Sacubitril/valsartan in Asian patients with heart failure with reduced ejection fraction
Journal article
Dewan, Pooja, Docherty, Kieran F. and McMurray, John J. V.. (2019). Sacubitril/valsartan in Asian patients with heart failure with reduced ejection fraction. Korean Circulation Journal. 49(6), pp. 469 - 484. https://doi.org/10.4070/kcj.2019.0136
Authors | Dewan, Pooja, Docherty, Kieran F. and McMurray, John J. V. |
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Abstract | The Prospective comparison of Angiotensin Receptor-neprilysin inhibitor (ARNI) with Angiotensin converting enzyme inhibitor (ACEI) to Determine Impact on Global Mortality and morbidity in Heart Failure (HF) trial (PARADIGM-HF) showed that adding a neprilysin inhibitor (sacubitril) to a renin-angiotensin system blocker (and other standard therapy) reduced morbidity and mortality in ambulatory patients with chronic HF with reduced ejection fraction (HFrEF). In PARADIGM-HF, valsartan combined with sacubitril (a so-called ARNI) was superior to the current gold standard of an ACEI, specifically enalapril, reducing the risk of the primary composite outcome of cardiovascular (CV) death or first HF hospitalization by 20% and all-cause death by 16%. Following the results of PARADIGM-HF, sacubitril/valsartan was approved by American and European regulatory authorities for the treatment of HFrEF. The burden of HF in Asia is substantial, both due to the huge population of the region and as a result of increasing CV risk factors and disease. Both the prevalence and mortality associated with HF are high in Asia. In the following review, we discuss the development of sacubitril/valsartan, the prototype ARNI, and the available evidence for its efficacy and safety in Asian patients with HFrEF. |
Keywords | Asians; sacubitril/valsartan; heart failure |
Year | 2019 |
Journal | Korean Circulation Journal |
Journal citation | 49 (6), pp. 469 - 484 |
Publisher | Korean Society of Circulation |
ISSN | 1738-5520 |
Digital Object Identifier (DOI) | https://doi.org/10.4070/kcj.2019.0136 |
Scopus EID | 2-s2.0-85071623264 |
Open access | Open access |
Page range | 469 - 484 |
Research Group | Mary MacKillop Institute for Health Research |
Publisher's version | License |
Place of publication | Republic of Korea |
https://acuresearchbank.acu.edu.au/item/8v072/sacubitril-valsartan-in-asian-patients-with-heart-failure-with-reduced-ejection-fraction
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Publisher's version
OA_Dewan_2019_Sacubitril_valsartan_in_Asian_patients_with.pdf | |
License: CC BY-NC 4.0 |
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