Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity : A randomized controlled trial
Journal article
Haganes, Kamilla, Silva, Catalina, Eyjolfsdottir, Svala, Steen, Sandra, Grindberg, Martine, Lydersen, Stian, Hawley, John Alan and Moholdt, Trine. (2022). Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity : A randomized controlled trial. Cell Metabolism. 34(10), pp. 1457-1471. https://doi.org/10.1016/j.cmet.2022.09.003
Authors | Haganes, Kamilla, Silva, Catalina, Eyjolfsdottir, Svala, Steen, Sandra, Grindberg, Martine, Lydersen, Stian, Hawley, John Alan and Moholdt, Trine |
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Abstract | Diet modification and exercise training are primary lifestyle strategies for obesity management, but poor adherence rates limit their effectiveness. Time-restricted eating (TRE) and high-intensity interval training (HIIT) improve cardiometabolic health in at-risk individuals, but whether these two interventions combined induce superior improvements in glycemic control than each individual intervention is not known. In this four-armed randomized controlled trial (ClinicalTrials.gov NCT04019860), we determined the isolated and combined effects of 7 weeks of TRE (≤10-h daily eating window, with ad libitum energy intake) and HIIT (three exercise sessions per week), compared with a non-intervention control group, on glycemic control and secondary cardiometabolic outcomes in 131 women (36.2 ± 6.2 years) with overweight/obesity. There were no statistically significant effects after isolated TRE, HIIT, or a combination (TREHIIT) on glucose area under the curve during an oral glucose tolerance test (the primary outcome) compared with the control group (TRE, -26.3 mmol/L; 95% confidence interval [CI], -82.3 to 29.7, p = 0.36; HIIT, -53.8 mmol/L; 95% CI, -109.2 to 1.6, p = 0.057; TREHIIT, -41.3 mmol/L; 95% CI, -96.4 to 13.8, p = 0.14). However, TREHIIT improved HbA1c and induced superior reductions in total and visceral fat mass compared with TRE and HIIT alone. High participant adherence rates suggest that TRE, HIIT, and a combination thereof may be realistic diet-exercise strategies for improving markers of metabolic health in women at risk of cardiometabolic disease. |
Keywords | body composition; cardiorespiratory fitness; circadian rhythm; diet; fasting; female; glycemic control; high-intensity interval training; insulin resistance; risk factors |
Year | 01 Jan 2022 |
Journal | Cell Metabolism |
Journal citation | 34 (10), pp. 1457-1471 |
Publisher | Cell Press |
ISSN | 1550-4131 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.cmet.2022.09.003 |
PubMed ID | 36198292 |
Scopus EID | 2-s2.0-85138777051 |
Web address (URL) | https://www.sciencedirect.com/science/article/pii/S155041312200393X |
Open access | Published as ‘gold’ (paid) open access |
Research or scholarly | Research |
Page range | 1457-1471 |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
04 Oct 2022 | |
Publication process dates | |
Accepted | 08 Sep 2022 |
Deposited | 17 Jan 2023 |
Additional information | © 2022 The Author(s). Published by Elsevier Inc. All rights reserved. |
Place of publication | United States |
https://acuresearchbank.acu.edu.au/item/8y944/time-restricted-eating-and-exercise-training-improve-hba1c-and-body-composition-in-women-with-overweight-obesity-a-randomized-controlled-trial
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Publisher's version
OA_Haganes_2022_Time_restricted_eating_and_exercise_training.pdf | |
License: CC BY-NC-ND 4.0 | |
File access level: Open |
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