Individual physiological and mitochondrial responses during 12 weeks of intensified exercise

Journal article

Jacques, Macsue, Landen, Shanie, Romero, Javier, Yan, Xu, Garnham, Andrew, Hiam, Danielle, Siegwald, Mélina, Mercier, Emma, Hecksteden, Anne, Eynon, Nir and Voisin, Sarah. (2021). Individual physiological and mitochondrial responses during 12 weeks of intensified exercise. Physiological Reports. 9(15), p. Article: e14962. https://doi.org/10.14814/phy2.14962
AuthorsJacques, Macsue, Landen, Shanie, Romero, Javier, Yan, Xu, Garnham, Andrew, Hiam, Danielle, Siegwald, Mélina, Mercier, Emma, Hecksteden, Anne, Eynon, Nir and Voisin, Sarah
Abstract

Aim
Observed effects of exercise are highly variable between individuals, and subject-by-training interaction (i.e., individual response variability) is often not estimated. Here, we measured mitochondrial (citrate synthetase, cytochrome-c oxidase, succinate dehydrogenase, and mitochondrial copy-number), performance markers (Wpeak, lactate threshold [LT], and VO2peak), and fiber type proportions/expression (type I, type IIa, and type IIx) in multiple time points during 12-week of high-intensity interval training (HIIT) to investigate effects of exercise at the individual level.

Methods
Sixteen young (age: 33.1 ± 9.0 years), healthy men (VO2peak 35–60 ml/min/kg and BMI: 26.4 ± 4.2) from the Gene SMART study completed 12-week of progressive HIIT. Performance markers and muscle biopsies were collected every 4 weeks. We used mixed-models and bivariate growth models to quantify individual response and to estimate correlations between variables.

Results
All performance markers exhibited significant (Wpeak 0.56 ± 0.33 p = 0.003, LT 0.37 ± 0.35 p = 0.007, VO2peak 3.81 ± 6.13 p = 0.02) increases overtime, with subject-by-training interaction being present (95% CI: Wpeak 0.09–0.24, LT 0.06–0.18, VO2peak 0.27–2.32). All other measurements did not exhibit significant changes. Fiber type IIa proportions at baseline was significantly associated with all physiological variables (p < 0.05), and citrate synthetase and cytochrome-c oxidase levels at baseline and overtime (i.e., intercept and slope) presented significant covariance (p < 0.05). Finally, low correlations between performance and mitochondrial markers were observed.

Conclusion
We identified a significant subject-by-training interaction for the performance markers. While for all other measures within-subject variability was too large and interindividual differences in training efficacy could not be verified. Changes in measurements in response to exercise were not correlated, and such disconnection should be further investigated by future studies.

Keywordsexercise; mitochondria; training variability; VO2peak
Year2021
JournalPhysiological Reports
Journal citation9 (15), p. Article: e14962
PublisherJohn Wiley & Sons
ISSN2051-817X
Digital Object Identifier (DOI)https://doi.org/10.14814/phy2.14962
PubMed ID34327858
Scopus EID2-s2.0-85112384146
PubMed Central IDPMC8322753
Open accessPublished as ‘gold’ (paid) open access
Research or scholarlyResearch
Page range1-12
FunderNational Health and Medical Research Council (NHMRC)
Australian Research Council (ARC)
Publisher's version
License
File Access Level
Open
Output statusPublished
Publication dates
Online29 Jul 2021
Publication process dates
Accepted17 Jun 2021
Deposited23 Nov 2021
ARC Funded ResearchThis output has been funded, wholly or partially, under the Australian Research Council Act 2001
Grant IDNHMRC/1140644
NHMRC/11577321
ARC/DP190103081
Permalink -

https://acuresearchbank.acu.edu.au/item/8x1qx/individual-physiological-and-mitochondrial-responses-during-12-weeks-of-intensified-exercise

Log in to edit

Download files

Publisher's version
OA_Jacques_2021_Individual_physiological_and_mitochondrial_responses_during.pdf
License: CC BY 4.0
File access level: Open

  • 95
    total views
  • 40
    total downloads
  • 3
    views this month
  • 2
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Gynostemma Pentaphyllum Increases Exercise Performance and Alters Mitochondrial Respiration and AMPK in Healthy Males
Nayyar, Deepti, Yan, Xu, Xu, Guoqin, Shi, Min, Garnham, Andrew Peter, Mathai, Michael and McAinch, Andrew. (2023). Gynostemma Pentaphyllum Increases Exercise Performance and Alters Mitochondrial Respiration and AMPK in Healthy Males. Nutrients. 15(22), pp. 1-18. https://doi.org/10.3390/nu15224721
