., McMurray, John J. V., Joseph, Philip G. and Yusuf, Salim |
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Abstract | The pharmacological inhibition of the renin-angiotensin-aldosterone system as a therapeutic strategy is one of the most significant advances in the treatment and prevention of cardiovascular disease in heart failure with reduced ejection fraction and in coronary artery disease. Recently, the addition of neprilysin inhibition to angiotensin receptor blockade has been shown to be even more effective than angiotensin-converting enzyme inhibition alone in heart failure with reduced ejection fraction, marking an important new milestone in heart failure treatment. This review summarizes the major trials that have informed the clinical role of inhibition of the renin-angiotensin-aldosterone and neprilysin pathways, as well as the limitations of these strategies. |
Keywords | ACE-I; ARB; ARNI; coronary disease; heart failure |
Year | 2019 |
Journal | Journal of the American College of Cardiology |
Journal citation | 74 (5), pp. 683 - 698 |
Publisher | Elsevier Inc. |
ISSN | 0735-1097 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.jacc.2019.04.068 |
Scopus EID | 2-s2.0-85069612823 |
Page range | 683 - 698 |
Research Group | Mary MacKillop Institute for Health Research |
Publisher's version | File Access Level Controlled |
Place of publication | United States of America |
https://acuresearchbank.acu.edu.au/item/86vv8/from-ace-inhibitors-arbs-to-arnis-in-coronary-artery-disease-and-heart-failure-part-2-5
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