Editor's Choice – Exercise Therapy for Chronic Symptomatic Peripheral Artery Disease : A Clinical Consensus Document of the European Society of Cardiology Working Group on Aorta and Peripheral Vascular Diseases in Collaboration With the European Society of Vascular Medicine and the European Society for Vascular Surgery

Journal article

Mazzolai, Lucia, Belch, Jill, Venermo, Maarit, Aboyans, Victor, Brodmann, Marianne, Bura-Rivière, Alessandra, Debus, Sebastien, Espinola-Klein, Christine, Harwood, Amy E., Hawley, John Alan, Lanzi, Stefano, Madaric, Juraj, Mahé, Guillaume, Malatesta, Davide, Schlager, Oliver, Schmidt-Trucksäss, Arno, Seenan, Chris, Sillesen, Henrik, Tew, Garry A. and Visonà, Adriana. (2024). Editor's Choice – Exercise Therapy for Chronic Symptomatic Peripheral Artery Disease : A Clinical Consensus Document of the European Society of Cardiology Working Group on Aorta and Peripheral Vascular Diseases in Collaboration With the European Society of Vascular Medicine and the European Society for Vascular Surgery. European Journal of Vascular and Endovascular Surgery. 67(3), pp. 373-392. https://doi.org/10.1016/j.ejvs.2024.01.009

Publication dates
Authors	Mazzolai, Lucia, Belch, Jill, Venermo, Maarit, Aboyans, Victor, Brodmann, Marianne, Bura-Rivière, Alessandra, Debus, Sebastien, Espinola-Klein, Christine, Harwood, Amy E., Hawley, John Alan, Lanzi, Stefano, Madaric, Juraj, Mahé, Guillaume, Malatesta, Davide, Schlager, Oliver, Schmidt-Trucksäss, Arno, Seenan, Chris, Sillesen, Henrik, Tew, Garry A. and Visonà, Adriana
Abstract	All guidelines worldwide strongly recommend exercise as a pillar in the management of patients affected by lower extremity peripheral artery disease (PAD). Exercise therapy in this setting presents different modalities, and a structured programme provides optimal results. This clinical consensus paper is intended to promote and assist the set up of comprehensive exercise programmes and best advice for patients with symptomatic chronic PAD. Different exercise training protocols specific for patients with PAD are presented. Data on patient assessment and outcome measures are described based on the current best evidence. The document ends by highlighting supervised exercise programme access disparities across Europe and the evidence gaps requiring further research.
Keywords	Exercise training; Intermittent claudication; Physical activity; Quality of life; Vascular rehabilitation
Year	01 Jan 2024
Journal	European Journal of Vascular and Endovascular Surgery
Journal citation	67 (3), pp. 373-392
Publisher	Elsevier Ltd
ISSN	1078-5884
Digital Object Identifier (DOI)	https://doi.org/10.1016/j.ejvs.2024.01.009
Web address (URL)	https://www.sciencedirect.com/science/article/pii/S107858842400011X
Open access	Published as non-open access
Research or scholarly	Research
Page range	373-392
Publisher's version	License All rights reserved File Access Level Controlled
Output status	Published
Print	03 Mar 2024
Publication process dates
Accepted	Feb 2024
Deposited	23 Feb 2025
Additional information	© 2024 the European Society of Cardiology, the European Society of Vascular Medicine, and the European Society for Vascular Surgery. Published by Oxford University Press on behalf of the European Society of Cardiology, by Hogrefe Verlag GmbH & Co. KG on behalf of European Society of Vascular Medicine and by Elsevier B.V on behalf of European Society for Vascular Surgery. All rights reserved.
Place of publication	United Kingdom

Permalink -

https://acuresearchbank.acu.edu.au/item/915v1/editor-s-choice-exercise-therapy-for-chronic-symptomatic-peripheral-artery-disease-a-clinical-consensus-document-of-the-european-society-of-cardiology-working-group-on-aorta-and-peripheral-vascular

Restricted files

Publisher's version

(1 files)

0
total views
0
total downloads
0
views this month
0
downloads this month

These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Exercise-regulated mitochondrial and nuclear signalling networks in skeletal muscle

Reisman, Elizabeth G., Hawley, John A. and Hoffman, Nolan J.. (2024). Exercise-regulated mitochondrial and nuclear signalling networks in skeletal muscle. Sports Medicine. 54, pp. 1097-1119. https://doi.org/10.1007/s40279-024-02007-2

Discordant skeletal muscle gene and protein responses to exercise

Bishop, David J., Hoffman, Nolan J., Taylor, Dale F., Saner, Nicholas J., Lee, Matthew J.-C. and Hawley, John A.. (2023). Discordant skeletal muscle gene and protein responses to exercise. Trends in Biochemical Sciences. 48(11), pp. 927-936. https://doi.org/10.1016/j.tibs.2023.08.005

Eight-hour time-restricted eating does not lower daily myofibrillar protein synthesis rates : A randomized control trial

Parr, Evelyn B., Kouw, Imre W. K., Wheeler, Michael J., Radford, Bridget E., Hall, Rebecca C., Senden, Joan M., Goessens, Joy P. B., Van Loon, Luc J. C. and Hawley, John A.. (2023). Eight-hour time-restricted eating does not lower daily myofibrillar protein synthesis rates : A randomized control trial. Obesity. 31(S1), pp. 116-126. https://doi.org/10.1002/oby.23637

Approaches to addressing the rise in obesity levels

Apovian, Caroline M., Guo, Xi-Rong, Hawley, John A., Karmali, Shahzeer, Loos, Ruth J. F. and Waterlander, Wilma E.. (2023). Approaches to addressing the rise in obesity levels. Nature Reviews Endocrinology. 19, pp. 76-81. https://doi.org/10.1038/s41574-022-00777-1

Interrelated but not time-aligned response in myogenic regulatory factors demethylation and mRNA expression after divergent exercise bouts

Telles, Guilherme Defante, Libardi, Cleiton Augusto, Conceição, Miguel Soares, Vechin, Felipe Cassaro, Lixandrão, Manoel Emílio, Mangone, Flavia Regina Rotea, Pavanelli, Ana Carolina, Nagai, Maria Aparecida, Camera, Donny Michael, Hawley, John A. and Ugrinowitsch, Carlos. (2023). Interrelated but not time-aligned response in myogenic regulatory factors demethylation and mRNA expression after divergent exercise bouts. Medicine and Science in Sports and Exercise. 55(2), pp. 199-208. https://doi.org/10.1249/MSS.0000000000003049

High-intensity interval training in polycystic ovary syndrome : A two-center, three-armed randomized

Kiel, Ida A., Lionett, Sofie, Parr, Evelyn B., Jones, Helen, Røset, Maria A. H., Salvesen, Øyvind, Hawley, John A., Vanky, Eszter and Moholdt, Trine. (2022). High-intensity interval training in polycystic ovary syndrome : A two-center, three-armed randomized. Medicine and Science in Sports and Exercise. 54(5), pp. 717-727. https://doi.org/10.1249/MSS.0000000000002849

Perspective : Time-restricted eating—integrating the what with the when

Parr, Evelyn B., Devlin, Brooke L. and Hawley, John A.. (2022). Perspective : Time-restricted eating—integrating the what with the when. Advances in Nutrition. 13(3), pp. 699-711. https://doi.org/10.1093/advances/nmac015

Reassessing the relationship between mRNA levels and protein abundance in exercised skeletal muscles

Bishop, David J. and Hawley, John A.. (2022). Reassessing the relationship between mRNA levels and protein abundance in exercised skeletal muscles. Nature Reviews Molecular Cell Biology. 23(12), pp. 773-774. https://doi.org/10.1038/s41580-022-00541-3

Disrupting AMPK-glycogen binding in mice increases carbohydrate utilization and reduces exercise capacity

Janzen, Natalie R., Whitfield, Jamie, Murray-Segal, Lisa, Kemp, Bruce E., Hawley, John A. and Hoffman, Nolan J.. (2022). Disrupting AMPK-glycogen binding in mice increases carbohydrate utilization and reduces exercise capacity. Frontiers in Physiology. 13, p. 859246. https://doi.org/10.3389/fphys.2022.859246

Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity : A randomized controlled trial

Haganes, Kamilla, Silva, Catalina, Eyjolfsdottir, Svala, Steen, Sandra, Grindberg, Martine, Lydersen, Stian, Hawley, John Alan and Moholdt, Trine. (2022). Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity : A randomized controlled trial. Cell Metabolism. 34(10), pp. 1457-1471. https://doi.org/10.1016/j.cmet.2022.09.003

Metabolomics reveals mouse plasma metabolite responses to acute exercise and effects of disrupting AMPK-glycogen interactions

Belhaj, Mehdi, Lawler, Nathan, Hawley, John Alan, Broadhurst, David, Hoffman, Nolan John and Reinke, Stacey. (2022). Metabolomics reveals mouse plasma metabolite responses to acute exercise and effects of disrupting AMPK-glycogen interactions. Frontiers in Molecular Biosciences. pp. 1-16. https://doi.org/10.3389/fmolb.2022.957549

Sleep, circadian biology and skeletal muscle interactions : Implications for metabolic health

Morrison, Matthew, Halson, Shona L., Weakley, Jonathon and Hawley, John A.. (2022). Sleep, circadian biology and skeletal muscle interactions : Implications for metabolic health. Sleep Medicine Reviews. 66, p. Article 101700. https://doi.org/10.1016/j.smrv.2022.101700

Isolated and combined effects of highintensity interval training and timerestricted eating on glycaemic control in reproductive-aged women with overweight or obesity : Study protocol for a four-armed randomised controlled trial

Moholdt, Trine, Silva, Catalina P., Lydersen, Stian and Hawley, John A.. (2021). Isolated and combined effects of highintensity interval training and timerestricted eating on glycaemic control in reproductive-aged women with overweight or obesity : Study protocol for a four-armed randomised controlled trial. BMJ Open. 11(2), p. Article e040020. https://doi.org/10.1136/bmjopen-2020-040020

Mimicking exercise : What matters most and where to next?