Outcomes following supervised exercise and home-based exercise for patients with intermittent claudication
Leslie, R., May, S., Scordis, C., Isgar, V., Poulton, P. and Garnham, A.. (2022). Outcomes following supervised exercise and home-based exercise for patients with intermittent claudication. Journal of Vascular Nursing. 40(4), pp. 157-161. https://doi.org/10.1016/j.jvn.2022.09.006
Exercise and training regulation of autophagy markers in human and rat skeletal muscle
Botella, Javier, Jamnick, Nicholas A., Granata, Cesare, Genders, Amanda J., Perri, Enrico, Jabar, Tamim, Garnham, Andrew, Lazarou, Michael and Bishop, David J.. (2022). Exercise and training regulation of autophagy markers in human and rat skeletal muscle. International Journal of Molecular Sciences. 23(5), p. Article 2619. https://doi.org/10.3390/ijms23052619
Methods to match high-intensity interval exercise intensity in hypoxia and normoxia – A pilot study
Li, Yanchun, Li, Jia, Atakan, Muhammed M., Wang, Zhenhuan, Hu, Yang, Nazif, Mostafa, Zarekookandeh, Navabeh, Ye, Henry, Kuang, Jujiao, Ferri, Alessandra, Petersen, Aaron, Garnham, Andrew, Bishop, David J., Girard, Olivier, Huang, Yaru and Yan, Xu. (2022). Methods to match high-intensity interval exercise intensity in hypoxia and normoxia – A pilot study. Journal of Exercise Science and Fitness. 20(1), pp. 70-76. https://doi.org/10.1016/j.jesf.2021.12.003
Interpretation of exercise-induced changes in human skeletal muscle mRNA expression depends on the timing of the post-exercise biopsies
Kuang, Jujiao, McGinley, Cian, Lee, Matthew J.-C., Saner, Nicholas J., Garnham, Andrew and Bishop, David J.. (2022). Interpretation of exercise-induced changes in human skeletal muscle mRNA expression depends on the timing of the post-exercise biopsies. PeerJ. 10, p. Article e12856. https://doi.org/10.7717/peerj.12856
Uncovering the effects of gender affirming hormone therapy on skeletal muscle and epigenetics : Protocol for a prospective matched cohort study in transgender individuals (the GAME study)
Jones, Patrice R., Voisin, Sarah, Nolan, Brendan J., Landen, Shanie, Jacques, Macsue, Newell, Beau, Zwickl, Sav, Cook, Teddy, Wong, Alex, Ginger, Ariel, Palmer, Andrew, Garnham, Andrew, Alvarez-Romero, Javier, Mohandas, Namitha, Seale, Kirsten, Cheung, Ada and Eynon, Nir. (2022). Uncovering the effects of gender affirming hormone therapy on skeletal muscle and epigenetics : Protocol for a prospective matched cohort study in transgender individuals (the GAME study). BMJ Open. 12(5), p. Article e060869. https://doi.org/10.1136/bmjopen-2022-060869
Sustained sleep restriction reduces resistance exercise quality and quantity in females
Knowles, Olivia E., Drinkwater, Eric J., Roberts, Spencer S. H., Alexander, Sarah E., Abbott, Gavin, Garnham, Andrew, Lamon, Séverine and Aisbett, Brad. (2022). Sustained sleep restriction reduces resistance exercise quality and quantity in females. Medicine and Science in Sports and Exercise. 54(12), pp. 2167-2177. https://doi.org/10.1249/MSS.0000000000003000
High-intensity training elicits greater improvements in cardio-metabolic and reproductive outcomes than moderate-intensity training in women with polycystic ovary syndrome : A randomized clinical trial
Patten, Rhiannon K., McIlvenna, Luke C., Levinger, Itamar, Garnham, Andrew P., Shorakae, Soulmaz, Parker, Alexandra G., McAinch, Andrew J., Rodgers, Raymond J., Hiam, Danielle, Moreno-Asso, Alba and Stepto, Nigel K.. (2022). High-intensity training elicits greater improvements in cardio-metabolic and reproductive outcomes than moderate-intensity training in women with polycystic ovary syndrome : A randomized clinical trial. Human Reproduction. 37(5), pp. 1018-1029. https://doi.org/10.1093/humrep/deac047
Higher bone remodeling biomarkers are related to a higher muscle function in older adults : Effects of acute exercise
Smith, Cassandra, Hiam, Danielle, Tacey, Alexander, Lin, Xuzhu, Woessner, Mary, Zarekookandeh, Navabeh, Garnham, Andrew Peter, Chubb, Paul, Lewis, Joshua, Sim, Marc, Herrmann, Markus, Duque, Gustavo and Levinger, Itamar. (2022). Higher bone remodeling biomarkers are related to a higher muscle function in older adults : Effects of acute exercise. Bone. 165, pp. 1-10. https://doi.org/10.1016/j.bone.2022.116545
The Effects of Acute High-Intensity Interval Exercise and Hyperinsulinemic-Euglycemic Clamp on Osteoglycin Levels in Young and Middle-Aged Men
