Particulate matter air pollution components and risk for lung cancer
Journal article
Raaschou-Nielsen, Ole, Beelen, Rob, Wang, Meng, Hoek, Gerard, Andersen, Zorana Jovanovic, Hoffmann, Barbara, Stafoggia, M., Samoli, E., Weinmayr, Gudrun, Dimakopoulou, Konstantina, Nieuwenhuijsen, Mark J., Xun, W. W., Fischer, P., Eriksen, Kirsten Thorup, Sørensen, Mette, Tjønneland, Anne, Ricceri, F., de Hoogh, Kees, Key, T., ... Vineis, P.. (2016). Particulate matter air pollution components and risk for lung cancer. Environment International. 87, pp. 66 - 73. https://doi.org/10.1016/j.envint.2015.11.007
Authors | Raaschou-Nielsen, Ole, Beelen, Rob, Wang, Meng, Hoek, Gerard, Andersen, Zorana Jovanovic, Hoffmann, Barbara, Stafoggia, M., Samoli, E., Weinmayr, Gudrun, Dimakopoulou, Konstantina, Nieuwenhuijsen, Mark J., Xun, W. W., Fischer, P., Eriksen, Kirsten Thorup, Sørensen, Mette, Tjønneland, Anne, Ricceri, F., de Hoogh, Kees, Key, T., Eeftens, Marloes, Peeters, P. H., Bueno-de-Mesquita, H. Bas, Meliefste, Kees, Oftedal, Bente, Schwarze, P. E., Nafstad, Per, Galassi, Claudia, Migliore, E., Ranzi, Andrea, Cesaroni, G., Badaloni, C., Forastiere, F., Penell, J., De Faire, U., Korek, M., Pedersen, N., Östenson, C.-G., Pershagen, G., Fratiglioni, L., Concin, H., Nagel, G., Jaensch, A., Ineichen, A., Naccarati, A., Katsoulis, M., Trichpoulou, A., Keuken, M., Jedynska, A., Kooterag, I. M., Kukkonen, J., Brunekreef, B., Sokhi, R. S., Katsouyannih, K. and Vineis, P. |
---|---|
Abstract | Background: Particulate matter (PM) air pollution is a human lung carcinogen; however, the components responsible have not been identified. We assessed the associations between PM components and lung cancer incidence. Methods: We used data from 14 cohort studies in eight European countries. We geocoded baseline addresses and assessed air pollution with land-use regression models for eight elements (Cu, Fe, K, Ni, S, Si, V and Zn) in size fractions of PM2.5 and PM10. We used Cox regression models with adjustment for potential confounders for cohort-specific analyses and random effect models for meta-analysis. Results: The 245,782 cohort members contributed 3,229,220 person–years at risk. During follow-up (mean, 13.1 years), 1878 incident cases of lung cancer were diagnosed. In the meta-analyses, elevated hazard ratios (HRs) for lung cancer were associated with all elements except V; none was statistically significant. In analyses restricted to participants who did not change residence during follow-up, statistically significant associations were found for PM2.5 Cu (HR, 1.25; 95% CI, 1.01–1.53 per 5 ng/m3), PM10 Zn (1.28; 1.02–1.59 per 20 ng/m3), PM10 S (1.58; 1.03–2.44 per 200 ng/m3), PM10 Ni (1.59; 1.12–2.26 per 2 ng/m3) and PM10 K (1.17; 1.02–1.33 per 100 ng/m3). In two-pollutant models, associations between PM10 and PM2.5 and lung cancer were largely explained by PM2.5 S. Conclusions: This study indicates that the association between PM in air pollution and lung cancer can be attributed to various PM components and sources. PM containing S and Ni might be particularly important. |
Keywords | air pollution; particulate matter; sulfur; nickel; cohort study; lung cancer |
Year | 2016 |
Journal | Environment International |
Journal citation | 87, pp. 66 - 73 |
Publisher | Pergamon |
ISSN | 0160-4120 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.envint.2015.11.007 |
Scopus EID | 2-s2.0-84948822910 |
Page range | 66 - 73 |
Research Group | Mary MacKillop Institute for Health Research |
Publisher's version | File Access Level Controlled |
Place of publication | United Kingdom |
https://acuresearchbank.acu.edu.au/item/857z4/particulate-matter-air-pollution-components-and-risk-for-lung-cancer
Restricted files
Publisher's version
79
total views0
total downloads0
views this month0
downloads this month