Hawley, John A., Joyner, Michael J. and Green, Daniel J.. (2021). Mimicking exercise : What matters most and where to next? The Journal of Physiology. 599(3), pp. 791-802. https://doi.org/10.1113/JP278761

The effect of morning vs evening exercise training on glycaemic control and serum metabolites in overweight/obese men : A randomised trial

Moholdt, Trine, Parr, Evelyn B., Devlin, Brooke L., Debik, Julia, Giskeødegård, Guro and Hawley, John A.. (2021). The effect of morning vs evening exercise training on glycaemic control and serum metabolites in overweight/obese men : A randomised trial. Diabetologia. 64(9), pp. 2061-2076. https://doi.org/10.1007/s00125-021-05477-5

Mice with whole-body disruption of AMPK-glycogen binding have increased adiposity, reduced fat oxidation and altered tissue glycogen dynamics

Janzen, Natalie, Whitfield, Jamie, Murray-Segal, Lisa, Kemp, Bruce E., Hawley, John A. and Hoffman, Nolan J.. (2021). Mice with whole-body disruption of AMPK-glycogen binding have increased adiposity, reduced fat oxidation and altered tissue glycogen dynamics. International Journal of Molecular Sciences. 22(17), p. Article: 9616. https://doi.org/10.3390/ijms22179616

Skeletal muscle adaptive responses to different types of short-term exercise training and detraining in middle-age men

Callahan, Marcus J., Parr, Evelyn B., Snijders, Tim, Conceição, Miguel S., Radford, Bridget E., Timmins, Ryan G., Devlin, Brooke L., Hawley, John A. and Camera, Donny M.. (2021). Skeletal muscle adaptive responses to different types of short-term exercise training and detraining in middle-age men. Medicine and Science in Sports and Exercise. 53(10), pp. 2023-2036. https://doi.org/10.1249/MSS.0000000000002684

Lower nocturnal blood glucose response to a potato-based mixed evening meal compared to rice in individuals with type 2 diabetes

Devlin, Brooke L., Parr, Evelyn B., Radford, Bridget E. and Hawley, John A.. (2021). Lower nocturnal blood glucose response to a potato-based mixed evening meal compared to rice in individuals with type 2 diabetes. Clinical Nutrition. 40(4), pp. 2200-2209. https://doi.org/10.1016/j.clnu.2020.09.049

Can high-intensity interval training promote skeletal muscle anabolism?

Callahan, Marcus J., Parr, Evelyn B., Hawley, John A. and Camera, Donny M.. (2021). Can high-intensity interval training promote skeletal muscle anabolism? Sports Medicine. 51, pp. 405-421. https://doi.org/10.1007/s40279-020-01397-3

Chrono-nutrition for the prevention and treatment of obesity and type 2 diabetes : From mice to men

Hawley, John A., Sassone-Corsi, Paolo and Zierath, Juleen R.. (2020). Chrono-nutrition for the prevention and treatment of obesity and type 2 diabetes : From mice to men. Diabetologia. 63(11), pp. 2253-2259. https://doi.org/10.1007/s00125-020-05238-w

Maternal lifestyle interventions : Targeting preconception health

Moholdt, Trine and Hawley, John A.. (2020). Maternal lifestyle interventions : Targeting preconception health. Trends in Endocrinology and Metabolism. 31(8), pp. 561-569. https://doi.org/10.1016/j.tem.2020.03.002

Time-restricted eating as a nutrition strategy for individuals with type 3 diabetes : A feasibility study

Parr, Evelyn B., Devlin, Brooke L., Lim, Karen H. C., Moresi, Laura N. Z., Geils, Claudia, Brennan, Leah and Hawley, John A.. (2020). Time-restricted eating as a nutrition strategy for individuals with type 3 diabetes : A feasibility study. Nutrients. 12(11), p. 3228. https://doi.org/10.3390/nu12113228

Circulating and adipose tissue miRNAs in women with polycystic ovary syndrome and responses to high-intensity interval training

Lionett,Sofie, Kiel,Ida A., Camera,Donny M., Vanky,Eszter, Parr, E., Lydersen,Stian, Hawley, J. and Moholdt,Trine. (2020). Circulating and adipose tissue miRNAs in women with polycystic ovary syndrome and responses to high-intensity interval training. Frontiers in Physiology. 11, p. 904. https://doi.org/10.3389/fphys.2020.00904

Omega-3 polyunsaturated fatty acids mitigate palmitate-induced impairments in skeletal muscle cell viability and differentiation

Tachtsis, Bill, Whitfield, Jamie, Hawley, John A. and Hoffman, Nolan J.. (2020). Omega-3 polyunsaturated fatty acids mitigate palmitate-induced impairments in skeletal muscle cell viability and differentiation. Frontiers in Physiology. 11, pp. 1-13. https://doi.org/10.3389/fphys.2020.00563

The Challenge of Maintaining Metabolic Health During a Global Pandemic

Andy J. King, Louise M. Burke, Shona L. Halson and John A. Hawley. (2020). The Challenge of Maintaining Metabolic Health During a Global Pandemic. Sports Medicine. 50(7), pp. 1233-1241. https://doi.org/10.1007/s40279-020-01295-8

Microbiota and muscle highway - two way traffic

John Hawley. (2020). Microbiota and muscle highway - two way traffic. Nature Reviews Endocrinology. 16(2), pp. 71-72. https://doi.org/10.1038/s41574-019-0291-6

Does high cardiorespiratory fitness confer some protection against pro-inflammatory responses after infection by SARS-CoV-2?

Zbinden-Foncea, Hermann, Francaux, Marc, Deldicque, Louise and Hawley, John A.. (2020). Does high cardiorespiratory fitness confer some protection against pro-inflammatory responses after infection by SARS-CoV-2? Obesity. 28(8), pp. 1378-1381. https://doi.org/10.1002/oby.22849

A time to eat and a time to exercise

Parr, Evelyn B., Heilbronn, Leonie K. and Hawley, John A.. (2020). A time to eat and a time to exercise. Exercise and Sport Sciences Reviews. 48(1), pp. 4-10. https://doi.org/10.1249/JES.0000000000000207

Genetic loss of AMPK-glycogen binding destabilizes AMPK and disrupts metabolism

Hoffman, Nolan J., Whitfield, Jamie, Janzen, Natalie R., Belhaj, Mehdi R., Galic, Sandra, Murray-Segal, Lisa, Smiles, William J., Ling, Naomi X. Y., Dite, Toby A., Scott, John W., Oakhill, Jonathan S., Brink, Robert, Kemp, Bruce E. and Hawley, John A.. (2020). Genetic loss of AMPK-glycogen binding destabilizes AMPK and disrupts metabolism. Molecular Metabolism. 41, pp. 1-13. https://doi.org/10.1016/j.molmet.2020.101048

Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression

Leonidas S Lundell, Evelyn Parr, Brooke Devlin, Lars R Ingerslev, Ali Altintas, Shogo Sato, Paolo Sassone-Corsi, Romain Barres, Juleen R Zierath and John Hawley. (2020). Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression. Nature Communications. 11(1), pp. 1-11. https://doi.org/10.1038/s41467-020-18412-w

Divergent regulation of myotube formation and gene expression by E2 and EPA during in-vitro differentiation of C2C12 myoblasts

Lacham-Kaplan, Orly, Camera, Donny and Hawley, John. (2020). Divergent regulation of myotube formation and gene expression by E2 and EPA during in-vitro differentiation of C2C12 myoblasts. International Journal of Molecular Sciences. 21(3), pp. 1-18. https://doi.org/10.3390/ijms21030745

Editorial: Cross Adaptation and Cross Tolerance in Human Health and Disease

Ben James Lee, Oliver R Gibson, Charles Douglas Thake, Mike Tipton, John Hawley and James D Cotter. (2019). Editorial: Cross Adaptation and Cross Tolerance in Human Health and Disease. Frontiers in Physiology. 9, pp. 1-3. https://doi.org/10.3389/fphys.2018.01827

Between-meal sucrose-sweetened beverage consumption impairs glycaemia and lipid metabolism during prolonged sitting : A randomized controlled trial

Varsamis, Pia, Formosa, Melissa F., Larsen, Robyn N., Reddy-Luthmoodoo, Medini, Jennings, Garry L., Cohen, Neale D., Grace, Megan S., Hawley, John A., Devlin, Brooke L., Owen, Neville, Dunstan, David W., Dempsey, Paddy C. and Kingwell, Bronwyn A.. (2019). Between-meal sucrose-sweetened beverage consumption impairs glycaemia and lipid metabolism during prolonged sitting : A randomized controlled trial. Clinical Nutrition. 38(4), pp. 1536-1543. https://doi.org/10.1016/j.clnu.2018.08.021

A single bout of strenuous exercise overcomes lipid-induced anabolic resistance to protein ingestion in overweight, middle-aged men

Smiles, William J., Churchward-Venne, Tyler A., van Loon, Luc J. C., Hawley, John A. and Camera, Donny M.. (2019). A single bout of strenuous exercise overcomes lipid-induced anabolic resistance to protein ingestion in overweight, middle-aged men. The FASEB Journal. 33(6), pp. 7009 - 7017. https://doi.org/10.1096/fj.201801917R

Winter peaks in heart failure: An inevitable or preventable consequence of seasonal vulnerability?