Bauer, Carlie, Tacey, Alexander, Garnham, Andrew Peter, Smith, Cassandra, Woessner, Mary, Lin, Xuzhu, Zarekookandeh, Navabeh, Hare, David, Lewis, Joshua, Parker, Lewan and Levinger, Itamar. (2022). The Effects of Acute High-Intensity Interval Exercise and Hyperinsulinemic-Euglycemic Clamp on Osteoglycin Levels in Young and Middle-Aged Men. JBMR Plus. 6(11), pp. 1-6. https://doi.org/10.1002/jbm4.10667
The effect of sleep restriction, with or without exercise, on skeletal muscle transcriptomic profiles in healthy young males
Lin, Wentao, Saner, Nicholas J., Weng, Xiquan, Caruana, Nikeisha J., Botella, Javier, Kuang, Jujiao, Lee, Matthew J.-C., Jamnick, Nicholas A., Pitchford, Nathan W., Garnham, Andrew, Bartlett, Jonathan D., Chen, Hao and Bishop, David J.. (2022). The effect of sleep restriction, with or without exercise, on skeletal muscle transcriptomic profiles in healthy young males. Frontiers in Endocrinology. 13, p. Article 863224. https://doi.org/10.3389/fendo.2022.863224
Oral digoxin effects on exercise performance, K+ regulation and skeletal muscle Na+,K+-ATPase in healthy humans
Sostaric, Simon, Petersen, Aaron C., Goodman, Craig A., Gong, Xiaofei, Aw, Tai-Juan, Brown, Malcolm J., Garnham, Andrew, Steward, Collene H., Murphy, Kate T., Carey, Kate A., Leppik, James, Fraser, Steve F., Cameron-Smith, David, Krum, Henry, Snow, Rodney J. and McKenna, Michael J.. (2022). Oral digoxin effects on exercise performance, K+ regulation and skeletal muscle Na+,K+-ATPase in healthy humans. The Journal of Physiology. 600(16), pp. 3749-3774. https://doi.org/10.1113/JP283017
Athletes with mild COVID-19 illness demonstrate subtle imaging abnormalities without exercise impairment or arrhythmias
Costello, Ben T., Climie, Rachel E., Wright, Leah, Janssens, Kristel, Mitchell, Amy, Wallace, Imogen, Lindqvist, Anniina, Foulkes, Steve, Paratz, Elizabeth D., Flannery, Michael D., Saner, Nicholas, Griffin, David, Green, Danny J., Cowie, Brian, Howden, Erin H., Garnham, Andrew and La Gerche, Andre. (2022). Athletes with mild COVID-19 illness demonstrate subtle imaging abnormalities without exercise impairment or arrhythmias. European Journal of Preventative Cardiology. 29(6), pp. e220-e223. https://doi.org/10.1093/eurjpc/zwab166
Recurrent primary hyperparathyroidism : A diagnostic and management dilemma
Wilkinson, Ben, Wan Muhamad Hatta, Sharifah Faradila, Garnham, Andrew Peter and Buch, Harit N.. (2021). Recurrent primary hyperparathyroidism : A diagnostic and management dilemma. Endocrinology, Diabetes and Metabolism Case Reports. 2021(1), pp. 1-5. https://doi.org/10.1530/EDM-20-0136
The effects of an acute "train-low" nutritional protocol on markers of recovery otpimization in endurance-trained male athletes
Russo, Isabella, Della Gatta, Paul A., Garnham, Andrew, Porter, Judi, Burke, Louise M. and Costa, Ricardo J. S.. (2021). The effects of an acute "train-low" nutritional protocol on markers of recovery otpimization in endurance-trained male athletes. International Journal of Sports Physiology and Performance. 16(12), pp. 1764-1776. https://doi.org/10.1123/ijspp.2020-0847
The effect of acute sleep deprivation on skeletal muscle protein synthesis and the hormonal environment
Lamon, Séverine, Morabito, Aimee, Arentson-Lantz, Emily, Knowles, Olivia, Vincent, Grace Elizabeth, Condo, Dominique, Alexander, Sarah Elizabeth, Garnham, Andrew, Paddon-Jones, Douglas and Aisbett, Brad. (2021). The effect of acute sleep deprivation on skeletal muscle protein synthesis and the hormonal environment. Physiological Reports. 9(1), p. e14660. https://doi.org/10.14814/phy2.14660
Exercise mitigates sleep-loss-induced changes in glucose tolerance, mitochondrial function, sarcoplasmic protein synthesis, and diurnal rhythms
Saner, Nicholas J., Lee, Matthew J. C., Kuang, Jujiao, Pitchford, Nathan W., Roach, Gregory D., Garnham, Andrew, Genders, Amanda J., Stokes, Tanner, Schroder, Elizabeth A., Huo, Zhiguang, Esser, Karyn A., Phillips, Stuart M., Bishop, David J. and Bartlett, Jonathan D.. (2021). Exercise mitigates sleep-loss-induced changes in glucose tolerance, mitochondrial function, sarcoplasmic protein synthesis, and diurnal rhythms. Molecular Metabolism. 43, p. 101110. https://doi.org/10.1016/j.molmet.2020.101110
Does the nutritional composition of dairy milk based recovery beverages influence post-exercise gastrointestinal and immune status, and subsequent markers of recovery optimisation in response to high intensity interval exercise?
