Individual physiological and mitochondrial responses during 12 weeks of intensified exercise

Journal article


Jacques, Macsue, Landen, Shanie, Romero, Javier, Yan, Xu, Garnham, Andrew, Hiam, Danielle, Siegwald, Mélina, Mercier, Emma, Hecksteden, Anne, Eynon, Nir and Voisin, Sarah. (2021). Individual physiological and mitochondrial responses during 12 weeks of intensified exercise. Physiological Reports. 9(15), p. Article: e14962. https://doi.org/10.14814/phy2.14962
AuthorsJacques, Macsue, Landen, Shanie, Romero, Javier, Yan, Xu, Garnham, Andrew, Hiam, Danielle, Siegwald, Mélina, Mercier, Emma, Hecksteden, Anne, Eynon, Nir and Voisin, Sarah
Abstract

Aim
Observed effects of exercise are highly variable between individuals, and subject-by-training interaction (i.e., individual response variability) is often not estimated. Here, we measured mitochondrial (citrate synthetase, cytochrome-c oxidase, succinate dehydrogenase, and mitochondrial copy-number), performance markers (Wpeak, lactate threshold [LT], and VO2peak), and fiber type proportions/expression (type I, type IIa, and type IIx) in multiple time points during 12-week of high-intensity interval training (HIIT) to investigate effects of exercise at the individual level.

Methods
Sixteen young (age: 33.1 ± 9.0 years), healthy men (VO2peak 35–60 ml/min/kg and BMI: 26.4 ± 4.2) from the Gene SMART study completed 12-week of progressive HIIT. Performance markers and muscle biopsies were collected every 4 weeks. We used mixed-models and bivariate growth models to quantify individual response and to estimate correlations between variables.

Results
All performance markers exhibited significant (Wpeak 0.56 ± 0.33 p = 0.003, LT 0.37 ± 0.35 p = 0.007, VO2peak 3.81 ± 6.13 p = 0.02) increases overtime, with subject-by-training interaction being present (95% CI: Wpeak 0.09–0.24, LT 0.06–0.18, VO2peak 0.27–2.32). All other measurements did not exhibit significant changes. Fiber type IIa proportions at baseline was significantly associated with all physiological variables (p < 0.05), and citrate synthetase and cytochrome-c oxidase levels at baseline and overtime (i.e., intercept and slope) presented significant covariance (p < 0.05). Finally, low correlations between performance and mitochondrial markers were observed.

Conclusion
We identified a significant subject-by-training interaction for the performance markers. While for all other measures within-subject variability was too large and interindividual differences in training efficacy could not be verified. Changes in measurements in response to exercise were not correlated, and such disconnection should be further investigated by future studies.

Keywordsexercise; mitochondria; training variability; VO2peak
Year2021
JournalPhysiological Reports
Journal citation9 (15), p. Article: e14962
PublisherJohn Wiley & Sons
ISSN2051-817X
Digital Object Identifier (DOI)https://doi.org/10.14814/phy2.14962
PubMed ID34327858
Scopus EID2-s2.0-85112384146
PubMed Central IDPMC8322753
Open accessPublished as ‘gold’ (paid) open access
Research or scholarlyResearch
Page range1-12
FunderNational Health and Medical Research Council
Australian Research Council
Publisher's version
License
File Access Level
Open
Output statusPublished
Publication dates
Online29 Jul 2021
Publication process dates
Accepted17 Jun 2021
Deposited23 Nov 2021
ARC Funded ResearchThis output has been funded, wholly or partially, under the Australian Research Council Act 2001
Grant IDNHMRC/1140644
NHMRC/11577321
ARC/DP190103081
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