Stewart, Simon, Moholdt, Trine T., Burrell, Louise M., Sliwa, Karen, Mocumbi, Ana O., McMurray, John J. V., Keates, Ashley K. and Hawley, John A.. (2019). Winter peaks in heart failure: An inevitable or preventable consequence of seasonal vulnerability? Cardiac Failure Review. 5(2), pp. 83 - 85. https://doi.org/10.15420/cfr.2018.40.2

Prevalence and profile of "seasonal frequent flyers" with chronic heart disease: Analysis of 1598 patients and 4588 patient-years follow-up

Loader, Jordan, Chan, Yih-Kai, Hawley, John A., Moholdt, Trine, McDonald, Christine F., Jhund, Pardeep, Petrie, Mark C., McMurray, John J., Scuffham, Paul A., Ramchand, Jay, Burrell, Louise M. and Stewart, Simon. (2019). Prevalence and profile of "seasonal frequent flyers" with chronic heart disease: Analysis of 1598 patients and 4588 patient-years follow-up. International Journal of Cardiology. 279, pp. 126 - 132. https://doi.org/10.1016/j.ijcard.2018.12.060

Effects of providing high-fat versus high-carbohydrate meals on daily and postprandial physical activity and glucose patterns: a randomised controlled trial

Parr, Evelyn, Devlin, Brooke, Callahan, Marcus J., Radford, Bridget, Blankenship, Jennifer M., Dunstan, David and Hawley, John. (2018). Effects of providing high-fat versus high-carbohydrate meals on daily and postprandial physical activity and glucose patterns: a randomised controlled trial. Nutrients. 10(5), pp. 1 - 16. https://doi.org/10.3390/nu10050557

Impact of first meal size during prolonged sitting on postprandial glycaemia in individuals with prediabetes: a randomised, crossover study

Parr, Evelyn, Devlin, Brooke, Pinto, Samuel, Dunstan, David and Hawley, John. (2018). Impact of first meal size during prolonged sitting on postprandial glycaemia in individuals with prediabetes: a randomised, crossover study. Nutrients. 10(6), pp. 1 - 15. https://doi.org/10.3390/nu10060733

Effects of creatine and carbohydrate loading on cycling time trial performance

Tomcik, Kristyen A., Camera, Donny, Bone, Julia L. L., Ross, Meg, Jeacocke, N. A., Tachtsis, Bill, Senden, Joan M., Van Loon, Luc, Hawley, John and Burke, Louise. (2018). Effects of creatine and carbohydrate loading on cycling time trial performance. Medicine and Science in Sports and Exercise. 50(1), pp. 141 - 150. https://doi.org/10.1249/MSS.0000000000001401

Sending the signal: Muscle glycogen availability as a regulator of training adaptation

Hawley, John A.. (2018). Sending the signal: Muscle glycogen availability as a regulator of training adaptation. In In B. Spiegelman (Ed.). Hormones, metabolism and the benefits of exercise pp. 43 - 55 Springer Nature. https://doi.org/10.1007/978-3-319-72790-5_4

Swifter, higher, stronger: what's on the menu?

Burke, Louise M. and Hawley, John A.. (2018). Swifter, higher, stronger: what's on the menu? Science. 362(6416), pp. 781 - 787. https://doi.org/10.1126/science.aau2093

Effect of resistance training and protein intake pattern on myofibrillar protein synthesis and proteome kinetics in older men in energy restriction

Murphy, Caoileann, Shankaran, Mahalakshmi, Churchward-Venne, T. A., Mitchell, Cameron J., Kolar, Nathan M., Burke, Louise, Hawley, John, Kassis, Amira, Karagounis, Leonidas G., Li, Kelvin, King, Chelsea, Hellerstein, Marc and Phillips, S. M.. (2018). Effect of resistance training and protein intake pattern on myofibrillar protein synthesis and proteome kinetics in older men in energy restriction. The Journal of Physiology. 596(11), pp. 2091 - 2120. https://doi.org/10.1113/JP275246

Protein availability and satellite cell dynamics in skeletal muscle

Shamim, Baubak, Hawley, John and Camera, Donny. (2018). Protein availability and satellite cell dynamics in skeletal muscle. Sports Medicine. 48(6), pp. 1329 - 1343. https://doi.org/10.1007/s40279-018-0883-7

Human metabolomics reveal daily variations under nutritional challenges specific to serum and skeletal muscle

Sato, Shogo, Evelyn, Parr B., Devlin, Brooke L., Hawley, John A. and Sassone-Corsi, Paolo. (2018). Human metabolomics reveal daily variations under nutritional challenges specific to serum and skeletal muscle. Molecular Metabolism. 16, pp. 1-11. https://doi.org/10.1016/j.molmet.2018.06.008

Toward a common understanding of diet-exercise strategies to manipulate fuel availability for training and competition preparation in endurance sport

Burke, Louise, Hawley, John, Jeukendrup, A. E., Morton, James P., Stellingwerff, T. and Maughan, Ronald J.. (2018). Toward a common understanding of diet-exercise strategies to manipulate fuel availability for training and competition preparation in endurance sport. International Journal of Sport Nutrition and Exercise Metabolism. 28(5), pp. 451 - 463. https://doi.org/10.1123/ijsnem.2018-0289

Molecular basis of exercise-induced skeletal muscle mitochondrial biogenesis: Historical advances, current knowledge, and future challenges

Perry, Christopher G. R. and Hawley, John. (2018). Molecular basis of exercise-induced skeletal muscle mitochondrial biogenesis: Historical advances, current knowledge, and future challenges. Cold Spring Harbor Perspectives in Medicine. 8(9), pp. 1 - 15. https://doi.org/10.1101/cshperspect.a029686

Adaptations to concurrent training in combination with high protein availability: A comparative trial in healthy, recreationally active men

Shamim, Baubak, Devlin, Brooke L., Timmins, Ryan G., Tofari, Paul, Dow, Connor Lee, Coffey, Vernon G., Hawley, John A. and Camera, Donny M.. (2018). Adaptations to concurrent training in combination with high protein availability: A comparative trial in healthy, recreationally active men. Sports Medicine. 48(12), pp. 2869 - 2883. https://doi.org/10.1007/s40279-018-0999-9

High dietary fat intake increases fat oxidation and reduces skeletal muscle mitochondrial respiration in trained humans

Leckey, Jill J., Hoffman, Nolan J., Parr, Evelyn B., Devlin, Brooke L., Trewin, Adam J., Stepto, Nigel K., Morton, James P., Burke, Louise M. and Hawley, John A.. (2018). High dietary fat intake increases fat oxidation and reduces skeletal muscle mitochondrial respiration in trained humans. FASEB Journal. 32(6), pp. 2979-2991. https://doi.org/10.1096/fj.201700993R

Maximizing cellular adaptation to endurance exercise in skeletal muscle

Hawley, John, Lundby, Carsten, Cotter, James D. and Burke, Louise. (2018). Maximizing cellular adaptation to endurance exercise in skeletal muscle. Cell Metabolism. 27(5), pp. 962 - 976. https://doi.org/10.1016/j.cmet.2018.04.014

Post-exercise muscle glycogen resynthesis in humans

Burke, Louise M., van Loon, Luc J. C. and Hawley, John A.. (2017). Post-exercise muscle glycogen resynthesis in humans. Journal of Applied Physiology. 122(5), pp. 1055-1067. https://doi.org/0.1152/japplphysiol.00860.2016

Ketone diester ingestion impairs time-trial performance in professional cyclists

Leckey, Jill J., Ross, Megan L., Quod, Marc, Hawley, John A. and Burke, Louise M.. (2017). Ketone diester ingestion impairs time-trial performance in professional cyclists. Frontiers in Physiology. 8(OCT), pp. 1 - 10. https://doi.org/10.3389/fphys.2017.00806

Fenugreek increases insulin-stimulated creatine content in l6C11 muscle myotubes

Tomcik, Kristyen, Smiles, William, Camera, Donny, Hugel, Helmut M., Hawley, John and Watts, Rani. (2017). Fenugreek increases insulin-stimulated creatine content in l6C11 muscle myotubes. European Journal of Nutrition. 56(3), pp. 973 - 979. https://doi.org/10.1007/s00394-015-1145-1

Acute low-intensity cycling with blood-flow restriction has no effect on metabolic signaling in human skeletal muscle compared to traditional exercise