Russo, Isabella, Della Gatta, Paul A., Garnham, Andrew, Porter, Judi, Burke, Louise M. and Costa, Ricardo J. S.. (2021). Does the nutritional composition of dairy milk based recovery beverages influence post-exercise gastrointestinal and immune status, and subsequent markers of recovery optimisation in response to high intensity interval exercise? Frontiers in Nutrition. 7, p. 622270. https://doi.org/10.3389/fnut.2020.622270
Assessing overall exercise recovery processes using carbohydrate and carbohydrate-protein containing recovery beverages
Russo, Isabella, Della Gatta, Paul A., Garnham, Andrew, Porter, Judi, Burke, Louise M. and Costa, Ricardo J. S.. (2021). Assessing overall exercise recovery processes using carbohydrate and carbohydrate-protein containing recovery beverages. Frontiers in Physiology. 12, p. 628863. https://doi.org/10.3389/fphys.2021.628863
The influence of biological sex and fitness status on markers of recovery optimisation in response to prolonged high intensity interval exercise
Russo, Isabella, Della Gatta, P. A., Garnham, Andrew, Porter, Judi, Burke, Louise and Costa, Ricardo J. S.. (2020). The influence of biological sex and fitness status on markers of recovery optimisation in response to prolonged high intensity interval exercise. International Journal of Sports Science. 10(6), pp. 145-163. https://doi.org/10.5923/j.sports.20201006.03
Resistance training upregulates skeletal muscle Na+, K+-ATPase content, with elevations in both α1 and α2, but not β isoforms
Altarawneh, Muath M., Petersen, Aaron C., Farr, Trevor, Garnham, Andrew, Broatch, James R., Halson, Shona, Bishop, David J. and McKenna, Michael J.. (2020). Resistance training upregulates skeletal muscle Na+, K+-ATPase content, with elevations in both α1 and α2, but not β isoforms. European Journal of Applied Physiology. 120(8), pp. 1777-1785. https://doi.org/10.1007/s00421-020-04408-3
The effect of sleep restriction, with or without high-intensity interval exercise, on myofibrillar protein synthesis in healthy young me
Saner, Nicholas J., Lee, Matthew J.-C., Pitchford, Nathan W., Kuang, Jujiao, Roach, Gregory D., Garnham, Andrew, Stokes, Tanner, Phillips, Stuart M., Bishop, David J. and Bartlett, Jonathan D.. (2020). The effect of sleep restriction, with or without high-intensity interval exercise, on myofibrillar protein synthesis in healthy young me. The Journal of Physiology. 598(8), pp. 1523-1536. https://doi.org/10.1113/JP278828
Mitochondrial respiration variability and simulations in human skeletal muscle : The Gene SMART study
Jacques, Macsue, Kuang, Jujiao, Bishop, David J., Yan, Xu, Alvarez-Romero, Javier, Munson, Fiona, Garnham, Andrew, Papadimitriou, Ioannis, Voisin, Sarah and Eynon, Nir. (2020). Mitochondrial respiration variability and simulations in human skeletal muscle : The Gene SMART study. The FASEB Journal. 34(2), pp. 2978-2986. https://doi.org/10.1096/fj.201901997RR
Effect of inorganic nitrate on exercise capacity, mitochondria respiration, and vascular function in heart failure with reduced ejection fraction
Woessner, Mary N., Neil, Christopher, Saner, Nicholas J., Goodman, Craig A., McIlvenna, Luke C., Ortiz de Zevallos, Joaquin, Garnham, Andrew, Levinger, Itamar and Allen, Jason D.. (2020). Effect of inorganic nitrate on exercise capacity, mitochondria respiration, and vascular function in heart failure with reduced ejection fraction. Journal of Applied Physiology. 128(5), pp. 1355-1364. https://doi.org/10.1152/japplphysiol.00850.2019
Cold water immersion attenuates anabolic signaling and skeletal muscle fiber hypertrophy, but not strength gain, following whole-body resistance training
Fyfe, Jackson J., Broatch, James R., Trewin, Adam J., Hanson, Erik D., Argus, Christos K., Garnham, Andrew P., Halson, Shona L., Polman, Remco C., Bishop, David J. and Petersen, Aaron C.. (2019). Cold water immersion attenuates anabolic signaling and skeletal muscle fiber hypertrophy, but not strength gain, following whole-body resistance training. Journal of Applied Physiology. 127(5), pp. 1403-1418. https://doi.org/10.1152/japplphysiol.00127.2019
