Exposure to drinking water trihalomethanes and their association with low birth weight and small for gestational age in genetically susceptible women
Journal article
Danileviciute, Asta, Grazuleviciene, Regina, Vencloviene, Jone, Paulauskas, Algimantas and Nieuwenhuijsen, Mark J.. (2012). Exposure to drinking water trihalomethanes and their association with low birth weight and small for gestational age in genetically susceptible women. International Journal of Environmental Research and Public Health. 9(12), pp. 4470-4485. https://doi.org/10.3390/ijerph9124470
Authors | Danileviciute, Asta, Grazuleviciene, Regina, Vencloviene, Jone, Paulauskas, Algimantas and Nieuwenhuijsen, Mark J. |
---|---|
Abstract | Little is known about genetic susceptibility to individual trihalomethanes (THM) in relation to adverse pregnancy outcomes. We conducted a nested case-control study of 682 pregnant women in Kaunas (Lithuania) and, using individual information on drinking water, ingestion, showering and bathing, and uptake factors of THMs in blood, estimated an internal THM dose. We used logistic regression to evaluate the relationship between internal THM dose, birth outcomes and individual and joint (modifying) effects of metabolic gene polymorphisms. THM exposure during entire pregnancy and specific trimesters slightly increased low birth weight (LBW) risk. When considering both THM exposure and maternal genotypes, the largest associations were found for third trimester among total THM (TTHM) and chloroform-exposed women with the GSTM1–0 genotype (OR: 4.37; 95% CI: 1.36–14.08 and OR: 5.06; 95% CI: 1.50–17.05, respectively). A test of interaction between internal THM dose and GSTM1–0 genotype suggested a modifying effect of exposure to chloroform and bromodichloromethane on LBW risk. However, the effect on small for gestational age (SGA) was not statistically significant. These data suggest that THM internal dose may affect foetal growth and that maternal GSTM1 genotype modifies the THM exposure effects on LBW. |
Keywords | trihalomethanes; LBW; SGA; GSTT1; GSTM1 |
Year | 2012 |
Journal | International Journal of Environmental Research and Public Health |
Journal citation | 9 (12), pp. 4470-4485 |
Publisher | Multidisciplinary Digital Publishing Institute (MDPI AG) |
ISSN | 1661-7827 |
Digital Object Identifier (DOI) | https://doi.org/10.3390/ijerph9124470 |
Scopus EID | 2-s2.0-84871534605 |
Open access | Published as ‘gold’ (paid) open access |
Research or scholarly | Research |
Page range | 4470-4485 |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 06 Dec 2012 |
Publication process dates | |
Accepted | 03 Dec 2012 |
Deposited | 16 Apr 2021 |
https://acuresearchbank.acu.edu.au/item/8vx34/exposure-to-drinking-water-trihalomethanes-and-their-association-with-low-birth-weight-and-small-for-gestational-age-in-genetically-susceptible-women
Download files
Publisher's version
OA_Danileviciute_2012_Exposure_to_drinking_water_trihalomethanes_and.pdf | |
License: CC BY 3.0 | |
File access level: Open |
113
total views35
total downloads3
views this month0
downloads this month