Smiles, William J., Conceição, Miguel S., Telles, Guilherme D., Chacon-Mikahil, Mara P. T., Cavaglieri, Cláudia R., Vechin, Felipe C., Libardi, Cleiton A., Hawley, John A. and Camera, Donny M.. (2017). Acute low-intensity cycling with blood-flow restriction has no effect on metabolic signaling in human skeletal muscle compared to traditional exercise. European Journal of Applied Physiology. 117(2), pp. 345-358. https://doi.org/10.1007/s00421-016-3530-8

Single and combined effects of beetroot crystals and sodium bicarbonate on 4-km cycling time trial performance

Callahan, Marcus J., Parr, Evelyn B., Hawley, John A. and Burke, Louise M.. (2017). Single and combined effects of beetroot crystals and sodium bicarbonate on 4-km cycling time trial performance. International Journal of Sport Nutrition and Exercise Metabolism. 27(3), pp. 271-278. https://doi.org/10.1123/ijsnem.2016-0228

Postexercise muscle glycogen resynthesis in humans

Burke, Louise, Van Loon, Luc and Hawley, John. (2017). Postexercise muscle glycogen resynthesis in humans. Journal of Applied Physiology. 122(5), pp. 1055 - 1067. https://doi.org/10.1152/japplphysiol.00860.2016

Molecular basis of exercise-induced skeletal muscle mitochondrial biogenesis: Historical advances, current knowledge, and future challenges

Perry, Christopher G. R. and Hawley, John. (2017). Molecular basis of exercise-induced skeletal muscle mitochondrial biogenesis: Historical advances, current knowledge, and future challenges. In In J. R. Zierath, M. J. Joyner and J. A. Hawley (Ed.). The biology of exercise: A subject collection from Cold Spring Harbor Persepectives in Medicine pp. 73 - 87 Cold Spring Harbor Laboratory Press. https://doi.org/10.1101/cshperspect.a029686

Concurrent exercise training: Do opposites distract?

Coffey, Vernon and Hawley, John. (2017). Concurrent exercise training: Do opposites distract? The Journal of Physiology. 595(9), pp. 2883 - 2896. https://doi.org/10.1113/JP272270

Low carbohydrate, high fat diet impairs exercise economy and negates the performance benefit from intensified training in elite race walkers

Burke, Louise, Ross, Megan L.L., Garvican, Laura A., Welvaert, Marijke, Heikura, Ida A., Forbes, Sara G., Mirtschin, Jo, Cato, Louise E., Strobel, Nicki, Sharma, Avish P. and Hawley, John. (2017). Low carbohydrate, high fat diet impairs exercise economy and negates the performance benefit from intensified training in elite race walkers. The Journal of Physiology. 595(9), pp. 2785 - 2807. https://doi.org/10.1113/JP273230

Dynamic proteome profiling of individual proteins in human skeletal muscle after a high-fat diet and resistance exercise

Camera, Donny M., Burniston, Jatin G., Pogson, Mark A., Smiles, William J. and Hawley, John A.. (2017). Dynamic proteome profiling of individual proteins in human skeletal muscle after a high-fat diet and resistance exercise. The FASEB Journal. 31(12), pp. 5478-5494. https://doi.org/10.1096/fj.201700531R

Transcriptomic and epigenetic responses to short-term nutrient-exercise stress in humans

Laker, R. C., Garde, C., Camera, Donny, Smiles, William, Zierath, J. R., Hawley, John and Barrès, R.. (2017). Transcriptomic and epigenetic responses to short-term nutrient-exercise stress in humans. Scientific Reports. 7(1), pp. 1 - 12. https://doi.org/10.1038/s41598-017-15420-7

Commentaries on Viewpoint: A time for exercise: the exercise window

Boule, Normand G., Terada, Tasuku, Francois, Monique E., Hawley, John, Cotter, James D., Kruse, Nicholas T., McDonald, Matthew W., Olver, T D., Paoli, Antonio, Sacchetti, Massimo, Di Luigi, Luigi, van Dijk, Jan W., Van Loon, Luc, Yardley, Jane E., DiPietro, Loretta, Gribok, Andrei and Rumpler, William. (2017). Commentaries on Viewpoint: A time for exercise: the exercise window. Journal of Applied Physiology. 122(1), pp. 210 - 213. https://doi.org/10.1152/japplphysiol.00938.2016

Sprinting toward fitness

Gibala, M. J. and Hawley, John. (2017). Sprinting toward fitness. Cell Metabolism. 25(5), pp. 988 - 990. https://doi.org/10.1016/j.cmet.2017.04.030

Expression of microRNAs and target proteins in skeletal muscle of rats selectively bred for high and low running capacity

Pinto, Samuel K., Lamon, Séverine, Stephenson, Erin J., Kalanon, M., Mikovic, Jasmine, Koch, L G., Britton, S. L., Hawley, John and Camera, Donny. (2017). Expression of microRNAs and target proteins in skeletal muscle of rats selectively bred for high and low running capacity. American Journal of Physiology - Endocrinology and Metabolism. 313(3), pp. 335 - 343. https://doi.org/10.1152/ajpendo.00043.2017

Postexercise high-fat feeding suppresses p70S6K1 activity in human skeletal muscle

Hammond, Kelly M., Impey, Samuel G., Currell, Kevin, Mitchell, Nigel, Shepherd, Sam O., Jeromson, Stewart, Hawley, John A., Close, Graeme L., Hamilton, Lee D., Sharples, Adam P. and Morton, James P.. (2016). Postexercise high-fat feeding suppresses p70S6K1 activity in human skeletal muscle. Medicine and Science in Sports and Exercise. 48(11), pp. 2108-2117. https://doi.org/10.1249/MSS.0000000000001009

Adaptations to prolonged, intense endurance training in human skeletal muscle

Hawley, J. A. (2016). Adaptations to prolonged, intense endurance training in human skeletal muscle. In In I Mujika and Y Le Meur (Ed.). Endurance Training pp. 119-126 Inigo Mujika.

Update on the effects of physical activity on insulin sensitivity in humans

Bird, Stephen R. and Hawley, John. (2016). Update on the effects of physical activity on insulin sensitivity in humans. 2(1), pp. 1 - 26. https://doi.org/10.1136/bmjsem-2016-000143

Revisiting the three component synthesis of isoxazolo[5,4-b]pyridines, 4-aryl-3,7,7-trimethyl-isoxazolo[5,4-b]quinolin-5(6H)-ones and related heterocycles

Lingham, Anthony R., Hawley, John A., Greaves, Tamar, Jackson, Neale, Antolasic, Frank and Hugel, Helmut M.. (2016). Revisiting the three component synthesis of isoxazolo[5,4-b]pyridines, 4-aryl-3,7,7-trimethyl-isoxazolo[5,4-b]quinolin-5(6H)-ones and related heterocycles. Polyhedron. 120, pp. 175 - 179. https://doi.org/10.1016/j.poly.2016.09.011

Carbohydrate dependence during prolonged simulated cycling time trials

Torrens, Samuel L., Areta, José L., Parr, Evelyn B. and Hawley, John A.. (2016). Carbohydrate dependence during prolonged simulated cycling time trials. European Journal of Applied Physiology. 116(4), pp. 781-790. https://doi.org/10.1007/s00421-016-3333-y

Acute endurance exercise induces nuclear p53 abundance in human skeletal muscle

Tachtsis, Bill, Smiles, William, Lane, Steven C., Hawley, John Alan and Camera, Donny Michael. (2016). Acute endurance exercise induces nuclear p53 abundance in human skeletal muscle. Frontiers in Physiology. 7(144), pp. 1 - 10. https://doi.org/10.3389/fphys.2016.00144

Circulating microRNA responses between 'high' and 'low' responders to a 16-wk diet and exercise weight loss intervention

Parr, Evelyn B., Camera, Donny M., Burke, Louise M., Phillips, Stuart M., Coffey, Vernon G. and Hawley, John Alan. (2016). Circulating microRNA responses between 'high' and 'low' responders to a 16-wk diet and exercise weight loss intervention. PLoS ONE. 11(4), pp. 1 - 14. https://doi.org/10.1371/journal.pone.0152545

Altering fatty acid availability does not impair prolonged, continuous running to fatigue: Evidence for carbohydrate dependence

Leckey, Jill, Burke, Louise Mary, Morton, James P. and Hawley, John Alan. (2016). Altering fatty acid availability does not impair prolonged, continuous running to fatigue: Evidence for carbohydrate dependence. Journal of Applied Physiology. 120(2), pp. 107 - 113. https://doi.org/10.1152/japplphysiol.00855.2015

Commentaries on Viewpoint: The rigorous study of exercise adaptations: Why mRNA might not be enough

Camera, Donny and Hawley, John. (2016). Commentaries on Viewpoint: The rigorous study of exercise adaptations: Why mRNA might not be enough. Journal of Applied Physiology. 121(2), pp. 598 - 598. https://doi.org/10.1152/japplphysiol.00509.2016

Exercise-induced skeletal muscle signaling pathways and human athletic performance

Camera, Donny Michael, Smiles, William J. and Hawley, John Alan. (2016). Exercise-induced skeletal muscle signaling pathways and human athletic performance. Free Radical Biology & Medicine. 98, pp. 131 - 143. https://doi.org/10.1016/j.freeradbiomed.2016.02.007

Effects of skeletal muscle energy availability on protein turnover responses to exercise

Smiles, William J., Hawley, John Alan and Camera, Donny Michael. (2016). Effects of skeletal muscle energy availability on protein turnover responses to exercise. Journal of Experimental Biology. 219(Pt 2), pp. 214 - 225. https://doi.org/10.1242/jeb.125104