Muscle glycogen utilization during an Australian Rules Football game
Routledge, Harry E., Leckey, Jill J., Lee, Matt J., Garnham, Andrew, Graham, Stuart, Burgess, Darren, Burke, Louise M., Erskine, Robert M., Close, Graeme L. and Morton, James P.. (2019). Muscle glycogen utilization during an Australian Rules Football game. International Journal of Sports Physiology and Performance. 14(1), pp. 122-124. https://doi.org/10.1123/ijspp.2018-0106
Single-dose prednisolone alters endocrine and haematologic responses and exercise performance in men
Tacey, Alexander, Parker, Lewan, Yeap, Bu B., Joseph, John, Lim, Ee Mun, Garnham, Andrew, Hare, David L., Brennan-Speranza, Tara C. and Levinger, Itamar. (2019). Single-dose prednisolone alters endocrine and haematologic responses and exercise performance in men. Endocrine Connections. 8(2), pp. 111 - 119. https://doi.org/10.1530/EC-18-0473
Glucocorticoid-induced insulin resistance in men is associated with suppressed undercarboxylated osteocalcin
Parker, Lewan, Lin, Xuzhu, Garnham, Andrew, McConell, Glenn, Stepto, Nigel K., Hare, David L., Byrnes, Elizabeth, Ebeling, Peter R., Seeman, Ego, Brennan-Speranza, Tara C. and Levinger, Itamar. (2019). Glucocorticoid-induced insulin resistance in men is associated with suppressed undercarboxylated osteocalcin. Journal of Bone and Mineral Research. 34(1), pp. 49-58. https://doi.org/10.1002/jbmr.3574
Exercise and GLUT4 in human subcutaneous adipose tissue
Flores-Opazo, Marcelo, Boland, Eva, Garnham, Andrew, Murphy, Robyn M., McGee, Sean L. and Hargreaves, Mark. (2018). Exercise and GLUT4 in human subcutaneous adipose tissue. Physiological Reports. 6(22), pp. 1 - 8. https://doi.org/10.14814/phy2.13918
ACE I/D gene variant predicts ACE enzyme content in blood but not the ACE, UCP2, and UCP3 protein content in human skeletal muscle in the GeneSMART study
Yan, Xu, Dvir, Noam, Jacques, Macsue, Cavalcante, Luiz, Papadimitriou, Ioannis D., Munson, Fiona, Kuang, Jujiao, Garnham, Andrew, Landen, Shanie, Li, Jia, O'Keefe, Lannie, Tirosh, Oren, Bishop, David, Voisin, Sarah and Eynon, Nir. (2018). ACE I/D gene variant predicts ACE enzyme content in blood but not the ACE, UCP2, and UCP3 protein content in human skeletal muscle in the GeneSMART study. Journal of Applied Physiology. 125(3), pp. 923 - 930. https://doi.org/10.1152/japplphysiol.00344.2018
No evidence of direct association between GLUT4 and glycogen in human skeletal muscle
Murphy, Robyn M., Flores-Opazo, Marcelo, Frankish, Barnaby P., Garnham, Andrew, Stapleton, David and Hargreaves, Mark. (2018). No evidence of direct association between GLUT4 and glycogen in human skeletal muscle. Physiological Reports. 6(21), pp. 1 - 5. https://doi.org/10.14814/phy2.13917
Acute HIIE elicits similar changes in human skeletal muscle mitochondrial H2O2 release, respiration, and cell signaling as endurance exercise even with less work
Trewin, Adam J., Parker, Lewan, Shaw, Christopher S., Hiam, Danielle S., Garnham, Andrew, Levinger, Itamar, McConell, Glenn K. and Stepto, Nigel K.. (2018). Acute HIIE elicits similar changes in human skeletal muscle mitochondrial H2O2 release, respiration, and cell signaling as endurance exercise even with less work. American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 315(5), pp. R1003 - R1016. https://doi.org/10.1152/ajpregu.00096.2018
Four days of simulated shift work reduces insulin sensitivity in humans
Bescos, Raul, Boden, Michael J., Jackson, Melinda L., Trewin, Adam J., Marin, Evelyn C., Levinger, Itamar, Garnham, Andrew, Hiam, Andrew, Falcao-Tebas, Filippe, Conte, F., Owens, Julie A., Kennaway, David J. and McConell, Glenn K.. (2018). Four days of simulated shift work reduces insulin sensitivity in humans. Acta Physiologica. 223(2), pp. 1 - 13. https://doi.org/10.1111/apha.13039
