Multi-omics signatures of the human early life exposome
Journal article
Maitre, Léa, Bustamante, Mariona, Hernández-Ferrer, Carles, Thiel, Denise, Lau, Chung-Ho E., Siskos, Alexandros P., Vives-Usano, Marta, Ruiz-Arenas, Carlos, Pelegrí-Sisó, Dolors, Robinson, Oliver, Mason, Dan, Wright, John, Cadiou, Solène, Slama, Rémy, Heude, Barbara, Casas, Maribel, Sunyer, Jordi, Papadopoulou, Eleni Z., Gutzkow, Kristine B., ... Vrijheid, Martine. (2022). Multi-omics signatures of the human early life exposome. Nature Communications. 13(1), p. Article 7024. https://doi.org/10.1038/s41467-022-34422-2
Authors | Maitre, Léa, Bustamante, Mariona, Hernández-Ferrer, Carles, Thiel, Denise, Lau, Chung-Ho E., Siskos, Alexandros P., Vives-Usano, Marta, Ruiz-Arenas, Carlos, Pelegrí-Sisó, Dolors, Robinson, Oliver, Mason, Dan, Wright, John, Cadiou, Solène, Slama, Rémy, Heude, Barbara, Casas, Maribel, Sunyer, Jordi, Papadopoulou, Eleni Z., Gutzkow, Kristine B., Andrusaityte, Sandra, Grazuleviciene, Regina, Vafeiadi, Marina, Chatzi, Leda, Sakhi, Amrit K., Thomsen, Cathrine, Tamayo, Ibon, Nieuwenhuijsen, Mark, Urquiza, Jose, Borràs, Eva, Sabidó, Eduard, Quintela, Inés, Carracedo, Ángel, Estivill, Xavier, Coen, Muireann, González, Juan R., Keun, Hector C. and Vrijheid, Martine |
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Abstract | Environmental exposures during early life play a critical role in life-course health, yet the molecular phenotypes underlying environmental effects on health are poorly understood. In the Human Early Life Exposome (HELIX) project, a multi-centre cohort of 1301 mother-child pairs, we associate individual exposomes consisting of >100 chemical, outdoor, social and lifestyle exposures assessed in pregnancy and childhood, with multi-omics profiles (methylome, transcriptome, proteins and metabolites) in childhood. We identify 1170 associations, 249 in pregnancy and 921 in childhood, which reveal potential biological responses and sources of exposure. Pregnancy exposures, including maternal smoking, cadmium and molybdenum, are predominantly associated with child DNA methylation changes. In contrast, childhood exposures are associated with features across all omics layers, most frequently the serum metabolome, revealing signatures for diet, toxic chemical compounds, essential trace elements, and weather conditions, among others. Our comprehensive and unique resource of all associations (https://helixomics.isglobal.org/) will serve to guide future investigation into the biological imprints of the early life exposome. |
Year | 2022 |
Journal | Nature Communications |
Journal citation | 13 (1), p. Article 7024 |
Publisher | Nature Publishing Group |
ISSN | 2041-1723 |
Digital Object Identifier (DOI) | https://doi.org/10.1038/s41467-022-34422-2 |
PubMed ID | 36411288 |
Scopus EID | 2-s2.0-85142372274 |
PubMed Central ID | PMC9678903 |
Open access | Published as ‘gold’ (paid) open access |
Page range | 1-18 |
Funder | European Research Council (ERC) |
Seventh Framework Programme, European Commission | |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 21 Nov 2022 |
Publication process dates | |
Accepted | 25 Oct 2022 |
Deposited | 06 Mar 2023 |
Grant ID | 874583 |
FP7/2007-206 | |
308333 |
https://acuresearchbank.acu.edu.au/item/8yw7x/multi-omics-signatures-of-the-human-early-life-exposome
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Publisher's version
OA_Maitre_2022_Multi_omics_signatures_of_the_human.pdf | |
License: CC BY 4.0 | |
File access level: Open |
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