Periodization of carbohydrate intake: Short-term effect on performance

Marquet, Laurie-Anne, Hausswirth, Christophe, Molle, Odeline, Hawley, John A., Burke, Louise M., Tiollier, Eve and Brisswalter, Jeanick. (2016). Periodization of carbohydrate intake: Short-term effect on performance. Nutrients. 8(12), pp. 1 - 13. https://doi.org/10.3390/nu8120755

A randomized trial of high-dairy-protein, variable-carbohydrate diets and exercise on body composition in adults with obesity

Parr, Evelyn B., Coffey, Vernon Glenn, Cato, Louise E., Phillips, Stuart M., Burke, Louise Mary and Hawley, John Alan. (2016). A randomized trial of high-dairy-protein, variable-carbohydrate diets and exercise on body composition in adults with obesity. Obesity. 24(5), pp. 1035 - 1045. https://doi.org/10.1002/oby.21451

Metabolism: One step forward for exercise

Hawley, John Alan and Krook, Anna. (2016). Metabolism: One step forward for exercise. Nature Reviews Endocrinology. 12(1), pp. 7 - 8. https://doi.org/10.1038/nrendo.2015.201

Protein coingestion with alcohol following strenuous exercise attenuates alcohol-induced intramyocellular apoptosis and inhibition of autophagy

Smiles, William J., Parr, Evelyn B., Coffey, Vernon G., Lacham-Kaplan, Orly, Hawley, John Alan and Camera, Donny Michael. (2016). Protein coingestion with alcohol following strenuous exercise attenuates alcohol-induced intramyocellular apoptosis and inhibition of autophagy. American Journal of Physiology - Endocrinology and Metabolism. 311(5), pp. E836 - E849. https://doi.org/10.1152/ajpendo.00303.2016

Attenuated PGC-1α isoforms following endurance exercise with blood flow restriction

Conceição, Miguel Soares, Chacon-Mikahil, Mara Patricia Traina, Telles, Guilherme Defante, Libardi, Cleiton Augusto, Júnior, Edson Manoel Mendes, Vechin, Felipe Cassaro, Lugani de Andrade, André Luis, Gáspari, Arthur Fernandes, Brum, Patrícia Chakur, Cavaglieri, Cláudia Regina, Serag, Sara, Spiegelman, Bruce M., Hawley, John A. and Camera, Donny M.. (2016). Attenuated PGC-1α isoforms following endurance exercise with blood flow restriction. Medicine and Science in Sports and Exercise. 16(4809), pp. 1699-1707. https://doi.org/10.1249/MSS.0000000000000970

SnapShot: Exercise metabolism

Egan, Brendan, Hawley, John Alan and Zierath, Juleen R.. (2016). SnapShot: Exercise metabolism. Cell Metabolism. 24(2), pp. 342 - 342. https://doi.org/10.1016/j.cmet.2016.07.013

Selective modulation of microRNA expression with protein ingestion following concurrent resistance and endurance exercise in human skeletal muscle

Camera, Donny Michael, Ong, Jun N., Coffey, Vernon Glenn and Hawley, John Alan. (2016). Selective modulation of microRNA expression with protein ingestion following concurrent resistance and endurance exercise in human skeletal muscle. Frontiers in Physiology. 7(Mar), pp. 1 - 8. https://doi.org/10.3389/fphys.2016.00087

Enhanced endurance performance by periodization of CHO intake: "Sleep Low" strategy

Marquet, Laurie-Anne, Brisswalter, Jeanick, Louis, Julien, Tiollier, Eve, Burke, Louise Mary, Hawley, John Alan and Hausswirth, Christophe. (2016). Enhanced endurance performance by periodization of CHO intake: "Sleep Low" strategy. Medicine and Science in Sports and Exercise. 48(4), pp. 663 - 672. https://doi.org/10.1249/MSS.0000000000000823

Modulation of autophagy signaling with resistance exercise and protein ingestion following short-term energy deficit

Smiles, William J., Areta, José L., Coffey, Vernon G., Phillips, Stuart M., Moore, Daniel R., Stellingwerff, Trent, Burke, Louise M., Hawley, John A. and Camera, Donny M.. (2015). Modulation of autophagy signaling with resistance exercise and protein ingestion following short-term energy deficit. American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 309(5), pp. R603-R612. https://doi.org/10.1152/ajpregu.00413.2014

Carbohydrate dependence during prolonged, intense endurance exercise

Hawley, John and Leckey, Jill. (2015). Carbohydrate dependence during prolonged, intense endurance exercise. Sports Medicine: reviews of applied medicine and science in sport and exercise. 45, pp. 5 - 12. https://doi.org/10.1007/s40279-015-0400-1

Carbohydrate availability and exercise training adaptation : Too much of a good thing?

Bartlett, Jonathan, Hawley, John and Morton, James. (2015). Carbohydrate availability and exercise training adaptation : Too much of a good thing? European Journal of Sport Science. 15(1), pp. 3 - 12. https://doi.org/10.1080/17461391.2014.920926

Nutritional strategies to enhance fat oxidation during aerobic exercise

Burke, Louise and Hawley, John. (2015). Nutritional strategies to enhance fat oxidation during aerobic exercise. In In L. Burke and V. Deakin (Ed.). Clinical sports nutrition pp. 463 - 492 McGraw-Hill Education (Australia) Pty Ltd.

Need for measures of satellite cell activation along with muscle protein synthesis?

Camera, Donny and Hawley, John. (2015). Need for measures of satellite cell activation along with muscle protein synthesis? Journal of Applied Physiology. 118(4), pp. 500 - 500. https://doi.org/10.1152/japplphysiol.00609.2014.

Alcohol ingestion impairs maximal post-exercise rates of myofibrillar protein synthesis following a single bout of concurrent training

Parr, Evelyn, Camera, Donny, Areta, José, Burke, Louise, Phillips, Stuart, Hawley, John A. and Coffey, Vernon. (2014). Alcohol ingestion impairs maximal post-exercise rates of myofibrillar protein synthesis following a single bout of concurrent training. PLoS ONE. 9(2), pp. 1 - 9. https://doi.org/10.1371/journal.pone.0088384

Ramping up the signal : Promoting endurance training adaptation in skeletal muscle by nutritional manipulation

Hawley, John and Morton, James. (2014). Ramping up the signal : Promoting endurance training adaptation in skeletal muscle by nutritional manipulation. Clinical and Experimental Pharmacology & Physiology. 41(8), pp. 608 - 613. https://doi.org/10.1111/1440-1681.12246

Single and combined effects of beetroot juice and caffeine supplementation on cycling time trial performance

Lane, Stephen C., Hawley, John, Desbrow, Ben, Jones, Andrew M., Blackwell, James R., Ross, Megan L. L., Zemski, Adam J. and Burke, Louise. (2014). Single and combined effects of beetroot juice and caffeine supplementation on cycling time trial performance. 39(9), pp. 1050 - 1057. https://doi.org/10.1139/apnm-2013-0336

'Exercise snacks' before meals: A novel strategy to improve glycaemic control in individuals with insulin resistance

Francois, Monique, Baldi, James, Manning, Patrick, Lucas, Samuel, Hawley, John Alan, Williams, Michael and Cotter, James. (2014). 'Exercise snacks' before meals: A novel strategy to improve glycaemic control in individuals with insulin resistance. Diabetologia. 57(7), pp. 1437 - 1445. https://doi.org/10.1007/s00125-014-3244-6

Mitochondrial function in metabolic health: A genetic and environmental tug of war

Stephenson, Erin and Hawley, John Alan. (2014). Mitochondrial function in metabolic health: A genetic and environmental tug of war. Biochimica et Biophysica Acta. 1840(4), pp. 1285 - 1294. https://doi.org/10.1016/j.bbagen.2013.12.004

Single and combined effects of betroot juice and caffeine supplementation on cycling time trial performance

Lane, Stephen, Hawley, John, Desbrow, Ben, Jones, Andrew, Blackwell, James, Ross, Megan, Zemski, Adam and Burke, Louise. (2014). Single and combined effects of betroot juice and caffeine supplementation on cycling time trial performance. Applied Physiology, Nutrition and Metabolism. 39(9), pp. 1050 - 1057. https://doi.org/10.1139/apnm-2013-0336

Beyond muscle hypertrophy: Why dietary protein is important for endurance athletes

Moore, Daniel, Camera, Donny, Areta, José and Hawley, John A.. (2014). Beyond muscle hypertrophy: Why dietary protein is important for endurance athletes. Applied Physiology, Nutrition and Metabolism. 39(9), pp. 987 - 997. https://doi.org/10.1139/apnm-2013-0591

Integrative Biology of Exercise

Hawley, John A., Hargreaves, Mark, Joyner, Michael J. and Zierath, Juleen R.. (2014). Integrative Biology of Exercise. Cell. 159(4), pp. 738 - 749. https://doi.org/10.1016/j.cell.2014.10.029

The relationship between exercise, nutrition and type 2 diabetes

Stephenson, Erin J., Smiles, William and Hawley, John Alan. (2014). The relationship between exercise, nutrition and type 2 diabetes. Medicine and Sport Science. 60, pp. 1 - 10. https://doi.org/10.1159/000357331