Striated muscle activator of rho signalling (STARS) is reduced in ageing human skeletal muscle and targeted by mir-628-5p
Russell, Andrew, Wallace, M. A., Kalanon, M., Zacharewicz, Evelyn, Gatta, P. A.D., Garnham, Andrew and Lamon, Séverine. (2017). Striated muscle activator of rho signalling (STARS) is reduced in ageing human skeletal muscle and targeted by mir-628-5p. Acta Physiologica. 220(2), pp. 263 - 274. https://doi.org/10.1111/apha.12819
Actin alpha cardiac muscle 1 gene expression is upregulated in the skeletal muscle of men undergoing androgen deprivation therapy for prostate cancer
Cheung, Ada S., Rooy, Casey D., Levinger, Itamar, Rana, Kesha, Clarke, Michele V., How, Jackie M., Garnham, Andrew, McLean, Catriona, Zajac, J. D., Davey, Rachel A. and Grossmann, M.. (2017). Actin alpha cardiac muscle 1 gene expression is upregulated in the skeletal muscle of men undergoing androgen deprivation therapy for prostate cancer. The Journal of Steroid Biochemistry and Molecular Biology. 174, pp. 56 - 64. https://doi.org/10.1016/j.jsbmb.2017.07.029
The effect of acute and short term glucocorticoid administration on exercise capacity and metabolism
Tacey, Alexander, Parker, Lewan, Garnham, Andrew, Brennan-Speranza, Tara C. and Levinger, Itamar. (2017). The effect of acute and short term glucocorticoid administration on exercise capacity and metabolism. Journal of Science and Medicine in Sport. 20(6), pp. 543 - 548. https://doi.org/10.1016/j.jsams.2016.10.016
Atraumatic tears of the ligamentum teres are more frequent in professional ballet dancers than a sporting population
Mayes, Susan, Ferris, April-Rose, Smith, Peter, Garnham, Andrew and Cook, Jill. (2016). Atraumatic tears of the ligamentum teres are more frequent in professional ballet dancers than a sporting population. Skeletal Radiology. 45(7), pp. 959 - 967. https://doi.org/10.1007/s00256-016-2379-6
A single dose of prednisolone as a modulator of undercarboxylated osteocalcin and insulin sensitivity post-exercise in healthy young men: A study protocol
Levinger, Itamar, Brennan-Speranza, Tara C., Stepto, Nigel K., Jerums, George, Parker, Lewan, McConell, Glenn K., Anderson, Mitchell, Garnham, Andrew, Hare, David L., Ebeling, Peter R. and Seeman, Ego. (2016). A single dose of prednisolone as a modulator of undercarboxylated osteocalcin and insulin sensitivity post-exercise in healthy young men: A study protocol. JMIR Research Protocols. 5(2), pp. 1 - 7. https://doi.org/10.2196/resprot.5119
Professional ballet dancers have a similar prevalence of articular cartilage defects compared to age- and sex-matched non-dancing athletes
Mayes, Susan, Ferris, April-Rose, Smith, Peter, Garnham, Andrew and Cook, Jill. (2016). Professional ballet dancers have a similar prevalence of articular cartilage defects compared to age- and sex-matched non-dancing athletes. Clinical Rheumatology. 35(12), pp. 3037 - 3043. https://doi.org/10.1007/s10067-016-3389-4
No effect of acute beetroot juice ingestion on oxygen consumption, glucose kinetics, or skeletal muscle metabolism during submaximal exercise in males
Betteridge, Scott, Bescós, Raúl, Martorell, Miquel, Pons, Antoni, Garnham, Andrew, Stathis, Christos C. and Mcconell, Glenn. (2016). No effect of acute beetroot juice ingestion on oxygen consumption, glucose kinetics, or skeletal muscle metabolism during submaximal exercise in males. Journal of Applied Physiology. 120(4), pp. 391 - 398. https://doi.org/10.1152/japplphysiol.00658.2015
Muscle atrophy in patients with Type 2 Diabetes Mellitus: Roles of inflammatory pathways, physical activity and exercise
Perry, Ben D., Caldow, Marissa K., Brennan-Speranza, Tara C., Sbaraglia, Melissa, Jerums, George, Garnham, Andrew, Wong, Chiew, Levinger, Pazit, ul Haq, Muhammad Asrar, Hare, David L., Price, S. Russ and Levinger, Itamar. (2016). Muscle atrophy in patients with Type 2 Diabetes Mellitus: Roles of inflammatory pathways, physical activity and exercise. Exercise Immunology Review. 22, pp. 94 - 108.
