Inflammaging and skeletal muscle : Can protein intake make a difference?

Journal article


Draganidis, Dimitrios, Karagounis, Leonidas G., Athanailidis, Ioannis, Chatzinikolaou, Athanasios, Jamurtas, Athanasios Z. and Fatouros, Ioannis G.. (2016). Inflammaging and skeletal muscle : Can protein intake make a difference? The Journal of Nutrition. 146(10), pp. 1940-1952. https://doi.org/10.3945/jn.116.230912
AuthorsDraganidis, Dimitrios, Karagounis, Leonidas G., Athanailidis, Ioannis, Chatzinikolaou, Athanasios, Jamurtas, Athanasios Z. and Fatouros, Ioannis G.
Abstract

Inflammaging is the chronic low-grade inflammatory state present in the elderly, characterized by increased systemic concentrations of proinflammatory cytokines. It has been shown that inflammaging increases the risk of pathologic conditions and age-related diseases, and that it also has been associated with increased skeletal muscle wasting, strength loss, and functional impairments. Experimental evidence suggests that the increased concentrations of proinflammatory cytokines and primary tumor necrosis factor α observed in chronic inflammation lead to protein degradation through proteasome activation and reduced skeletal muscle protein synthesis (MPS) via protein kinase B/Akt downregulation. Dairy and soy proteins contain all the essential amino acids, demonstrate sufficient absorption kinetics, and include other bioactive peptides that may offer nutritional benefits, in addition to those of stimulating MPS. Whey protein has antioxidative effects, primarily because of its ability to enhance the availability of reduced glutathione and the activity of the endogenous antioxidative enzyme system. Soy protein and isoflavone-enriched soy protein, meanwhile, may counteract chronic inflammation through regulation of the nuclear transcription factor κB signaling pathway and cytokine production. Although evidence suggests that whey protein, soy protein, and isoflavone-enriched soy proteins may be promising nutritional interventions against the oxidative stress and chronic inflammation present in pathologic conditions and aging (inflammaging), there is a lack of information about the anabolic potential of dietary protein intake and protein supplementation in elderly people with increased systemic inflammation. The antioxidative and anti-inflammatory effects, as well as the anabolic potential of protein supplementation, should be further investigated in the future with well-designed clinical trials focusing on inflammaging and its associated skeletal muscle loss.

Keywordsinflammaging; oxidative stress; skeletal muscle loss; frailty; whey protein; soy protein
Year2016
JournalThe Journal of Nutrition
Journal citation146 (10), pp. 1940-1952
PublisherAmerican Society for Nutrition
ISSN0022-3166
Digital Object Identifier (DOI)https://doi.org/10.3945/jn.116.230912
PubMed ID27581584
Scopus EID2-s2.0-84992724019
Page range1940-1952
Publisher's version
License
All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online31 Aug 2016
Publication process dates
Accepted18 Jul 2016
Deposited20 Nov 2023
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