Increasing leucine concentration stimulates mechanistic target of rapamycin signaling an cell growth in C2C12 skeletal muscle cells

Areta, José, Hawley, John A., Ye, Ji-Ming, Chan, M. H. Stanley and Coffey, Vernon. (2014). Increasing leucine concentration stimulates mechanistic target of rapamycin signaling an cell growth in C2C12 skeletal muscle cells. Nutrition Research. 34(11), pp. 1000 - 1007. https://doi.org/10.1016/j.nutres.2014.09.011

Reduced resting skeletal muscle protein synthesis is reduced by resistance exercise and protein ingestion following short-term energy deficit

Areta, José, Burke, Louise, Camera, Donny, West, Daniel, Crawshay, Siobhan, Moore, Daniel, Stellingwerff, Trent, Phillips, Stuart, Hawley, John A. and Coffey, Vernon. (2014). Reduced resting skeletal muscle protein synthesis is reduced by resistance exercise and protein ingestion following short-term energy deficit. American Journal of Physiology - Endocrinology and Metabolism. 306(8), pp. E989 - E997. https://doi.org/10.1152/ajpendo.00590.2013

Ramping up the signal: Promoting endurance training adaptation in skeletal muscle by nutritional manipulation

Hawley, John Alan and Morton, James. (2014). Ramping up the signal: Promoting endurance training adaptation in skeletal muscle by nutritional manipulation. Clinical and Experimental Pharmacology & Physiology. 41(8), pp. 608 - 613. https://doi.org/10.1111/1440-1681.12246

Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis

Rao, Rajesh, Long, Jonathan, White, James, Svensson, Katrin, Lou, Jesse, Lokurkar, Isha, Jedrychowski, Mark, Ruas, Jorge, Wrann, Christiane, Lo, James, Camera, Donny, Lachey, Jenn, Gygi, Steven, Seehra, Jasbir, Hawley, John and Spiegelman, Bruce. (2014). Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis. Cell. 157(6), pp. 1279 - 1291. https://doi.org/10.1016/j.cell.2014.03.065

Integrative biology of exercise

Hawley, John A., Hargreaves, Mark, Joyner, Michael J. and Zierath, Juleen R.. (2014). Integrative biology of exercise. Cell. 159(6), pp. 738 - 749. https://doi.org/10.1016/j.cell.2014.10.029

Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis

Rao, Rajesh, Long, Jonathan Z., White, James P., Svensson, Katrin J., Lou, Jesse, Lokurkar, Isha, Jedrychowski, Mark P., Ruas, Jorge L., Wrann, Christine D., Camera, Donny, Lachey, Jenn, Gygi, Steven, Seehra, Jasbir, Hawley, John and Spiegelman, Bruce M.. (2014). Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis. Cell. 157(6), pp. 1279 - 1291. https://doi.org/10.1016/j.cell.2014.03.065

Acute changes to biomarkers as a consequence of prolonged strenuous running

Bird, Stephen R., Linden, Matthew and Hawley, John Alan. (2014). Acute changes to biomarkers as a consequence of prolonged strenuous running. Annals of Clinical Biochemistry. 51(2), pp. 137 - 150. https://doi.org/10.1177/0004563213492147

Two weeks of reduced-volume sprint interval or traditional exercise training does not improve metabolic functioning in sedentary obese men

Skleryk, J, Karagounis, Leonidas, Hawley, John, Sharman, Matthew, Laursen, Paul and Watson, Greg. (2013). Two weeks of reduced-volume sprint interval or traditional exercise training does not improve metabolic functioning in sedentary obese men. Diabetes, Obesity and Metabolism: a journal of pharmacology and therapeutics. https://doi.org/10.1111/dom.12150

Nutritional strategies to modulate the adaptive response to endurance training

Hawley, John Alan. (2013). Nutritional strategies to modulate the adaptive response to endurance training. Nestle Nutrition Institute Workshop Series. 75, pp. 1 - 14. https://doi.org/10.1159/000345813

Exercise training enhances white adipose tissue metabolism in rats selectively bred for low- or high-endurance running capacity

Stephenson, Erin, Lessard, Sarah, Rivas, Donato, Watt, Matthew, Yaspelkis III, Ben, Koch, Lauren, Britton, Steven and Hawley, John. (2013). Exercise training enhances white adipose tissue metabolism in rats selectively bred for low- or high-endurance running capacity. American Journal of Physiology - Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.00544.2012

Caffeine ingestion and cycling power output in a low or normal muscle glycogen state

Lane, Suzanne, Areta, José, Bird, S, Coffey, Vernon, Burke, Louise, Desbrow, B, Karagounis, L and Hawley, John A.. (2013). Caffeine ingestion and cycling power output in a low or normal muscle glycogen state. Medicine and Science in Sports and Exercise. https://doi.org/10.1249/MSS.0b013e31828af183

Effect of a carbohydrate mouth rinse on simulated cycling time-trial performance commenced in a fed or fasted state

Lane, Stephen, Bird, S, Burke, Louise and Hawley, John. (2013). Effect of a carbohydrate mouth rinse on simulated cycling time-trial performance commenced in a fed or fasted state. Applied Physiology, Nutrition and Metabolism. https://doi.org/10.1139/apnm-2012-0300

ERK1/2 in the brain mediates the effects of central resistin on reducing thermogenesis in brown adipose tissue

Kosari, Samin, Camera, Donny Michael, Hawley, John Alan, Stebbing, Martin and Badoer, Emilio. (2013). ERK1/2 in the brain mediates the effects of central resistin on reducing thermogenesis in brown adipose tissue. International Journal of Physiology, Pathophysiology and Pharmacology. 5(3), pp. 184 - 189.

Preexercise aminoacidemia and muscle protein synthesis after resistance exercise

Burke, Louise, Hawley, John, Ross, M, Moore, Daniel, Phillips, S, Slater, G, Stellingwerff, T, Tipton, K, Garnham, A and Coffey, Vernon. (2012). Preexercise aminoacidemia and muscle protein synthesis after resistance exercise. Medicine and Science in Sports and Exercise. 44(10), pp. 1968 - 1977. https://doi.org/10.1249/MSS.0b013e31825d28fa

Skeletal muscle respiratory capacity is enhanced in rats consuming an obesogenic Western diet

Stephenson, E, Camera, Donny, Jenkins, T, Kosari, S, Lee, Joohyung, Hawley, John and Stepto, N. (2012). Skeletal muscle respiratory capacity is enhanced in rats consuming an obesogenic Western diet. American Journal of Physiology - Endocrinology and Metabolism. 302(12), pp. E1541 - E1549. https://doi.org/10.1152/ajpendo.00590.2011

What's new since Hippocrates? : Preventing type 2 diabetes by physical exercise and diet

Hawley, John and Gibala, M. (2012). What's new since Hippocrates? : Preventing type 2 diabetes by physical exercise and diet. Diabetologia. 55(3), pp. 535 - 539. https://doi.org/10.1007/s00125-012-2460-1

Daytime pattern of post-exercise protein intake affects whole-body protein turnover in resistance-trained males

Moore, Daniel, Areta, José, Coffey, Vernon, Stellingwerff, Trent, Phillips, Stuart, Burke, Louise, Cleroux, Marilyn, Godin, Jean-Philippe and Hawley, John Alan. (2012). Daytime pattern of post-exercise protein intake affects whole-body protein turnover in resistance-trained males. Nutrition and Metabolism. 9(91), pp. 1 - 5. https://doi.org/10.1186/1743-7075-9-91

Divergent skeletal muscle respiratory capacities in rats artificially selected for high and low running ability : A role for Nor1?

Stephenson, E, Stepto, N, Koch, L, Britton, S and Hawley, John. (2012). Divergent skeletal muscle respiratory capacities in rats artificially selected for high and low running ability : A role for Nor1? Journal of Applied Physiology. 113(9), pp. 1403 - 1412. https://doi.org/10.1152/japplphysiol.00788.2012

Reply from M. J. Gibala, J. P. Little, M. J. MadDonald and J. A. Hawley

Gibala, M. J., Little, John, Macdonald, M. J. and Hawley, John. (2012). Reply from M. J. Gibala, J. P. Little, M. J. MadDonald and J. A. Hawley. The Journal of Physiology. 590(14), pp. 3391 - 3391. https://doi.org/10.1113/jphysiol.2012.235127

Preexercise nutrient timing in endurance activity

Broad, E., Karagounis, L. and Hawley, John Alan. (2012). Preexercise nutrient timing in endurance activity. In In C. M. Kerksick (Ed.). Nutrient Timing: Metabolic Optimization for Health, Performance, and Recovery pp. 118 - 118 Taylor & Francis.