Similar prevalence of acetabular labral tear in professional ballet dancers and sporting participants
Mayes, Susan, Ferris, April-Rose, Smith, Peter W. F., Garnham, Andrew and Cook, Jill. (2016). Similar prevalence of acetabular labral tear in professional ballet dancers and sporting participants. Clinical Journal of Sport Medicine. 26(4), pp. 307 - 313. https://doi.org/10.1097/JSM.0000000000000257
Erythropoietin does not enhance skeletal muscle protein synthesis following exercise in young and older adults
Lamon, Séverine, Zacharewicz, Evelyn, Arentson-Lantz, Emily, Della Gatta, Paul A., Ghobrial, Lobna, Gerlinger-Romero, Frederico, Garnham, Andrew, Paddon-Jones, Douglas and Russell, Aaron P.. (2016). Erythropoietin does not enhance skeletal muscle protein synthesis following exercise in young and older adults. Frontiers in Physiology. 7, pp. 1 - 9. https://doi.org/10.3389/fphys.2016.00292
The effects of knee injury on skeletal muscle function, Na+-ATPase content, and isoform abundance
Perry, Ben D., Levinger, P, Morris, Hayden G., Petersen, Aaron C., Garnham, Andrew, Levinger, Itamar and McKenna, Michael J.. (2015). The effects of knee injury on skeletal muscle function, Na+-ATPase content, and isoform abundance. Physiological Reports. 3(2), pp. 1 - 14. https://doi.org/10.14814/phy2.12294
Identification of MicroRNAs linked to regulators of muscle protein synthesis and regeneration in young and old skeletal muscle
Zacharewicz, Evelyn, Della Gatta, P. A., Reynolds, John, Garnham, Andrew, Crowley, Tamsyn, Russell, Andrew and Lamon, Séverine. (2014). Identification of MicroRNAs linked to regulators of muscle protein synthesis and regeneration in young and old skeletal muscle. PLoS ONE. 9(12), pp. 1 - 25. https://doi.org/10.1371/journal.pone.0114009
Ageing has no effect on the regulation of the ubiquitin proteasome-related genes and proteins following resistance exercise
Stefanetti, Renae J., Zacharewicz, Evelyn, Della Gatta, Paul A., Garnham, Andrew, Russell, Aaron P. and Lamon, Séverine. (2014). Ageing has no effect on the regulation of the ubiquitin proteasome-related genes and proteins following resistance exercise. Frontiers in Physiology. 5, pp. 1 - 10. https://doi.org/10.3389/fphys.2014.00030
Effect of exercise training on skeletal muscle cytokine expression in the elderly
Della Gatta, Paul A., Garnham, Andrew P., Peake, Jonathan M. and Cameron-Smith, David. (2014). Effect of exercise training on skeletal muscle cytokine expression in the elderly. Brain, Behavior, and Immunity. 39, pp. 80 - 86. https://doi.org/10.1016/j.bbi.2014.01.006
Effect of exercise on the skeletal muscle proteome in patients with type 2 diabetes
Hussey, Sophie E., Sharoff, Carrie G., Garnham, Andrew, Yi, Zhengping, Bowen, Benjamin P., Mandarino, Lawrence J. and Hargreaves, Mark. (2013). Effect of exercise on the skeletal muscle proteome in patients with type 2 diabetes. Medicine and Science in Sports and Exercise. 45(6), pp. 1069 - 1076. https://doi.org/10.1249/MSS.0b013e3182814917
Preexercise aminoacidemia and muscle protein synthesis after resistance exercise
Burke, Louise, Hawley, John, Ross, M, Moore, Daniel, Phillips, S, Slater, G, Stellingwerff, T, Tipton, K, Garnham, A and Coffey, Vernon. (2012). Preexercise aminoacidemia and muscle protein synthesis after resistance exercise. Medicine and Science in Sports and Exercise. 44(10), pp. 1968 - 1977. https://doi.org/10.1249/MSS.0b013e31825d28fa
Early inflammatory and myogenic responses to resistance exercise in the elderly
Mathers, Jessica L., Farnfield, Michelle M., Garnham, Andrew P., Caldow, Marissa K., Cameron-Smith, David and Peake, Jonathan M.. (2012). Early inflammatory and myogenic responses to resistance exercise in the elderly. Muscle & Nerve. 46(3), pp. 407 - 412. https://doi.org/10.1002/mus.23317
Evaluation of the MAIIA dipstick test to detect recombinant human erythropoietin in plasma
Ashenden, Michael, Sharpe, Ken, Garnham, Andrew and Gore, Christopher J.. (2012). Evaluation of the MAIIA dipstick test to detect recombinant human erythropoietin in plasma. Journal of Pharmaceutical and Biomedical Analysis. 67-68, pp. 123 - 128. https://doi.org/10.1016/j.jpba.2012.04.025
Activation of mTOR signalling in young and old human skeletal muscle in response to combined resistance exercise and whey protein ingestion
Farnfield, Michelle M., Breen, Leigh, Carey, Kate A., Garnham, Andrew and Cameron-Smith, David. (2012). Activation of mTOR signalling in young and old human skeletal muscle in response to combined resistance exercise and whey protein ingestion. Applied Physiology, Nutrition and Metabolism. 37(1), pp. 21 - 30. https://doi.org/10.1139/H11-132
Low muscle glycogen concentration does not suppress the anabolic response to resistance exercise
Camera, Donny, West, D, Burd, N, Phillips, S, Garnham, A, Hawley, John and Coffey, Vernon. (2012). Low muscle glycogen concentration does not suppress the anabolic response to resistance exercise. Journal of Applied Physiology. 113(2), pp. 206 - 214. https://doi.org/10.1152/japplphysiol.00395.2012
Nutrient provision increases signalling and protein synthesis in human skeletal muscle after repeated sprints
Coffey, Vernon, Moore, Daniel, Burd, N, Rerecich, T, Stellingwerff, T, Garnham, A, Phillips, S and Hawley, John. (2011). Nutrient provision increases signalling and protein synthesis in human skeletal muscle after repeated sprints. European Journal of Applied Physiology. 111(7), pp. 1473 - 1483. https://doi.org/10.1007/s00421-010-1768-0
Impact of resistance exercise training on interleukin-6 and JAK/STAT in young men
Trenerry, Marissa K., Della Gatta, Paul A., Larsen, Amy E., Garnham, Andrew P. and Cameron-Smith, David. (2011). Impact of resistance exercise training on interleukin-6 and JAK/STAT in young men. Muscle & Nerve. 43(3), pp. 385 - 392. https://doi.org/10.1002/mus.21875
Impact of resistance exercise training on interleukin-6 and JAK/STAT in young men
Trenerry, Melissa K., Della Gatta, Paul A., Larson, Amy E. and Garnham, Andrew P.. (2011). Impact of resistance exercise training on interleukin-6 and JAK/STAT in young men. Muscle & Nerve. 43(3), pp. 385 - 392. https://doi.org/10.1002/mus.21875
Vitamin D status and musculoskeletal health in adolescent male ballet dancers a pilot study
Ducher, Gaele, Kukuljan, Sonja, Hill, B., Garnham, Andrew P., Nowson, Carol A., Kimlin, M. G. and Cook, Jill. (2011). Vitamin D status and musculoskeletal health in adolescent male ballet dancers a pilot study. Journal of Dance Medicine and Science. 15(3), pp. 99 - 107.