Sex-based comparisons of myofibrillar protein synthesis after resistance exercise in the fed state

West, D, Burd, N, Churchward-Venne, T, Camera, Donny, Mitchell, Cameron, Baker, S, Hawley, John, Coffey, Vernon and Phillips, S. (2012). Sex-based comparisons of myofibrillar protein synthesis after resistance exercise in the fed state. Journal of Applied Physiology. 112(11), pp. 1805 - 1813. https://doi.org/10.1152/japplphysiol.00170.2012

Low muscle glycogen concentration does not suppress the anabolic response to resistance exercise

Camera, Donny, West, D, Burd, N, Phillips, S, Garnham, A, Hawley, John and Coffey, Vernon. (2012). Low muscle glycogen concentration does not suppress the anabolic response to resistance exercise. Journal of Applied Physiology. 113(2), pp. 206 - 214. https://doi.org/10.1152/japplphysiol.00395.2012

Physiological adaptations to low-volume, high-intensity interval training in health and disease

Gibala, M, Little, John, Macdonald, M and Hawley, John. (2012). Physiological adaptations to low-volume, high-intensity interval training in health and disease. The Journal of Physiology. 590(5), pp. 1077 - 1084. https://doi.org/10.1113/jphysiol.2011.224725

Nutrient provision increases signalling and protein synthesis in human skeletal muscle after repeated sprints

Coffey, Vernon, Moore, Daniel, Burd, N, Rerecich, T, Stellingwerff, T, Garnham, A, Phillips, S and Hawley, John. (2011). Nutrient provision increases signalling and protein synthesis in human skeletal muscle after repeated sprints. European Journal of Applied Physiology. 111(7), pp. 1473 - 1483. https://doi.org/10.1007/s00421-010-1768-0

Rapid aminoacidemia enhances myofibrillar protein synthesis and anabolic intramuscular signaling responses after resistance exercise

West, D, Burd, N, Coffey, Vernon, Baker, S, Burke, Louise, Hawley, John, Moore, Daniel, Stellingwerff, T and Phillips, S. (2011). Rapid aminoacidemia enhances myofibrillar protein synthesis and anabolic intramuscular signaling responses after resistance exercise. American Journal of Clinical Nutrition: A journal reporting the practical application of our world-wide knowledge of nutrition. 94(3), pp. 795 - 803. https://doi.org/10.3945/ajcn.111.013722

Nutritional modulation of training-induced skeletal muscle adaptations

Hawley, John, Burke, Louise, Phillips, S and Spriet, L. (2011). Nutritional modulation of training-induced skeletal muscle adaptations. Journal of Applied Physiology. 110(3), pp. 834 - 845. https://doi.org/10.1152/japplphysiol.00949.2010

Single-leg cycle training is superior to double-leg cycling in improving the oxidative potential and metabolic profile of trained skeletal muscle

Abbiss, Chris, Karagounis, L, Laursen, P, Peiffer, J, Martin, D, Hawley, John, Fatehee, N and Martin, J.. (2011). Single-leg cycle training is superior to double-leg cycling in improving the oxidative potential and metabolic profile of trained skeletal muscle. Journal of Applied Physiology. 110(5), pp. 1248 - 1255. https://doi.org/10.1152/japplphysiol.01247.2010

Carbohydrates for training and competition

Burke, Louise, Hawley, John, Wong, S and Jeukendrup, A. (2011). Carbohydrates for training and competition. Journal of Sports Sciences. 29(Suppl 1), pp. S17 - S27. https://doi.org/10.1080/02640414.2011.585473

Exercise training reverses impaired skeletal muscle metabolism induced by artificial selection for low aerobic capacity

Lessard, S, Rivas, D, Stephenson, E, Yaspelkis, Koch, L, Britton, S, Hawley, John and III, B Yaspelkis. (2011). Exercise training reverses impaired skeletal muscle metabolism induced by artificial selection for low aerobic capacity. American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 300(1), pp. R175 - R182. https://doi.org/10.1152/ajpregu.00338.2010

Low intrinsic running capacity is associated with reduced skeletal muscle substrate oxidation and lower mitochondrial content in white skeletal muscle

Rivas, D, Lessard, S, Saito, M, Friedhuber, A, Koch, L, Britton, S, Yaspelkis III, B and Hawley, John. (2011). Low intrinsic running capacity is associated with reduced skeletal muscle substrate oxidation and lower mitochondrial content in white skeletal muscle. American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 300(4), pp. 835 - 843. https://doi.org/10.1152/ajpregu.00659.2010

Substrate oxidation

Hawley, John A.. (2010). Substrate oxidation. In In Connes, Philippe, Hue, Olivier and Perrey, Stéphane (Ed.). Exercise physiology : From a cellular to an integrative approach pp. 340-347 IOS Press.

The effect of exercise on the skeletal muscle phospholipidome of rats fed a high-fat diet

Mitchell, Todd, Turner, Nigel, Else, Paul, Hulbert, Anthony and Hawley, John. (2010). The effect of exercise on the skeletal muscle phospholipidome of rats fed a high-fat diet. International Journal of Molecular Sciences. 11(10), pp. 3954 - 3964. https://doi.org/10.3390/ijms11103954

Acute signalling responses to intense endurance training commenced with low or normal muscle glycogen : Experimental Physiology-Research Paper

Yeo, W, McGee, S, Carey, A, Paton, C, Garnham, A, Hargreaves, M and Hawley, John. (2010). Acute signalling responses to intense endurance training commenced with low or normal muscle glycogen : Experimental Physiology-Research Paper. Experimental Physiology. 95(2), pp. 351 - 358. https://doi.org/10.1113/expphysiol.2009.049353

Reply

Hawley, John and Martin, David. (2010). Reply. International Journal of Sports Physiology and Performance. 5(4), pp. 434 - 436.

Early time course of akt phosphorylation after endurance and resistance exercise

Camera, Donny, Edge, J, Short, M, Hawley, John and Coffey, Vernon. (2010). Early time course of akt phosphorylation after endurance and resistance exercise. Medicine and Science in Sports and Exercise. 42(10), pp. 1843 - 1852. https://doi.org/10.1249/MSS.0b013e3181d964e4

Short-term endurance training does not alter the oxidative capacity of human subcutaneous adipose tissue

Camera, Donny, Anderson, Malcolm, Hawley, John and Carey, A. (2010). Short-term endurance training does not alter the oxidative capacity of human subcutaneous adipose tissue. European Journal of Applied Physiology. 109(2), pp. 307 - 316. https://doi.org/10.1007/s00421-010-1356-3

Contraction-induced changes in TNFalpha and Akt-mediated signalling are associated with increased myofibrillar protein in rat skeletal muscle

Karagounis, L, Yaspelkis III, B, Reeder, D, Lancaster, G, Hawley, John and Coffey, Vernon. (2010). Contraction-induced changes in TNFalpha and Akt-mediated signalling are associated with increased myofibrillar protein in rat skeletal muscle. European Journal of Applied Physiology. 109(5), pp. 839 - 848. https://doi.org/10.1007/s00421-010-1427-5

Gamma tocopherol supplementation prevents exercise induced coagulation and platelet aggregation

Vucinic, L, Singh, I, Spargo, F, Hawley, John and Linden, M. (2010). Gamma tocopherol supplementation prevents exercise induced coagulation and platelet aggregation. Thrombosis Research: vascular obstruction, hemorrhage and hemostasis. 125(2), pp. 196 - 199. https://doi.org/10.1016/j.thromres.2009.11.015

Carbohydrate availability and training adaptation: Effects on cell metabolism

Hawley, John and Burke, Louise. (2010). Carbohydrate availability and training adaptation: Effects on cell metabolism. Exercise and Sport Sciences Reviews. 38(4), pp. 152 - 160. https://doi.org/10.1097/JES.0b013e3181f44dd9

Daily training with high carbohydrate availability increases exogenous carbohydrate oxidation during endurance cycling

Cox, Geoffrey, Clark, Sally, Cox, A, Halson, Shona, Hargreaves, M, Hawley, John, Jeacocke, N, Snow, Rod, Yeo, W and Burke, Louise. (2010). Daily training with high carbohydrate availability increases exogenous carbohydrate oxidation during endurance cycling. Journal of Applied Physiology. 109(1), pp. 126 - 134. https://doi.org/10.1152/japplphysiol.00950.2009

Aerobic training reverses high-fat diet-induced pro-inflammatory signalling in rat skeletal muscle

Yaspelkis III, B, Kvasha, I, Lessard, S, Rivas, D and Hawley, John. (2010). Aerobic training reverses high-fat diet-induced pro-inflammatory signalling in rat skeletal muscle. European Journal of Applied Physiology. 110(4), pp. 779 - 788. https://doi.org/10.1007/s00421-010-1559-7

Cytokine responses to carbohydrate ingestion during recovery from exercise-induced muscle injury

Ross, M, Halson, Shona, Suzuki, K, Garnham, A, Hawley, John, Cameron-Smith, David and Peake, J. (2010). Cytokine responses to carbohydrate ingestion during recovery from exercise-induced muscle injury. Journal of Interferon and Cytokine Research. 30(5), pp. 329 - 337. https://doi.org/10.1089/jir.2009.0079

Skeletal muscle : increasing the size of the locomotor cell

Karagounis, L and Hawley, John. (2010). Skeletal muscle : increasing the size of the locomotor cell. The International Journal of Biochemistry and Cell Biology. 42(9), pp. 1376 - 1379. https://doi.org/10.1016/j.biocel.2010.05.013

Global gene expression in skeletal muscle from well-trained strength and endurance athletes

Stepto, Nigel K., Coffey, Vernon Glenn, Carey, Andrew L., Ponnampalam, Anna P., Canny, Benedict J., Powell, David and Hawley, John Alan. (2009). Global gene expression in skeletal muscle from well-trained strength and endurance athletes. Medicine and Science in Sports and Exercise. 41(3), pp. 546 - 565. https://doi.org/10.1249/MSS.0b013e31818c6be9

Effect of consecutive repeated sprint and resistance exercise bouts on acute adaptive responses in human skeletal muscle

Coffey, Vernon Glenn, Jemiolo, Bozena, Edge, Johann, Garnham, Andrew P., Trappe, Scott W. and Hawley, John Alan. (2009). Effect of consecutive repeated sprint and resistance exercise bouts on acute adaptive responses in human skeletal muscle. American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 297(5), pp. 1441 - 1451. https://doi.org/10.1152/ajpregu.00351.2009

Exercise intensity and insulin sensitivity: How low can you go?

Hawley, John Alan and Gibala, M. J.. (2009). Exercise intensity and insulin sensitivity: How low can you go? Diabetologia. 52(9), pp. 1709 - 1713. https://doi.org/10.1007/s00125-009-1425-5

Lipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside

Rivas, Donato A., Yaspelkis, Ben B., Hawley, John Alan and Lessard, Sarah J.. (2009). Lipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside. Journal of Endocrinology. 202(3), pp. 441 - 451. https://doi.org/10.1677/JOE-09-0202

Molecular responses to strength and endurance training: Are they incompatible?

Hawley, John Alan. (2009). Molecular responses to strength and endurance training: Are they incompatible? Applied Physiology, Nutrition and Metabolism. 34(3), pp. 355 - 361. https://doi.org/10.1139/H09-023

The 5' adenosine monophosphate-activated protein kinase: Regulating the ebb and flow of cellular energetics

Karagounis, Leonidas G. and Hawley, John Alan. (2009). The 5' adenosine monophosphate-activated protein kinase: Regulating the ebb and flow of cellular energetics. The International Journal of Biochemistry and Cell Biology. 41(12), pp. 2360 - 2363. https://doi.org/10.1016/j.biocel.2009.07.004

Exercise: It's the real thing!

Hawley, John Alan and Holloszy, J O.. (2009). Exercise: It's the real thing! Nutrition Reviews. 67(3), pp. 172 - 178. https://doi.org/10.1111/j.1753-4887.2009.00185.x

Impaired skeletal muscle beta-adrenergic activation and lipolysis are associated with whole-body insulin resistance in rats bred for low intrinsic exercise capacity

Lessard, Sarah J., Rivas, Donato A., Chen, Zhu-Ping, van Denderen, Bryce J., Watt, Matthew J., Koch, Lauren G., Britton, Steven L., Kemp, Bruce Ernest and Hawley, John Alan. (2009). Impaired skeletal muscle beta-adrenergic activation and lipolysis are associated with whole-body insulin resistance in rats bred for low intrinsic exercise capacity. Endocrinology. 150(11), pp. 4883 - 4891. https://doi.org/10.1210/en.2009-0158

Spectroscopic correlation analysis of NMR-based metabonomics in exercise science

Kirwan, Gemma M., Coffey, Vernon Glenn, Niere, Julie O., Hawley, John Alan and Adams, Michael J.. (2009). Spectroscopic correlation analysis of NMR-based metabonomics in exercise science. Analytica Chimica Acta. 652(1-2), pp. 173 - 179. https://doi.org/10.1016/j.aca.2009.07.011

Consecutive bouts of diverse contractile activity alter acute responses in human skeletal muscle

Coffey, Vernon Glenn, Pilegaard, Henriette, Garnham, Andrew P., O'Brien, Brendan J. and Hawley, John Alan. (2009). Consecutive bouts of diverse contractile activity alter acute responses in human skeletal muscle. Journal of Applied Physiology. 106(4), pp. 1187 - 1197. https://doi.org/10.1152/japplphysiol.91221.2008

Specificity of training adaptation: Time for a rethink?

Hawley, John Alan. (2008). Specificity of training adaptation: Time for a rethink? The Journal of Physiology. 586(1), pp. 1 - 2. https://doi.org/10.1113/jphysiol.2007.147397

Evidence for presribing exercise as a therapy for treating patients with type 2 diabetes

Lessard, Sarah J. and Hawley, John Alan. (2008). Evidence for presribing exercise as a therapy for treating patients with type 2 diabetes. In In J.A. Hawley and J. R. Zierath (Ed.). Physical activity and type 2 diabetes: Therapeutic effects and mechanisms of action pp. 203 - 214 Human Kinetics Publishers Inc..

The effects of polyphenols in olive leaves on platelet function

Singh, Indu, Mok, Michelle, Christensen, Anne-Marie, Turner, Alan H. and Hawley, John Alan. (2008). The effects of polyphenols in olive leaves on platelet function. Nutrition Metabolism and Cardiovascular Diseases. 18(2), pp. 127 - 132. https://doi.org/10.1016/j.numecd.2006.09.001

Skeletal muscle adaptation and performance responses to once a day versus twice every second day endurance training regimens

Yeo, Wee Kian, Paton, Carl D., Garnham, Andrew P., Burke, Louise M., Carey, Andrew L. and Hawley, John Alan. (2008). Skeletal muscle adaptation and performance responses to once a day versus twice every second day endurance training regimens. Journal of Applied Physiology. 105(5), pp. 1462 - 1470. https://doi.org/10.1152/japplphysiol.90882.2008

Commentary on viewpoint: Exercise and cardiovascular risk reduction: Time to update the rationale for exercise?

Reid, Julianne J. and Hawley, John Alan. (2008). Commentary on viewpoint: Exercise and cardiovascular risk reduction: Time to update the rationale for exercise? Journal of Applied Physiology. 105(2), pp. 772 - 772. https://doi.org/10.1152/japplphysiol.90362.2008

Metabolic adaptations to training

Hawley, John Alan and Nader, Gustavo A.. (2008). Metabolic adaptations to training. In In M.P. Schwellnus (Ed.). Olympic textbook of medicine in sport pp. 78 - 87 Wiley-Blackwell.

Exercise training-induced improvements in insulin action

Hawley, John Alan and Lessard, S. J.. (2008). Exercise training-induced improvements in insulin action. Acta Physiologica. 192(1), pp. 127 - 135. https://doi.org/10.1111/j.1748-1716.2007.01783.x

Exercise-induced phospho-proteins in skeletal muscle

Deshmukh, A. S., Hawley, John Alan and Zierath, J. R.. (2008). Exercise-induced phospho-proteins in skeletal muscle. International Journal of Obesity. 32(SUPPL.4), pp. S18 - S23. https://doi.org/10.1038/ijo.2008.118

Activation of atypical protein kinase Czeta toward TC10 is regulated by high-fat diet and aerobic exercise in skeletal muscle

Saito, Misato, Lessard, S. J., Rivas, Donato A., Reeder, Donald W., Hawley, John Alan and Yaspelkis, Ben B.. (2008). Activation of atypical protein kinase Czeta toward TC10 is regulated by high-fat diet and aerobic exercise in skeletal muscle. Metabolism: Clinical and experimental. 57(9), pp. 1173 - 1180. https://doi.org/10.1016/j.metabol.2008.03.023

Commentary on viewpoint: Perspective on the future use of genomics in exercise prescription

Hawley, John Alan. (2008). Commentary on viewpoint: Perspective on the future use of genomics in exercise prescription. Journal of Applied Physiology. 104(4), pp. 1249 - 1249. https://doi.org/10.1152/japplphysiol.00047.2008

Oxidative stress-induced insulin resistance in skeletal muscle cells is ameliorated by gamma-tocopherol treatment

Singh, Indu, Carey, Andrew L., Watson, Nadine, Febbraio, Mark A. and Hawley, John Alan. (2008). Oxidative stress-induced insulin resistance in skeletal muscle cells is ameliorated by gamma-tocopherol treatment. European Journal of Nutrition. 47(7), pp. 387 - 392. https://doi.org/10.1007/s00394-008-0739-2

High rates of muscle glycogen resynthesis after exhaustive exercise when carbohydrate is coingested with caffeine

Pedersen, David J., Lessard, Sarah J., Coffey, Vernon Glenn, Churchley, Emmanuel G., Wootton, Andrew M., Ng, They, Watt, Matthew J. and Hawley, John Alan. (2008). High rates of muscle glycogen resynthesis after exhaustive exercise when carbohydrate is coingested with caffeine. Journal of Applied Physiology. 105(1), pp. 7 - 13. https://doi.org/10.1152/japplphysiol.01121.2007

Overweight and obesity in Australia

Hawley, John Alan and Dunstan, David Wayne. (2008). Overweight and obesity in Australia. Medical Journal of Australia. 188(11), pp. 678 - 679.

Fat adaptation followed by carbohydrate restoration increases AMPK activity in skeletal muscle from trained humans

Yeo, Wee Kian, Lessard, Sarah J., Chen, Zhi-Ping, Garnham, Andrew P., Burke, Louise, Rivas, Donato A., Kemp, Bruce Ernest and Hawley, John Alan. (2008). Fat adaptation followed by carbohydrate restoration increases AMPK activity in skeletal muscle from trained humans. Journal of Applied Physiology. 105(5), pp. 1519 - 1526. https://doi.org/10.1152/japplphysiol.90540.2008

The battle against obesity - Attacking physical inactivity as a primary means of defense

Hawley, John and Dunstan, David. (2008). The battle against obesity - Attacking physical inactivity as a primary means of defense. Nature Reviews Endocrinology. 4(10), pp. 548 - 549. https://doi.org/10.1038/ncpendmet0918