Current markers of the Athlete Blood Passport do not flag microdose EPO doping
Ashenden, Michael, Gough, Clare E., Garnham, Andrew, Gore, Christopher J. and Sharpe, Ken. (2011). Current markers of the Athlete Blood Passport do not flag microdose EPO doping. European Journal of Applied Physiology. 111(9), pp. 2307 - 2314. https://doi.org/10.1007/s00421-011-1867-6
Exercise training increases adipose tissue GLUT4 expression in patients with type 2 diabetes
Hussey, Sophie E., McGee, S. L., Garnham, Andrew, Wentworth, John M., Jeukendrup, A. E. and Hargreaves, M.. (2011). Exercise training increases adipose tissue GLUT4 expression in patients with type 2 diabetes. Diabetes, Obesity and Metabolism. 13(10), pp. 959 - 962. https://doi.org/10.1111/j.1463-1326.2011.01426.x
Acute signalling responses to intense endurance training commenced with low or normal muscle glycogen : Experimental Physiology-Research Paper
Yeo, W, McGee, S, Carey, A, Paton, C, Garnham, A, Hargreaves, M and Hawley, John. (2010). Acute signalling responses to intense endurance training commenced with low or normal muscle glycogen : Experimental Physiology-Research Paper. Experimental Physiology. 95(2), pp. 351 - 358. https://doi.org/10.1113/expphysiol.2009.049353
Cytokine responses to carbohydrate ingestion during recovery from exercise-induced muscle injury
Ross, M, Halson, Shona, Suzuki, K, Garnham, A, Hawley, John, Cameron-Smith, David and Peake, J. (2010). Cytokine responses to carbohydrate ingestion during recovery from exercise-induced muscle injury. Journal of Interferon and Cytokine Research. 30(5), pp. 329 - 337. https://doi.org/10.1089/jir.2009.0079
Effect of consecutive repeated sprint and resistance exercise bouts on acute adaptive responses in human skeletal muscle
Coffey, Vernon Glenn, Jemiolo, Bozena, Edge, Johann, Garnham, Andrew P., Trappe, Scott W. and Hawley, John Alan. (2009). Effect of consecutive repeated sprint and resistance exercise bouts on acute adaptive responses in human skeletal muscle. American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 297(5), pp. 1441 - 1451. https://doi.org/10.1152/ajpregu.00351.2009
Consecutive bouts of diverse contractile activity alter acute responses in human skeletal muscle
Coffey, Vernon Glenn, Pilegaard, Henriette, Garnham, Andrew P., O'Brien, Brendan J. and Hawley, John Alan. (2009). Consecutive bouts of diverse contractile activity alter acute responses in human skeletal muscle. Journal of Applied Physiology. 106(4), pp. 1187 - 1197. https://doi.org/10.1152/japplphysiol.91221.2008
Skeletal muscle adaptation and performance responses to once a day versus twice every second day endurance training regimens
Yeo, Wee Kian, Paton, Carl D., Garnham, Andrew P., Burke, Louise M., Carey, Andrew L. and Hawley, John Alan. (2008). Skeletal muscle adaptation and performance responses to once a day versus twice every second day endurance training regimens. Journal of Applied Physiology. 105(5), pp. 1462 - 1470. https://doi.org/10.1152/japplphysiol.90882.2008
Fat adaptation followed by carbohydrate restoration increases AMPK activity in skeletal muscle from trained humans
Yeo, Wee Kian, Lessard, Sarah J., Chen, Zhi-Ping, Garnham, Andrew P., Burke, Louise, Rivas, Donato A., Kemp, Bruce Ernest and Hawley, John Alan. (2008). Fat adaptation followed by carbohydrate restoration increases AMPK activity in skeletal muscle from trained humans. Journal of Applied Physiology. 105(5), pp. 1519 - 1526. https://doi.org/10.1152/japplphysiol.90540.2008